UniProtKB - P40189 (IL6RB_HUMAN)
Interleukin-6 receptor subunit beta
IL6ST
Functioni
GO - Molecular functioni
- ciliary neurotrophic factor receptor activity Source: BHF-UCL
- ciliary neurotrophic factor receptor binding Source: BHF-UCL
- cytokine binding Source: GO_Central
- cytokine receptor activity Source: GO_Central
- growth factor binding Source: BHF-UCL
- identical protein binding Source: IntAct
- interleukin-11 binding Source: Ensembl
- interleukin-11 receptor activity Source: Ensembl
- interleukin-27 receptor activity Source: BHF-UCL
GO - Biological processi
- ciliary neurotrophic factor-mediated signaling pathway Source: BHF-UCL
- cytokine-mediated signaling pathway Source: BHF-UCL
- glycogen metabolic process Source: Ensembl
- interleukin-27-mediated signaling pathway Source: BHF-UCL
- interleukin-35-mediated signaling pathway Source: Reactome
- interleukin-6-mediated signaling pathway Source: UniProtKB
- intestinal epithelial cell development Source: UniProtKB
- leukemia inhibitory factor signaling pathway Source: BHF-UCL
- negative regulation of apoptotic process Source: BHF-UCL
- negative regulation of interleukin-6-mediated signaling pathway Source: BHF-UCL
- oncostatin-M-mediated signaling pathway Source: BHF-UCL
- positive regulation of acute inflammatory response Source: BHF-UCL
- positive regulation of adaptive immune response Source: BHF-UCL
- positive regulation of astrocyte differentiation Source: Ensembl
- positive regulation of cardiac muscle hypertrophy Source: BHF-UCL
- positive regulation of cell population proliferation Source: BHF-UCL
- positive regulation of Notch signaling pathway Source: UniProtKB
- positive regulation of osteoblast differentiation Source: BHF-UCL
- positive regulation of T cell proliferation Source: BHF-UCL
- positive regulation of tyrosine phosphorylation of STAT protein Source: BHF-UCL
- positive regulation of vascular endothelial growth factor production Source: BHF-UCL
- response to cytokine Source: BHF-UCL
- viral process Source: UniProtKB-KW
Keywordsi
Molecular function | Receptor |
Biological process | Host-virus interaction |
Enzyme and pathway databases
PathwayCommonsi | P40189 |
Reactomei | R-HSA-1059683, Interleukin-6 signaling R-HSA-110056, MAPK3 (ERK1) activation [P40189-1] R-HSA-112411, MAPK1 (ERK2) activation [P40189-1] R-HSA-6788467, IL-6-type cytokine receptor ligand interactions R-HSA-8984722, Interleukin-35 Signalling R-HSA-9020956, Interleukin-27 signaling |
SignaLinki | P40189 |
SIGNORi | P40189 |
Names & Taxonomyi
Protein namesi | Recommended name: Interleukin-6 receptor subunit betaCuratedShort name: IL-6 receptor subunit beta Short name: IL-6R subunit beta Short name: IL-6R-beta Short name: IL-6RB Alternative name(s): CDw130 Interleukin-6 signal transducer Membrane glycoprotein 130 Short name: gp1301 Publication Oncostatin-M receptor subunit alpha CD_antigen: CD130 |
Gene namesi | Name:IL6STImported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6021, IL6ST |
MIMi | 600694, gene |
neXtProti | NX_P40189 |
VEuPathDBi | HostDB:ENSG00000134352.19 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein Sequence analysis
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
- extracellular space Source: BHF-UCL
Plasma Membrane
- ciliary neurotrophic factor receptor complex Source: BHF-UCL
- external side of plasma membrane Source: GO_Central
- interleukin-6 receptor complex Source: BHF-UCL
- oncostatin-M receptor complex Source: BHF-UCL
- plasma membrane Source: Reactome
Other locations
- dendrite Source: Ensembl
- membrane Source: UniProtKB
- neuronal cell body Source: Ensembl
- receptor complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 23 – 619 | ExtracellularSequence analysisAdd BLAST | 597 | |
Transmembranei | 620 – 641 | HelicalSequence analysisAdd BLAST | 22 | |
Topological domaini | 642 – 918 | CytoplasmicSequence analysisAdd BLAST | 277 |
Keywords - Cellular componenti
Cell membrane, Membrane, SecretedPathology & Biotechi
Involvement in diseasei
