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Protein

Interleukin-6 receptor subunit beta

Gene

IL6ST

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:2261637). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Does not bind IL6 (PubMed:2261637). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity).By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ciliary neurotrophic factor receptor activity Source: BHF-UCL
  • ciliary neurotrophic factor receptor binding Source: BHF-UCL
  • cytokine binding Source: GO_Central
  • cytokine receptor activity Source: GO_Central
  • growth factor binding Source: BHF-UCL
  • identical protein binding Source: IntAct
  • interleukin-11 binding Source: Ensembl
  • interleukin-11 receptor activity Source: Ensembl
  • interleukin-27 receptor activity Source: BHF-UCL
  • protein homodimerization activity Source: BHF-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processHost-virus interaction

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1059683 Interleukin-6 signaling
R-HSA-110056 MAPK3 (ERK1) activation
R-HSA-112411 MAPK1 (ERK2) activation
R-HSA-6788467 IL-6-type cytokine receptor ligand interactions
R-HSA-8984722 Interleukin-35 Signalling
R-HSA-9020956 Interleukin-27 signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P40189

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P40189

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interleukin-6 receptor subunit beta
Short name:
IL-6 receptor subunit beta
Short name:
IL-6R subunit beta
Short name:
IL-6R-beta
Short name:
IL-6RB
Alternative name(s):
CDw130
Interleukin-6 signal transducer
Membrane glycoprotein 130
Short name:
gp130
Oncostatin-M receptor subunit alpha
CD_antigen: CD130
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IL6ST
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000134352.19

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6021 IL6ST

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600694 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P40189

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini23 – 619ExtracellularSequence analysisAdd BLAST597
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei620 – 641HelicalSequence analysisAdd BLAST22
Topological domaini642 – 918CytoplasmicSequence analysisAdd BLAST277

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi172C → S: Induces ligand-independent activation. 1 Publication1
Mutagenesisi186 – 190Missing : Induces ligand-independent activation. 1 Publication5
Mutagenesisi189V → G: Does not induce ligand-independent activation. 1 Publication1
Mutagenesisi190Y → G: Does not induce ligand-independent activation. 1 Publication1
Mutagenesisi215D → G: Induces ligand-independent activation. 1 Publication1
Mutagenesisi252V → G: Induces ligand-independent activation. 1 Publication1
Mutagenesisi782S → A: Increases cell surface expression. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
3572

Open Targets

More...
OpenTargetsi
ENSG00000134352

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29837

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3124734

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2317

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IL6ST

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215273999

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Add BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001089923 – 918Interleukin-6 receptor subunit betaAdd BLAST896

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi28 ↔ 542 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi43N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi48 ↔ 1032 Publications
Glycosylationi83N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi131N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi134 ↔ 1442 Publications
Glycosylationi157N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi172 ↔ 1822 Publications
Glycosylationi227N-linked (GlcNAc...) asparagine3 Publications1
Glycosylationi379N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi383N-linked (GlcNAc...) asparagine3 Publications1
Glycosylationi390N-linked (GlcNAc...) (complex) asparagine2 Publications1
Disulfide bondi458 ↔ 4662 Publications
Glycosylationi553N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi564N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei661PhosphoserineCombined sources1
Modified residuei667PhosphoserineCombined sources1
Modified residuei782Phosphoserine1 Publication1
Modified residuei789PhosphoserineBy similarity1
Modified residuei829PhosphoserineCombined sources1
Modified residuei839PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation of Ser-782 down-regulates cell surface expression.1 Publication
Heavily N-glycosylated (PubMed:11098061, PubMed:16335952, PubMed:19159218, PubMed:19139490, PubMed:11251120). Glycosylation is required for protein stability and localization in plasma membrane but not for ligand binding (PubMed:19915009).6 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P40189

MaxQB - The MaxQuant DataBase

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MaxQBi
P40189

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P40189

PeptideAtlas

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PeptideAtlasi
P40189

PRoteomics IDEntifications database

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PRIDEi
P40189

ProteomicsDB human proteome resource

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ProteomicsDBi
55338
55339 [P40189-2]
55340 [P40189-3]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
649

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P40189

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P40189

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P40189

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
P40189

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found in all the tissues and cell lines examined (PubMed:2261637). Expression not restricted to IL6 responsive cells (PubMed:2261637). Expressed in blood serum (at protein level) (PubMed:24629561).2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

LIF and OSM activate the type I OSM receptor while only OSM can activate the type II OSM receptor.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000134352 Expressed in 248 organ(s), highest expression level in female gonad

