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Entry version 172 (29 Sep 2021)
Sequence version 1 (01 Feb 1995)
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Protein

Conserved oligomeric Golgi complex subunit 3

Gene

COG3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis- Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events. COG3 is also involved in actin cytoskeleton organization.

3 Publications

Miscellaneous

Present with 4140 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cargo adaptor activity Source: SGD

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Conserved oligomeric Golgi complex subunit 3
Short name:
COG complex subunit 3
Alternative name(s):
Component of oligomeric Golgi complex 3
Protein SEC34
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COG3
Synonyms:GRD20, SEC34
Ordered Locus Names:YER157W
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

Saccharomyces Genome Database

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SGDi
S000000959, COG3

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YER157W

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002135031 – 801Conserved oligomeric Golgi complex subunit 3Add BLAST801

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei507PhosphoserineCombined sources1
Modified residuei647PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P40094

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P40094

PRoteomics IDEntifications database

More...
PRIDEi
P40094

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P40094

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the conserved oligomeric Golgi (COG or Sec34/Sec35) complex which consists of eight different proteins COG1-COG8.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
36907, 1029 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1840, COG Golgi transport complex

Database of interacting proteins

More...
DIPi
DIP-4728N

Protein interaction database and analysis system

More...
IntActi
P40094, 24 interactors

Molecular INTeraction database

More...
MINTi
P40094

STRING: functional protein association networks

More...
STRINGi
4932.YER157W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P40094, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P40094

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni470 – 489DisorderedSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the COG3 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2604, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015682

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011639_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P40094

Identification of Orthologs from Complete Genome Data

More...
OMAi
LDEFELW

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007265, COG_su3

The PANTHER Classification System

More...
PANTHERi
PTHR13302, PTHR13302, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04136, Sec34, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P40094-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARSRKNSLV RDIASHPTIP ESQTIVGLLD DSYLFDKLKK LSLAVENSDS
60 70 80 90 100
LQRTDVSEGC SEVNGSEATT SADVKKTNKY LYYTTYLDQL NIKIDEYKVV
110 120 130 140 150
LDQTRQVNDQ LDSSIKKFRK ISQDTGAFIE ETKTIYEKQS KLSNLTESIP
160 170 180 190 200
KALHYFEVLD PIMRRLNHAT SPAIVKKSSF TTMLATIDES LRFLDENSDL
210 220 230 240 250
KDAAAYRIKF KQCLIRACEL ISHFLTNLLK QTNQEILDKT KNKNSLTGLP
260 270 280 290 300
STTRDAFLYS KFYTIADTFK IQVSEIVKRS NEKAYNKYHD ELNSILYECF
310 320 330 340 350
NHYFQTRLRL LTPVIWSHID EIVVKDKDQG LVKFIQDGKV YFQQLCADEY
360 370 380 390 400
KLFVEFFPEK ECRFKINQWF LQLCEPLYDS IRVRVLKETD ICTLCDSVTL
410 420 430 440 450
FAPYYEFEEG SEEYVKQFTD IQYDKLFEPI VQKVQARLIL RVQIYVQQNI
460 470 480 490 500
LSYRPTRDVF MISNRRRKSK TSLQGGNEDA TTSDDNPDPL LESYLSSFKN
510 520 530 540 550
RSILPISPND ADDKSIDSEE STDKISQLQT YYPPLLKTLA LLSKIYEMIN
560 570 580 590 600
SVVFDDLAHH VVHDCIVSLR NAYDMVIKSS AGKSDFNNLD ISLAYLKNLL
610 620 630 640 650
MLRDSIQNFN IQYTVNETYL DFSGVEGFFK SLKENGRNVL KKTKSSSILT
660 670 680 690 700
LARELVPKVV NNMVDARTEL ISELRNVIKD FTESTSLELI DDTLDINSDE
710 720 730 740 750
DLLSKNVKLR ENIKARLPRI YEQILNYIDD QEIVTNLLDA VQELITQSYS
760 770 780 790 800
KYYETITELA ENGKFAKDQV ADVMYLDVFT DFFAKEVADL LRNGDIDTIT

K
Length:801
Mass (Da):92,544
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC7AFBE99010FE571
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U18917 Genomic DNA Translation: AAB64684.1
BK006939 Genomic DNA Translation: DAA07818.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S50660

NCBI Reference Sequences

More...
RefSeqi
NP_011084.1, NM_001179047.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YER157W_mRNA; YER157W; YER157W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
856901

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YER157W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18917 Genomic DNA Translation: AAB64684.1
BK006939 Genomic DNA Translation: DAA07818.1
PIRiS50660
RefSeqiNP_011084.1, NM_001179047.1

3D structure databases

SMRiP40094
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi36907, 1029 interactors
ComplexPortaliCPX-1840, COG Golgi transport complex
DIPiDIP-4728N
IntActiP40094, 24 interactors
MINTiP40094
STRINGi4932.YER157W

PTM databases

iPTMnetiP40094

Proteomic databases

MaxQBiP40094
PaxDbiP40094
PRIDEiP40094

Genome annotation databases

EnsemblFungiiYER157W_mRNA; YER157W; YER157W
GeneIDi856901
KEGGisce:YER157W

Organism-specific databases

SGDiS000000959, COG3
VEuPathDBiFungiDB:YER157W

Phylogenomic databases

eggNOGiKOG2604, Eukaryota
GeneTreeiENSGT00390000015682
HOGENOMiCLU_011639_2_0_1
InParanoidiP40094
OMAiLDEFELW

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P40094
RNActiP40094, protein

Family and domain databases

InterProiView protein in InterPro
IPR007265, COG_su3
PANTHERiPTHR13302, PTHR13302, 1 hit
PfamiView protein in Pfam
PF04136, Sec34, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOG3_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P40094
Secondary accession number(s): D3DM64
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 29, 2021
This is version 172 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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