E3 ubiquitin-protein ligase RSP5

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

• S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.26

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• phosphatidylinositol binding Source: SGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "The C2 domain of the Rsp5 ubiquitin ligase binds membrane phosphoinositides and directs ubiquitination of endosomal cargo."
    Dunn R., Klos D.A., Adler A.S., Hicke L.
    J. Cell Biol. 165:135-144(2004) [PubMed] [Europe PMC] [Abstract]
• ubiquitin binding Source: SGDInferred from direct assayⁱ
  • "Regulation of the RSP5 ubiquitin ligase by an intrinsic ubiquitin-binding site."
    French M.E., Kretzmann B.R., Hicke L.
    J. Biol. Chem. 284:12071-12079(2009) [PubMed] [Europe PMC] [Abstract]
• ubiquitin protein ligase activity Source: MGIInferred from direct assayⁱ
  • "The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice."
    Perry W.L., Hustad C.M., Swing D.A., O'Sullivan T.N., Jenkins N.A., Copeland N.G.
    Nat. Genet. 18:143-146(1998) [PubMed] [Europe PMC] [Abstract]
• ubiquitin-protein transferase activity Source: SGDInferred from direct assayⁱ
  • "Pheromone- and RSP5-dependent ubiquitination of the G protein beta subunit Ste4 in yeast."
    Zhu M., Torres M.P., Kelley J.B., Dohlman H.G., Wang Y.
    J. Biol. Chem. 286:27147-27155(2011) [PubMed] [Europe PMC] [Abstract]
  • "SUMOylation regulates the homologous to E6-AP carboxyl terminus (HECT) ubiquitin ligase Rsp5p."
    Novoselova T.V., Rose R.S., Marks H.M., Sullivan J.A.
    J. Biol. Chem. 288:10308-10317(2013) [PubMed] [Europe PMC] [Abstract]
  • "A bacterial genetic selection system for ubiquitylation cascade discovery."
    Levin-Kravets O., Tanner N., Shohat N., Attali I., Keren-Kaplan T., Shusterman A., Artzi S., Varvak A., Reshef Y., Shi X., Zucker O., Baram T., Katina C., Pilzer I., Ben-Aroya S., Prag G.
    Nat. Methods 13:945-952(2016) [PubMed] [Europe PMC] [Abstract]
  • "The large subunit of RNA polymerase II is a substrate of the Rsp5 ubiquitin-protein ligase."
    Huibregtse J.M., Yang J.C., Beaudenon S.L.
    Proc. Natl. Acad. Sci. U.S.A. 94:3656-3661(1997) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• cellular response to UV Source: SGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Rsp5 ubiquitin-protein ligase mediates DNA damage-induced degradation of the large subunit of RNA polymerase II in Saccharomyces cerevisiae."
    Beaudenon S.L., Huacani M.R., Wang G., McDonnell D.P., Huibregtse J.M.
    Mol. Cell. Biol. 19:6972-6979(1999) [PubMed] [Europe PMC] [Abstract]
• chromatin assembly or disassembly Source: SGDInferred from mutant phenotypeⁱ
  • "The ubiquitin-dependent targeting pathway in Saccharomyces cerevisiae plays a critical role in multiple chromatin assembly regulatory steps."
    Harkness T.A., Davies G.F., Ramaswamy V., Arnason T.G.
    Genetics 162:615-632(2002) [PubMed] [Europe PMC] [Abstract]
• late endosome to vacuole transport via multivesicular body sorting pathway Source: SGDInferred from mutant phenotypeⁱ
  • "Characterization of multiple multivesicular body sorting determinants within Sna3: a role for the ubiquitin ligase Rsp5."
    Oestreich A.J., Aboian M., Lee J., Azmi I., Payne J., Issaka R., Davies B.A., Katzmann D.J.
    Mol. Biol. Cell 18:707-720(2007) [PubMed] [Europe PMC] [Abstract]
• mitochondria-associated ubiquitin-dependent protein catabolic process Source: SGDInferred from mutant phenotypeⁱ
  • "A stress-responsive system for mitochondrial protein degradation."
