Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Macrophage-capping protein

Gene

CAPG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.

Caution

This protein was originally thought to be a DNA-binding protein with a helix-loop-helix domain.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin filament binding Source: InterPro
  • cadherin binding Source: BHF-UCL
  • protein-containing complex binding Source: UniProtKB
  • protein domain specific binding Source: UniProtKB

GO - Biological processi

  • barbed-end actin filament capping Source: ProtInc
  • protein-containing complex assembly Source: ProtInc

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin capping, Actin-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Macrophage-capping protein
Alternative name(s):
Actin regulatory protein CAP-G
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CAPG
Synonyms:AFCP, MCP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000042493.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1474 CAPG

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
153615 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P40121

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
822

Open Targets

More...
OpenTargetsi
ENSG00000042493

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26056

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CAPG

Domain mapping of disease mutations (DMDM)

More...
DMDMi
313104088

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002187531 – 348Macrophage-capping proteinAdd BLAST348

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei337PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P40121

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P40121

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P40121

PeptideAtlas

More...
PeptideAtlasi
P40121

PRoteomics IDEntifications database

More...
PRIDEi
P40121

ProteomicsDB human proteome resource

More...
ProteomicsDBi
55333

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P40121-1 [P40121-1]

2D gel databases

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00027341

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P40121

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P40121

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Macrophages and macrophage-like cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000042493 Expressed in 200 organ(s), highest expression level in esophagus mucosa

CleanEx database of gene expression profiles

More...
CleanExi
HS_CAPG

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P40121 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P40121 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA018843
HPA019080
HPA019092

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NUP62 (PubMed:18266911). Interacts with NUTF2 and RAN; involved in CAPG nuclear import (PubMed:18266911).1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
SIAH1Q8IUQ43EBI-4291044,EBI-747107

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107272, 35 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P40121

Database of interacting proteins

More...
DIPi
DIP-61547N

Protein interaction database and analysis system

More...
IntActi
P40121, 6 interactors

Molecular INTeraction database

More...
MINTi
P40121

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000263867

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1348
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J72X-ray2.50A1-348[»]
1JHWX-ray2.80A1-348[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P40121

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P40121

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P40121

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati27 – 75Gelsolin-like 1Add BLAST49
Repeati148 – 188Gelsolin-like 2Add BLAST41
Repeati261 – 307Gelsolin-like 3Add BLAST47

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi137 – 146Nuclear localization signalSequence analysis10

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the villin/gelsolin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0443 Eukaryota
ENOG410XR0A LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159305

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000235030

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG001093

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P40121

KEGG Orthology (KO)

More...
KOi
K10368

Identification of Orthologs from Complete Genome Data

More...
OMAi
FISRMRY

Database of Orthologous Groups

More...
OrthoDBi
1376537at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P40121

TreeFam database of animal gene trees

More...
TreeFami
TF313468

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.20.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR029917 CapG
IPR007123 Gelsolin-like_dom
IPR007122 Villin/Gelsolin

The PANTHER Classification System

More...
PANTHERi
PTHR11977 PTHR11977, 1 hit
PTHR11977:SF13 PTHR11977:SF13, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00626 Gelsolin, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00597 GELSOLIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00262 GEL, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P40121-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYTAIPQSGS PFPGSVQDPG LHVWRVEKLK PVPVAQENQG VFFSGDSYLV
60 70 80 90 100
LHNGPEEVSH LHLWIGQQSS RDEQGACAVL AVHLNTLLGE RPVQHREVQG
110 120 130 140 150
NESDLFMSYF PRGLKYQEGG VESAFHKTST GAPAAIKKLY QVKGKKNIRA
160 170 180 190 200
TERALNWDSF NTGDCFILDL GQNIFAWCGG KSNILERNKA RDLALAIRDS
210 220 230 240 250
ERQGKAQVEI VTDGEEPAEM IQVLGPKPAL KEGNPEEDLT ADKANAQAAA
260 270 280 290 300
LYKVSDATGQ MNLTKVADSS PFALELLISD DCFVLDNGLC GKIYIWKGRK
310 320 330 340
ANEKERQAAL QVAEGFISRM QYAPNTQVEI LPQGHESPIF KQFFKDWK
Length:348
Mass (Da):38,499
Last modified:November 30, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBE6E5641D15E9C07
GO
Isoform 2 (identifier: P40121-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     207-221: Missing.

Note: No experimental confirmation available.
Show »
Length:333
Mass (Da):36,857
Checksum:iD0CFFAF6C1F8147F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B8ZZL6B8ZZL6_HUMAN
Macrophage-capping protein
CAPG
218Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ENU9E7ENU9_HUMAN
Macrophage-capping protein
CAPG
253Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0X8H7C0X8_HUMAN
Macrophage-capping protein
CAPG
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04777641V → I. Corresponds to variant dbSNP:rs2229668Ensembl.1
Natural variantiVAR_047777198R → W. Corresponds to variant dbSNP:rs11539103Ensembl.1
Natural variantiVAR_047778335H → RCombined sources5 PublicationsCorresponds to variant dbSNP:rs6886Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_045538207 – 221Missing in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M94345 mRNA Translation: AAA59570.1
AK225374 mRNA No translation available.
AC062037 Genomic DNA Translation: AAY24128.1
CH471053 Genomic DNA Translation: EAW99517.1
CH471053 Genomic DNA Translation: EAW99518.1
CH471053 Genomic DNA Translation: EAW99519.1
CH471053 Genomic DNA Translation: EAW99520.1
BC000728 mRNA Translation: AAH00728.1
BC014549 mRNA Translation: AAH14549.1
U12026 Genomic DNA Translation: AAA92670.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1974.1 [P40121-1]
CCDS58715.1 [P40121-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A43358

