UniProtKB - P40066 (GLE2_YEAST)
mRNA export factor GLE2
GLE2
Functioni
Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. It is specifically important for nuclear mRNA export.
5 PublicationsMiscellaneous
GO - Molecular functioni
- RNA binding Source: GO_Central
- ubiquitin binding Source: GO_Central
GO - Biological processi
- nuclear pore localization Source: SGD
- poly(A)+ mRNA export from nucleus Source: SGD
- posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery Source: SGD
- protein transport Source: UniProtKB-KW
- regulation of mRNA export from nucleus in response to heat stress Source: SGD
- RNA export from nucleus Source: GO_Central
- transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery Source: SGD
Keywordsi
Biological process | mRNA transport, Protein transport, Translocation, Transport |
Enzyme and pathway databases
Reactomei | R-SCE-3232142, SUMOylation of ubiquitinylation proteins R-SCE-4085377, SUMOylation of SUMOylation proteins R-SCE-4551638, SUMOylation of chromatin organization proteins R-SCE-4570464, SUMOylation of RNA binding proteins |
Protein family/group databases
TCDBi | 1.I.1.1.1, the nuclear pore complex (npc) family |
Names & Taxonomyi
Protein namesi | Recommended name: mRNA export factor GLE21 PublicationAlternative name(s): Nuclear pore protein GLE2Curated Nucleoporin GLE2Curated poly(A) RNA export protein RAE11 Publication |
Gene namesi | Name:GLE2 Synonyms:RAE1 Ordered Locus Names:YER107C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000000909, GLE2 |
VEuPathDBi | FungiDB:YER107C |
Subcellular locationi
Nucleus
Note: Symmetric distribution.
Nucleus
- nuclear membrane Source: UniProtKB-SubCell
- nuclear pore Source: SGD
Other locations
- cytoplasm Source: SGD
Keywords - Cellular componenti
Membrane, Nuclear pore complex, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051007 | 1 – 365 | mRNA export factor GLE2Add BLAST | 365 |
Proteomic databases
MaxQBi | P40066 |
PaxDbi | P40066 |
PRIDEi | P40066 |
PTM databases
iPTMneti | P40066 |
Interactioni
Subunit structurei
Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof. GLE2 interacts with the NUP82 subcomplex via NUP116. It also interacts with NUP42.
3 PublicationsBinary interactionsi
P40066
With | #Exp. | IntAct |
---|---|---|
NUP116 [Q02630] | 5 | EBI-22648,EBI-11703 |
GO - Molecular functioni
- ubiquitin binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 36853, 316 interactors |
ComplexPortali | CPX-824, Nuclear pore complex |
DIPi | DIP-2452N |
IntActi | P40066, 16 interactors |
MINTi | P40066 |
STRINGi | 4932.YER107C |
Miscellaneous databases
RNActi | P40066, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 34 – 74 | WD 1Add BLAST | 41 | |
Repeati | 78 – 117 | WD 2Add BLAST | 40 | |
Repeati | 119 – 162 | WD 3Add BLAST | 44 | |
Repeati | 267 – 306 | WD 4Add BLAST | 40 |
Sequence similaritiesi
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG0647, Eukaryota |
GeneTreei | ENSGT00950000183091 |
HOGENOMi | CLU_038526_1_0_1 |
InParanoidi | P40066 |
OMAi | ADFICEN |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR020472, G-protein_beta_WD-40_rep IPR037631, Gle2/RAE1 IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR10971:SF11, PTHR10971:SF11, 1 hit |
Pfami | View protein in Pfam PF00400, WD40, 4 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00320, WD40, 4 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50082, WD_REPEATS_2, 4 hits PS50294, WD_REPEATS_REGION, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MSFFNRSNTT SALGTSTAMA NEKDLANDIV INSPAEDSIS DIAFSPQQDF
60 70 80 90 100
MFSASSWDGK VRIWDVQNGV PQGRAQHESS SPVLCTRWSN DGTKVASGGC
110 120 130 140 150
DNALKLYDIA SGQTQQIGMH SAPIKVLRFV QCGPSNTECI VTGSWDKTIK
160 170 180 190 200
YWDMRQPQPV STVMMPERVY SMDNKQSLLV VATAERHIAI INLANPTTIF
210 220 230 240 250
KATTSPLKWQ TRCVACYNEA DGYAIGSVEG RCSIRYIDDG MQKKSGFSFK
260 270 280 290 300
CHRQTNPNRA PGSNGQSLVY PVNSIAFHPL YGTFVTAGGD GTFNFWDKNQ
310 320 330 340 350
RHRLKGYPTL QASIPVCSFN RNGSVFAYAL SYDWHQGHMG NRPDYPNVIR
360
LHATTDEEVK EKKKR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18839 Genomic DNA Translation: AAB64662.1 AY692884 Genomic DNA Translation: AAT92903.1 BK006939 Genomic DNA Translation: DAA07768.1 |
PIRi | S50610 |
RefSeqi | NP_011033.3, NM_001178998.3 |
Genome annotation databases
EnsemblFungii | YER107C_mRNA; YER107C; YER107C |
GeneIDi | 856844 |
KEGGi | sce:YER107C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18839 Genomic DNA Translation: AAB64662.1 AY692884 Genomic DNA Translation: AAT92903.1 BK006939 Genomic DNA Translation: DAA07768.1 |
PIRi | S50610 |
RefSeqi | NP_011033.3, NM_001178998.3 |
3D structure databases
SMRi | P40066 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 36853, 316 interactors |
ComplexPortali | CPX-824, Nuclear pore complex |
DIPi | DIP-2452N |
IntActi | P40066, 16 interactors |
MINTi | P40066 |
STRINGi | 4932.YER107C |
Protein family/group databases
TCDBi | 1.I.1.1.1, the nuclear pore complex (npc) family |
PTM databases
iPTMneti | P40066 |
Proteomic databases
MaxQBi | P40066 |
PaxDbi | P40066 |
PRIDEi | P40066 |
Genome annotation databases
EnsemblFungii | YER107C_mRNA; YER107C; YER107C |
GeneIDi | 856844 |
KEGGi | sce:YER107C |
Organism-specific databases
SGDi | S000000909, GLE2 |
VEuPathDBi | FungiDB:YER107C |
Phylogenomic databases
eggNOGi | KOG0647, Eukaryota |
GeneTreei | ENSGT00950000183091 |
HOGENOMi | CLU_038526_1_0_1 |
InParanoidi | P40066 |
OMAi | ADFICEN |
Enzyme and pathway databases
Reactomei | R-SCE-3232142, SUMOylation of ubiquitinylation proteins R-SCE-4085377, SUMOylation of SUMOylation proteins R-SCE-4551638, SUMOylation of chromatin organization proteins R-SCE-4570464, SUMOylation of RNA binding proteins |
Miscellaneous databases
PROi | PR:P40066 |
RNActi | P40066, protein |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR020472, G-protein_beta_WD-40_rep IPR037631, Gle2/RAE1 IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR10971:SF11, PTHR10971:SF11, 1 hit |
Pfami | View protein in Pfam PF00400, WD40, 4 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00320, WD40, 4 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50082, WD_REPEATS_2, 4 hits PS50294, WD_REPEATS_REGION, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GLE2_YEAST | |
Accessioni | P40066Primary (citable) accession number: P40066 Secondary accession number(s): D3DM14 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | February 23, 2022 | |
This is version 191 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome V
Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names - SIMILARITY comments
Index of protein domains and families