    Heo J.M., Livnat-Levanon N., Taylor E.B., Jones K.T., Dephoure N., Ring J., Xie J., Brodsky J.L., Madeo F., Gygi S.P., Ashrafi K., Glickman M.H., Rutter J.
    Mol. Cell 40:465-480(2010) [PubMed] [Europe PMC] [Abstract]
• mitochondrion organization Source: SGDInferred from mutant phenotypeⁱ
  • "A role for ubiquitination in mitochondrial inheritance in Saccharomyces cerevisiae."
    Fisk H.A., Yaffe M.P.
    J. Cell Biol. 145:1199-1208(1999) [PubMed] [Europe PMC] [Abstract]
• poly(A)+ mRNA export from nucleus Source: SGDInferred from mutant phenotypeⁱ
  • "Altered RNA processing and export lead to retention of mRNAs near transcription sites and nuclear pore complexes or within the nucleolus."
    Paul B., Montpetit B.
    Mol. Biol. Cell 27:2742-2756(2016) [PubMed] [Europe PMC] [Abstract]
• positive regulation of endocytosis Source: SGDInferred from mutant phenotypeⁱ
  • "Vps9p CUE domain ubiquitin binding is required for efficient endocytic protein traffic."
    Davies B.A., Topp J.D., Sfeir A.J., Katzmann D.J., Carney D.S., Tall G.G., Friedberg A.S., Deng L., Chen Z., Horazdovsky B.F.
    J. Biol. Chem. 278:19826-19833(2003) [PubMed] [Europe PMC] [Abstract]
• positive regulation of fatty acid biosynthetic process Source: SGDInferred from mutant phenotypeⁱ
  • "Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasome-dependent processing."
    Hoppe T., Matuschewski K., Rape M., Schlenker S., Ulrich H.D., Jentsch S.
    Cell 102:577-586(2000) [PubMed] [Europe PMC] [Abstract]
• positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: SGDInferred from mutant phenotypeⁱ
  • "The ESCRT-III adaptor protein Bro1 controls functions of regulator for free ubiquitin chains 1 (Rfu1) in ubiquitin homeostasis."
    Kimura Y., Kawawaki J., Kakiyama Y., Shimoda A., Tanaka K.
    J. Biol. Chem. 289:21760-21769(2014) [PubMed] [Europe PMC] [Abstract]
• positive regulation of protein catabolic process Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of receptor-mediated endocytosis Source: SGDInferred from mutant phenotypeⁱ
  • "Domains of the Rsp5 ubiquitin-protein ligase required for receptor-mediated and fluid-phase endocytosis."
    Dunn R., Hicke L.
    Mol. Biol. Cell 12:421-435(2001) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: SGDInferred from mutant phenotypeⁱ
  • "Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasome-dependent processing."
    Hoppe T., Matuschewski K., Rape M., Schlenker S., Ulrich H.D., Jentsch S.
    Cell 102:577-586(2000) [PubMed] [Europe PMC] [Abstract]
• proteasome-mediated ubiquitin-dependent protein catabolic process Source: SGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "The mRNA nuclear export factor Hpr1 is regulated by Rsp5-mediated ubiquitylation."
    Gwizdek C., Hobeika M., Kus B., Ossareh-Nazari B., Dargemont C., Rodriguez M.S.
    J. Biol. Chem. 280:13401-13405(2005) [PubMed] [Europe PMC] [Abstract]
• protein autoubiquitination Source: SGD <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Ubp2 regulates Rsp5 ubiquitination activity in vivo and in vitro."
    Lam M.H., Emili A.
    PLoS ONE 8:e75372-e75372(2013) [PubMed] [Europe PMC] [Abstract]
• protein monoubiquitination Source: SGDInferred from direct assayⁱ
  • "G Protein Mono-ubiquitination by the Rsp5 Ubiquitin Ligase."
    Torres M.P., Lee M.J., Ding F., Purbeck C., Kuhlman B., Dokholyan N.V., Dohlman H.G.
