UniProtKB - P40013 (BIM1_YEAST)
Protein
Protein BIM1
Gene
BIM1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Binds microtubules.
Miscellaneous
Present with 3630 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- microtubule binding Source: GO_Central
- microtubule plus-end binding Source: SGD
GO - Biological processi
- 2-micrometer plasmid partitioning Source: SGD
- cell division Source: UniProtKB-KW
- microtubule depolymerization Source: SGD
- mitotic sister chromatid cohesion Source: SGD
- mitotic spindle orientation checkpoint Source: SGD
- negative regulation of microtubule depolymerization Source: SGD
- nuclear migration along microtubule Source: SGD
- positive regulation of microtubule polymerization Source: SGD
- protein localization to microtubule Source: GO_Central
- protein localization to microtubule plus-end Source: SGD
- regulation of microtubule polymerization or depolymerization Source: GO_Central
- spindle assembly Source: GO_Central
Keywordsi
Biological process | Cell cycle, Cell division, Mitosis |
Names & Taxonomyi
Protein namesi | Recommended name: Protein BIM1 |
Gene namesi | Name:BIM1 Ordered Locus Names:YER016W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YER016W |
SGDi | S000000818, BIM1 |
Subcellular locationi
Cytoskeleton
Cytoskeleton
- cytoplasmic microtubule Source: SGD
- microtubule Source: GO_Central
- microtubule organizing center Source: GO_Central
- microtubule plus-end Source: SGD
- spindle Source: SGD
- spindle midzone Source: SGD
- spindle pole Source: SGD
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, MicrotubulePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000213432 | 2 – 344 | Protein BIM1Add BLAST | 343 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | |
Modified residuei | 157 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
MaxQBi | P40013 |
PaxDbi | P40013 |
PRIDEi | P40013 |
PTM databases
iPTMneti | P40013 |
Interactioni
Binary interactionsi
P40013
With | #Exp. | IntAct |
---|---|---|
DAM1 [P53267] | 2 | EBI-3614,EBI-23268 |
GO - Molecular functioni
- microtubule binding Source: GO_Central
- microtubule plus-end binding Source: SGD
Protein-protein interaction databases
BioGRIDi | 36749, 558 interactors |
DIPi | DIP-1295N |
IntActi | P40013, 17 interactors |
MINTi | P40013 |
STRINGi | 4932.YER016W |
Miscellaneous databases
RNActi | P40013, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P40013 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P40013 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 6 – 107 | Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST | 102 | |
Domaini | 188 – 281 | EB1 C-terminalPROSITE-ProRule annotationAdd BLAST | 94 |
Sequence similaritiesi
Belongs to the MAPRE family.Curated
Phylogenomic databases
eggNOGi | KOG3000, Eukaryota |
GeneTreei | ENSGT00490000043329 |
HOGENOMi | CLU_041744_2_0_1 |
InParanoidi | P40013 |
OMAi | AYCQIID |
Family and domain databases
Gene3Di | 1.10.418.10, 1 hit |
InterProi | View protein in InterPro IPR001715, CH-domain IPR036872, CH_dom_sf IPR004953, EB1_C IPR036133, EB1_C_sf IPR027328, MAPRE |
PANTHERi | PTHR10623, PTHR10623, 1 hit |
Pfami | View protein in Pfam PF03271, EB1, 1 hit |
SUPFAMi | SSF140612, SSF140612, 1 hit SSF47576, SSF47576, 1 hit |
PROSITEi | View protein in PROSITE PS50021, CH, 1 hit PS51230, EB1_C, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P40013-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSAGIGESRT ELLTWLNGLL NLNYKKIEEC GTGAAYCQIM DSIYGDLPMN
60 70 80 90 100
RVKFNATAEY EFQTNYKILQ SCFSRHGIEK TVYVDKLIRC KFQDNLEFLQ
110 120 130 140 150
WLKKHWIRHK DESVYDPDAR RKYRPIITNN SATKPRTVSN PTTAKRSSST
160 170 180 190 200
GTGSAMSGGL ATRHSSLGIN GSRKTSVTQG QLVAIQAELT KSQETIGSLN
210 220 230 240 250
EEIEQYKGTV STLEIEREFY FNKLRDIEIL VHTTQDLINE GVYKFNDETI
260 270 280 290 300
TGHGNGNGGA LLRFVKKVES ILYATAEGFE MNDGEDELND KNLGEHGTVP
310 320 330 340
NQGGYANSNG EVNGNEGSNH DVIMQNDEGE VGVSNNLIID EETF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18778 Genomic DNA Translation: AAB64549.1 BK006939 Genomic DNA Translation: DAA07668.1 |
PIRi | S50474 |
RefSeqi | NP_010932.1, NM_001178907.1 |
Genome annotation databases
EnsemblFungii | YER016W_mRNA; YER016W; YER016W |
GeneIDi | 856736 |
KEGGi | sce:YER016W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18778 Genomic DNA Translation: AAB64549.1 BK006939 Genomic DNA Translation: DAA07668.1 |
PIRi | S50474 |
RefSeqi | NP_010932.1, NM_001178907.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2QJX | X-ray | 1.90 | A | 1-124 | [»] | |
4E61 | X-ray | 2.45 | A/B | 182-282 | [»] | |
6FC6 | X-ray | 1.80 | B | 334-344 | [»] | |
SMRi | P40013 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 36749, 558 interactors |
DIPi | DIP-1295N |
IntActi | P40013, 17 interactors |
MINTi | P40013 |
STRINGi | 4932.YER016W |
PTM databases
iPTMneti | P40013 |
Proteomic databases
MaxQBi | P40013 |
PaxDbi | P40013 |
PRIDEi | P40013 |
Genome annotation databases
EnsemblFungii | YER016W_mRNA; YER016W; YER016W |
GeneIDi | 856736 |
KEGGi | sce:YER016W |
Organism-specific databases
EuPathDBi | FungiDB:YER016W |
SGDi | S000000818, BIM1 |
Phylogenomic databases
eggNOGi | KOG3000, Eukaryota |
GeneTreei | ENSGT00490000043329 |
HOGENOMi | CLU_041744_2_0_1 |
InParanoidi | P40013 |
OMAi | AYCQIID |
Miscellaneous databases
EvolutionaryTracei | P40013 |
PROi | PR:P40013 |
RNActi | P40013, protein |
Family and domain databases
Gene3Di | 1.10.418.10, 1 hit |
InterProi | View protein in InterPro IPR001715, CH-domain IPR036872, CH_dom_sf IPR004953, EB1_C IPR036133, EB1_C_sf IPR027328, MAPRE |
PANTHERi | PTHR10623, PTHR10623, 1 hit |
Pfami | View protein in Pfam PF03271, EB1, 1 hit |
SUPFAMi | SSF140612, SSF140612, 1 hit SSF47576, SSF47576, 1 hit |
PROSITEi | View protein in PROSITE PS50021, CH, 1 hit PS51230, EB1_C, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BIM1_YEAST | |
Accessioni | P40013Primary (citable) accession number: P40013 Secondary accession number(s): D3DLR4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | December 2, 2020 | |
This is version 175 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast chromosome V
Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD