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Protein

Probable proline--tRNA ligase, mitochondrial

Gene

AIM10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 477 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).

GO - Molecular functioni

  • aminoacyl-tRNA editing activity Source: InterPro
  • ATP binding Source: UniProtKB-KW
  • proline-tRNA ligase activity Source: SGD

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30256-MONOMER
SABIO-RKiP39965

Names & Taxonomyi

Protein namesi
Recommended name:
Probable proline--tRNA ligase, mitochondrial (EC:6.1.1.15)
Alternative name(s):
Altered inheritance rate of mitochondria protein 10
Prolyl-tRNA synthetase
Short name:
ProRS
Gene namesi
Name:AIM10
Ordered Locus Names:YER087W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER087W
SGDiS000000889 AIM10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001393541 – 576Probable proline--tRNA ligase, mitochondrialAdd BLAST576

Proteomic databases

MaxQBiP39965
PaxDbiP39965
PRIDEiP39965

PTM databases

iPTMnetiP39965

Interactioni

Protein-protein interaction databases

BioGridi36831, 77 interactors
DIPiDIP-4922N
IntActiP39965, 8 interactors
MINTiP39965
STRINGi4932.YER087W

Structurei

3D structure databases

ProteinModelPortaliP39965
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000010922
HOGENOMiHOG000076895
InParanoidiP39965
KOiK01881
OMAiIQPAELW
OrthoDBiEOG092C1X8M

Family and domain databases

CDDicd00779 ProRS_core_prok, 1 hit
Gene3Di3.40.50.800, 1 hit
3.90.960.10, 1 hit
InterProiView protein in InterPro
IPR002314 aa-tRNA-synt_IIb
IPR006195 aa-tRNA-synth_II
IPR036621 Anticodon-bd_dom_sf
IPR002316 Pro-tRNA-ligase_IIa
IPR004500 Pro-tRNA-synth_IIa_bac-type
IPR033730 ProRS_core_prok
IPR036754 YbaK/aa-tRNA-synt-asso_dom_sf
PfamiView protein in Pfam
PF00587 tRNA-synt_2b, 1 hit
PRINTSiPR01046 TRNASYNTHPRO
TIGRFAMsiTIGR00409 proS_fam_II, 1 hit
PROSITEiView protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

P39965-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKYRTLSRS CHIFHPKSLS NNTLKSETTQ ELLQTVGFVR RSQVGLFQWL
60 70 80 90 100
PLGLRSLNKV SNAIRNRMDS DGGAIEVSLS AISSKALWQA TDRWNNSELF
110 120 130 140 150
KLKDSKGKQY CLTATCEEDI TDLMKNYIAS YKDMPITIYQ MTRKYRDEIR
160 170 180 190 200
PRGGILRGRE FLMKDAYSFA SNEEDAFASF QKLDDTYNKI FKDLKIPFVS
210 220 230 240 250
AWADSGDIGG EFSKEFHLIH ESGEDTLMSC KHCGDISTLD MSQSYPEKDG
260 270 280 290 300
QYSGDVDCKY ALTKDHSTLI CFYYPKDRQL NWNLALNAMD KDIDLTLRNK
310 320 330 340 350
PNDHVLQVYE KDNEDIMFSK ILRVMDCRLN SKSNFPDFPL KKYLKNNFGQ
360 370 380 390 400
ISDVSIVDAQ ENEICGKCEE GRLEPLKSIE VGHIFLLGNK YSKPLNVKFV
410 420 430 440 450
DKENKNETFV HMGCYGIGVS RLVGAIAELG RDSNGFRWPA IMAPYKVSIC
460 470 480 490 500
TGPNNPENSQ RLQDVKSELL NDPTMQNLQN DILDQFNEKL GIGARIKLSH
510 520 530 540 550
AMGIPLCVIV GSKSWPNVEI EVRGIRWGEK DLWRKQFEKR CSELQWKCTK
560 570
NEHGIEKHTV PIQHLAEVIG VLLKDM
Length:576
Mass (Da):65,880
Last modified:February 1, 1995 - v1
Checksum:iD8C5BD76B47CCAF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18839 Genomic DNA Translation: AAB64642.1
BK006939 Genomic DNA Translation: DAA07747.1
PIRiS50590
RefSeqiNP_011010.1, NM_001178978.1

Genome annotation databases

EnsemblFungiiYER087W; YER087W; YER087W
GeneIDi856820
KEGGisce:YER087W

Similar proteinsi

Entry informationi

Entry nameiSYPM_YEAST
AccessioniPrimary (citable) accession number: P39965
Secondary accession number(s): D3DLZ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 18, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

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