UniProtKB - P39995 (EAF5_YEAST)
Protein
Chromatin modification-related protein EAF5
Gene
EAF5
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.
Miscellaneous
Present with 937 molecules/cell in log phase SD medium.1 Publication
GO - Biological processi
- chromatin organization Source: UniProtKB-KW
- DNA repair Source: SGD
Keywordsi
Molecular function | Chromatin regulator |
Biological process | DNA damage, DNA repair, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Chromatin modification-related protein EAF5Alternative name(s): ESA1-associated factor 5 |
Gene namesi | Name:EAF5 Ordered Locus Names:YEL018W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000000744, EAF5 |
VEuPathDBi | FungiDB:YEL018W |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Cytosol
- cytosol Source: SGD
Nucleus
- NuA4 histone acetyltransferase complex Source: SGD
- nucleus Source: SGD
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000086892 | 1 – 279 | Chromatin modification-related protein EAF5Add BLAST | 279 |
Proteomic databases
MaxQBi | P39995 |
PaxDbi | P39995 |
PRIDEi | P39995 |
Interactioni
Subunit structurei
Component of the NuA4 histone acetyltransferase complex composed of at least ACT1, ARP4, YAF9, VID21, SWC4, EAF3, EAF5, EAF6, EAF7, EPL1, ESA1, TRA1 and YNG2.
2 PublicationsBinary interactionsi
P39995
With | #Exp. | IntAct |
---|---|---|
EAF3 [Q12432] | 11 | EBI-22312,EBI-6281 |
Protein-protein interaction databases
BioGRIDi | 36712, 346 interactors |
ComplexPortali | CPX-3155, NuA4 histone acetyltransferase complex CPX-3184, EAF5-7-3 nucleosome disassembly/reassembly complex |
DIPi | DIP-5280N |
IntActi | P39995, 23 interactors |
MINTi | P39995 |
STRINGi | 4932.YEL018W |
Miscellaneous databases
RNActi | P39995, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the EAF5 family.Curated
Phylogenomic databases
eggNOGi | ENOG502S0AH, Eukaryota |
HOGENOMi | CLU_071344_0_0_1 |
InParanoidi | P39995 |
OMAi | HMAHSMD |
Family and domain databases
InterProi | View protein in InterPro IPR026226, EAF5 |
PRINTSi | PR02067, PROTEINEAF5 |
i Sequence
Sequence statusi: Complete.
P39995-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDKEVSELVV LQLIHTLISN KNEELVRNGG GINMIGNNLR ISLVKLTNEI
60 70 80 90 100
QNNLLINELT NLRRQSNVAN GNRKLGINDI LTIVKNLFPE YRTTLNDGQL
110 120 130 140 150
SLHGLEMHDI EKLLDEKYDR FKKTQVEQIR MMEDEILKNG IKTGASQLQP
160 170 180 190 200
HANAGKSGSA GTSATITTTT PHMAHSMDPK REKLLKLYRD TVLNKLESKT
210 220 230 240 250
GNFQKLFKSP DGSIIKNEIN YEDIKNETPG SVHELQLILQ KSITDGVMRK
260 270
VIGTDDWKLA RQVQFELDDT VQFMRRALE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18530 Genomic DNA Translation: AAB64495.1 BK006939 Genomic DNA Translation: DAA07635.1 |
PIRi | S50441 |
RefSeqi | NP_010897.1, NM_001178833.1 |
Genome annotation databases
EnsemblFungii | YEL018W_mRNA; YEL018W; YEL018W |
GeneIDi | 856696 |
KEGGi | sce:YEL018W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18530 Genomic DNA Translation: AAB64495.1 BK006939 Genomic DNA Translation: DAA07635.1 |
PIRi | S50441 |
RefSeqi | NP_010897.1, NM_001178833.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5Y81 | electron microscopy | 4.70 | H | 1-279 | [»] | |
SMRi | P39995 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 36712, 346 interactors |
ComplexPortali | CPX-3155, NuA4 histone acetyltransferase complex CPX-3184, EAF5-7-3 nucleosome disassembly/reassembly complex |
DIPi | DIP-5280N |
IntActi | P39995, 23 interactors |
MINTi | P39995 |
STRINGi | 4932.YEL018W |
Proteomic databases
MaxQBi | P39995 |
PaxDbi | P39995 |
PRIDEi | P39995 |
Genome annotation databases
EnsemblFungii | YEL018W_mRNA; YEL018W; YEL018W |
GeneIDi | 856696 |
KEGGi | sce:YEL018W |
Organism-specific databases
SGDi | S000000744, EAF5 |
VEuPathDBi | FungiDB:YEL018W |
Phylogenomic databases
eggNOGi | ENOG502S0AH, Eukaryota |
HOGENOMi | CLU_071344_0_0_1 |
InParanoidi | P39995 |
OMAi | HMAHSMD |
Miscellaneous databases
PROi | PR:P39995 |
RNActi | P39995, protein |
Family and domain databases
InterProi | View protein in InterPro IPR026226, EAF5 |
PRINTSi | PR02067, PROTEINEAF5 |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EAF5_YEAST | |
Accessioni | P39995Primary (citable) accession number: P39995 Secondary accession number(s): D3DLN1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | February 10, 2021 | |
This is version 136 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome V
Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families