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Protein

Homeobox protein cut-like 1

Gene

CUX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator (By similarity).By similarity

Miscellaneous

Asn-1290 may participate in regulating DNA-binding activity by promoting homo- and heterodimerization.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi542 – 629CUT 1PROSITE-ProRule annotationAdd BLAST88
DNA bindingi934 – 1021CUT 2PROSITE-ProRule annotationAdd BLAST88
DNA bindingi1117 – 1204CUT 3PROSITE-ProRule annotationAdd BLAST88
DNA bindingi1244 – 1303HomeoboxPROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants
R-HSA-5655302 Signaling by FGFR1 in disease

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P39880

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Homeobox protein cut-like 1
Alternative name(s):
CCAAT displacement protein
Short name:
CDP
Homeobox protein cux-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CUX1
Synonyms:CUTL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000257923.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2557 CUX1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
116896 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P39880

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1523

Open Targets

More...
OpenTargetsi
ENSG00000257923

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162382924

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
UGT3A1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002023931 – 1505Homeobox protein cut-like 1Add BLAST1505

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei763PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki785Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki811Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki842Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei909PhosphoserineBy similarity1
Modified residuei1059PhosphoserineCombined sources1
Modified residuei1069PhosphoserineBy similarity1
Modified residuei1270PhosphoserineCombined sources1
Cross-linki1284Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1337PhosphoserineBy similarity1
Modified residuei1455PhosphoserineCombined sources1
Modified residuei1486PhosphoserineCombined sources1
Modified residuei1496PhosphoserineBy similarity1
Isoform 11 (identifier: P39880-9)
Modified residuei540PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P39880

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P39880

PeptideAtlas

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PeptideAtlasi
P39880

PRoteomics IDEntifications database

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PRIDEi
P39880

ProteomicsDB human proteome resource

More...
ProteomicsDBi
55321
55322 [P39880-2]
55323 [P39880-3]
55324 [P39880-4]
55325 [P39880-5]
55326 [P39880-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P39880

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P39880

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P39880

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000257923 Expressed in 235 organ(s), highest expression level in secondary oocyte

CleanEx database of gene expression profiles

More...
CleanExi
HS_CUX1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P39880 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P39880 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA003277
HPA003317

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with BANP. Interacts with SATB1 (via DNA-binding domains); the interaction inhibits the attachment of both proteins to DNA (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107903, 59 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
P39880

Protein interaction database and analysis system

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IntActi
P39880, 28 interactors

Molecular INTeraction database

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MINTi
P39880

STRING: functional protein association networks

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STRINGi
9606.ENSP00000353401

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P39880

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P39880

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili56 – 407Sequence analysisAdd BLAST352

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1406 – 1438Ala-richAdd BLAST33

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CUT homeobox family.Curated

Keywords - Domaini

Coiled coil, Homeobox, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0963 Eukaryota
KOG2252 Eukaryota
ENOG410XPKP LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159751

