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UniProtKB - P39953 (YEA6_YEAST)
Protein
Mitochondrial nicotinamide adenine dinucleotide transporter 2
Gene
YEA6
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Mitochondrial inner membrane carrier protein that mediates the import of NAD+ into mitochondria (PubMed:16291748, PubMed:32906142).
Can transport NAD+ by unidirectional transport or by exchange with intramitochondrially generated dAMP and dGMP (PubMed:16291748).
Also able to transport NAD+ by exchange with AMP, GMP or deamido-NAD (+) in vitro (PubMed:16291748).
2 PublicationsMiscellaneous
Present with 1630 molecules/cell in log phase SD medium.1 Publication
Catalytic activityi
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
GO - Molecular functioni
- NAD transmembrane transporter activity Source: UniProtKB
GO - Biological processi
- mitochondrial NAD transmembrane transport Source: UniProtKB
- NAD transmembrane transport Source: SGD
Keywordsi
Biological process | Transport |
Protein family/group databases
TCDBi | 2.A.29.10.8, the mitochondrial carrier (mc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Mitochondrial nicotinamide adenine dinucleotide transporter 2CuratedAlternative name(s): Mitochondrial NAD(+) transporter 21 Publication |
Gene namesi | Name:YEA6 Synonyms:NDT21 Publication Ordered Locus Names:YEL006W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000000732, YEA6 |
VEuPathDBi | FungiDB:YEL006W |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane Curated; Multi-pass membrane protein Curated
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB-SubCell
- mitochondrion Source: SGD
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 42 – 62 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Transmembranei | 104 – 124 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Transmembranei | 142 – 162 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Transmembranei | 198 – 218 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Transmembranei | 247 – 267 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Transmembranei | 298 – 318 | Helical; Name=6Sequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000090694 | 1 – 335 | Mitochondrial nicotinamide adenine dinucleotide transporter 2Add BLAST | 335 |
Proteomic databases
MaxQBi | P39953 |
PaxDbi | P39953 |
PRIDEi | P39953 |
PTM databases
iPTMneti | P39953 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 36725, 32 interactors |
DIPi | DIP-4659N |
STRINGi | 4932.YEL006W |
Miscellaneous databases
RNActi | P39953, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 36 – 128 | Solcar 1Sequence analysisAdd BLAST | 93 | |
Repeati | 136 – 225 | Solcar 2Sequence analysisAdd BLAST | 90 | |
Repeati | 241 – 329 | Solcar 3Sequence analysisAdd BLAST | 89 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0764, Eukaryota |
GeneTreei | ENSGT00940000176809 |
HOGENOMi | CLU_015166_6_1_1 |
InParanoidi | P39953 |
OMAi | TYELIVC |
Family and domain databases
Gene3Di | 1.50.40.10, 2 hits |
InterProi | View protein in InterPro IPR002067, Mit_carrier IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf IPR044712, SLC25A32-like |
PANTHERi | PTHR45683, PTHR45683, 1 hit |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
PRINTSi | PR00926, MITOCARRIER |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
i Sequence
Sequence statusi: Complete.
P39953-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNNGDNKTTL ENSKNASLAN GNYAIPTKLN RLKKNADPRV AAISGALSGA
60 70 80 90 100
LSAMLVCPFD VAKTRLQAQG LQNMTHQSQH YKGFFGTFAT IFKDEGAAGL
110 120 130 140 150
YKGLQPTVLG YIPTLMIYFS VYDFCRKYSV DIFPHSPFLS NASSAITAGA
160 170 180 190 200
ISTVATNPIW VVKTRLMLQT GIGKYSTHYK GTIDTFRKII QQEGAKALYA
210 220 230 240 250
GLVPALLGML NVAIQFPLYE NLKIRFGYSE STDVSTDVTS SNFQKLILAS
260 270 280 290 300
MLSKMVASTV TYPHEILRTR MQLKSDLPNT VQRHLLPLIK ITYRQEGFAG
310 320 330
FYSGFATNLV RTVPAAVVTL VSFEYSKKYL TTFFQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18530 Genomic DNA Translation: AAB64483.1 BK006939 Genomic DNA Translation: DAA07645.1 |
PIRi | S50453 |
RefSeqi | NP_010910.1, NM_001178821.1 |
Genome annotation databases
EnsemblFungii | YEL006W_mRNA; YEL006W; YEL006W |
GeneIDi | 856712 |
KEGGi | sce:YEL006W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18530 Genomic DNA Translation: AAB64483.1 BK006939 Genomic DNA Translation: DAA07645.1 |
PIRi | S50453 |
RefSeqi | NP_010910.1, NM_001178821.1 |
3D structure databases
AlphaFoldDBi | P39953 |
SMRi | P39953 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 36725, 32 interactors |
DIPi | DIP-4659N |
STRINGi | 4932.YEL006W |
Protein family/group databases
TCDBi | 2.A.29.10.8, the mitochondrial carrier (mc) family |
PTM databases
iPTMneti | P39953 |
Proteomic databases
MaxQBi | P39953 |
PaxDbi | P39953 |
PRIDEi | P39953 |
Genome annotation databases
EnsemblFungii | YEL006W_mRNA; YEL006W; YEL006W |
GeneIDi | 856712 |
KEGGi | sce:YEL006W |
Organism-specific databases
SGDi | S000000732, YEA6 |
VEuPathDBi | FungiDB:YEL006W |
Phylogenomic databases
eggNOGi | KOG0764, Eukaryota |
GeneTreei | ENSGT00940000176809 |
HOGENOMi | CLU_015166_6_1_1 |
InParanoidi | P39953 |
OMAi | TYELIVC |
Miscellaneous databases
PROi | PR:P39953 |
RNActi | P39953, protein |
Family and domain databases
Gene3Di | 1.50.40.10, 2 hits |
InterProi | View protein in InterPro IPR002067, Mit_carrier IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf IPR044712, SLC25A32-like |
PANTHERi | PTHR45683, PTHR45683, 1 hit |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
PRINTSi | PR00926, MITOCARRIER |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | YEA6_YEAST | |
Accessioni | P39953Primary (citable) accession number: P39953 Secondary accession number(s): D3DLP1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | May 25, 2022 | |
This is version 164 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome V
Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names - SIMILARITY comments
Index of protein domains and families