Hyper-IgE recurrent infection syndrome 4, autosomal recessive (HIES4)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_083197 | 404 | N → Y in HIES4; results in defective cytokine-mediated signaling pathway. 1 Publication | 1 | |
Natural variantiVAR_083198 | 498 | P → L in HIES4; results in defective cytokine-mediated signaling pathway. 1 Publication | 1 |
Biotechnological usei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 172 | C → S: Induces ligand-independent activation. 1 Publication | 1 | |
Mutagenesisi | 186 – 190 | Missing : Induces ligand-independent activation. 1 Publication | 5 | |
Mutagenesisi | 189 | V → G: Does not induce ligand-independent activation. 1 Publication | 1 | |
Mutagenesisi | 190 | Y → G: Does not induce ligand-independent activation. 1 Publication | 1 | |
Mutagenesisi | 215 | D → G: Induces ligand-independent activation. 1 Publication | 1 | |
Mutagenesisi | 252 | V → G: Induces ligand-independent activation. 1 Publication | 1 | |
Mutagenesisi | 759 | Y → F: Refractory to inhibition by SOCS3. 1 Publication | 1 | |
Mutagenesisi | 782 | S → A: Increases cell surface expression. 1 Publication | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 3572 |
MalaCardsi | IL6ST |
MIMi | 618523, phenotype |
OpenTargetsi | ENSG00000134352 |
PharmGKBi | PA29837 |
Miscellaneous databases
Pharosi | P40189, Tclin |
Chemistry databases
ChEMBLi | CHEMBL3124734 |
DrugCentrali | P40189 |
GuidetoPHARMACOLOGYi | 2317 |
Genetic variation databases
BioMutai | IL6ST |
DMDMi | 215273999 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Add BLAST | 22 | |
ChainiPRO_0000010899 | 23 – 918 | Interleukin-6 receptor subunit betaAdd BLAST | 896 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 28 ↔ 54 | 2 Publications | ||
Glycosylationi | 43 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Disulfide bondi | 48 ↔ 103 | 2 Publications | ||
Glycosylationi | 83 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Glycosylationi | 131 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 134 ↔ 144 | 2 Publications | ||
Glycosylationi | 157 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 172 ↔ 182 | 2 Publications | ||
Glycosylationi | 227 | N-linked (GlcNAc...) asparagine3 Publications | 1 | |
Glycosylationi | 379 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Glycosylationi | 383 | N-linked (GlcNAc...) asparagine3 Publications | 1 | |
Glycosylationi | 390 | N-linked (GlcNAc...) (complex) asparagine2 Publications | 1 | |
Disulfide bondi | 458 ↔ 466 | 2 Publications | ||
Glycosylationi | 553 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Glycosylationi | 564 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Modified residuei | 661 | PhosphoserineCombined sources | 1 | |
Modified residuei | 667 | PhosphoserineCombined sources | 1 | |
Modified residuei | 782 | Phosphoserine1 Publication | 1 | |
Modified residuei | 789 | PhosphoserineBy similarity | 1 | |
Modified residuei | 829 | PhosphoserineCombined sources | 1 | |
Modified residuei | 839 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
EPDi | P40189 |
jPOSTi | P40189 |
MassIVEi | P40189 |
MaxQBi | P40189 |
PaxDbi | P40189 |
PeptideAtlasi | P40189 |
PRIDEi | P40189 |
ProteomicsDBi | 55338 [P40189-1] 55339 [P40189-2] 55340 [P40189-3] |
PTM databases
GlyConnecti | 649, 16 N-Linked glycans (9 sites) |
GlyGeni | P40189, 13 sites, 3 N-linked glycans (3 sites) |
iPTMneti | P40189 |
PhosphoSitePlusi | P40189 |
SwissPalmi | P40189 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000134352, Expressed in female gonad and 259 other tissues |
ExpressionAtlasi | P40189, baseline and differential |
Genevisiblei | P40189, HS |
Organism-specific databases
HPAi | ENSG00000134352, Low tissue specificity |
Interactioni
Subunit structurei
Component of a hexamer of two molecules each of IL6, IL6R and IL6ST; associates with the complex IL6:IL6R but does not interact with IL6 (PubMed:12829785, PubMed:2261637). Forms heterodimers composed of LIFR and IL6ST (type I OSM receptor) which are activated by LIF and OSM (PubMed:8999038). Also forms heterodimers composed of OSMR and IL6ST (type II receptor) which are activated by OSM but not by LIF (PubMed:8999038).