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG053415

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P39880

Database of Orthologous Groups

More...
OrthoDBi
EOG091G011E

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P39880

TreeFam database of animal gene trees

More...
TreeFami
TF318206

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00086 homeodomain, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003350 CUT_dom
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02376 CUT, 3 hits
PF00046 Homeodomain, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01109 CUT, 3 hits
SM00389 HOX, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51042 CUT, 3 hits
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (11+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 11 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 11 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P39880-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLCVAGARLK RELDATATVL ANRQDESEQS RKRLIEQSRE FKKNTPEDLR
60 70 80 90 100
KQVAPLLKSF QGEIDALSKR SKEAEAAFLN VYKRLIDVPD PVPALDLGQQ
110 120 130 140 150
LQLKVQRLHD IETENQKLRE TLEEYNKEFA EVKNQEVTIK ALKEKIREYE
160 170 180 190 200
QTLKNQAETI ALEKEQKLQN DFAEKERKLQ ETQMSTTSKL EEAEHKVQSL
210 220 230 240 250
QTALEKTRTE LFDLKTKYDE ETTAKADEIE MIMTDLERAN QRAEVAQREA
260 270 280 290 300
ETLREQLSSA NHSLQLASQI QKAPDVEQAI EVLTRSSLEV ELAAKEREIA
310 320 330 340 350
QLVEDVQRLQ ASLTKLRENS ASQISQLEQQ LSAKNSTLKQ LEEKLKGQAD
360 370 380 390 400
YEEVKKELNI LKSMEFAPSE GAGTQDAAKP LEVLLLEKNR SLQSENAALR
410 420 430 440 450
ISNSDLSGSA RRKGKDQPES RRPGSLPAPP PSQLPRNPGE QASNTNGTHQ
460 470 480 490 500
FSPAGLSQDF FSSSLASPSL PLASTGKFAL NSLLQRQLMQ SFYSKAMQEA
510 520 530 540 550
GSTSMIFSTG PYSTNSISSQ SPLQQSPDVN GMAPSPSQSE SAGSVSEGEE
560 570 580 590 600
MDTAEIARQV KEQLIKHNIG QRIFGHYVLG LSQGSVSEIL ARPKPWNKLT
610 620 630 640 650
VRGKEPFHKM KQFLSDEQNI LALRSIQGRQ RENPGQSLNR LFQEVPKRRN
660 670 680 690 700
GSEGNITTRI RASETGSDEA IKSILEQAKR ELQVQKTAEP AQPSSASGSG
710 720 730 740 750
NSDDAIRSIL QQARREMEAQ QAALDPALKQ APLSQSDITI LTPKLLSTSP
760 770 780 790 800
MPTVSSYPPL AISLKKPSAA PEAGASALPN PPALKKEAQD APGLDPQGAA
810 820 830 840 850
DCAQGVLRQV KNEVGRSGAW KDHWWSAVQP ERRNAASSEE AKAEETGGGK
860 870 880 890 900
EKGSGGSGGG SQPRAERSQL QGPSSSEYWK EWPSAESPYS QSSELSLTGA
910 920 930 940 950
SRSETPQNSP LPSSPIVPMS KPTKPSVPPL TPEQYEVYMY QEVDTIELTR
960 970 980 990 1000
QVKEKLAKNG ICQRIFGEKV LGLSQGSVSD MLSRPKPWSK LTQKGREPFI
1010 1020 1030 1040 1050
RMQLWLNGEL GQGVLPVQGQ QQGPVLHSVT SLQDPLQQGC VSSESTPKTS
1060 1070 1080 1090 1100
ASCSPAPESP MSSSESVKSL TELVQQPCPP IEASKDSKPP EPSDPPASDS
1110 1120 1130 1140 1150
QPTTPLPLSG HSALSIQELV AMSPELDTYG ITKRVKEVLT DNNLGQRLFG
1160 1170 1180 1190 1200
ETILGLTQGS VSDLLARPKP WHKLSLKGRE PFVRMQLWLN DPNNVEKLMD
1210 1220 1230 1240 1250
MKRMEKKAYM KRRHSSVSDS QPCEPPSVGT EYSQGASPQP QHQLKKPRVV
1260 1270 1280 1290 1300
LAPEEKEALK RAYQQKPYPS PKTIEDLATQ LNLKTSTVIN WFHNYRSRIR
1310 1320 1330 1340 1350
RELFIEEIQA GSQGQAGASD SPSARSGRAA PSSEGDSCDG VEATEGPGSA
1360 1370 1380 1390 1400
DTEEPKSQGE AEREEVPRPA EQTEPPPSGT PGPDDARDDD HEGGPVEGPG
1410 1420 1430 1440 1450
PLPSPASATA TAAPAAPEDA ATSAAAAPGE GPAAPSSAPP PSNSSSSSAP
1460 1470 1480 1490 1500
RRPSSLQSLF GLPEAAGARD SRDNPLRKKK AANLNSIIHR LEKAASREEP

IEWEF
Length:1,505
Mass (Da):164,187
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0F9027E5B8F08D95
GO
Isoform 2 (identifier: P39880-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     632-653: Missing.

Show »
Length:1,483
Mass (Da):161,650
Checksum:i369D44022E3FF3D7
GO
Isoform 3 (identifier: P39880-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MLCVAGARLK → MAANVGSMFQYWKRFDLQQLQ

Note: No experimental confirmation available.
Show »
Length:1,516
Mass (Da):165,688
Checksum:i13E5E97E8569C5AA
GO
Isoform 5 (identifier: P39880-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     408-509: Missing.

Show »
Length:1,403
Mass (Da):153,364
Checksum:iB10F9B5E864C9D8F
GO
Isoform 6 (identifier: P39880-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     632-687: Missing.

Show »
Length:1,449
Mass (Da):157,895
Checksum:iEC08BD990BA5321C
GO
Isoform 7 (identifier: P39880-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     408-509: Missing.
     632-687: Missing.

