We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - P39886 (TCMA_STRGA)
Protein
Tetracenomycin C resistance and export protein
Gene
tcmA
Organism
Streptomyces glaucescens
Status
Functioni
Resistance to tetracenomycin C by an active tetracenomycin C efflux system which is probably energized by transmembrane electrochemical gradients.
: tetracenomycin C biosynthesis Pathwayi
This protein is involved in the pathway tetracenomycin C biosynthesis, which is part of Antibiotic biosynthesis.View all proteins of this organism that are known to be involved in the pathway tetracenomycin C biosynthesis and in Antibiotic biosynthesis.
GO - Molecular functioni
- transmembrane transporter activity Source: InterPro
GO - Biological processi
- antibiotic biosynthetic process Source: UniProtKB-KW
- response to antibiotic Source: UniProtKB-KW
Keywordsi
Biological process | Antibiotic biosynthesis, Antibiotic resistance, Transport |
Enzyme and pathway databases
UniPathwayi | UPA00174 |
Protein family/group databases
TCDBi | 2.A.1.3.12, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Tetracenomycin C resistance and export protein |
Gene namesi | Name:tcmA |
Organismi | Streptomyces glaucescens |
Taxonomic identifieri | 1907 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Streptomycetales › Streptomycetaceae › Streptomyces |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 28 – 48 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 65 – 85 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 100 – 120 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 126 – 146 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 154 – 174 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 181 – 201 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 213 – 233 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 239 – 259 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 286 – 306 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 319 – 339 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 342 – 362 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 371 – 391 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 413 – 433 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 494 – 514 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000173366 | 1 – 538 | Tetracenomycin C resistance and export proteinAdd BLAST | 538 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG0477, Bacteria |
OMAi | ICAYISE |
OrthoDBi | 1108236at2 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR004638, EmrB-like IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00711, efflux_EmrB, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
i Sequence
Sequence statusi: Complete.
P39886-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTETHDEPS GVAHTPASGL RGRPWPTLLA VAVGVMMVAL DSTIVAIANP
60 70 80 90 100
AIQQDLHASL ADVQWITNGY LLALAVSLIT AGKLGDRFGH RQTFLVGVAG
110 120 130 140 150
FAVTSAAIGL SGSVAAIVVF RVLQGLFGAL MQPSALGLLR VTFPPGKLNM
160 170 180 190 200
AIGIWSGVVG ASTAAGPIIG GLLVQHVGWE AVFFINVPVG LAALVAGLVI
210 220 230 240 250
LTDARAERAP KSFDVSGIVL LSGAMFCLVW GLIKAPAWGW GDLRTLGFLA
260 270 280 290 300
AAVLAFAGFT LRESRATEPL MPLAMFRSVP LSAGTVLMVL MAFSFIGGLF
310 320 330 340 350
FVTFYLQNVH GMSPVESGVH LLPLTGMMIV GAPVSGIVIS RFGPGGPLVV
360 370 380 390 400
GMLLTAASLW GMSTLEADSG MGITSLWFVL LGLGLAPVMV GTTDVIVSNA
410 420 430 440 450
PAELAGVAGG LQQSAMQVGG SLGTAVLGVL MASRVGDVFP DKWAEANLPR
460 470 480 490 500
VGPREAAAIE DAAEVGAVPP AGTLPGRHAG TLSEVVHSSF ISGMGLAFTV
510 520 530
AGAVALVAAA VALFTRKAEP DERAPEEFPV PASTAGRG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M80674 Genomic DNA Translation: AAA67509.1 |
PIRi | A41901 |
RefSeqi | WP_052413892.1, NZ_CP009438.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M80674 Genomic DNA Translation: AAA67509.1 |
PIRi | A41901 |
RefSeqi | WP_052413892.1, NZ_CP009438.1 |
3D structure databases
SMRi | P39886 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 1907.SGLAU_26325 |
Protein family/group databases
TCDBi | 2.A.1.3.12, the major facilitator superfamily (mfs) |
Phylogenomic databases
eggNOGi | COG0477, Bacteria |
OMAi | ICAYISE |
OrthoDBi | 1108236at2 |
Enzyme and pathway databases
UniPathwayi | UPA00174 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR004638, EmrB-like IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00711, efflux_EmrB, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TCMA_STRGA | |
Accessioni | P39886Primary (citable) accession number: P39886 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | February 23, 2022 | |
This is version 95 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families