Interacts with HCK (PubMed:9406996).
Interacts with INPP5D/SHIP1 (By similarity).
Interacts with SRC and YES (PubMed:25731159).
By similarity6 Publications(Microbial infection) The homodimer binds two molecules of herpes virus 8/HHV-8 protein vIL-6.
2 PublicationsBinary interactionsi
Hide detailsP40189
Isoform 1 [P40189-1]
With | #Exp. | IntAct |
---|---|---|
JAK1 [P23458] | 3 | EBI-15742214,EBI-1383438 |
GO - Molecular functioni
- ciliary neurotrophic factor receptor binding Source: BHF-UCL
- cytokine binding Source: GO_Central
- growth factor binding Source: BHF-UCL
- identical protein binding Source: IntAct
- interleukin-11 binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 109786, 46 interactors |
CORUMi | P40189 |
DIPi | DIP-95N |
IntActi | P40189, 28 interactors |
MINTi | P40189 |
STRINGi | 9606.ENSP00000370698 |
Chemistry databases
BindingDBi | P40189 |
Miscellaneous databases
RNActi | P40189, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P40189 |
SMRi | P40189 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P40189 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 120 | Ig-like C2-typeAdd BLAST | 95 | |
Domaini | 125 – 216 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 92 | |
Domaini | 224 – 324 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 101 | |
Domaini | 329 – 424 | Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 426 – 517 | Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST | 92 | |
Domaini | 518 – 613 | Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST | 96 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 310 – 314 | WSXWS motif | 5 | |
Motifi | 651 – 659 | Box 1 motif | 9 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 725 – 755 | Ser-richAdd BLAST | 31 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QXEG, Eukaryota |
GeneTreei | ENSGT00940000159608 |
HOGENOMi | CLU_017990_0_0_1 |
InParanoidi | P40189 |
OMAi | YLITVYP |
PhylomeDBi | P40189 |
TreeFami | TF338122 |
Family and domain databases
CDDi | cd00063, FN3, 2 hits |
Gene3Di | 2.60.40.10, 6 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR003529, Hematopoietin_rcpt_Gp130_CS IPR013783, Ig-like_fold IPR010457, IgC2-like_lig-bd IPR015321, TypeI_recpt_CBD |
Pfami | View protein in Pfam PF00041, fn3, 2 hits PF09240, IL6Ra-bind, 1 hit PF06328, Lep_receptor_Ig, 1 hit |
SMARTi | View protein in SMART SM00060, FN3, 5 hits |
SUPFAMi | SSF49265, SSF49265, 5 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 4 hits PS01353, HEMATOPO_REC_L_F2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLTLQTWLVQ ALFIFLTTES TGELLDPCGY ISPESPVVQL HSNFTAVCVL
60 70 80 90 100
KEKCMDYFHV NANYIVWKTN HFTIPKEQYT IINRTASSVT FTDIASLNIQ
110 120 130 140 150
LTCNILTFGQ LEQNVYGITI ISGLPPEKPK NLSCIVNEGK KMRCEWDGGR
160 170 180 190 200
ETHLETNFTL KSEWATHKFA DCKAKRDTPT SCTVDYSTVY FVNIEVWVEA
210 220 230 240 250
ENALGKVTSD HINFDPVYKV KPNPPHNLSV INSEELSSIL KLTWTNPSIK