Show »
Length:1,347
Mass (Da):147,072
Checksum:iD50586280B4D0B81
GO
Isoform 11 (identifier: P39880-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MLCVAGARLK → MAANVGSMFQYWKRFDLQQLQ
     90-135: Missing.
     409-667: SARRKGKDQP...TRIRASETGS → RCAELQVRIT...NGAAAGDLWQ
     668-1505: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:632
Mass (Da):72,024
Checksum:iA399B4B63B891AA6
GO
Isoform 4 (identifier: Q13948-1) [UniParc]FASTAAdd to basket
Also known as: CASP
The sequence of this isoform can be found in the external entry Q13948.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:678
Mass (Da):77,455
GO
Isoform 8 (identifier: Q13948-2) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q13948.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: No experimental confirmation available.
Length:676
Mass (Da):77,198
GO
Isoform 9 (identifier: Q13948-9) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q13948.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: No experimental confirmation available.
Length:639
Mass (Da):72,841
GO
Isoform 10 (identifier: Q13948-10) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q13948.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: No experimental confirmation available.
Length:662
Mass (Da):75,644
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y852A0A2R8Y852_HUMAN
Homeobox protein cut-like
CUX1
1,460Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YDI1A0A2R8YDI1_HUMAN
Homeobox protein cut-like
CUX1
1,358Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y8D0A0A2R8Y8D0_HUMAN
Homeobox protein cut-like 1
CUX1
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti5A → R in M74099 (PubMed:1301999).Curated1
Sequence conflicti145K → I in BAG53691 (PubMed:14702039).Curated1
Sequence conflicti260A → V in BAG53691 (PubMed:14702039).Curated1
Sequence conflicti704 – 705DA → EP in M74099 (PubMed:1301999).Curated2
Sequence conflicti844E → R in M74099 (PubMed:1301999).Curated1
Sequence conflicti1436S → T in M74099 (PubMed:1301999).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0157471 – 10MLCVAGARLK → MAANVGSMFQYWKRFDLQQL Q in isoform 3 and isoform 11. 2 Publications10
Alternative sequenceiVSP_04592490 – 135Missing in isoform 11. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_017358408 – 509Missing in isoform 5 and isoform 7. CuratedAdd BLAST102
Alternative sequenceiVSP_045925409 – 667SARRK…SETGS → RCAELQVRITEAVATATEQR ELIARLEQDLSIIQSIQRPD AEGAAEHRLEKIPEPIKEAT ALFYGPAAPASGALPEGQVD SLLSIISSQRERFRARNQEL EAENRLAQHTLQALQSELDS LRADNIKLFEKIKFLQSYPG RGSGSDDTELRYSSQYEERL DPFSSFSKRERQRKYLSLSP WDKATLSMGRLVLSNKMART IGFFYTLFLHCLVFLVLYKL AWSESMERDCATFCAKKFAD HLHKFHENDNGAAAGDLWQ in isoform 11. 1 PublicationAdd BLAST259
Alternative sequenceiVSP_017359632 – 687Missing in isoform 6 and isoform 7. CuratedAdd BLAST56
Alternative sequenceiVSP_002310632 – 653Missing in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_045926668 – 1505Missing in isoform 11. 1 PublicationAdd BLAST838

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M74099 mRNA No translation available.
AK122726 mRNA Translation: BAG53691.1
AC005072 Genomic DNA No translation available.
AC005086 Genomic DNA Translation: AAP22331.1
AC005088 Genomic DNA No translation available.
AC005096 Genomic DNA Translation: AAS07410.1
AC005103 Genomic DNA Translation: AAS07388.1
AC092788 Genomic DNA Translation: AAS07523.1
BC066592 mRNA Translation: AAH66592.1
AF047825 Genomic DNA Translation: AAC78778.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS56498.1 [P39880-3]
CCDS56499.1 [P39880-9]
CCDS5721.1 [P39880-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001189472.1, NM_001202543.1 [P39880-3]
NP_001189473.1, NM_001202544.2
NP_001189474.1, NM_001202545.2 [P39880-9]
NP_852477.1, NM_181500.3
NP_853530.2, NM_181552.3 [P39880-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.191482

