The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - P40005 (PFD2_YEAST)
Protein
Prefoldin subunit 2
Gene
GIM4
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
Miscellaneous
Present with 1660 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- protein folding chaperone Source: GO_Central
- tubulin binding Source: SGD
- unfolded protein binding Source: InterPro
GO - Biological processi
- protein folding Source: GO_Central
- tubulin complex assembly Source: SGD
Keywordsi
Molecular function | Chaperone |
Names & Taxonomyi
Protein namesi | Recommended name: Prefoldin subunit 2Alternative name(s): Genes involved in microtubule biogenesis protein 4 Gim complex subunit 4 Short name: GimC subunit 4 |
Gene namesi | Name:GIM4 Synonyms:PFD2 Ordered Locus Names:YEL003W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000000729, GIM4 |
VEuPathDBi | FungiDB:YEL003W |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Other locations
- cytoplasm Source: SGD
- prefoldin complex Source: SGD
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000124841 | 1 – 111 | Prefoldin subunit 2Add BLAST | 111 |
Proteomic databases
MaxQBi | P40005 |
PaxDbi | P40005 |
PRIDEi | P40005 |
PTM databases
iPTMneti | P40005 |
Interactioni
Subunit structurei
Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.
1 PublicationGO - Molecular functioni
- tubulin binding Source: SGD
- unfolded protein binding Source: InterPro
Protein-protein interaction databases
BioGRIDi | 36728, 588 interactors |
ComplexPortali | CPX-1671, Prefoldin co-chaperone complex |
DIPi | DIP-7472N |
IntActi | P40005, 1 interactor |
MINTi | P40005 |
STRINGi | 4932.YEL003W |
Miscellaneous databases
RNActi | P40005, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1 – 36 | Sequence analysisAdd BLAST | 36 | |
Coiled coili | 72 – 92 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the prefoldin subunit beta family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG4098, Eukaryota |
GeneTreei | ENSGT00390000009272 |
HOGENOMi | CLU_113004_1_1_1 |
InParanoidi | P40005 |
OMAi | RKCFRQI |
Family and domain databases
Gene3Di | 1.10.287.370, 1 hit |
InterProi | View protein in InterPro IPR027235, PFD2 IPR002777, PFD_beta-like IPR009053, Prefoldin |
PANTHERi | PTHR13303, PTHR13303, 1 hit |
Pfami | View protein in Pfam PF01920, Prefoldin_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P40005-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEQRNNVFQA KYNEYKQILE ELQTKIIELG HDKDEHTIVI KTLKDAEPTR
60 70 80 90 100
KCYRMIGGAL VESDVQTSLP ILETKKENIE GTISKMKETL IQTAKEFEKW
110
KKDNKIQVVK N
Sequence cautioni
The sequence AAB64480 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAS56665 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 59 | A → T in ABM97488 (PubMed:17244705).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18530 Genomic DNA Translation: AAB64480.1 Sequence problems. EF123144 mRNA Translation: ABM97488.1 AY558339 Genomic DNA Translation: AAS56665.1 Sequence problems. BK006939 Genomic DNA Translation: DAA07648.1 |
PIRi | S50456 |
RefSeqi | NP_010913.2, NM_001178818.1 |
Genome annotation databases
EnsemblFungii | YEL003W_mRNA; YEL003W; YEL003W |
GeneIDi | 856715 |
KEGGi | sce:YEL003W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18530 Genomic DNA Translation: AAB64480.1 Sequence problems. EF123144 mRNA Translation: ABM97488.1 AY558339 Genomic DNA Translation: AAS56665.1 Sequence problems. BK006939 Genomic DNA Translation: DAA07648.1 |
PIRi | S50456 |
RefSeqi | NP_010913.2, NM_001178818.1 |
3D structure databases
AlphaFoldDBi | P40005 |
SMRi | P40005 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 36728, 588 interactors |
ComplexPortali | CPX-1671, Prefoldin co-chaperone complex |
DIPi | DIP-7472N |
IntActi | P40005, 1 interactor |
MINTi | P40005 |
STRINGi | 4932.YEL003W |
PTM databases
iPTMneti | P40005 |
Proteomic databases
MaxQBi | P40005 |
PaxDbi | P40005 |
PRIDEi | P40005 |
Genome annotation databases
EnsemblFungii | YEL003W_mRNA; YEL003W; YEL003W |
GeneIDi | 856715 |
KEGGi | sce:YEL003W |
Organism-specific databases
SGDi | S000000729, GIM4 |
VEuPathDBi | FungiDB:YEL003W |
Phylogenomic databases
eggNOGi | KOG4098, Eukaryota |
GeneTreei | ENSGT00390000009272 |
HOGENOMi | CLU_113004_1_1_1 |
InParanoidi | P40005 |
OMAi | RKCFRQI |
Miscellaneous databases
PROi | PR:P40005 |
RNActi | P40005, protein |
Family and domain databases
Gene3Di | 1.10.287.370, 1 hit |
InterProi | View protein in InterPro IPR027235, PFD2 IPR002777, PFD_beta-like IPR009053, Prefoldin |
PANTHERi | PTHR13303, PTHR13303, 1 hit |
Pfami | View protein in Pfam PF01920, Prefoldin_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PFD2_YEAST | |
Accessioni | P40005Primary (citable) accession number: P40005 Secondary accession number(s): A2TBP1, D3DLP4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | June 26, 2007 | |
Last modified: | May 25, 2022 | |
This is version 144 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome V
Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names - SIMILARITY comments
Index of protein domains and families