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Protein

Adenylyl cyclase-associated protein 2

Gene

CAP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May have a regulatory bifunctional role.

GO - Molecular functioni

  • actin binding Source: GO_Central
  • adenylate cyclase binding Source: GO_Central
  • identical protein binding Source: IntAct

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-428890 Role of ABL in ROBO-SLIT signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylyl cyclase-associated protein 2
Short name:
CAP 2
Gene namesi
Name:CAP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000112186.11
HGNCiHGNC:20039 CAP2
neXtProtiNX_P40123

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10486
OpenTargetsiENSG00000112186
PharmGKBiPA134989437

Polymorphism and mutation databases

BioMutaiCAP2
DMDMi729015

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002057002 – 477Adenylyl cyclase-associated protein 2Add BLAST476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei301PhosphoserineBy similarity1
Modified residuei309PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP40123
MaxQBiP40123
PaxDbiP40123
PeptideAtlasiP40123
PRIDEiP40123
ProteomicsDBi55334
TopDownProteomicsiP40123-1 [P40123-1]

PTM databases

iPTMnetiP40123
PhosphoSitePlusiP40123

Expressioni

Gene expression databases

BgeeiENSG00000112186 Expressed in 219 organ(s), highest expression level in biceps brachii
CleanExiHS_CAP2
ExpressionAtlasiP40123 baseline and differential
GenevisibleiP40123 HS

Organism-specific databases

HPAiHPA050530
HPA054147

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115749, 29 interactors
IntActiP40123, 11 interactors
MINTiP40123
STRINGi9606.ENSP00000229922

Structurei

3D structure databases

ProteinModelPortaliP40123
SMRiP40123
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini317 – 455C-CAP/cofactor C-likePROSITE-ProRule annotationAdd BLAST139

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi232 – 245Poly-ProAdd BLAST14

Sequence similaritiesi

Belongs to the CAP family.Curated

Phylogenomic databases

eggNOGiKOG2675 Eukaryota
ENOG410XPXJ LUCA
GeneTreeiENSGT00390000017955
HOGENOMiHOG000206192
HOVERGENiHBG003080
InParanoidiP40123
KOiK17261
OMAiDIQIQVM
OrthoDBiEOG091G0DLX
PhylomeDBiP40123
TreeFamiTF313791

Family and domain databases

Gene3Di1.25.40.330, 1 hit
2.160.20.70, 1 hit
InterProiView protein in InterPro
IPR001837 Adenylate_cyclase-assoc_CAP
IPR013912 Adenylate_cyclase-assoc_CAP_C
IPR013992 Adenylate_cyclase-assoc_CAP_N
IPR017901 C-CAP_CF_C-like
IPR016098 CAP/MinC_C
IPR028418 CAP2
IPR036223 CAP_C_sf
IPR028417 CAP_CS_C
IPR018106 CAP_CS_N
IPR036222 CAP_N_sf
IPR006599 CARP_motif
PANTHERiPTHR10652 PTHR10652, 1 hit
PTHR10652:SF2 PTHR10652:SF2, 1 hit
PfamiView protein in Pfam
PF08603 CAP_C, 1 hit
PF01213 CAP_N, 1 hit
SMARTiView protein in SMART
SM00673 CARP, 2 hits
SUPFAMiSSF101278 SSF101278, 1 hit
SSF69340 SSF69340, 1 hit
PROSITEiView protein in PROSITE
PS51329 C_CAP_COFACTOR_C, 1 hit
PS01088 CAP_1, 1 hit
PS01089 CAP_2, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P40123-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MANMQGLVER LERAVSRLES LSAESHRPPG NCGEVNGVIA GVAPSVEAFD
60 70 80 90 100
KLMDSMVAEF LKNSRILAGD VETHAEMVHS AFQAQRAFLL MASQYQQPHE
110 120 130 140 150
NDVAALLKPI SEKIQEIQTF RERNRGSNMF NHLSAVSESI PALGWIAVSP
160 170 180 190 200
KPGPYVKEMN DAATFYTNRV LKDYKHSDLR HVDWVKSYLN IWSELQAYIK
210 220 230 240 250
EHHTTGLTWS KTGPVASTVS AFSVLSSGPG LPPPPPPLPP PGPPPLFENE
260 270 280 290 300
GKKEESSPSR SALFAQLNQG EAITKGLRHV TDDQKTYKNP SLRAQGGQTQ
310 320 330 340 350
SPTKSHTPSP TSPKSYPSQK HAPVLELEGK KWRVEYQEDR NDLVISETEL
360 370 380 390 400
KQVAYIFKCE KSTIQIKGKV NSIIIDNCKK LGLVFDNVVG IVEVINSQDI
410 420 430 440 450
QIQVMGRVPT ISINKTEGCH IYLSEDALDC EIVSAKSSEM NILIPQDGDY
460 470
REFPIPEQFK TAWDGSKLIT EPAEIMA
Length:477
Mass (Da):52,824
Last modified:February 1, 1995 - v1
Checksum:i2FD3950C094F5AF7
GO
Isoform 2 (identifier: P40123-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     149-212: Missing.

