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Protein

Mitochondrial nicotinamide adenine dinucleotide transporter 2

Gene

YEA6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial inner membrane carrier protein involved in the import of NAD+ into mitochondria by unidirectional transport or by exchange with intramitochondrially generated dAMP and dGMP.2 Publications

Miscellaneous

Present with 1630 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • NAD transmembrane transporter activity Source: SGD
  • transmembrane transporter activity Source: GO_Central

GO - Biological processi

  • mitochondrial transport Source: GO_Central
  • NAD transmembrane transport Source: SGD

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciYEAST:G3O-30135-MONOMER
ReactomeiR-SCE-196757 Metabolism of folate and pterines
R-SCE-389599 Alpha-oxidation of phytanate

Protein family/group databases

TCDBi2.A.29.10.8 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial nicotinamide adenine dinucleotide transporter 2
Alternative name(s):
Mitochondrial NAD(+) transporter 2
Gene namesi
Name:YEA6
Synonyms:NDT2
Ordered Locus Names:YEL006W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YEL006W
SGDiS000000732 YEA6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei42 – 62Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei104 – 124Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei142 – 162Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei198 – 218Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei247 – 267Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei298 – 318Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906941 – 335Mitochondrial nicotinamide adenine dinucleotide transporter 2Add BLAST335

Proteomic databases

MaxQBiP39953
PaxDbiP39953
PRIDEiP39953

PTM databases

iPTMnetiP39953

Interactioni

Protein-protein interaction databases

BioGridi36725, 31 interactors
DIPiDIP-4659N
STRINGi4932.YEL006W

Structurei

3D structure databases

ProteinModelPortaliP39953
SMRiP39953
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati36 – 128Solcar 1Add BLAST93
Repeati136 – 225Solcar 2Add BLAST90
Repeati241 – 329Solcar 3Add BLAST89

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00920000149129
HOGENOMiHOG000188210
InParanoidiP39953
KOiK15115
OMAiLVMLIYE
OrthoDBiEOG092C43EV

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

P39953-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNGDNKTTL ENSKNASLAN GNYAIPTKLN RLKKNADPRV AAISGALSGA
60 70 80 90 100
LSAMLVCPFD VAKTRLQAQG LQNMTHQSQH YKGFFGTFAT IFKDEGAAGL
110 120 130 140 150
YKGLQPTVLG YIPTLMIYFS VYDFCRKYSV DIFPHSPFLS NASSAITAGA
160 170 180 190 200
ISTVATNPIW VVKTRLMLQT GIGKYSTHYK GTIDTFRKII QQEGAKALYA
210 220 230 240 250
GLVPALLGML NVAIQFPLYE NLKIRFGYSE STDVSTDVTS SNFQKLILAS
260 270 280 290 300
MLSKMVASTV TYPHEILRTR MQLKSDLPNT VQRHLLPLIK ITYRQEGFAG
310 320 330
FYSGFATNLV RTVPAAVVTL VSFEYSKKYL TTFFQ
Length:335
Mass (Da):36,961
Last modified:February 1, 1995 - v1
Checksum:i91555A2CE81286AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18530 Genomic DNA Translation: AAB64483.1
BK006939 Genomic DNA Translation: DAA07645.1
PIRiS50453
RefSeqiNP_010910.1, NM_001178821.1

Genome annotation databases

EnsemblFungiiYEL006W; YEL006W; YEL006W
GeneIDi856712
KEGGisce:YEL006W

Similar proteinsi

Entry informationi

Entry nameiYEA6_YEAST
AccessioniPrimary (citable) accession number: P39953
Secondary accession number(s): D3DLP1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 20, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

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