UniProtKB - P39966 (PP2C2_YEAST)
Protein
Protein phosphatase 2C homolog 2
Gene
PTC2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Responsible, together with PTC3, for the dephosphorylation of the cyclin-dependent protein kinase CDC28.1 Publication
Miscellaneous
Present with 12600 molecules/cell in log phase SD medium.1 Publication
Catalytic activityi
Cofactori
Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 62 | Manganese 1By similarity | 1 | |
Metal bindingi | 62 | Manganese 2By similarity | 1 | |
Metal bindingi | 63 | Manganese 1; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 234 | Manganese 2By similarity | 1 | |
Metal bindingi | 283 | Manganese 2By similarity | 1 |
GO - Molecular functioni
- magnesium-dependent protein serine/threonine phosphatase activity Source: SGD
- MAP kinase serine/threonine phosphatase activity Source: SGD
- metal ion binding Source: UniProtKB-KW
- protein serine/threonine phosphatase activity Source: SGD
- protein serine phosphatase activity Source: UniProtKB-EC
- protein threonine phosphatase activity Source: UniProtKB-EC
GO - Biological processi
- inactivation of MAPK activity Source: SGD
- negative regulation of endoplasmic reticulum unfolded protein response Source: SGD
- peptidyl-threonine dephosphorylation Source: SGD
- protein dephosphorylation Source: SGD
- regulation of cyclin-dependent protein serine/threonine kinase activity Source: SGD
Keywordsi
Molecular function | Hydrolase, Protein phosphatase |
Ligand | Magnesium, Manganese, Metal-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:PTC2 Ordered Locus Names:YER089C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000000891, PTC2 |
VEuPathDBi | FungiDB:YER089C |
Subcellular locationi
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000057775 | 1 – 464 | Protein phosphatase 2C homolog 2Add BLAST | 464 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 376 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 380 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P39966 |
PaxDbi | P39966 |
PRIDEi | P39966 |
PTM databases
iPTMneti | P39966 |
Interactioni
Binary interactionsi
P39966
With | #Exp. | IntAct |
---|---|---|
PAA1 [Q12447] | 8 | EBI-12795,EBI-33397 |
Protein-protein interaction databases
BioGRIDi | 36834, 210 interactors |
DIPi | DIP-1539N |
IntActi | P39966, 14 interactors |
MINTi | P39966 |
STRINGi | 4932.YER089C |
Miscellaneous databases
RNActi | P39966, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 292 | PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST | 270 |
Sequence similaritiesi
Belongs to the PP2C family.Curated
Phylogenomic databases
eggNOGi | KOG0698, Eukaryota |
GeneTreei | ENSGT00940000172210 |
HOGENOMi | CLU_013173_4_2_1 |
InParanoidi | P39966 |
OMAi | HKPNNEA |
Family and domain databases
CDDi | cd00143, PP2Cc, 1 hit |
Gene3Di | 3.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR015655, PP2C IPR000222, PP2C_BS IPR036457, PPM-type_dom_sf IPR001932, PPM-type_phosphatase_dom |
PANTHERi | PTHR13832, PTHR13832, 1 hit |
Pfami | View protein in Pfam PF00481, PP2C, 1 hit |
SMARTi | View protein in SMART SM00332, PP2Cc, 1 hit |
SUPFAMi | SSF81606, SSF81606, 1 hit |
PROSITEi | View protein in PROSITE PS01032, PPM_1, 1 hit PS51746, PPM_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P39966-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGQILSNPVI DKESHSGADS LTAFGLCAMQ GWRMSMEDSH ILEPNVLTKS
60 70 80 90 100
DKDHIAFYGI FDGHGGAKVA EYCGNKIVEI LQEQKSFHEG NLPRALIDTF
110 120 130 140 150
INTDVKLLQD PVMKEDHSGC TATSILVSKS QNLLVCGNAG DSRTVLATDG
160 170 180 190 200
NAKALSYDHK PTLASEKSRI VAADGFVEMD RVNGNLALSR AIGDFEFKSN
210 220 230 240 250
PKLGPEEQIV TCVPDILEHS LDYDRDEFVI LACDGIWDCL TSQDCVDLVH
260 270 280 290 300
LGLREGKTLN EISSRIIDVC CAPTTEGTGI GCDNMSIVVV ALLKEGEDVA
310 320 330 340 350
QWSDRMKSKA HRTSVRSFAD KRRRVFSYYD FSKCNDEQVF AITTKKPQDK
360 370 380 390 400
FTRDHEAAVA SVTAADNDDP MDIDDTDADT DAENLDPSSQ SKSKTSGPID
410 420 430 440 450
LASLEALLGA TGGVKTDSNG NKVTYTLPQS ALAQLLQTMG HDPASSHPEN
460
DSNTDHKAGR SHLQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18839 Genomic DNA Translation: AAB64644.1 U72498 Genomic DNA Translation: AAB17392.1 BK006939 Genomic DNA Translation: DAA07750.1 |
PIRi | S50592 |
RefSeqi | NP_011013.1, NM_001178980.1 |
Genome annotation databases
EnsemblFungii | YER089C_mRNA; YER089C; YER089C |
GeneIDi | 856823 |
KEGGi | sce:YER089C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18839 Genomic DNA Translation: AAB64644.1 U72498 Genomic DNA Translation: AAB17392.1 BK006939 Genomic DNA Translation: DAA07750.1 |
PIRi | S50592 |
RefSeqi | NP_011013.1, NM_001178980.1 |
3D structure databases
SMRi | P39966 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 36834, 210 interactors |
DIPi | DIP-1539N |
IntActi | P39966, 14 interactors |
MINTi | P39966 |
STRINGi | 4932.YER089C |
PTM databases
iPTMneti | P39966 |
Proteomic databases
MaxQBi | P39966 |
PaxDbi | P39966 |
PRIDEi | P39966 |
Genome annotation databases
EnsemblFungii | YER089C_mRNA; YER089C; YER089C |
GeneIDi | 856823 |
KEGGi | sce:YER089C |
Organism-specific databases
SGDi | S000000891, PTC2 |
VEuPathDBi | FungiDB:YER089C |
Phylogenomic databases
eggNOGi | KOG0698, Eukaryota |
GeneTreei | ENSGT00940000172210 |
HOGENOMi | CLU_013173_4_2_1 |
InParanoidi | P39966 |
OMAi | HKPNNEA |
Miscellaneous databases
PROi | PR:P39966 |
RNActi | P39966, protein |
Family and domain databases
CDDi | cd00143, PP2Cc, 1 hit |
Gene3Di | 3.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR015655, PP2C IPR000222, PP2C_BS IPR036457, PPM-type_dom_sf IPR001932, PPM-type_phosphatase_dom |
PANTHERi | PTHR13832, PTHR13832, 1 hit |
Pfami | View protein in Pfam PF00481, PP2C, 1 hit |
SMARTi | View protein in SMART SM00332, PP2Cc, 1 hit |
SUPFAMi | SSF81606, SSF81606, 1 hit |
PROSITEi | View protein in PROSITE PS01032, PPM_1, 1 hit PS51746, PPM_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PP2C2_YEAST | |
Accessioni | P39966Primary (citable) accession number: P39966 Secondary accession number(s): D3DLZ6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | April 7, 2021 | |
This is version 196 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome V
Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names - SIMILARITY comments
Index of protein domains and families