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Entry version 141 (02 Jun 2021)
Sequence version 2 (01 Nov 1997)
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Protein

Y' element ATP-dependent helicase protein 1 copy 2

Gene

YRF1-2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi696 – 703ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • telomere maintenance via recombination Source: SGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Y' element ATP-dependent helicase protein 1 copy 2 (EC:3.6.4.12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:YRF1-2
Ordered Locus Names:YER190W
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000000992, YRF1-2

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YER190W

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001022021 – 1681Y' element ATP-dependent helicase protein 1 copy 2Add BLAST1681

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P40105

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P40105

PRoteomics IDEntifications database

More...
PRIDEi
P40105

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced in absence of telomerase TLC1.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
36943, 5 interactors

STRING: functional protein association networks

More...
STRINGi
4932.YER190W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P40105, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini683 – 860Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST178
Domaini917 – 1066Helicase C-terminalPROSITE-ProRule annotationAdd BLAST150

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1140 – 1307DisorderedSequence analysisAdd BLAST168

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1140 – 1283Polar residuesSequence analysisAdd BLAST144
Compositional biasi1284 – 1307Basic and acidic residuesSequence analysisAdd BLAST24

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QWCT, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153173

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003044_2_0_1

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011545, DEAD/DEAH_box_helicase_dom
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00270, DEAD, 1 hit
PF00271, Helicase_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P40105-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVYTLFQVHT LKFNRKDYDT LSLFYLNRGY YNELSFRVLE RCHEKASARP
60 70 80 90 100
NDSSTMRTFT DFVSGAPIVR SLQKSTIRKY GYNLAPYMFL LLHVDELSIF
110 120 130 140 150
SAYQASLPGE KKVDTERLKR DLCPRKPTEI KYFSQICNDM MNKKDRLGDI
160 170 180 190 200
LHIILRACAL NFGAGPRGGA GDEEDRSITN EEPIIPSVDE HGLKVCKLRS
210 220 230 240 250
PNTPRRLRKT LDAVKALLVS SCACTARDLD IFDDNNGVAM WKWIKILYHE
260 270 280 290 300
VAQETALKDS YRITLVPSSD GVSVCGKLFN REYVRGFYFA CKAQFDNLWE
310 320 330 340 350
ELNDCFYMPT VVDIASLILR NREVLFREPK RGIDEYLEND SFLQMIPVKY
360 370 380 390 400
REIVLPKLRR DTNKMTAALK NKVTVAIDEL TVPLMWMIHF AVGYPYRYPE
410 420 430 440 450
LQLLAFAGPQ RNVYVDDTTR RIQLYTDYNK NGSSEPRLKT LDGLTSDYVF
460 470 480 490 500
YFVTVLRQMQ ICALGNSYDA FNHDPWMDVV GFEDPDQVTN RDISRIVLYS
510 520 530 540 550
YMFLNTAKGC LVEYATFRQY MRELPKNAPQ KLNFREMRQG LIALGRHCVG
560 570 580 590 600
SRFETDLYES ATSELMANHS VQTGRNIYGV DSFSLTSVSG TTATLLQERA
610 620 630 640 650
SERWIQWLGL ESDYHCSFSS TRNAEDVVAG EAASSDHHQK ISRVTRKRPR
660 670 680 690 700
EPKSTNDILV AGQKLFGSSF EFRDLHQLRL CHEIYMADTP SVAVQAPPGY
710 720 730 740 750
GKTELFHLPL IALASKGDVK YVSFLFVPYT VLLANCMIRL SRCGCLNVAP
760 770 780 790 800
VRNFIEEGCD GVTDLYVGIY DDLASTNFTD RIAAWENIVE CTFRTNNVKL
810 820 830 840 850
GYLIVDEFHN FETEVYRQSQ FGGITNLDFD AFEKAIFLSG TAPEAVADAA
860 870 880 890 900
LQRIGLTGLA KKSMDINELK RSEDLSRGLS SYPTRMFNLI KEKSEVPLGH
910 920 930 940 950
VHKIWKKVES QPEEALKLLL ALFEIEPESK AIVVASTTNE VEELACSWRK
960 970 980 990 1000
YFRVVWIHGK LGAAEKVSRT KEFVTDGSMR VLIGTKLVTE GIDIKQLMMV
1010 1020 1030 1040 1050
IMLDNRLNII ELIQGVGRLR DGGLCYLLSR KNSWAARNRK GELPPIKEGC
1060 1070 1080 1090 1100
ITEQVREFYG LESKKGKKGQ HVGCCGSRTD LSADTVELIE RMDRLAEKQA
1110 1120 1130 1140 1150
TASMSIVALP SSFQESNSSD RCRKYCSSDE DSDTCIHGSA NASTNATTNS
1160 1170 1180 1190 1200
STNATTTAST NVRTSATTTA SINVRTSATT TESTNSSTNA TTTASTNVRT
1210 1220 1230 1240 1250
SATTTASINV RTSATTTEST NSNTSATTTE STDSNTSATT TESTDSNTSA
1260 1270 1280 1290 1300
TTTASTNSST NATTTASTNS STNATTTEST NASAKEDANK DGNAEDNRFH
1310 1320 1330 1340 1350
PVTDINKESY KRKGSQMVLL ERKKLKAQFP NTSENMNVLQ FLGFRSDEIK
1360 1370 1380 1390 1400
HLFLYGIDVY FCPEGVFTQY GLCKGCQKMF ELCVCWAGQK VSYRRMAWEA
1410 1420 1430 1440 1450
LAVERMLRND EEYKEYLEDI EPYHGDPVGY LKYFSVKRGE IYSQIQRNYA
1460 1470 1480 1490 1500
WYLAITRRRE TISVLDSTRG KQGSQVFRMS GRQIKELYYK VWSNLRESKT
1510 1520 1530 1540 1550
EVLQYFLNWD EKKCREEWEA KDDTVFVEAL EKVGVFQRLR SMTSAGLQGP
1560 1570 1580 1590 1600
QYVKLQFSRH HRQLRSRYEL SLGMHLRDQL ALGVTPSKVP HWTAFLSMLI
1610 1620 1630 1640 1650
GLFCNKTFRQ KLEYLLEQIS EVWLLPHWLD LANVEVLAAD NTRVPLYMLM
1660 1670 1680
VAVHKELDSD DVPDGRFDIL LCRDSSREVG E
Length:1,681
Mass (Da):190,503
Last modified:November 1, 1997 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC6A37BB6EB6CFF13
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U34775 Genomic DNA Translation: AAB65037.1
U18922 Genomic DNA Translation: AAB64717.1
BK006939 Genomic DNA Translation: DAA07853.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S59693