    J. Biol. Chem. 284:8940-8950(2009) [PubMed] [Europe PMC] [Abstract]
  • "Pheromone- and RSP5-dependent ubiquitination of the G protein beta subunit Ste4 in yeast."
    Zhu M., Torres M.P., Kelley J.B., Dohlman H.G., Wang Y.
    J. Biol. Chem. 286:27147-27155(2011) [PubMed] [Europe PMC] [Abstract]
• protein polyubiquitination Source: SGDInferred from direct assayⁱ
  • "The large subunit of RNA polymerase II is a substrate of the Rsp5 ubiquitin-protein ligase."
    Huibregtse J.M., Yang J.C., Beaudenon S.L.
    Proc. Natl. Acad. Sci. U.S.A. 94:3656-3661(1997) [PubMed] [Europe PMC] [Abstract]
• protein ubiquitination Source: SGDInferred from direct assayⁱ
  • "SUMOylation regulates the homologous to E6-AP carboxyl terminus (HECT) ubiquitin ligase Rsp5p."
    Novoselova T.V., Rose R.S., Marks H.M., Sullivan J.A.
    J. Biol. Chem. 288:10308-10317(2013) [PubMed] [Europe PMC] [Abstract]
• regulation of actin cytoskeleton organization Source: SGDInferred from genetic interactionⁱ
  • "Identification of an upstream regulatory pathway controlling actin-mediated apoptosis in yeast."
    Gourlay C.W., Ayscough K.R.
    J. Cell. Sci. 118:2119-2132(2005) [PubMed] [Europe PMC] [Abstract]
• regulation of dolichol biosynthetic process Source: SGDInferred from mutant phenotypeⁱ
  • "Rsp5p ubiquitin ligase and the transcriptional activators Spt23p and Mga2p are involved in co-regulation of biosynthesis of end products of the mevalonate pathway and triacylglycerol in yeast Saccharomyces cerevisiae."
    Kaliszewski P., Szkopinska A., Ferreira T., Swiezewska E., Berges T., Zoladek T.
    Biochim. Biophys. Acta 1781:627-634(2008) [PubMed] [Europe PMC] [Abstract]
• regulation of ergosterol biosynthetic process Source: SGDInferred from mutant phenotypeⁱ
  • "Rsp5p ubiquitin ligase and the transcriptional activators Spt23p and Mga2p are involved in co-regulation of biosynthesis of end products of the mevalonate pathway and triacylglycerol in yeast Saccharomyces cerevisiae."
    Kaliszewski P., Szkopinska A., Ferreira T., Swiezewska E., Berges T., Zoladek T.
    Biochim. Biophys. Acta 1781:627-634(2008) [PubMed] [Europe PMC] [Abstract]
• regulation of initiation of mating projection growth Source: SGDInferred from mutant phenotypeⁱ
  • "Pheromone- and RSP5-dependent ubiquitination of the G protein beta subunit Ste4 in yeast."
    Zhu M., Torres M.P., Kelley J.B., Dohlman H.G., Wang Y.
    J. Biol. Chem. 286:27147-27155(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of mRNA export from nucleus Source: SGDInferred from mutant phenotypeⁱ
  • "Formation and nuclear export of tRNA, rRNA and mRNA is regulated by the ubiquitin ligase Rsp5p."
    Neumann S., Petfalski E., Brugger B., Grosshans H., Wieland F., Tollervey D., Hurt E.
    EMBO Rep. 4:1156-1162(2003) [PubMed] [Europe PMC] [Abstract]
• regulation of multivesicular body size Source: SGDInferred from mutant phenotypeⁱ
  • "Direct binding to Rsp5 mediates ubiquitin-independent sorting of Sna3 via the multivesicular body pathway."
    McNatt M.W., McKittrick I., West M., Odorizzi G.
    Mol. Biol. Cell 18:697-706(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of nitrogen utilization Source: SGDInferred from genetic interactionⁱ
  • Ref.13

    "NPR1 kinase and RSP5-BUL1/2 ubiquitin ligase control GLN3-dependent transcription in Saccharomyces cerevisiae."