260 270 280 290 300
SVIILKYNIQ YRTKDASTWS QIPPEDTAST RSSFTVQDLK PFTEYVFRIR
310 320 330 340 350
CMKEDGKGYW SDWSEEASGI TYEDRPSKAP SFWYKIDPSH TQGYRTVQLV
360 370 380 390 400
WKTLPPFEAN GKILDYEVTL TRWKSHLQNY TVNATKLTVN LTNDRYLATL
410 420 430 440 450
TVRNLVGKSD AAVLTIPACD FQATHPVMDL KAFPKDNMLW VEWTTPRESV
460 470 480 490 500
KKYILEWCVL SDKAPCITDW QQEDGTVHRT YLRGNLAESK CYLITVTPVY
510 520 530 540 550
ADGPGSPESI KAYLKQAPPS KGPTVRTKKV GKNEAVLEWD QLPVDVQNGF
560 570 580 590 600
IRNYTIFYRT IIGNETAVNV DSSHTEYTLS SLTSDTLYMV RMAAYTDEGG
610 620 630 640 650
KDGPEFTFTT PKFAQGEIEA IVVPVCLAFL LTTLLGVLFC FNKRDLIKKH
660 670 680 690 700
IWPNVPDPSK SHIAQWSPHT PPRHNFNSKD QMYSDGNFTD VSVVEIEAND
710 720 730 740 750
KKPFPEDLKS LDLFKKEKIN TEGHSSGIGG SSCMSSSRPS ISSSDENESS
760 770 780 790 800
QNTSSTVQYS TVVHSGYRHQ VPSVQVFSRS ESTQPLLDSE ERPEDLQLVD
810 820 830 840 850
HVDGGDGILP RQQYFKQNCS QHESSPDISH FERSKQVSSV NEEDFVRLKQ
860 870 880 890 900
QISDHISQSC GSGQMKMFQE VSAADAFGPG TEGQVERFET VGMEAATDEG
910
MPKSYLPQTV RQGGYMPQ
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A494BZU0 | A0A494BZU0_HUMAN | Interleukin-6 receptor subunit beta | IL6ST | 642 | Annotation score: | ||
D6RH03 | D6RH03_HUMAN | Interleukin-6 receptor subunit beta | IL6ST | 333 | Annotation score: | ||
Q5FC05 | Q5FC05_HUMAN | IL6ST nirs variant 3 | IL6ST | 203 | Annotation score: | ||
Q5FC02 | Q5FC02_HUMAN | IL6ST nirs variant 6 | IL6ST | 66 | Annotation score: | ||
Q5FC07 | Q5FC07_HUMAN | IL6ST nirs variant 1 | IL6ST | 55 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_047782 | 8 | L → V2 PublicationsCorresponds to variant dbSNP:rs1063560Ensembl. | 1 | |
Natural variantiVAR_047783 | 148 | G → R Associated with increased levels of soluble IL6RB in blood serum. 1 PublicationCorresponds to variant dbSNP:rs2228044Ensembl. | 1 | |
Natural variantiVAR_074654 | 200 | A → G Found in patient with lung cancer; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs199905033Ensembl. | 1 | |
Natural variantiVAR_047784 | 397 | L → V. Corresponds to variant dbSNP:rs2228043Ensembl. | 1 | |
Natural variantiVAR_083197 | 404 | N → Y in HIES4; results in defective cytokine-mediated signaling pathway. 1 Publication | 1 | |
Natural variantiVAR_036165 | 415 | T → I in a colorectal cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_047785 | 454 | I → T. Corresponds to variant dbSNP:rs2228046Ensembl. | 1 | |
Natural variantiVAR_083198 | 498 | P → L in HIES4; results in defective cytokine-mediated signaling pathway. 1 Publication | 1 | |
Natural variantiVAR_047786 | 499 | V → I. Corresponds to variant dbSNP:rs34417936Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001684 | 325 – 329 | RPSKA → NIASF in isoform 2. 1 Publication | 5 | |
Alternative sequenceiVSP_001685 | 330 – 918 | Missing in isoform 2. 1 PublicationAdd BLAST | 589 | |