CleanEx database of gene expression profiles

More...
CleanExi
HS_IL6ST

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P40189 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P40189 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB025784
HPA010558

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a hexamer of two molecules each of IL6, IL6R and IL6ST (PubMed:12829785). Forms heterodimers composed of LIFR and IL6ST (type I OSM receptor) which are activated by LIF and OSM (PubMed:8999038). Also forms heterodimers composed of OSMR and IL6ST (type II receptor) which are activated by OSM but not by LIF (PubMed:8999038). Homodimer. Interacts with HCK (PubMed:9406996). Interacts with INPP5D/SHIP1 (By similarity).By similarity4 Publications
(Microbial infection) The homodimer binds two molecules of herpes virus 8/HHV-8 protein vIL-6.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
109786, 33 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P40189

Database of interacting proteins

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DIPi
DIP-95N

Protein interaction database and analysis system

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IntActi
P40189, 22 interactors

Molecular INTeraction database

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MINTi
P40189

STRING: functional protein association networks

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STRINGi
9606.ENSP00000338799

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P40189

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1918
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P40189

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P40189

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P40189

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 120Ig-like C2-typeAdd BLAST95
Domaini125 – 216Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST92
Domaini224 – 324Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST101
Domaini329 – 424Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST96
Domaini426 – 517Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST92
Domaini518 – 613Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST96

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi310 – 314WSXWS motif5
Motifi651 – 659Box 1 motif9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi725 – 755Ser-richAdd BLAST31

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IF1N Eukaryota
ENOG410YNQ4 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159608

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000015771

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052119

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P40189

KEGG Orthology (KO)

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KOi
K05060

Identification of Orthologs from Complete Genome Data

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OMAi
MMCQWDP

Database of Orthologous Groups

More...
OrthoDBi
EOG091G01XM

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P40189

TreeFam database of animal gene trees

More...
TreeFami
TF338122

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 6 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR003529 Hematopoietin_rcpt_Gp130_CS
IPR013783 Ig-like_fold
IPR010457 IgC2-like_lig-bd
IPR015321 TypeI_recpt_CBD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 2 hits
PF09240 IL6Ra-bind, 1 hit
PF06328 Lep_receptor_Ig, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 5 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF49265 SSF49265, 5 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50853 FN3, 4 hits
PS01353 HEMATOPO_REC_L_F2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P40189-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLTLQTWLVQ ALFIFLTTES TGELLDPCGY ISPESPVVQL HSNFTAVCVL
60 70 80 90 100
KEKCMDYFHV NANYIVWKTN HFTIPKEQYT IINRTASSVT FTDIASLNIQ
110 120 130 140 150
LTCNILTFGQ LEQNVYGITI ISGLPPEKPK NLSCIVNEGK KMRCEWDGGR
160 170 180 190 200
ETHLETNFTL KSEWATHKFA DCKAKRDTPT SCTVDYSTVY FVNIEVWVEA
210 220 230 240 250
ENALGKVTSD HINFDPVYKV KPNPPHNLSV INSEELSSIL KLTWTNPSIK
260 270 280 290 300
SVIILKYNIQ YRTKDASTWS QIPPEDTAST RSSFTVQDLK PFTEYVFRIR
310 320 330 340 350
CMKEDGKGYW SDWSEEASGI TYEDRPSKAP SFWYKIDPSH TQGYRTVQLV
360 370 380 390 400
WKTLPPFEAN GKILDYEVTL TRWKSHLQNY TVNATKLTVN LTNDRYLATL
410 420 430 440 450
TVRNLVGKSD AAVLTIPACD FQATHPVMDL KAFPKDNMLW VEWTTPRESV
460 470 480 490 500
KKYILEWCVL SDKAPCITDW QQEDGTVHRT YLRGNLAESK CYLITVTPVY
510 520 530 540 550
ADGPGSPESI KAYLKQAPPS KGPTVRTKKV GKNEAVLEWD QLPVDVQNGF
560 570 580 590 600
IRNYTIFYRT IIGNETAVNV DSSHTEYTLS SLTSDTLYMV RMAAYTDEGG
610 620 630 640 650
KDGPEFTFTT PKFAQGEIEA IVVPVCLAFL LTTLLGVLFC FNKRDLIKKH
660 670 680 690 700
IWPNVPDPSK SHIAQWSPHT PPRHNFNSKD QMYSDGNFTD VSVVEIEAND
710 720 730 740 750
KKPFPEDLKS LDLFKKEKIN TEGHSSGIGG SSCMSSSRPS ISSSDENESS
760 770 780 790 800
QNTSSTVQYS TVVHSGYRHQ VPSVQVFSRS ESTQPLLDSE ERPEDLQLVD
810 820 830 840 850
HVDGGDGILP RQQYFKQNCS QHESSPDISH FERSKQVSSV NEEDFVRLKQ
860 870 880 890 900
QISDHISQSC GSGQMKMFQE VSAADAFGPG TEGQVERFET VGMEAATDEG
910
MPKSYLPQTV RQGGYMPQ
Length:918
Mass (Da):103,537
Last modified:November 25, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6510A4409FFCF08C
GO
Isoform 2 (identifier: P40189-2) [UniParc]FASTAAdd to basket
Also known as: GP130-RAPS

