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Protein

Intermediate cleaving peptidase 55

Gene

ICP55

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Aminopeptidase which cleaves preprotein intermediates that carry destabilizing N-ter amino acid residues after the mitochondrial processing peptidase (MPP) cleavage site and is thus critical for stabilization of the mitochondrial proteome.2 Publications

Miscellaneous

Present with 5080 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

The enzyme cleaves the 36-Pro-Pro-37 bond of cysteine desulfurase (EC 2.8.1.7) removing three amino acid residues (Tyr-Ser-Pro) from the N-terminus after cleavage by mitochondrial processing peptidase.2 Publications

Cofactori

Mn2+CuratedNote: Binds 2 manganese ions per subunit.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi327Manganese 2Sequence analysis1
Metal bindingi338Manganese 1Sequence analysis1
Metal bindingi338Manganese 2Sequence analysis1
Metal bindingi417Manganese 1Sequence analysis1
Metal bindingi444Manganese 1Sequence analysis1
Metal bindingi467Manganese 1Sequence analysis1
Metal bindingi467Manganese 2Sequence analysis1

GO - Molecular functioni

  • aminopeptidase activity Source: SGD
  • manganese ion binding Source: InterPro
  • metallopeptidase activity Source: UniProtKB-KW

GO - Biological processi

  • protein processing Source: SGD
  • protein stabilization Source: SGD

Keywordsi

Molecular functionAminopeptidase, Hydrolase, Metalloprotease, Protease
LigandManganese, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:G3O-30249-MONOMER
YEAST:G3O-30249-MONOMER
BRENDAi3.4.11.26 984

Protein family/group databases

MEROPSiM24.026

Names & Taxonomyi

Protein namesi
Recommended name:
Intermediate cleaving peptidase 55 (EC:3.4.11.262 Publications)
Alternative name(s):
Intermediate cleaving peptidase of 55 kDa
Gene namesi
Name:ICP55
Ordered Locus Names:YER078C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER078C
SGDiS000000880 ICP55

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001850981 – 511Intermediate cleaving peptidase 55Add BLAST511

Proteomic databases

MaxQBiP40051
PaxDbiP40051
PRIDEiP40051

Interactioni

Protein-protein interaction databases

BioGridi36823, 120 interactors
DIPiDIP-4941N
IntActiP40051, 9 interactors
MINTiP40051
STRINGi4932.YER078C

Structurei

3D structure databases

ProteinModelPortaliP40051
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M24B family.Curated

Phylogenomic databases

GeneTreeiENSGT00550000074909
HOGENOMiHOG000008762
InParanoidiP40051
KOiK18573
OMAiKKYFMHG
OrthoDBiEOG092C1YL8

Family and domain databases

Gene3Di3.40.350.10, 1 hit
InterProiView protein in InterPro
IPR007865 Aminopep_P_N
IPR029149 Creatin/AminoP/Spt16_NTD
IPR036005 Creatinase/aminopeptidase-like
IPR000994 Pept_M24
IPR001131 Peptidase_M24B_aminopep-P_CS
PfamiView protein in Pfam
PF05195 AMP_N, 1 hit
PF00557 Peptidase_M24, 1 hit
SMARTiView protein in SMART
SM01011 AMP_N, 1 hit
SUPFAMiSSF53092 SSF53092, 1 hit
SSF55920 SSF55920, 1 hit
PROSITEiView protein in PROSITE
PS00491 PROLINE_PEPTIDASE, 1 hit

Sequencei

Sequence statusi: Complete.

P40051-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLHRINPVRF SMQSCQRYFS KLVSPLEQHK SNTFTNRVRI PIEAGQPLHE
60 70 80 90 100
TRPFLIKSGE LTPGISALEY YERRIRLAET LPPKSCVILA GNDIQFASGA
110 120 130 140 150
VFYPFQQEND LFYLSGWNEP NSVMILEKPT DSLSDTIFHM LVPPKDAFAE
160 170 180 190 200
KWEGFRSGVY GVQEIFNADE SASINDLSKY LPKIINRNDF IYFDMLSTSN
210 220 230 240 250
PSSSNFKHIK SLLDGSGNSN RSLNSIANKT IKPISKRIAE FRKIKSPQEL
260 270 280 290 300
RIMRRAGQIS GRSFNQAFAK RFRNERTLDS FLHYKFISGG CDKDAYIPVV
310 320 330 340 350
ATGSNSLCIH YTRNDDVMFD DEMVLVDAAG SLGGYCADIS RTWPNSGKFT
360 370 380 390 400
DAQRDLYEAV LNVQRDCIKL CKASNNYSLH DIHEKSITLM KQELKNLGID
410 420 430 440 450
KVSGWNVEKL YPHYIGHNLG LDVHDVPKVS RYEPLKVGQV ITIEPGLYIP
460 470 480 490 500
NEESFPSYFR NVGIRIEDDI AIGEDTYTNL TVEAVKEIDD LENVMQNGLS
510
TKFEEDQVAP L
Length:511
Mass (Da):57,990
Last modified:February 1, 1995 - v1
Checksum:iB62FB0D0C53B5F2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18839 Genomic DNA Translation: AAB64633.1
BK006939 Genomic DNA Translation: DAA07738.1
PIRiS50581
RefSeqiNP_011001.1, NM_001178969.1

Genome annotation databases

EnsemblFungiiYER078C; YER078C; YER078C
GeneIDi856811
KEGGisce:YER078C

Similar proteinsi

Entry informationi

Entry nameiICP55_YEAST
AccessioniPrimary (citable) accession number: P40051
Secondary accession number(s): D3DLY4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 18, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

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