GIM4

Functionⁱ

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

Miscellaneous

Present with 1660 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functionⁱ

protein binding involved in protein folding Source: GO_Central
tubulin binding
Source: SGD
Inferred from direct assayⁱ
- 9463374
unfolded protein binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

protein folding Source: GO_Central
tubulin complex assembly
Source: SGD
Inferred from mutant phenotypeⁱ
- 9463374

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chaperone

Molecular function

Chaperone

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-30132-MONOMER

BioCycⁱ

YEAST:G3O-30132-MONOMER

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Prefoldin subunit 2 Alternative name(s): Genes involved in microtubule biogenesis protein 4 Gim complex subunit 4 Short name: GimC subunit 4
Gene namesⁱ	Name:GIM4 Synonyms:PFD2 Ordered Locus Names:YEL003W
Organismⁱ	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifierⁱ	559292 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae
Proteomesⁱ	UP000002311 Componentⁱ: Chromosome V

Organism-specific databases

EuPathDBⁱ	FungiDB:YEL003W
Saccharomyces Genome Database More...SGDⁱ	S000000729 GIM4

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000124841	1 – 111	Prefoldin subunit 2Add BLAST		111

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P40005
PaxDbⁱ	P40005
PRIDEⁱ	P40005

Interactionⁱ

Subunit structureⁱ

Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.1 Publication

GO - Molecular functionⁱ

protein binding involved in protein folding Source: GO_Central
tubulin binding
Source: SGD
Inferred from direct assayⁱ
- 9463374
unfolded protein binding Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	36728, 588 interactors
ComplexPortalⁱ	CPX-1671 Prefoldin complex
Database of interacting proteins More...DIPⁱ	DIP-7472N
IntActⁱ	P40005, 1 interactor
Molecular INTeraction database More...MINTⁱ	P40005
STRINGⁱ	4932.YEL003W

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P40005
SMRⁱ	P40005
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	1 – 36	Sequence analysisAdd BLAST		36
Coiled coilⁱ	72 – 92	Sequence analysisAdd BLAST		21

Sequence similaritiesⁱ

Belongs to the prefoldin subunit beta family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000009272
HOGENOMⁱ	HOG000211843
InParanoidⁱ	P40005
KEGG Orthology (KO) More...KOⁱ	K09549
OMAⁱ	DPERKCF
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C5GR9

Family and domain databases

Gene3Dⁱ	1.10.287.370, 1 hit
InterProⁱ	View protein in InterPro IPR027235 PFD2 IPR002777 PFD_beta-like IPR009053 Prefoldin
PANTHERⁱ	PTHR13303 PTHR13303, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01920 Prefoldin_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P40005-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEQRNNVFQA KYNEYKQILE ELQTKIIELG HDKDEHTIVI KTLKDAEPTR 
        60         70         80         90        100
KCYRMIGGAL VESDVQTSLP ILETKKENIE GTISKMKETL IQTAKEFEKW 
       110 
KKDNKIQVVK N

Length:111

Mass (Da):12,994

Last modified:June 26, 2007 - v2

Checksum:ⁱE12DC1BE53C8C936

GO

Sequence cautionⁱ

The sequence AAB64480 differs from that shown. Reason: Erroneous gene model prediction.Curated

The sequence AAS56665 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	59	A → T in ABM97488 (PubMed:17244705).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U18530 Genomic DNA Translation: AAB64480.1 Sequence problems. EF123144 mRNA Translation: ABM97488.1 AY558339 Genomic DNA Translation: AAS56665.1 Sequence problems. BK006939 Genomic DNA Translation: DAA07648.1
PIRⁱ	S50456
NCBI Reference Sequences More...RefSeqⁱ	NP_010913.2, NM_001178818.1

Genome annotation databases

EnsemblFungiⁱ	YEL003W; YEL003W; YEL003W
GeneIDⁱ	856715
KEGGⁱ	sce:YEL003W

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P40005	Gim4p		YEAS8		111	UniRef100_P40005
Gim4p		YEASC		111

Protein	Similar proteins		Species	Score	Length	Source
P40005	Gim4p		YEAS8		111	UniRef90_P40005
Gim4p		YEASC		111
Gim4p		YEASB		123
Prefoldin subunit 2		YEAS1		123
K7_Gim4p		YEASK		123
+7

Protein	Similar proteins		Species	Score	Length	Source
P40005	Gim4p		YEAS8		111	UniRef50_P40005
Gim4p		YEASC		111
Gim4p		YEASB		123
Prefoldin subunit 2		YEAS1		123
K7_Gim4p		YEASK		123
+12

Entry informationⁱ

Entry nameⁱ	PFD2_YEAST
Accessionⁱ	P40005Primary (citable) accession number: P40005 Secondary accession number(s): A2TBP1, D3DLP4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
	Last sequence update:	June 26, 2007
	Last modified:	September 12, 2018
	This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P40005 (PFD2_YEAST)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Prefoldin subunit 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