The sequence of this isoform differs from the canonical sequence as follows:
     325-329: RPSKA → NIASF
     330-918: Missing.

Show »
Length:329
Mass (Da):37,499
Checksum:iD556124C867984E4
GO
Isoform 3 (identifier: P40189-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     423-483: Missing.

Show »
Length:857
Mass (Da):96,276
Checksum:i726208A5073B5451
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5FC05Q5FC05_HUMAN
IL6ST nirs variant 3
IL6ST
203Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RH03D6RH03_HUMAN
Interleukin-6 receptor subunit beta
IL6ST
333Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5FC07Q5FC07_HUMAN
IL6ST nirs variant 1
IL6ST
55Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5FC02Q5FC02_HUMAN
IL6ST nirs variant 6
IL6ST
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0477828L → V2 PublicationsCorresponds to variant dbSNP:rs1063560Ensembl.1
Natural variantiVAR_047783148G → R Polymorphism; associated with increased levels of soluble IL6RB in blood serum. 1 PublicationCorresponds to variant dbSNP:rs2228044Ensembl.1
Natural variantiVAR_074654200A → G Found in patient with lung cancer; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs199905033Ensembl.1
Natural variantiVAR_047784397L → V. Corresponds to variant dbSNP:rs2228043Ensembl.1
Natural variantiVAR_036165415T → I in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_047785454I → T. Corresponds to variant dbSNP:rs2228046Ensembl.1
Natural variantiVAR_047786499V → I. Corresponds to variant dbSNP:rs34417936Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_001684325 – 329RPSKA → NIASF in isoform 2. 1 Publication5
Alternative sequenceiVSP_001685330 – 918Missing in isoform 2. 1 PublicationAdd BLAST589
Alternative sequenceiVSP_043716423 – 483Missing in isoform 3. 1 PublicationAdd BLAST61

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M57230 mRNA Translation: AAA59155.1
AB015706 mRNA Translation: BAA78112.1
AB102802 mRNA Translation: BAD89393.1
EF064722 Genomic DNA Translation: ABK41905.1
AC008914 Genomic DNA No translation available.
AC016596 Genomic DNA No translation available.
CH471123 Genomic DNA Translation: EAW54936.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3971.1 [P40189-1]
CCDS47209.1 [P40189-2]
CCDS54856.1 [P40189-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
A36337

NCBI Reference Sequences

More...
RefSeqi
NP_001177910.1, NM_001190981.1 [P40189-3]
NP_002175.2, NM_002184.3 [P40189-1]
NP_786943.1, NM_175767.2 [P40189-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.532082
Hs.706627

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000336909; ENSP00000338799; ENSG00000134352 [P40189-1]
ENST00000381287; ENSP00000370687; ENSG00000134352 [P40189-2]
ENST00000381294; ENSP00000370694; ENSG00000134352 [P40189-3]
ENST00000381298; ENSP00000370698; ENSG00000134352 [P40189-1]
ENST00000502326; ENSP00000462158; ENSG00000134352 [P40189-1]
ENST00000522633; ENSP00000435399; ENSG00000134352 [P40189-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3572

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3572

UCSC genome browser

More...
UCSCi
uc003jqq.4 human [P40189-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57230 mRNA Translation: AAA59155.1
AB015706 mRNA Translation: BAA78112.1
AB102802 mRNA Translation: BAD89393.1
EF064722 Genomic DNA Translation: ABK41905.1
AC008914 Genomic DNA No translation available.
AC016596 Genomic DNA No translation available.
CH471123 Genomic DNA Translation: EAW54936.1
CCDSiCCDS3971.1 [P40189-1]
CCDS47209.1 [P40189-2]
CCDS54856.1 [P40189-3]
PIRiA36337
RefSeqiNP_001177910.1, NM_001190981.1 [P40189-3]
NP_002175.2, NM_002184.3 [P40189-1]
NP_786943.1, NM_175767.2 [P40189-2]
UniGeneiHs.532082
Hs.706627