Note: No experimental confirmation available.
Show »
Length:413
Mass (Da):45,245
Checksum:i9733239D20559B64
GO
Isoform 3 (identifier: P40123-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     75-334: Missing.

Note: No experimental confirmation available.
Show »
Length:217
Mass (Da):24,018
Checksum:iA112774A5C374E3C
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PDI2E9PDI2_HUMAN
Adenylyl cyclase-associated protein
CAP2
451Annotation score:
B7Z385B7Z385_HUMAN
Adenylyl cyclase-associated protein
CAP2
365Annotation score:
A0A087WZ15A0A087WZ15_HUMAN
Adenylyl cyclase-associated protein
CAP2
394Annotation score:
A0A087X0J3A0A087X0J3_HUMAN
Adenylyl cyclase-associated protein
CAP2
394Annotation score:
F8WEW0F8WEW0_HUMAN
Adenylyl cyclase-associated protein...
CAP2
104Annotation score:
F8WDB9F8WDB9_HUMAN
Adenylyl cyclase-associated protein...
CAP2
194Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033717311T → A. Corresponds to variant dbSNP:rs34620829Ensembl.1
Natural variantiVAR_033718316Y → C. Corresponds to variant dbSNP:rs34206659Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05551975 – 334Missing in isoform 3. 1 PublicationAdd BLAST260
Alternative sequenceiVSP_055520149 – 212Missing in isoform 2. 1 PublicationAdd BLAST64

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02390 mRNA Translation: AAA20587.1
CR457022 mRNA Translation: CAG33303.1
AK294215 mRNA Translation: BAH11700.1
AL034372 Genomic DNA No translation available.
AL138824 Genomic DNA No translation available.
AK293134 mRNA Translation: BAH11460.1
AK312362 mRNA Translation: BAG35280.1
CH471087 Genomic DNA Translation: EAW55380.1
BC008481 mRNA Translation: AAH08481.1
CCDSiCCDS4539.1 [P40123-1]
PIRiI38409
RefSeqiNP_006357.1, NM_006366.2 [P40123-1]
UniGeneiHs.132902

Genome annotation databases

EnsembliENST00000229922; ENSP00000229922; ENSG00000112186 [P40123-1]
ENST00000465994; ENSP00000418604; ENSG00000112186 [P40123-2]
ENST00000493172; ENSP00000417208; ENSG00000112186 [P40123-3]
GeneIDi10486
KEGGihsa:10486
UCSCiuc003ncb.4 human [P40123-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02390 mRNA Translation: AAA20587.1
CR457022 mRNA Translation: CAG33303.1
AK294215 mRNA Translation: BAH11700.1
AL034372 Genomic DNA No translation available.
AL138824 Genomic DNA No translation available.
AK293134 mRNA Translation: BAH11460.1
AK312362 mRNA Translation: BAG35280.1
CH471087 Genomic DNA Translation: EAW55380.1
BC008481 mRNA Translation: AAH08481.1
CCDSiCCDS4539.1 [P40123-1]
PIRiI38409
RefSeqiNP_006357.1, NM_006366.2 [P40123-1]
UniGeneiHs.132902

3D structure databases

ProteinModelPortaliP40123
SMRiP40123
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115749, 29 interactors
IntActiP40123, 11 interactors
MINTiP40123
STRINGi9606.ENSP00000229922

PTM databases

iPTMnetiP40123
PhosphoSitePlusiP40123

Polymorphism and mutation databases

BioMutaiCAP2
DMDMi729015

Proteomic databases

EPDiP40123
MaxQBiP40123
PaxDbiP40123
PeptideAtlasiP40123
PRIDEiP40123
ProteomicsDBi55334
TopDownProteomicsiP40123-1 [P40123-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000229922; ENSP00000229922; ENSG00000112186 [P40123-1]
ENST00000465994; ENSP00000418604; ENSG00000112186 [P40123-2]
ENST00000493172; ENSP00000417208; ENSG00000112186 [P40123-3]
GeneIDi10486
KEGGihsa:10486
UCSCiuc003ncb.4 human [P40123-1]

Organism-specific databases

CTDi10486
DisGeNETi10486
EuPathDBiHostDB:ENSG00000112186.11
GeneCardsiCAP2
HGNCiHGNC:20039 CAP2
HPAiHPA050530
HPA054147
neXtProtiNX_P40123
OpenTargetsiENSG00000112186
PharmGKBiPA134989437
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2675 Eukaryota
ENOG410XPXJ LUCA
GeneTreeiENSGT00390000017955
HOGENOMiHOG000206192
HOVERGENiHBG003080
InParanoidiP40123
KOiK17261
OMAiDIQIQVM
OrthoDBiEOG091G0DLX
PhylomeDBiP40123
TreeFamiTF313791

Enzyme and pathway databases

ReactomeiR-HSA-428890 Role of ABL in ROBO-SLIT signaling

Miscellaneous databases

ChiTaRSiCAP2 human
GeneWikiiCAP2
GenomeRNAii10486
PROiPR:P40123

Gene expression databases

BgeeiENSG00000112186 Expressed in 219 organ(s), highest expression level in biceps brachii
CleanExiHS_CAP2
ExpressionAtlasiP40123 baseline and differential
GenevisibleiP40123 HS

Family and domain databases

Gene3Di1.25.40.330, 1 hit
2.160.20.70, 1 hit
InterProiView protein in InterPro
IPR001837 Adenylate_cyclase-assoc_CAP
IPR013912 Adenylate_cyclase-assoc_CAP_C
IPR013992 Adenylate_cyclase-assoc_CAP_N
IPR017901 C-CAP_CF_C-like
IPR016098 CAP/MinC_C
IPR028418 CAP2
IPR036223 CAP_C_sf
IPR028417 CAP_CS_C
IPR018106 CAP_CS_N
IPR036222 CAP_N_sf
IPR006599 CARP_motif
PANTHERiPTHR10652 PTHR10652, 1 hit
PTHR10652:SF2 PTHR10652:SF2, 1 hit
PfamiView protein in Pfam
PF08603 CAP_C, 1 hit
PF01213 CAP_N, 1 hit
SMARTiView protein in SMART
SM00673 CARP, 2 hits
SUPFAMiSSF101278 SSF101278, 1 hit
SSF69340 SSF69340, 1 hit
PROSITEiView protein in PROSITE
PS51329 C_CAP_COFACTOR_C, 1 hit
PS01088 CAP_1, 1 hit
PS01089 CAP_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCAP2_HUMAN
AccessioniPrimary (citable) accession number: P40123
Secondary accession number(s): B2R5Y3
, B7Z1C4, B7Z214, Q6IAY2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 12, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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