Alternative sequenceiVSP_043716 | 423 – 483 | Missing in isoform 3. 1 PublicationAdd BLAST | 61 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M57230 mRNA Translation: AAA59155.1 AB015706 mRNA Translation: BAA78112.1 AB102802 mRNA Translation: BAD89393.1 EF064722 Genomic DNA Translation: ABK41905.1 AC008914 Genomic DNA No translation available. AC016596 Genomic DNA No translation available. CH471123 Genomic DNA Translation: EAW54936.1 |
CCDSi | CCDS3971.1 [P40189-1] CCDS47209.1 [P40189-2] CCDS54856.1 [P40189-3] |
PIRi | A36337 |
RefSeqi | NP_001177910.1, NM_001190981.1 [P40189-3] NP_002175.2, NM_002184.3 [P40189-1] NP_786943.1, NM_175767.2 [P40189-2] |
Genome annotation databases
Ensembli | ENST00000336909; ENSP00000338799; ENSG00000134352 [P40189-1] ENST00000381287; ENSP00000370687; ENSG00000134352 [P40189-2] ENST00000381294; ENSP00000370694; ENSG00000134352 [P40189-3] ENST00000381298; ENSP00000370698; ENSG00000134352 [P40189-1] ENST00000502326; ENSP00000462158; ENSG00000134352 [P40189-1] ENST00000522633; ENSP00000435399; ENSG00000134352 [P40189-2] |
GeneIDi | 3572 |
KEGGi | hsa:3572 |
UCSCi | uc003jqq.4, human [P40189-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M57230 mRNA Translation: AAA59155.1 AB015706 mRNA Translation: BAA78112.1 AB102802 mRNA Translation: BAD89393.1 EF064722 Genomic DNA Translation: ABK41905.1 AC008914 Genomic DNA No translation available. AC016596 Genomic DNA No translation available. CH471123 Genomic DNA Translation: EAW54936.1 |
CCDSi | CCDS3971.1 [P40189-1] CCDS47209.1 [P40189-2] CCDS54856.1 [P40189-3] |
PIRi | A36337 |
RefSeqi | NP_001177910.1, NM_001190981.1 [P40189-3] NP_002175.2, NM_002184.3 [P40189-1] NP_786943.1, NM_175767.2 [P40189-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1BJ8 | NMR | - | A | 219-325 | [»] | |
1BQU | X-ray | 2.00 | A/B | 122-333 | [»] | |
1I1R | X-ray | 2.40 | A | 23-325 | [»] | |
1N2Q | model | - | A/B | 23-324 | [»] | |
1P9M | X-ray | 3.65 | A | 23-321 | [»] | |
1PVH | X-ray | 2.50 | A/C | 123-323 | [»] | |
3L5H | X-ray | 3.60 | A | 24-612 | [»] | |
3L5I | X-ray | 1.90 | A | 323-612 | [»] | |
3L5J | X-ray | 3.04 | A/B | 323-610 | [»] | |
BMRBi | P40189 | |||||
SMRi | P40189 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109786, 46 interactors |
CORUMi | P40189 |
DIPi | DIP-95N |
IntActi | P40189, 28 interactors |
MINTi | P40189 |
STRINGi | 9606.ENSP00000370698 |
Chemistry databases
BindingDBi | P40189 |
ChEMBLi | CHEMBL3124734 |
DrugCentrali | P40189 |
GuidetoPHARMACOLOGYi | 2317 |
PTM databases
GlyConnecti | 649, 16 N-Linked glycans (9 sites) |
GlyGeni | P40189, 13 sites, 3 N-linked glycans (3 sites) |
iPTMneti | P40189 |
PhosphoSitePlusi | P40189 |
SwissPalmi | P40189 |
Genetic variation databases
BioMutai | IL6ST |
DMDMi | 215273999 |
Proteomic databases
EPDi | P40189 |
jPOSTi | P40189 |
MassIVEi | P40189 |
MaxQBi | P40189 |
PaxDbi | P40189 |
PeptideAtlasi | P40189 |
PRIDEi | P40189 |
ProteomicsDBi | 55338 [P40189-1] 55339 [P40189-2] 55340 [P40189-3] |
