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Protein

rDNA transcriptional regulator POL5

Gene

POL5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an important role in the regulation of rRNA transcription. Binds near or at the enhancer region of rRNA repeating units. May have DNA polymerase activity, but it is not required for in vivo function.1 Publication

Miscellaneous

Present with 4490 molecules/cell in log phase SD medium.1 Publication

Caution

Was originally thought to belong to the DNA polymerase type-B family based on conserved motifs (PubMed:12093911). Has later been shown to be unrelated to B class DNA polymerases. The observation of a low level of polymerase activity in vitro, which is not required for its essential cellular function, may require further validation (PubMed:12695662).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Stimulated by PCNA and inhibited by aphidicolin.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA-directed DNA polymerase activity Source: SGD
  • nucleotide binding Source: InterPro
  • rDNA binding Source: GO_Central
  • transcription factor binding Source: InterPro

GO - Biological processi

  • regulation of transcription, DNA-templated Source: InterPro
  • rRNA transcription Source: SGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-30173-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
rDNA transcriptional regulator POL5 (EC:2.7.7.7)
Alternative name(s):
DNA polymerase V
Short name:
POL V
DNA polymerase phi1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:POL51 Publication
Ordered Locus Names:YEL055C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000000781 POL5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi623D → N in POL5dn; has no DNA synthesis activity, but complements the lethality of a pol5 null mutant; when associated with N-625. 1 Publication1
Mutagenesisi625D → N in POL5dn; has no DNA synthesis activity, but complements the lethality of a pol5 null mutant; when associated with N-623. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000464721 – 1022rDNA transcriptional regulator POL5Add BLAST1022

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei789PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P39985

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P39985

PRoteomics IDEntifications database

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PRIDEi
P39985

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P39985

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FRK1.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
36674, 386 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1604 Small ribosomal subunit processome, variant 1
CPX-1607 Small ribosomal subunit processome, variant 2
CPX-1608 Small ribosomal subunit processome, variant 3

Database of interacting proteins

More...
DIPi
DIP-6314N

Protein interaction database and analysis system

More...
IntActi
P39985, 20 interactors

Molecular INTeraction database

More...
MINTi
P39985

STRING: functional protein association networks

More...
STRINGi
4932.YEL055C

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P39985

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MYBBP1A family.1 Publication

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017457

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000247925

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P39985

KEGG Orthology (KO)

More...
KOi
K02331

Identification of Orthologs from Complete Genome Data

More...
OMAi
RKWIIHR

Database of Orthologous Groups

More...
OrthoDBi
EOG092C0MFS

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR017964 DNA-dir_DNA_pol_B_CS
IPR007015 DNA_pol_V/MYBBP1A

