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Protein

Macrophage-capping protein

Gene

CAPG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.

Caution

This protein was originally thought to be a DNA-binding protein with a helix-loop-helix domain.Curated

GO - Molecular functioni

  • actin filament binding Source: InterPro
  • cadherin binding Source: BHF-UCL
  • protein-containing complex binding Source: UniProtKB
  • protein domain specific binding Source: UniProtKB

GO - Biological processi

  • barbed-end actin filament capping Source: ProtInc
  • protein-containing complex assembly Source: ProtInc

Keywordsi

Molecular functionActin capping, Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Macrophage-capping protein
Alternative name(s):
Actin regulatory protein CAP-G
Gene namesi
Name:CAPG
Synonyms:AFCP, MCP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000042493.15
HGNCiHGNC:1474 CAPG
MIMi153615 gene
neXtProtiNX_P40121

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi822
OpenTargetsiENSG00000042493
PharmGKBiPA26056

Polymorphism and mutation databases

BioMutaiCAPG
DMDMi313104088

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002187531 – 348Macrophage-capping proteinAdd BLAST348

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei337PhosphoserineCombined sources1

Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP40121
PaxDbiP40121
PeptideAtlasiP40121
PRIDEiP40121
ProteomicsDBi55333
TopDownProteomicsiP40121-1 [P40121-1]

2D gel databases

REPRODUCTION-2DPAGEiIPI00027341

PTM databases

iPTMnetiP40121
PhosphoSitePlusiP40121

Expressioni

Tissue specificityi

Macrophages and macrophage-like cells.

Gene expression databases

BgeeiENSG00000042493 Expressed in 200 organ(s), highest expression level in esophagus mucosa
CleanExiHS_CAPG
ExpressionAtlasiP40121 baseline and differential
GenevisibleiP40121 HS

Organism-specific databases

HPAiHPA018843
HPA019080
HPA019092

Interactioni

Subunit structurei

Interacts with NUP62 (PubMed:18266911). Interacts with NUTF2 and RAN; involved in CAPG nuclear import (PubMed:18266911).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SIAH1Q8IUQ43EBI-4291044,EBI-747107

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107272, 35 interactors
DIPiDIP-61547N
IntActiP40121, 6 interactors
MINTiP40121
STRINGi9606.ENSP00000263867

Structurei

Secondary structure

1348
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP40121
SMRiP40121
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP40121

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati27 – 75Gelsolin-like 1Add BLAST49
Repeati148 – 188Gelsolin-like 2Add BLAST41
Repeati261 – 307Gelsolin-like 3Add BLAST47

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi137 – 146Nuclear localization signalSequence analysis10

Sequence similaritiesi

Belongs to the villin/gelsolin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0443 Eukaryota
ENOG410XR0A LUCA
GeneTreeiENSGT00760000119111
HOGENOMiHOG000235030
HOVERGENiHBG001093
InParanoidiP40121
KOiK10368
OMAiHNGPEEV
OrthoDBiEOG091G05SC
PhylomeDBiP40121
TreeFamiTF313468

Family and domain databases

Gene3Di3.40.20.10, 3 hits
InterProiView protein in InterPro
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR029917 CapG
IPR007123 Gelsolin-like_dom
IPR007122 Villin/Gelsolin
PANTHERiPTHR11977 PTHR11977, 1 hit
PTHR11977:SF13 PTHR11977:SF13, 1 hit
PfamiView protein in Pfam
PF00626 Gelsolin, 3 hits
PRINTSiPR00597 GELSOLIN
SMARTiView protein in SMART
SM00262 GEL, 3 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: P40121-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYTAIPQSGS PFPGSVQDPG LHVWRVEKLK PVPVAQENQG VFFSGDSYLV
60 70 80 90 100
LHNGPEEVSH LHLWIGQQSS RDEQGACAVL AVHLNTLLGE RPVQHREVQG
110 120 130 140 150
NESDLFMSYF PRGLKYQEGG VESAFHKTST GAPAAIKKLY QVKGKKNIRA
160 170 180 190 200
TERALNWDSF NTGDCFILDL GQNIFAWCGG KSNILERNKA RDLALAIRDS
210 220 230 240 250
ERQGKAQVEI VTDGEEPAEM IQVLGPKPAL KEGNPEEDLT ADKANAQAAA
260 270 280 290 300
LYKVSDATGQ MNLTKVADSS PFALELLISD DCFVLDNGLC GKIYIWKGRK
310 320 330 340
ANEKERQAAL QVAEGFISRM QYAPNTQVEI LPQGHESPIF KQFFKDWK
Length:348
Mass (Da):38,499
Last modified:November 30, 2010 - v2
Checksum:iBE6E5641D15E9C07
GO
Isoform 2 (identifier: P40121-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     207-221: Missing.

Note: No experimental confirmation available.
Show »
Length:333
Mass (Da):36,857
Checksum:iD0CFFAF6C1F8147F
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B8ZZL6B8ZZL6_HUMAN
Macrophage-capping protein
CAPG
218Annotation score:
E7ENU9E7ENU9_HUMAN
Macrophage-capping protein
CAPG
253Annotation score:
H7C0X8H7C0X8_HUMAN
Macrophage-capping protein
CAPG
103Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04777641V → I. Corresponds to variant dbSNP:rs2229668Ensembl.1
Natural variantiVAR_047777198R → W. Corresponds to variant dbSNP:rs11539103Ensembl.1
Natural variantiVAR_047778335H → RCombined sources5 PublicationsCorresponds to variant dbSNP:rs6886Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_045538207 – 221Missing in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94345 mRNA Translation: AAA59570.1
AK225374 mRNA No translation available.
AC062037 Genomic DNA Translation: AAY24128.1
CH471053 Genomic DNA Translation: EAW99517.1
CH471053 Genomic DNA Translation: EAW99518.1
CH471053 Genomic DNA Translation: EAW99519.1
CH471053 Genomic DNA Translation: EAW99520.1
BC000728 mRNA Translation: AAH00728.1
BC014549 mRNA Translation: AAH14549.1
U12026 Genomic DNA Translation: AAA92670.1
CCDSiCCDS1974.1 [P40121-1]
CCDS58715.1 [P40121-2]
PIRiA43358
RefSeqiNP_001243068.1, NM_001256139.1 [P40121-1]
NP_001243069.1, NM_001256140.1 [P40121-2]
NP_001307661.1, NM_001320732.1 [P40121-1]
NP_001307662.1, NM_001320733.1 [P40121-1]
NP_001738.2, NM_001747.3 [P40121-1]
XP_011531424.1, XM_011533122.1 [P40121-1]
XP_011531425.1, XM_011533123.1 [P40121-1]
UniGeneiHs.516155

Genome annotation databases

EnsembliENST00000263867; ENSP00000263867; ENSG00000042493 [P40121-1]
ENST00000409670; ENSP00000386315; ENSG00000042493 [P40121-1]
ENST00000409724; ENSP00000386965; ENSG00000042493 [P40121-1]
ENST00000409921; ENSP00000387063; ENSG00000042493 [P40121-2]
GeneIDi822
KEGGihsa:822
UCSCiuc002spm.3 human [P40121-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94345 mRNA Translation: AAA59570.1
AK225374 mRNA No translation available.
AC062037 Genomic DNA Translation: AAY24128.1
CH471053 Genomic DNA Translation: EAW99517.1
CH471053 Genomic DNA Translation: EAW99518.1
CH471053 Genomic DNA Translation: EAW99519.1
CH471053 Genomic DNA Translation: EAW99520.1
BC000728 mRNA Translation: AAH00728.1
BC014549 mRNA Translation: AAH14549.1
U12026 Genomic DNA Translation: AAA92670.1
CCDSiCCDS1974.1 [P40121-1]
CCDS58715.1 [P40121-2]
PIRiA43358
RefSeqiNP_001243068.1, NM_001256139.1 [P40121-1]
NP_001243069.1, NM_001256140.1 [P40121-2]
NP_001307661.1, NM_001320732.1 [P40121-1]
NP_001307662.1, NM_001320733.1 [P40121-1]
NP_001738.2, NM_001747.3 [P40121-1]
XP_011531424.1, XM_011533122.1 [P40121-1]
XP_011531425.1, XM_011533123.1 [P40121-1]
UniGeneiHs.516155

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J72X-ray2.50A1-348[»]
1JHWX-ray2.80A1-348[»]
ProteinModelPortaliP40121
SMRiP40121
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107272, 35 interactors
DIPiDIP-61547N
IntActiP40121, 6 interactors
MINTiP40121
STRINGi9606.ENSP00000263867

PTM databases

iPTMnetiP40121
PhosphoSitePlusiP40121

Polymorphism and mutation databases

BioMutaiCAPG
DMDMi313104088

2D gel databases

REPRODUCTION-2DPAGEiIPI00027341

Proteomic databases

EPDiP40121
PaxDbiP40121
PeptideAtlasiP40121
PRIDEiP40121
ProteomicsDBi55333
TopDownProteomicsiP40121-1 [P40121-1]

Protocols and materials databases

DNASUi822
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263867; ENSP00000263867; ENSG00000042493 [P40121-1]
ENST00000409670; ENSP00000386315; ENSG00000042493 [P40121-1]
ENST00000409724; ENSP00000386965; ENSG00000042493 [P40121-1]
ENST00000409921; ENSP00000387063; ENSG00000042493 [P40121-2]
GeneIDi822
KEGGihsa:822
UCSCiuc002spm.3 human [P40121-1]

Organism-specific databases

CTDi822
DisGeNETi822
EuPathDBiHostDB:ENSG00000042493.15
GeneCardsiCAPG
HGNCiHGNC:1474 CAPG
HPAiHPA018843
HPA019080
HPA019092
MIMi153615 gene
neXtProtiNX_P40121
OpenTargetsiENSG00000042493
PharmGKBiPA26056
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0443 Eukaryota
ENOG410XR0A LUCA
GeneTreeiENSGT00760000119111
HOGENOMiHOG000235030
HOVERGENiHBG001093
InParanoidiP40121
KOiK10368
OMAiHNGPEEV
OrthoDBiEOG091G05SC
PhylomeDBiP40121
TreeFamiTF313468

Miscellaneous databases

ChiTaRSiCAPG human
EvolutionaryTraceiP40121
GeneWikiiCAPG
GenomeRNAii822
PROiPR:P40121
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000042493 Expressed in 200 organ(s), highest expression level in esophagus mucosa
CleanExiHS_CAPG
ExpressionAtlasiP40121 baseline and differential
GenevisibleiP40121 HS

Family and domain databases

Gene3Di3.40.20.10, 3 hits
InterProiView protein in InterPro
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR029917 CapG
IPR007123 Gelsolin-like_dom
IPR007122 Villin/Gelsolin
PANTHERiPTHR11977 PTHR11977, 1 hit
PTHR11977:SF13 PTHR11977:SF13, 1 hit
PfamiView protein in Pfam
PF00626 Gelsolin, 3 hits
PRINTSiPR00597 GELSOLIN
SMARTiView protein in SMART
SM00262 GEL, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCAPG_HUMAN
AccessioniPrimary (citable) accession number: P40121
Secondary accession number(s): B8ZZS7, D6W5K8, Q53SA7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 30, 2010
Last modified: September 12, 2018
This is version 173 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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