Protocols and materials databases
Antibodypediai | 2448, 785 antibodies |
DNASUi | 3572 |
Genome annotation databases
Ensembli | ENST00000336909; ENSP00000338799; ENSG00000134352 [P40189-1] ENST00000381287; ENSP00000370687; ENSG00000134352 [P40189-2] ENST00000381294; ENSP00000370694; ENSG00000134352 [P40189-3] ENST00000381298; ENSP00000370698; ENSG00000134352 [P40189-1] ENST00000502326; ENSP00000462158; ENSG00000134352 [P40189-1] ENST00000522633; ENSP00000435399; ENSG00000134352 [P40189-2] |
GeneIDi | 3572 |
KEGGi | hsa:3572 |
UCSCi | uc003jqq.4, human [P40189-1] |
Organism-specific databases
CTDi | 3572 |
DisGeNETi | 3572 |
GeneCardsi | IL6ST |
HGNCi | HGNC:6021, IL6ST |
HPAi | ENSG00000134352, Low tissue specificity |
MalaCardsi | IL6ST |
MIMi | 600694, gene 618523, phenotype |
neXtProti | NX_P40189 |
OpenTargetsi | ENSG00000134352 |
PharmGKBi | PA29837 |
VEuPathDBi | HostDB:ENSG00000134352.19 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QXEG, Eukaryota |
GeneTreei | ENSGT00940000159608 |
HOGENOMi | CLU_017990_0_0_1 |
InParanoidi | P40189 |
OMAi | YLITVYP |
PhylomeDBi | P40189 |
TreeFami | TF338122 |
Enzyme and pathway databases
PathwayCommonsi | P40189 |
Reactomei | R-HSA-1059683, Interleukin-6 signaling R-HSA-110056, MAPK3 (ERK1) activation [P40189-1] R-HSA-112411, MAPK1 (ERK2) activation [P40189-1] R-HSA-6788467, IL-6-type cytokine receptor ligand interactions R-HSA-8984722, Interleukin-35 Signalling R-HSA-9020956, Interleukin-27 signaling |
SignaLinki | P40189 |
SIGNORi | P40189 |
Miscellaneous databases
BioGRID-ORCSi | 3572, 26 hits in 887 CRISPR screens |
ChiTaRSi | IL6ST, human |
EvolutionaryTracei | P40189 |
GeneWikii | Glycoprotein_130 |
GenomeRNAii | 3572 |
Pharosi | P40189, Tclin |
PROi | PR:P40189 |
RNActi | P40189, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000134352, Expressed in female gonad and 259 other tissues |
ExpressionAtlasi | P40189, baseline and differential |
Genevisiblei | P40189, HS |
Family and domain databases
CDDi | cd00063, FN3, 2 hits |
Gene3Di | 2.60.40.10, 6 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR003529, Hematopoietin_rcpt_Gp130_CS IPR013783, Ig-like_fold IPR010457, IgC2-like_lig-bd IPR015321, TypeI_recpt_CBD |
Pfami | View protein in Pfam PF00041, fn3, 2 hits PF09240, IL6Ra-bind, 1 hit PF06328, Lep_receptor_Ig, 1 hit |
SMARTi | View protein in SMART SM00060, FN3, 5 hits |
SUPFAMi | SSF49265, SSF49265, 5 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 4 hits PS01353, HEMATOPO_REC_L_F2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IL6RB_HUMAN | |
Accessioni | P40189Primary (citable) accession number: P40189 Secondary accession number(s): A0N0L4, Q5FC04, Q9UQ41 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | November 25, 2008 | |
Last modified: | February 10, 2021 | |
This is version 230 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries