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Entry version 170 (02 Jun 2021)
Sequence version 1 (01 Feb 1995)
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Protein

Nucleoporin NUP157

Gene

NUP157

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors.

2 Publications

Miscellaneous

Present with 4420 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.I.1.1.1, the nuclear pore complex (npc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nucleoporin NUP157
Alternative name(s):
Nuclear pore protein NUP157
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NUP157
Ordered Locus Names:YER105C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000000907, NUP157

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YER105C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002048481 – 1391Nucleoporin NUP157Add BLAST1391

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei1034PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P40064

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P40064

PRoteomics IDEntifications database

More...
PRIDEi
P40064

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P40064

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P40064

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof. NUP157 may be part of a NPC subcomplex containing NUP53, NUP170, and NUP59. In addition it may bind to MAD2.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
36851, 86 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-824, Nuclear pore complex

Database of interacting proteins

More...
DIPi
DIP-846N

Protein interaction database and analysis system

More...
IntActi
P40064, 16 interactors

Molecular INTeraction database

More...
MINTi
P40064

STRING: functional protein association networks

More...
STRINGi
4932.YER105C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P40064, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11391
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P40064

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni21 – 50DisorderedSequence analysisAdd BLAST30
Regioni1372 – 1391DisorderedSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1900, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016532

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000429_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P40064

Identification of Orthologs from Complete Genome Data

More...
OMAi
VWNDTIC

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.440, 1 hit
1.25.40.450, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007187, Nucleoporin_Nup133/Nup155_C
IPR014908, Nucleoporin_Nup133/Nup155_N
IPR004870, Nucleoporin_Nup155
IPR042533, Nucleoporin_Nup155_C_1
IPR042537, Nucleoporin_Nup155_C_2

The PANTHER Classification System

More...
PANTHERi
PTHR10350, PTHR10350, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03177, Nucleoporin_C, 1 hit
PF08801, Nucleoporin_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P40064-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYSTPLKKRI DYDRETFTAS ASLGGNRLRN RPRDDQNNGK PNLSSRSFLS
60 70 80 90 100
ERKTRKDVLN KYGEAGNTIE SELRDVTTHV KISGLTSSEP LQLASEFVQD
110 120 130 140 150
LSFRDRNTPI LDNPDYYSKG LDYNFSDEVG GLGAFTPFQR QQVTNIPDEV
160 170 180 190 200
LSQVSNTEIK SDMGIFLELN YCWITSDNKL ILWNINNSSE YHCIDEIEHT
210 220 230 240 250
ILKVKLVKPS PNTFVSSVEN LLIVATLFDI YILTISFNDR THELNIFNTG
260 270 280 290 300
LKVNVTGFNV SNIISYERTG QIFFTGATDG VNVWELQYNC SENLFNSKSN
310 320 330 340 350
KICLTKSNLA NLLPTKLIPS IPGGKLIQKV LEGDAGTEEE TISQLEVDQS
360 370 380 390 400
RGVLHTLSTK SIVRSYLITS NGLVGPVLID AAHIRRGMNA LGVKNSPLLS
410 420 430 440 450
NRAFKIAKIV SISMCENNDL FLAVITTTGV RLYFKGSISR RSIGSLKLDS
460 470 480 490 500
VKFPPTSISS SLEQNKSFII GHHPLNTHDT GPLSTQKASS TYINTTCAST
510 520 530 540 550
IISPGIYFTC VRKRANSGEL SKGITNKALL ENKEEHKLYV SAPDYGILKN
560 570 580 590 600
YGKYVENTAL LDTTDEIKEI VPLTRSFNYT STPQGYANVF ASQYSAEPLK
610 620 630 640 650
VAVLTSNALE IYCYRTPDEV FESLIENPLP FIHSYGLSEA CSTALYLACK
660 670 680 690 700
FNKSEHIKSS ALAFFSAGIP GVVEIKPKSS RESGSVPPIS QNLFDKSGEC
710 720 730 740 750
DGIVLSPRFY GSALLITRLF SQIWEERVFV FKRASKTEKM DAFGISITRP
760 770 780 790 800
QVEYYLSSIS VLADFFNIHR PSFVSFVPPK GSNAITASDA ESIAMNALIL
810 820 830 840 850
LINSIKDALS LINVFYEDID AFKSLLNTLM GAGGVYDSKT REYFFDLKFH
860 870 880 890 900
DLFTPNAKTK QLIKEILIEV VNANIASGTS ADYIVNVLKE RFGSFCHSAD
910 920 930 940 950
ILCYRAGEHL EAAQKFEMID SKISRNHLDT AIDLYERCAE NIELCELRRV
960 970 980 990 1000
VDIMVKLNYQ PKTVGFLLRF ADKIDKGNQA QEYVSRGCNT ADPRKVFYDK
1010 1020 1030 1040 1050
RINVYTLIFE IVKSVDDYTS IEQSPSIANI SIFSPASSLK KRVYSVIMNS
1060 1070 1080 1090 1100
NNRFFHYCFY DWLVANKRQD YLLRLDSQFV LPYLKERAEK SLEISNLLWF
1110 1120 1130 1140 1150
YLFKEEHFLE AADVLYALAS SDFDLKLSER IECLARANGL CDSSTSFDQK
1160 1170 1180 1190 1200
PALVQLSENI HELFDIASIQ DDLLNLVRNE TRIDEDYRKQ LTLKLNGRVL
1210 1220 1230 1240 1250
PLSDLFNDCA DPLDYYEIKL RIFKVSQFKD EKVIQGEWNR LLDSMKNAPS
1260 1270 1280 1290 1300
PDVGSVGQES FLSSISNTLI RIGKTTRDTD VVFPVHFLMN KILESFIDKS
1310 1320 1330 1340 1350
SAADGSVCSM FLLAGVSHLK LYYILSRIIE NSEGNVELAK KEMVWLIKDW
1360 1370 1380 1390
YQSDSDLRGS IAPEQIKKLE KYDPNTDPVQ DYVKDRHHGL K
Length:1,391
Mass (Da):156,649
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCB47CEE27AB4FCE3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U18839 Genomic DNA Translation: AAB64660.1
BK006939 Genomic DNA Translation: DAA07766.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S50608

NCBI Reference Sequences

More...
RefSeqi
NP_011031.1, NM_001178996.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YER105C_mRNA; YER105C; YER105C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
856842

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YER105C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18839 Genomic DNA Translation: AAB64660.1
BK006939 Genomic DNA Translation: DAA07766.1
PIRiS50608
RefSeqiNP_011031.1, NM_001178996.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4MHCX-ray2.40A70-893[»]
SMRiP40064
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi36851, 86 interactors
ComplexPortaliCPX-824, Nuclear pore complex
DIPiDIP-846N
IntActiP40064, 16 interactors
MINTiP40064
STRINGi4932.YER105C

Protein family/group databases

TCDBi1.I.1.1.1, the nuclear pore complex (npc) family

PTM databases

iPTMnetiP40064

Proteomic databases

MaxQBiP40064
PaxDbiP40064
PRIDEiP40064
TopDownProteomicsiP40064

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
856842

Genome annotation databases

EnsemblFungiiYER105C_mRNA; YER105C; YER105C
GeneIDi856842
KEGGisce:YER105C

Organism-specific databases

SGDiS000000907, NUP157
VEuPathDBiFungiDB:YER105C

Phylogenomic databases

eggNOGiKOG1900, Eukaryota
GeneTreeiENSGT00390000016532
HOGENOMiCLU_000429_0_1_1
InParanoidiP40064
OMAiVWNDTIC

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P40064
RNActiP40064, protein

Family and domain databases

Gene3Di1.25.40.440, 1 hit
1.25.40.450, 1 hit
InterProiView protein in InterPro
IPR007187, Nucleoporin_Nup133/Nup155_C
IPR014908, Nucleoporin_Nup133/Nup155_N
IPR004870, Nucleoporin_Nup155
IPR042533, Nucleoporin_Nup155_C_1
IPR042537, Nucleoporin_Nup155_C_2
PANTHERiPTHR10350, PTHR10350, 1 hit
PfamiView protein in Pfam
PF03177, Nucleoporin_C, 1 hit
PF08801, Nucleoporin_N, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNU157_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P40064
Secondary accession number(s): D3DM12
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 2, 2021
This is version 170 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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