NCBI Reference Sequences

More...
RefSeqi
NP_011117.3, NM_001179080.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YER190W_mRNA; YER190W; YER190W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
856940

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YER190W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34775 Genomic DNA Translation: AAB65037.1
U18922 Genomic DNA Translation: AAB64717.1
BK006939 Genomic DNA Translation: DAA07853.1
PIRiS59693
RefSeqiNP_011117.3, NM_001179080.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi36943, 5 interactors
STRINGi4932.YER190W

Proteomic databases

MaxQBiP40105
PaxDbiP40105
PRIDEiP40105

Genome annotation databases

EnsemblFungiiYER190W_mRNA; YER190W; YER190W
GeneIDi856940
KEGGisce:YER190W

Organism-specific databases

SGDiS000000992, YRF1-2
VEuPathDBiFungiDB:YER190W

Phylogenomic databases

eggNOGiENOG502QWCT, Eukaryota
GeneTreeiENSGT00940000153173
HOGENOMiCLU_003044_2_0_1

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P40105
RNActiP40105, protein

Family and domain databases

InterProiView protein in InterPro
IPR011545, DEAD/DEAH_box_helicase_dom
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF00270, DEAD, 1 hit
PF00271, Helicase_C, 1 hit
SMARTiView protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYRF12_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P40105
Secondary accession number(s): D3DM99
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 1, 1997
Last modified: June 2, 2021
This is version 141 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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