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BJ8NMR-A219-325[»]
1BQUX-ray2.00A/B122-333[»]
1I1RX-ray2.40A23-325[»]
1N2Qmodel-A/B23-324[»]
1P9MX-ray3.65A23-321[»]
1PVHX-ray2.50A/C123-323[»]
3L5HX-ray3.60A24-612[»]
3L5IX-ray1.90A323-612[»]
3L5JX-ray3.04A/B323-610[»]
ProteinModelPortaliP40189
SMRiP40189
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109786, 33 interactors
CORUMiP40189
DIPiDIP-95N
IntActiP40189, 22 interactors
MINTiP40189
STRINGi9606.ENSP00000338799

Chemistry databases

BindingDBiP40189
ChEMBLiCHEMBL3124734
GuidetoPHARMACOLOGYi2317

PTM databases

GlyConnecti649
iPTMnetiP40189
PhosphoSitePlusiP40189
SwissPalmiP40189
UniCarbKBiP40189

Polymorphism and mutation databases

BioMutaiIL6ST
DMDMi215273999

Proteomic databases

EPDiP40189
MaxQBiP40189
PaxDbiP40189
PeptideAtlasiP40189
PRIDEiP40189
ProteomicsDBi55338
55339 [P40189-2]
55340 [P40189-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3572
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336909; ENSP00000338799; ENSG00000134352 [P40189-1]
ENST00000381287; ENSP00000370687; ENSG00000134352 [P40189-2]
ENST00000381294; ENSP00000370694; ENSG00000134352 [P40189-3]
ENST00000381298; ENSP00000370698; ENSG00000134352 [P40189-1]
ENST00000502326; ENSP00000462158; ENSG00000134352 [P40189-1]
ENST00000522633; ENSP00000435399; ENSG00000134352 [P40189-2]
GeneIDi3572
KEGGihsa:3572
UCSCiuc003jqq.4 human [P40189-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3572
DisGeNETi3572
EuPathDBiHostDB:ENSG00000134352.19

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IL6ST
HGNCiHGNC:6021 IL6ST
HPAiCAB025784
HPA010558
MIMi600694 gene
neXtProtiNX_P40189
OpenTargetsiENSG00000134352
PharmGKBiPA29837

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IF1N Eukaryota
ENOG410YNQ4 LUCA
GeneTreeiENSGT00940000159608
HOGENOMiHOG000015771
HOVERGENiHBG052119
InParanoidiP40189
KOiK05060
OMAiMMCQWDP
OrthoDBiEOG091G01XM
PhylomeDBiP40189
TreeFamiTF338122

Enzyme and pathway databases

ReactomeiR-HSA-1059683 Interleukin-6 signaling
R-HSA-110056 MAPK3 (ERK1) activation
R-HSA-112411 MAPK1 (ERK2) activation
R-HSA-6788467 IL-6-type cytokine receptor ligand interactions
R-HSA-8984722 Interleukin-35 Signalling
R-HSA-9020956 Interleukin-27 signaling
SignaLinkiP40189
SIGNORiP40189

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
IL6ST human
EvolutionaryTraceiP40189

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Glycoprotein_130

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3572

Protein Ontology

More...
PROi
PR:P40189

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000134352 Expressed in 248 organ(s), highest expression level in female gonad
CleanExiHS_IL6ST
ExpressionAtlasiP40189 baseline and differential
GenevisibleiP40189 HS

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.40.10, 6 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR003529 Hematopoietin_rcpt_Gp130_CS
IPR013783 Ig-like_fold
IPR010457 IgC2-like_lig-bd
IPR015321 TypeI_recpt_CBD
PfamiView protein in Pfam
PF00041 fn3, 2 hits
PF09240 IL6Ra-bind, 1 hit
PF06328 Lep_receptor_Ig, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 5 hits
SUPFAMiSSF49265 SSF49265, 5 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 4 hits
PS01353 HEMATOPO_REC_L_F2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIL6RB_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P40189
Secondary accession number(s): A0N0L4, Q5FC04, Q9UQ41
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 25, 2008
Last modified: December 5, 2018
This is version 214 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  4. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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