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000292535; ENSP00000292535; ENSG00000257923 [P39880-1]
ENST00000360264; ENSP00000353401; ENSG00000257923 [P39880-3]
ENST00000425244; ENSP00000409745; ENSG00000257923 [P39880-9]
ENST00000546411; ENSP00000450125; ENSG00000257923 [P39880-1]
ENST00000549414; ENSP00000446630; ENSG00000257923 [P39880-2]
ENST00000550008; ENSP00000447373; ENSG00000257923 [P39880-5]
ENST00000556210; ENSP00000451558; ENSG00000257923 [P39880-6]

Database of genes from NCBI RefSeq genomes

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GeneIDi
1523

UCSC genome browser

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UCSCi
uc003uys.5 human [P39880-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74099 mRNA No translation available.
AK122726 mRNA Translation: BAG53691.1
AC005072 Genomic DNA No translation available.
AC005086 Genomic DNA Translation: AAP22331.1
AC005088 Genomic DNA No translation available.
AC005096 Genomic DNA Translation: AAS07410.1
AC005103 Genomic DNA Translation: AAS07388.1
AC092788 Genomic DNA Translation: AAS07523.1
BC066592 mRNA Translation: AAH66592.1
AF047825 Genomic DNA Translation: AAC78778.1
CCDSiCCDS56498.1 [P39880-3]
CCDS56499.1 [P39880-9]
CCDS5721.1 [P39880-1]
RefSeqiNP_001189472.1, NM_001202543.1 [P39880-3]
NP_001189473.1, NM_001202544.2
NP_001189474.1, NM_001202545.2 [P39880-9]
NP_852477.1, NM_181500.3
NP_853530.2, NM_181552.3 [P39880-1]
UniGeneiHs.191482

3D structure databases

ProteinModelPortaliP39880
SMRiP39880
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107903, 59 interactors
ELMiP39880
IntActiP39880, 28 interactors
MINTiP39880
STRINGi9606.ENSP00000353401

PTM databases

iPTMnetiP39880
PhosphoSitePlusiP39880

Polymorphism and mutation databases

BioMutaiUGT3A1

Proteomic databases

EPDiP39880
PaxDbiP39880
PeptideAtlasiP39880
PRIDEiP39880
ProteomicsDBi55321
55322 [P39880-2]
55323 [P39880-3]
55324 [P39880-4]
55325 [P39880-5]
55326 [P39880-6]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1523
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292535; ENSP00000292535; ENSG00000257923 [P39880-1]
ENST00000360264; ENSP00000353401; ENSG00000257923 [P39880-3]
ENST00000425244; ENSP00000409745; ENSG00000257923 [P39880-9]
ENST00000546411; ENSP00000450125; ENSG00000257923 [P39880-1]
ENST00000549414; ENSP00000446630; ENSG00000257923 [P39880-2]
ENST00000550008; ENSP00000447373; ENSG00000257923 [P39880-5]
ENST00000556210; ENSP00000451558; ENSG00000257923 [P39880-6]
GeneIDi1523
UCSCiuc003uys.5 human [P39880-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1523
DisGeNETi1523
EuPathDBiHostDB:ENSG00000257923.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CUX1
HGNCiHGNC:2557 CUX1
HPAiHPA003277
HPA003317
MIMi116896 gene
neXtProtiNX_P39880
OpenTargetsiENSG00000257923
PharmGKBiPA162382924

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0963 Eukaryota
KOG2252 Eukaryota
ENOG410XPKP LUCA
GeneTreeiENSGT00940000159751
HOVERGENiHBG053415
InParanoidiP39880
OrthoDBiEOG091G011E
PhylomeDBiP39880
TreeFamiTF318206

Enzyme and pathway databases

ReactomeiR-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants
R-HSA-5655302 Signaling by FGFR1 in disease
SIGNORiP39880

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CUX1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CUTL1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1523
PMAP-CutDBiP39880

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000257923 Expressed in 235 organ(s), highest expression level in secondary oocyte
CleanExiHS_CUX1
ExpressionAtlasiP39880 baseline and differential
GenevisibleiP39880 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR003350 CUT_dom
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
PfamiView protein in Pfam
PF02376 CUT, 3 hits
PF00046 Homeodomain, 1 hit
SMARTiView protein in SMART
SM01109 CUT, 3 hits
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 3 hits
PROSITEiView protein in PROSITE
PS51042 CUT, 3 hits
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCUX1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P39880
Secondary accession number(s): B3KV79
, J3KQV9, Q6NYH4, Q75LE5, Q75MT2, Q75MT3, Q86UJ7, Q9UEV5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: May 18, 2010
Last modified: December 5, 2018
This is version 180 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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