    Crespo J.L., Helliwell S.B., Wiederkehr C., Demougin P., Fowler B., Primig M., Hall M.N.
    J. Biol. Chem. 279:37512-37517(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION OF THE RSP5-BUL1/2 COMPLEX.
• regulation of phosphate metabolic process Source: SGDInferred from genetic interactionⁱ
  • "The Rsp5 E3 ligase mediates turnover of low affinity phosphate transporters in Saccharomyces cerevisiae."
    Estrella L.A., Krishnamurthy S., Timme C.R., Hampsey M.
    J. Biol. Chem. 283:5327-5334(2008) [PubMed] [Europe PMC] [Abstract]
• regulation of protein localization Source: SGDInferred from mutant phenotypeⁱ
  • "Rsp5p is required for ER bound Mga2p120 polyubiquitination and release of the processed/tethered transactivator Mga2p90."
    Shcherbik N., Zoladek T., Nickels J.T., Haines D.S.
    Curr. Biol. 13:1227-1233(2003) [PubMed] [Europe PMC] [Abstract]
• regulation of ribosomal large subunit export from nucleus Source: SGDInferred from mutant phenotypeⁱ
  • "Formation and nuclear export of tRNA, rRNA and mRNA is regulated by the ubiquitin ligase Rsp5p."
    Neumann S., Petfalski E., Brugger B., Grosshans H., Wieland F., Tollervey D., Hurt E.
    EMBO Rep. 4:1156-1162(2003) [PubMed] [Europe PMC] [Abstract]
• regulation of rRNA processing Source: SGDInferred from mutant phenotypeⁱ
  • "Formation and nuclear export of tRNA, rRNA and mRNA is regulated by the ubiquitin ligase Rsp5p."
    Neumann S., Petfalski E., Brugger B., Grosshans H., Wieland F., Tollervey D., Hurt E.
    EMBO Rep. 4:1156-1162(2003) [PubMed] [Europe PMC] [Abstract]
• regulation of tRNA export from nucleus Source: SGDInferred from mutant phenotypeⁱ
  • "Formation and nuclear export of tRNA, rRNA and mRNA is regulated by the ubiquitin ligase Rsp5p."
    Neumann S., Petfalski E., Brugger B., Grosshans H., Wieland F., Tollervey D., Hurt E.
    EMBO Rep. 4:1156-1162(2003) [PubMed] [Europe PMC] [Abstract]
• regulation of tRNA processing Source: SGDInferred from mutant phenotypeⁱ
  • "Formation and nuclear export of tRNA, rRNA and mRNA is regulated by the ubiquitin ligase Rsp5p."
    Neumann S., Petfalski E., Brugger B., Grosshans H., Wieland F., Tollervey D., Hurt E.
    EMBO Rep. 4:1156-1162(2003) [PubMed] [Europe PMC] [Abstract]
• regulation of ubiquinone biosynthetic process Source: SGDInferred from mutant phenotypeⁱ
  • "Rsp5p ubiquitin ligase and the transcriptional activators Spt23p and Mga2p are involved in co-regulation of biosynthesis of end products of the mevalonate pathway and triacylglycerol in yeast Saccharomyces cerevisiae."
    Kaliszewski P., Szkopinska A., Ferreira T., Swiezewska E., Berges T., Zoladek T.
    Biochim. Biophys. Acta 1781:627-634(2008) [PubMed] [Europe PMC] [Abstract]
• response to drug Source: SGDInferred from mutant phenotypeⁱ
  • Ref.10

    "PY motifs of Rod1 are required for binding to Rsp5 and for drug resistance."
    Andoh T., Hirata Y., Kikuchi A.
    FEBS Lett. 525:131-134(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH ROD1 AND ROG3.
• ribophagy Source: SGDInferred from genetic interactionⁱ
  • "Is the Rsp5 ubiquitin ligase involved in the regulation of ribophagy?"
    Kraft C., Peter M.