The PANTHER Classification System

More...
PANTHERi
PTHR13213 PTHR13213, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04931 DNA_pol_phi, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00116 DNA_POLYMERASE_B, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P39985-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTGKVNRDLF FKLASDLREE RLHAAVALIK DLSALDLPDD AEEWSYVLNR
60 70 80 90 100
LIKGLSSDRN SARLGFSLCL TEVINLAVNM PPGQRPKGLE STNEFLSTLS
110 120 130 140 150
TILNVNVNEG TKKSMKGKDE RGILFGKLFG LKSLLNEPLF SEIFVKDLEK
160 170 180 190 200
GNTEFFIRFT EQLIDLALKK NWIKEPCFFT LFQTMKMLLP FMDESSAEKI
210 220 230 240 250
LLIYDKYDLT LTNEGLSTYL LLKYEGDESL IPSVLDLKNP GWKDNDPLAR
260 270 280 290 300
GNLPLLTKVL RNSSVIPDAN GGLKETKKQK NTNWNPRLHF VWSVLLPLFG
310 320 330 340 350
NGKLENTSHI SKKRKKTNNK KVQNSIQFPE FWKMAVDESF FNEKASSERK
360 370 380 390 400
YLGFLIIDAA FKAVPGSYIG FCFSQNVMRT LINQSIDSQR VLNKISQLTL
410 420 430 440 450
DSIVKACEED SANRLVPCLN AMLFGPHGSI NFDKLTKSGT VSKLIAIKEL
460 470 480 490 500
PSTVLAQLLD VFFLQLQDKK GVLSHTLFAL DSILHIVRAH KVEINDMDIM
510 520 530 540 550
KPVLRPIVYM AFFKHTSDDL KLEQLHELAK ERLYSILGEL TINKEIRCKD
560 570 580 590 600
PEINSWQYLT LKLILDIENS HVGDLINPLD ENLENIKNEA ISCLSKVCRS
610 620 630 640 650
RTAQSWGLST LLSMCLVQLY AGDTDSISVI EELCEFSKHE NNSMVGITEI
660 670 680 690 700
LLSLLAQKKA LLRKLSLIIW QQFIEEVGLE ELQILLDILK ARENKQGFAQ
710 720 730 740 750
LFEGEEEFEE IKEENDASED ESKTGSESES ESESDSDDAD EKDEEDEANE
760 770 780 790 800
DILNIDKEAT SALVKALNLP DNIVNDKGEV DLDQLEGLSD DGGDDEDEES
810 820 830 840 850
MDDEKMMELD DQLSEIFKRR KEALSSISTG NQRKFEVKQS RENVISFKHR
860 870 880 890 900
VVDMLAVYVK YCEKLTLANK SEHSNNLGGS LSKLVYFIIP MLKCVNETLD
910 920 930 940 950
RPLADKISKL LKGKIFKIKV TAFKDMNKDI ELMDLLKKTH KLMLTSKPGQ
960 970 980 990 1000
HAAVFYSMCS TSSLFLSKLY VEIGGNDKLD ELIDLYTATT KEWMQKGKCG
1010 1020
PNIFIDFINW LSSKKQTVMD KE
Length:1,022
Mass (Da):115,894
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA9F32B1D15039D18
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB027253 Genomic DNA Translation: BAA77722.1
U18795 Genomic DNA Translation: AAB65032.1
BK006939 Genomic DNA Translation: DAA07599.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S50534

NCBI Reference Sequences

More...
RefSeqi
NP_010859.1, NM_001178870.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YEL055C_mRNA; YEL055C_mRNA; YEL055C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
856655

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YEL055C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB027253 Genomic DNA Translation: BAA77722.1
U18795 Genomic DNA Translation: AAB65032.1
BK006939 Genomic DNA Translation: DAA07599.1
PIRiS50534
RefSeqiNP_010859.1, NM_001178870.1

3D structure databases

ProteinModelPortaliP39985
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36674, 386 interactors
ComplexPortaliCPX-1604 Small ribosomal subunit processome, variant 1
CPX-1607 Small ribosomal subunit processome, variant 2
CPX-1608 Small ribosomal subunit processome, variant 3
DIPiDIP-6314N
IntActiP39985, 20 interactors
MINTiP39985
STRINGi4932.YEL055C

PTM databases

iPTMnetiP39985

Proteomic databases

MaxQBiP39985
PaxDbiP39985
PRIDEiP39985

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYEL055C_mRNA; YEL055C_mRNA; YEL055C
GeneIDi856655
KEGGisce:YEL055C

Organism-specific databases

SGDiS000000781 POL5

Phylogenomic databases

GeneTreeiENSGT00390000017457
HOGENOMiHOG000247925
InParanoidiP39985
KOiK02331
OMAiRKWIIHR
OrthoDBiEOG092C0MFS

Enzyme and pathway databases

BioCyciYEAST:G3O-30173-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P39985

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR017964 DNA-dir_DNA_pol_B_CS
IPR007015 DNA_pol_V/MYBBP1A
PANTHERiPTHR13213 PTHR13213, 1 hit
PfamiView protein in Pfam
PF04931 DNA_pol_phi, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS00116 DNA_POLYMERASE_B, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDPO5_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P39985
Secondary accession number(s): D3DLJ5, Q9Y737
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: December 5, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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