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Entry version 161 (18 Sep 2019)
Sequence version 1 (01 Feb 1995)
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Protein

GDP-mannose transporter 1

Gene

VRG4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen. Defective copy causes severe glycosylation defect and abnormal retention of soluble endoplasmic reticulum proteins. Involved in vanadate sensitivity.12 Publications

Miscellaneous

Present with 31900 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • carbohydrate transport Source: UniProtKB-KW
  • GDP-mannose transmembrane transport Source: SGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-30699-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.7.13.1 the drug/metabolite transporter (dmt) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GDP-mannose transporter 1
Short name:
GMT 1
Alternative name(s):
Low dye-binding protein 3
Morphogenesis checkpoint-dependent protein 3
Vanadate resistance glycosylation protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VRG4
Synonyms:GOG5, LDB3, MCD3, VAN2, VIG4
Ordered Locus Names:YGL225W
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VII

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YGL225W

Saccharomyces Genome Database

More...
SGDi
S000003193 VRG4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 16CytoplasmicSequence analysisAdd BLAST16
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Topological domaini38 – 51LumenalSequence analysisAdd BLAST14
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Topological domaini73 – 92CytoplasmicSequence analysisAdd BLAST20
Transmembranei93 – 113HelicalSequence analysisAdd BLAST21
Topological domaini114 – 119LumenalSequence analysis6
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Topological domaini141 – 144CytoplasmicSequence analysis4
Transmembranei145 – 165HelicalSequence analysisAdd BLAST21
Topological domaini166 – 180LumenalSequence analysisAdd BLAST15
Transmembranei181 – 201HelicalSequence analysisAdd BLAST21
Topological domaini202 – 215CytoplasmicSequence analysisAdd BLAST14
Transmembranei216 – 236HelicalSequence analysisAdd BLAST21
Topological domaini237 – 252LumenalSequence analysisAdd BLAST16
Transmembranei253 – 273HelicalSequence analysisAdd BLAST21
Topological domaini274 – 279CytoplasmicSequence analysis6
Transmembranei280 – 300HelicalSequence analysisAdd BLAST21
Topological domaini301 – 304LumenalSequence analysis4
Transmembranei305 – 325HelicalSequence analysisAdd BLAST21
Topological domaini326 – 337CytoplasmicSequence analysisAdd BLAST12

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi278S → C in VIG4-2; increases drug sensitivity and decreases protein glycolysis. 1 Publication1
Mutagenesisi280T → A: Decreases transport activity and GDP-mannose-binding. 1 Publication1
Mutagenesisi282S → A: Decreases transport activity and GDP-mannose-binding. 1 Publication1
Mutagenesisi285G → A or D: Decreases transport activity and GDP-mannose-binding. 1 Publication1
Mutagenesisi286A → V in VIG4-1; increases drug sensitivity and decreases protein glycolysis. 2 Publications1
Mutagenesisi287L → A: Decreases transport activity and GDP-mannose-binding. 1 Publication1
Mutagenesisi288N → A: Decreases transport activity and GDP-mannose-binding. 1 Publication1
Mutagenesisi289K → A or D: Decreases transport activity and GDP-mannose-binding. 1 Publication1
Mutagenesisi291P → A: Decreases transport activity and GDP-mannose-binding. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002133981 – 337GDP-mannose transporter 1Add BLAST337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi119N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi242N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi246N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi249N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P40107

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P40107

PRoteomics IDEntifications database

More...
PRIDEi
P40107

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer.

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
33034, 129 interactors

Database of interacting proteins

More...
DIPi
DIP-5108N

Protein interaction database and analysis system

More...
IntActi
P40107, 6 interactors

STRING: functional protein association networks

More...
STRINGi
4932.YGL225W

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1337
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P40107

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni279 – 291GDP-mannose-bindingAdd BLAST13
Regioni326 – 337RET2-bindingAdd BLAST12

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000031183

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P40107

KEGG Orthology (KO)

More...
KOi
K15356

Identification of Orthologs from Complete Genome Data

More...
OMAi
KAWFPIS

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038736 Vrg4-like

The PANTHER Classification System

More...
PANTHERi
PTHR11132:SF251 PTHR11132:SF251, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P40107-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSELKTGHAG HNPWASVANS GPISILSYCG SSILMTVTNK FVVNLKDFNM
60 70 80 90 100
NFVMLFVQSL VCTITLIILR ILGYAKFRSL NKTDAKNWFP ISFLLVLMIY
110 120 130 140 150
TSSKALQYLA VPIYTIFKNL TIILIAYGEV LFFGGSVTSM ELSSFLLMVL
160 170 180 190 200
SSVVATWGDQ QAVAAKAASL AEGAAGAVAS FNPGYFWMFT NCITSALFVL
210 220 230 240 250
IMRKRIKLTN FKDFDTMFYN NVLALPILLL FSFCVEDWSS VNLTNNFSND
260 270 280 290 300
SLTAMIISGV ASVGISYCSG WCVRVTSSTT YSMVGALNKL PIALSGLIFF
310 320 330
DAPRNFLSIL SIFIGFLSGI IYAVAKQKKQ QAQPLRK
Length:337
Mass (Da):37,019
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5C7EE07B05DA8E61
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L33915 Genomic DNA Translation: AAC37468.1
U15599 Genomic DNA Translation: AAA81537.1
Z72747 Genomic DNA Translation: CAA96941.1
BK006941 Genomic DNA Translation: DAA07894.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S50238

NCBI Reference Sequences

More...
RefSeqi
NP_011290.1, NM_001181090.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YGL225W_mRNA; YGL225W; YGL225W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
852647

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YGL225W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33915 Genomic DNA Translation: AAC37468.1
U15599 Genomic DNA Translation: AAA81537.1
Z72747 Genomic DNA Translation: CAA96941.1
BK006941 Genomic DNA Translation: DAA07894.1
PIRiS50238
RefSeqiNP_011290.1, NM_001181090.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5OGEX-ray3.22A/B/C/D/E/F/G/H1-337[»]
5OGKX-ray3.60A/B/C/D/E/F/G/H1-337[»]
SMRiP40107
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi33034, 129 interactors
DIPiDIP-5108N
IntActiP40107, 6 interactors
STRINGi4932.YGL225W

Protein family/group databases

TCDBi2.A.7.13.1 the drug/metabolite transporter (dmt) superfamily

Proteomic databases

MaxQBiP40107
PaxDbiP40107
PRIDEiP40107

Genome annotation databases

EnsemblFungiiYGL225W_mRNA; YGL225W; YGL225W
GeneIDi852647
KEGGisce:YGL225W

Organism-specific databases

EuPathDBiFungiDB:YGL225W
SGDiS000003193 VRG4

Phylogenomic databases

HOGENOMiHOG000031183
InParanoidiP40107
KOiK15356
OMAiKAWFPIS

Enzyme and pathway databases

BioCyciYEAST:G3O-30699-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P40107

Family and domain databases

InterProiView protein in InterPro
IPR038736 Vrg4-like
PANTHERiPTHR11132:SF251 PTHR11132:SF251, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGMT1_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P40107
Secondary accession number(s): D6VVB0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 18, 2019
This is version 161 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names
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