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UniProtKB - P40086 (COX15_YEAST)
Protein
Cytochrome c oxidase assembly protein COX15
Gene
COX15
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Required for the assembly of yeast cytochrome oxidase. Involved in the biosynthesis of heme A and the initial step in this pathway, the hydroxylation of heme O, is thought to be catalyzed by a three-component mono-oxygenase consisting of COX15, ferredoxin and ferredoxin reductase.
2 PublicationsGO - Molecular functioni
GO - Biological processi
- heme A biosynthetic process Source: SGD
Enzyme and pathway databases
Reactomei | R-SCE-189451, Heme biosynthesis |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome c oxidase assembly protein COX15 |
Gene namesi | Name:COX15 Ordered Locus Names:YER141W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000000943, COX15 |
VEuPathDBi | FungiDB:YER141W |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane 1 Publication; Multi-pass membrane protein 1 Publication
Mitochondrion
- mitochondrial inner membrane Source: SGD
- mitochondrion Source: SGD
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 86 – 106 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 171 – 191 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 201 – 221 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 244 – 264 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 294 – 314 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 403 – 423 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 425 – 445 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000183933 | 1 – 486 | Cytochrome c oxidase assembly protein COX15Add BLAST | 486 |
Proteomic databases
MaxQBi | P40086 |
PaxDbi | P40086 |
PRIDEi | P40086 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 36890, 75 interactors |
IntActi | P40086, 12 interactors |
MINTi | P40086 |
STRINGi | 4932.YER141W |
Miscellaneous databases
RNActi | P40086, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the COX15/CtaA family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2725, Eukaryota |
GeneTreei | ENSGT00390000002223 |
HOGENOMi | CLU_017627_4_1_1 |
InParanoidi | P40086 |
OMAi | YWWEWGH |
Family and domain databases
HAMAPi | MF_01665, HemeA_synth_type2, 1 hit |
InterProi | View protein in InterPro IPR003780, COX15/CtaA_fam IPR023754, HemeA_Synthase_type2 |
PANTHERi | PTHR23289, PTHR23289, 1 hit |
Pfami | View protein in Pfam PF02628, COX15-CtaA, 1 hit |
i Sequence
Sequence statusi: Complete.
P40086-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLFRNIEVGR QAAKLLTRTS SRLAWQSIGA SRNISTIRQQ IRKTQLYNFK
60 70 80 90 100
KTVSIRPFSL SSPVFKPHVA SESNPIESRL KTSKNVAYWL IGTSGLVFGI
110 120 130 140 150
VVLGGLTRLT ESGLSITEWK PVTGTLPPMN QKEWEEEFIK YKESPEFKLL
160 170 180 190 200
NSHIDLDEFK FIFFMEWIHR LWGRAIGAVF ILPAVYFAVS KKTSGHVNKR
210 220 230 240 250
LFGLAGLLGL QGFVGWWMVK SGLDQEQLDA RKSKPTVSQY RLTTHLGTAF
260 270 280 290 300
FLYMGMLWTG LEILRECKWI KNPVQAISLF KKLDNPAIGP MRKISLALLA
310 320 330 340 350
VSFLTAMSGG MVAGLDAGWV YNTWPKMGER WFPSSRELMD ENFCRREDKK
360 370 380 390 400
DLWWRNLLEN PVTVQLVHRT CAYVAFTSVL AAHMYAIKKK AVIPRNAMTS
410 420 430 440 450
LHVMMGVVTL QATLGILTIL YLVPISLASI HQAGALALLT SSLVFASQLR
460 470 480
KPRAPMRNVI ITLPHSSKVT SGKILSEASK LASKPL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L38643 Genomic DNA Translation: AAA57471.1 U18917 Genomic DNA Translation: AAB64668.1 BK006939 Genomic DNA Translation: DAA07802.1 |
PIRi | S50644 |
RefSeqi | NP_011068.1, NM_001179031.1 |
Genome annotation databases
EnsemblFungii | YER141W_mRNA; YER141W; YER141W |
GeneIDi | 856884 |
KEGGi | sce:YER141W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L38643 Genomic DNA Translation: AAA57471.1 U18917 Genomic DNA Translation: AAB64668.1 BK006939 Genomic DNA Translation: DAA07802.1 |
PIRi | S50644 |
RefSeqi | NP_011068.1, NM_001179031.1 |
3D structure databases
SMRi | P40086 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 36890, 75 interactors |
IntActi | P40086, 12 interactors |
MINTi | P40086 |
STRINGi | 4932.YER141W |
Proteomic databases
MaxQBi | P40086 |
PaxDbi | P40086 |
PRIDEi | P40086 |
Genome annotation databases
EnsemblFungii | YER141W_mRNA; YER141W; YER141W |
GeneIDi | 856884 |
KEGGi | sce:YER141W |
Organism-specific databases
SGDi | S000000943, COX15 |
VEuPathDBi | FungiDB:YER141W |
Phylogenomic databases
eggNOGi | KOG2725, Eukaryota |
GeneTreei | ENSGT00390000002223 |
HOGENOMi | CLU_017627_4_1_1 |
InParanoidi | P40086 |
OMAi | YWWEWGH |
Enzyme and pathway databases
Reactomei | R-SCE-189451, Heme biosynthesis |
Miscellaneous databases
PHI-basei | PHI:503 |
PROi | PR:P40086 |
RNActi | P40086, protein |
Family and domain databases
HAMAPi | MF_01665, HemeA_synth_type2, 1 hit |
InterProi | View protein in InterPro IPR003780, COX15/CtaA_fam IPR023754, HemeA_Synthase_type2 |
PANTHERi | PTHR23289, PTHR23289, 1 hit |
Pfami | View protein in Pfam PF02628, COX15-CtaA, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | COX15_YEAST | |
Accessioni | P40086Primary (citable) accession number: P40086 Secondary accession number(s): D3DM48 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | February 23, 2022 | |
This is version 154 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome V
Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names - SIMILARITY comments
Index of protein domains and families