NCBI Reference Sequences

More...
RefSeqi
NP_001243068.1, NM_001256139.1 [P40121-1]
NP_001243069.1, NM_001256140.1 [P40121-2]
NP_001307661.1, NM_001320732.1 [P40121-1]
NP_001307662.1, NM_001320733.1 [P40121-1]
NP_001738.2, NM_001747.3 [P40121-1]
XP_011531424.1, XM_011533122.1 [P40121-1]
XP_011531425.1, XM_011533123.1 [P40121-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.516155

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000263867; ENSP00000263867; ENSG00000042493 [P40121-1]
ENST00000409670; ENSP00000386315; ENSG00000042493 [P40121-1]
ENST00000409724; ENSP00000386965; ENSG00000042493 [P40121-1]
ENST00000409921; ENSP00000387063; ENSG00000042493 [P40121-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
822

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:822

UCSC genome browser

More...
UCSCi
uc002spm.3 human [P40121-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94345 mRNA Translation: AAA59570.1
AK225374 mRNA No translation available.
AC062037 Genomic DNA Translation: AAY24128.1
CH471053 Genomic DNA Translation: EAW99517.1
CH471053 Genomic DNA Translation: EAW99518.1
CH471053 Genomic DNA Translation: EAW99519.1
CH471053 Genomic DNA Translation: EAW99520.1
BC000728 mRNA Translation: AAH00728.1
BC014549 mRNA Translation: AAH14549.1
U12026 Genomic DNA Translation: AAA92670.1
CCDSiCCDS1974.1 [P40121-1]
CCDS58715.1 [P40121-2]
PIRiA43358
RefSeqiNP_001243068.1, NM_001256139.1 [P40121-1]
NP_001243069.1, NM_001256140.1 [P40121-2]
NP_001307661.1, NM_001320732.1 [P40121-1]
NP_001307662.1, NM_001320733.1 [P40121-1]
NP_001738.2, NM_001747.3 [P40121-1]
XP_011531424.1, XM_011533122.1 [P40121-1]
XP_011531425.1, XM_011533123.1 [P40121-1]
UniGeneiHs.516155

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J72X-ray2.50A1-348[»]
1JHWX-ray2.80A1-348[»]
ProteinModelPortaliP40121
SMRiP40121
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107272, 35 interactors
CORUMiP40121
DIPiDIP-61547N
IntActiP40121, 6 interactors
MINTiP40121
STRINGi9606.ENSP00000263867

PTM databases

iPTMnetiP40121
PhosphoSitePlusiP40121

Polymorphism and mutation databases

BioMutaiCAPG
DMDMi313104088

2D gel databases

REPRODUCTION-2DPAGEiIPI00027341

Proteomic databases

EPDiP40121
jPOSTiP40121
PaxDbiP40121
PeptideAtlasiP40121
PRIDEiP40121
ProteomicsDBi55333
TopDownProteomicsiP40121-1 [P40121-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
822
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263867; ENSP00000263867; ENSG00000042493 [P40121-1]
ENST00000409670; ENSP00000386315; ENSG00000042493 [P40121-1]
ENST00000409724; ENSP00000386965; ENSG00000042493 [P40121-1]
ENST00000409921; ENSP00000387063; ENSG00000042493 [P40121-2]
GeneIDi822
KEGGihsa:822
UCSCiuc002spm.3 human [P40121-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
822
DisGeNETi822
EuPathDBiHostDB:ENSG00000042493.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CAPG
HGNCiHGNC:1474 CAPG
HPAiHPA018843
HPA019080
HPA019092
MIMi153615 gene
neXtProtiNX_P40121
OpenTargetsiENSG00000042493
PharmGKBiPA26056

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0443 Eukaryota
ENOG410XR0A LUCA
GeneTreeiENSGT00940000159305
HOGENOMiHOG000235030
HOVERGENiHBG001093
InParanoidiP40121
KOiK10368
OMAiFISRMRY
OrthoDBi1376537at2759
PhylomeDBiP40121
TreeFamiTF313468

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CAPG human
EvolutionaryTraceiP40121

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CAPG

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
822

Protein Ontology

More...
PROi
PR:P40121

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000042493 Expressed in 200 organ(s), highest expression level in esophagus mucosa
CleanExiHS_CAPG
ExpressionAtlasiP40121 baseline and differential
GenevisibleiP40121 HS

Family and domain databases

Gene3Di3.40.20.10, 3 hits
InterProiView protein in InterPro
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR029917 CapG
IPR007123 Gelsolin-like_dom
IPR007122 Villin/Gelsolin
PANTHERiPTHR11977 PTHR11977, 1 hit
PTHR11977:SF13 PTHR11977:SF13, 1 hit
PfamiView protein in Pfam
PF00626 Gelsolin, 3 hits
PRINTSiPR00597 GELSOLIN
SMARTiView protein in SMART
SM00262 GEL, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAPG_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P40121
Secondary accession number(s): B8ZZS7, D6W5K8, Q53SA7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 30, 2010
Last modified: January 16, 2019
This is version 176 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again