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UniProtKB - P40120 (OPGD_ECOLI)

Entry version 149 (07 Apr 2021)
Sequence version 3 (03 Jul 2003)
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Protein

Glucans biosynthesis protein D

Gene

mdoD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probably involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans (OPGs).

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: osmoregulated periplasmic glucan (OPG) biosynthesis

This protein is involved in the pathway osmoregulated periplasmic glucan (OPG) biosynthesis, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway osmoregulated periplasmic glucan (OPG) biosynthesis and in Glycan metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:EG12859-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00637

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glucans biosynthesis protein D
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mdoD
Synonyms:opgD, ydcG, yzzZ
Ordered Locus Names:b1424, JW1420
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Periplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 32Tat-type signal1 PublicationAdd BLAST32
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002020633 – 551Glucans biosynthesis protein DAdd BLAST519

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Exported by the Tat system. The position of the signal peptide cleavage has been experimentally proven. Can also be exported by the Sec system.

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P40120

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P40120

PRoteomics IDEntifications database

More...PRIDEi		P40120

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed essentially during the stationary growth phase when OPG synthesis has stopped.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4261154, 12 interactors

Protein interaction database and analysis system

More...IntActi		P40120, 6 interactors

STRING: functional protein association networks

More...STRINGi		511145.b1424

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P40120

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the OpgD/OpgG family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG3131, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_023403_2_0_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P40120

Database for complete collections of gene phylogenies

More...PhylomeDBi		P40120

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 1 hit
2.70.98.10, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_01068, MdoD_OpgD, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011013, Gal_mutarotase_sf_dom
IPR014718, GH-type_carb-bd
IPR023724, Glucan_biosyn_MdoD
IPR014438, Glucan_biosyn_MdoG/MdoD
IPR007444, Glucan_biosyn_MdoG_C
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR006311, TAT_signal
IPR019546, TAT_signal_bac_arc

The PANTHER Classification System

More...PANTHERi		PTHR30504, PTHR30504, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04349, MdoG, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF006281, MdoG, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF74650, SSF74650, 1 hit
SSF81296, SSF81296, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01409, TAT_signal_seq, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51318, TAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P40120-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDRRRFIKGS MAMAAVCGTS GIASLFSQAA FAADSDIADG QTQRFDFSIL 
        60         70         80         90        100
QSMAHDLAQT AWRGAPRPLP DTLATMTPQA YNSIQYDAEK SLWHNVENRQ 
       110        120        130        140        150
LDAQFFHMGM GFRRRVRMFS VDPATHLARE IHFRPELFKY NDAGVDTKQL 
       160        170        180        190        200
EGQSDLGFAG FRVFKAPELA RRDVVSFLGA SYFRAVDDTY QYGLSARGLA 
       210        220        230        240        250
IDTYTDSKEE FPDFTAFWFD TVKPGATTFT VYALLDSASI TGAYKFTIHC 
       260        270        280        290        300
EKSQVIMDVE NHLYARKDIK QLGIAPMTSM FSCGTNERRM CDTIHPQIHD 
       310        320        330        340        350
SDRLSMWRGN GEWICRPLNN PQKLQFNAYT DNNPKGFGLL QLDRDFSHYQ 
       360        370        380        390        400
DIMGWYNKRP SLWVEPRNKW GKGTIGLMEI PTTGETLDNI VCFWQPEKAV 
       410        420        430        440        450
KAGDEFAFQY RLYWSAQPPV HCPLARVMAT RTGMGGFSEG WAPGEHYPEK 
       460        470        480        490        500
WARRFAVDFV GGDLKAAAPK GIEPVITLSS GEAKQIEILY IEPIDGYRIQ 
       510        520        530        540        550
FDWYPTSDST DPVDMRMYLR CQGDAISETW LYQYFPPAPD KRQYVDDRVM 

S
Length:551
Mass (Da):62,758
Last modified:July 3, 2003 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4FC3BE21F70D4C46
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA15046 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74506.3
AP009048 Genomic DNA Translation: BAA15046.1 Different initiation.
X15860 Genomic DNA No translation available.

Protein sequence database of the Protein Information Resource

More...PIRi		C64894

NCBI Reference Sequences

More...RefSeqi		NP_415941.5, NC_000913.3
WP_000375961.1, NZ_SSZK01000021.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC74506; AAC74506; b1424
BAA15046; BAA15046; BAA15046

Database of genes from NCBI RefSeq genomes

More...GeneIDi		945994

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW1420
eco:b1424

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|511145.12.peg.1487

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74506.3
AP009048 Genomic DNA Translation: BAA15046.1 Different initiation.
X15860 Genomic DNA No translation available.
PIRiC64894
RefSeqiNP_415941.5, NC_000913.3
WP_000375961.1, NZ_SSZK01000021.1

3D structure databases

SMRiP40120
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi4261154, 12 interactors
IntActiP40120, 6 interactors
STRINGi511145.b1424

Proteomic databases

jPOSTiP40120
PaxDbiP40120
PRIDEiP40120

Genome annotation databases

EnsemblBacteriaiAAC74506; AAC74506; b1424
BAA15046; BAA15046; BAA15046
GeneIDi945994
KEGGiecj:JW1420
eco:b1424
PATRICifig|511145.12.peg.1487

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB2701

Phylogenomic databases

eggNOGiCOG3131, Bacteria
HOGENOMiCLU_023403_2_0_6
InParanoidiP40120
PhylomeDBiP40120

Enzyme and pathway databases

UniPathwayiUPA00637
BioCyciEcoCyc:EG12859-MONOMER

Miscellaneous databases

Protein Ontology

More...PROi		PR:P40120

Family and domain databases

Gene3Di2.60.40.10, 1 hit
2.70.98.10, 1 hit
HAMAPiMF_01068, MdoD_OpgD, 1 hit
InterProiView protein in InterPro
IPR011013, Gal_mutarotase_sf_dom
IPR014718, GH-type_carb-bd
IPR023724, Glucan_biosyn_MdoD
IPR014438, Glucan_biosyn_MdoG/MdoD
IPR007444, Glucan_biosyn_MdoG_C
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR006311, TAT_signal
IPR019546, TAT_signal_bac_arc
PANTHERiPTHR30504, PTHR30504, 1 hit
PfamiView protein in Pfam
PF04349, MdoG, 1 hit
PIRSFiPIRSF006281, MdoG, 1 hit
SUPFAMiSSF74650, SSF74650, 1 hit
SSF81296, SSF81296, 1 hit
TIGRFAMsiTIGR01409, TAT_signal_seq, 1 hit
PROSITEiView protein in PROSITE
PS51318, TAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOPGD_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P40120
Secondary accession number(s): P46134, P76098, P77631
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 3, 2003
Last modified: April 7, 2021
This is version 149 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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