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Protein

Thioredoxin reductase

Gene

trxB

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Miscellaneous

The active site is a redox-active disulfide bond.

Catalytic activityi

Thioredoxin + NADP+ = thioredoxin disulfide + NADPH.

Cofactori

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi36 – 43FADBy similarity8
Nucleotide bindingi287 – 296FADBy similarity10

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, NADP

Enzyme and pathway databases

BioCyciCBUR227377:G1G0B-1178-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin reductase (EC:1.8.1.9)
Short name:
TRXR
Gene namesi
Name:trxB
Ordered Locus Names:CBU_1193
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
Proteomesi
  • UP000002671 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001667281 – 320Thioredoxin reductaseAdd BLAST320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi136 ↔ 139Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP39916

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi227377.CBU_1193

Structurei

3D structure databases

ProteinModelPortaliP39916
SMRiP39916
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG4105C3M Bacteria
COG0492 LUCA
HOGENOMiHOG000072912
KOiK00384
OMAiDPIQGPW

Family and domain databases

Gene3Di3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR008255 Pyr_nucl-diS_OxRdtase_2_AS
IPR000103 Pyridine_nuc-diS_OxRdtase_2
IPR005982 Thioredox_Rdtase
PfamiView protein in Pfam
PF07992 Pyr_redox_2, 1 hit
PRINTSiPR00469 PNDRDTASEII
SUPFAMiSSF51905 SSF51905, 1 hit
TIGRFAMsiTIGR01292 TRX_reduct, 1 hit
PROSITEiView protein in PROSITE
PS00573 PYRIDINE_REDOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P39916-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKPQHHSLI ILGSGPAGYT AAIYAARANL KPIMITGMEQ GGQLMTTTDV
60 70 80 90 100
DNWPGEAPGL QGPQLMERMQ KHAERLDTQF IFDHINEADL NQRPFLLKGD
110 120 130 140 150
NATYSCDALI IATGASARYL GLPSEKAYMG KGVSACATCD GFFYRGKKVA
160 170 180 190 200
VVGGGNTAVE EALYLSHIAS HVTLIHRRDK LRAEKMLSAQ LIKKVEEGKV
210 220 230 240 250
AIVWSHVIEE VLGDDQGVTG VHLKHVKEEK TQDLTIDGLF IAIGHDPNTK
260 270 280 290 300
IFKEQLEMDE AGYLRAKSGL QGNATATNIP GVFAAGDVTD HVYRQAITAA
310 320
GMGCMAALDA ERYLDSLNQA
Length:320
Mass (Da):34,620
Last modified:May 9, 2003 - v2
Checksum:i750851B6FDDEB5E3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21A → D in CAA53288 (Ref. 1) Curated1
Sequence conflicti25A → V in CAA53288 (Ref. 1) Curated1
Sequence conflicti51D → A in CAA53288 (Ref. 1) Curated1
Sequence conflicti64 – 66QLM → KLL in CAA53288 (Ref. 1) Curated3
Sequence conflicti74 – 77ERLD → GGALN in CAA53288 (Ref. 1) Curated4
Sequence conflicti87 – 88EA → KP in CAA53288 (Ref. 1) Curated2
Sequence conflicti92Q → P in CAA53288 (Ref. 1) Curated1
Sequence conflicti98K → Q in CAA53288 (Ref. 1) Curated1
Sequence conflicti127A → P in CAA53288 (Ref. 1) Curated1
Sequence conflicti146G → A in CAA53288 (Ref. 1) Curated1
Sequence conflicti158A → S in CAA53288 (Ref. 1) Curated1
Sequence conflicti284 – 292AAGDVTDHV → PAVVVRGQL in CAA53288 (Ref. 1) Curated9
Sequence conflicti296 – 298AIT → TIA in CAA53288 (Ref. 1) Curated3
Sequence conflicti306A → P in CAA53288 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75627 Genomic DNA Translation: CAA53288.1
AE016828 Genomic DNA Translation: AAO90702.1
PIRiS43131
RefSeqiNP_820188.1, NC_002971.3
WP_005770716.1, NZ_LM994641.1

Genome annotation databases

EnsemblBacteriaiAAO90702; AAO90702; CBU_1193
GeneIDi1209097
31483896
KEGGicbu:CBU_1193
PATRICifig|227377.7.peg.1190

Similar proteinsi

Entry informationi

Entry nameiTRXB_COXBU
AccessioniPrimary (citable) accession number: P39916
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: May 9, 2003
Last modified: February 28, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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