    Autophagy 4:838-840(2008) [PubMed] [Europe PMC] [Abstract]
• ubiquitin-dependent endocytosis Source: SGDInferred from mutant phenotypeⁱ
  • "GGA2- and ubiquitin-dependent trafficking of Arn1, the ferrichrome transporter of Saccharomyces cerevisiae."
    Kim Y., Deng Y., Philpott C.C.
    Mol. Biol. Cell 18:1790-1802(2007) [PubMed] [Europe PMC] [Abstract]
• ubiquitin-dependent protein catabolic process Source: MGIInferred from direct assayⁱ
  • "The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice."
    Perry W.L., Hustad C.M., Swing D.A., O'Sullivan T.N., Jenkins N.A., Copeland N.G.
    Nat. Genet. 18:143-146(1998) [PubMed] [Europe PMC] [Abstract]
• ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: SGDInferred from mutant phenotypeⁱ
  • "GGA2- and ubiquitin-dependent trafficking of Arn1, the ferrichrome transporter of Saccharomyces cerevisiae."
    Kim Y., Deng Y., Philpott C.C.
    Mol. Biol. Cell 18:1790-1802(2007) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• ubiquitin binding Source: SGDInferred from direct assayⁱ
  • "Regulation of the RSP5 ubiquitin ligase by an intrinsic ubiquitin-binding site."
    French M.E., Kretzmann B.R., Hicke L.
    J. Biol. Chem. 284:12071-12079(2009) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MPSSISVKLV AAESLYKRDV FRSPDPFAVL TIDGYQTKST SAAKKTLNPY 
        60         70         80         90        100
WNETFKFDDI NENSILTIQV FDQKKFKKKD QGFLGVVNVR VGDVLGHLDE 
       110        120        130        140        150
DTATSSGRPR EETITRDLKK SNDGMAVSGR LIVVLSKLPS SSPHSQAPSG 
       160        170        180        190        200
HTASSSTNTS STTRTNGHST SSTRNHSTSH PSRGTAQAVE STLQSGTTAA 
       210        220        230        240        250
TNTATTSHRS TNSTSSATRQ YSSFEDQYGR LPPGWERRTD NFGRTYYVDH 
       260        270        280        290        300
NTRTTTWKRP TLDQTEAERG NQLNANTELE RRQHRGRTLP GGSSDNSSVT 
       310        320        330        340        350
VQVGGGSNIP PVNGAAAAAF AATGGTTSGL GELPSGWEQR FTPEGRAYFV 
       360        370        380        390        400
DHNTRTTTWV DPRRQQYIRT YGPTNTTIQQ QPVSQLGPLP SGWEMRLTNT 
       410        420        430        440        450
ARVYFVDHNT KTTTWDDPRL PSSLDQNVPQ YKRDFRRKVI YFRSQPALRI 
       460        470        480        490        500
LPGQCHIKVR RKNIFEDAYQ EIMRQTPEDL KKRLMIKFDG EEGLDYGGVS 
       510        520        530        540        550
REFFFLLSHE MFNPFYCLFE YSAYDNYTIQ INPNSGINPE HLNYFKFIGR 
       560        570        580        590        600
VVGLGVFHRR FLDAFFVGAL YKMMLRKKVV LQDMEGVDAE VYNSLNWMLE 
       610        620        630        640        650
NSIDGVLDLT FSADDERFGE VVTVDLKPDG RNIEVTDGNK KEYVELYTQW 
       660        670        680        690        700
RIVDRVQEQF KAFMDGFNEL IPEDLVTVFD ERELELLIGG IAEIDIEDWK 
       710        720        730        740        750
KHTDYRGYQE SDEVIQWFWK CVSEWDNEQR ARLLQFTTGT SRIPVNGFKD 
       760        770        780        790        800
LQGSDGPRRF TIEKAGEVQQ LPKSHTCFNR VDLPQYVDYD SMKQKLTLAV 

EETIGFGQE                                              

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. PATHWAY comments
   Index of metabolic and biosynthesis pathways
2. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
3. SIMILARITY comments
   Index of protein domains and families
4. Yeast
   Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
5. Yeast chromosome V
   Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names