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UniProtKB - P39880 (CUX1_HUMAN)

Entry version 198 (29 Sep 2021)
Sequence version 3 (18 May 2010)
Previous versions | rss
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Protein

Homeobox protein cut-like 1

Gene

CUX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator.

By similarity

Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1.

1 Publication

Miscellaneous

Asn-1290 may participate in regulating DNA-binding activity by promoting homo- and heterodimerization.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi542 – 629CUT 1PROSITE-ProRule annotationAdd BLAST88
DNA bindingi934 – 1021CUT 2PROSITE-ProRule annotationAdd BLAST88
DNA bindingi1117 – 1204CUT 3PROSITE-ProRule annotationAdd BLAST88
DNA bindingi1244 – 1303HomeoboxPROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P39880

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1839117, Signaling by cytosolic FGFR1 fusion mutants
R-HSA-5655302, Signaling by FGFR1 in disease

SIGNOR Signaling Network Open Resource

More...SIGNORi		P39880

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Homeobox protein cut-like 1Curated
Alternative name(s):
CCAAT displacement protein
Short name:
CDP
CDP/Cux p2001 Publication
Homeobox protein cux-1
Cleaved into the following chain:
CDP/Cux p1101 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CUX1Imported
Synonyms:CUTL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:2557, CUX1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		116896, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P39880

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000257923

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Global developmental delay with or without impaired intellectual development (GDDI)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant disorder characterized by global developmental delay associated with mild-to-moderate intellectual disability, hypotonia and short stature in some patients.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_081977862 – 1505Missing in GDDI. 1 PublicationAdd BLAST644

Keywords - Diseasei

Disease variant, Mental retardation

Organism-specific databases

DisGeNET

More...DisGeNETi		1523

MalaCards human disease database

More...MalaCardsi		CUX1
MIMi618330, phenotype

Open Targets

More...OpenTargetsi		ENSG00000257923

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		178469, Autosomal dominant non-syndromic intellectual disability

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162382924

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P39880, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CUX1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002023931 – 1505Homeobox protein cut-like 1Add BLAST1505
ChainiPRO_0000450797756 – 1505CDP/Cux p1101 PublicationAdd BLAST750

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei763PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki785Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki811Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki842Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei909PhosphoserineBy similarity1
Modified residuei1059PhosphoserineCombined sources1
Modified residuei1069PhosphoserineBy similarity1
Modified residuei1270PhosphoserineCombined sources1
Cross-linki1284Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1337PhosphoserineBy similarity1
Modified residuei1455PhosphoserineCombined sources1
Modified residuei1486PhosphoserineCombined sources1
Modified residuei1496PhosphoserineBy similarity1
Isoform 11 (identifier: P39880-9)
Modified residuei540PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by PKA.By similarity
As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa by CTSL. Cell cycle-dependent processing of CUX1 serves to generate a CDP/Cux p110 with distinct DNA binding and transcriptional properties.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei643 – 644Cleavage; by CTSL1 Publication2
Sitei747 – 755Cleavage; by CTSL1 Publication9

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P39880

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P39880

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P39880

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P39880

PeptideAtlas

More...PeptideAtlasi		P39880

PRoteomics IDEntifications database

More...PRIDEi		P39880

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		55321 [P39880-1]
55322 [P39880-2]
55323 [P39880-3]
55324 [P39880-4]
55325 [P39880-5]
55326 [P39880-6]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P39880, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P39880

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P39880

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P39880

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000257923, Expressed in secondary oocyte and 246 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P39880, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P39880, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000257923, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with BANP.

Interacts with SATB1 (via DNA-binding domains); the interaction inhibits the attachment of both proteins to DNA (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107903, 91 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		P39880

Protein interaction database and analysis system

More...IntActi		P39880, 39 interactors

Molecular INTeraction database

More...MINTi		P39880

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000353401

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P39880, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P39880

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni396 – 455DisorderedSequence analysisAdd BLAST60
Regioni512 – 552DisorderedSequence analysisAdd BLAST41
Regioni646 – 669DisorderedSequence analysisAdd BLAST24
Regioni682 – 704DisorderedSequence analysisAdd BLAST23
Regioni768 – 802DisorderedSequence analysisAdd BLAST35
Regioni815 – 930DisorderedSequence analysisAdd BLAST116
Regioni1036 – 1110DisorderedSequence analysisAdd BLAST75
Regioni1210 – 1247DisorderedSequence analysisAdd BLAST38
Regioni1312 – 1480DisorderedSequence analysisAdd BLAST169

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili56 – 407Sequence analysisAdd BLAST352

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi437 – 455Polar residuesSequence analysisAdd BLAST19
Compositional biasi512 – 546Polar residuesSequence analysisAdd BLAST35
Compositional biasi650 – 664Polar residuesSequence analysisAdd BLAST15
Compositional biasi687 – 704Polar residuesSequence analysisAdd BLAST18
Compositional biasi835 – 849Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi861 – 910Polar residuesSequence analysisAdd BLAST50
Compositional biasi911 – 929Pro residuesSequence analysisAdd BLAST19
Compositional biasi1036 – 1073Polar residuesSequence analysisAdd BLAST38
Compositional biasi1083 – 1102Pro residuesSequence analysisAdd BLAST20
Compositional biasi1219 – 1241Polar residuesSequence analysisAdd BLAST23
Compositional biasi1312 – 1330Polar residuesSequence analysisAdd BLAST19
Compositional biasi1355 – 1370Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi1440 – 1455Polar residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CUT homeobox family.Curated

Keywords - Domaini

Coiled coil, Homeobox, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0963, Eukaryota
KOG2252, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159751

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_016758_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P39880

Identification of Orthologs from Complete Genome Data

More...OMAi		VANWRRT

Database of Orthologous Groups

More...OrthoDBi		181575at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P39880

TreeFam database of animal gene trees

More...TreeFami		TF318206

Family and domain databases

Conserved Domains Database

More...CDDi		cd00086, homeodomain, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.260.40, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003350, CUT_dom
IPR009057, Homeobox-like_sf
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR010982, Lambda_DNA-bd_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02376, CUT, 3 hits
PF00046, Homeodomain, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01109, CUT, 3 hits
SM00389, HOX, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46689, SSF46689, 1 hit
SSF47413, SSF47413, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51042, CUT, 3 hits
PS00027, HOMEOBOX_1, 1 hit
PS50071, HOMEOBOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (11+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 11 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 11 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P39880-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLCVAGARLK RELDATATVL ANRQDESEQS RKRLIEQSRE FKKNTPEDLR 
        60         70         80         90        100
KQVAPLLKSF QGEIDALSKR SKEAEAAFLN VYKRLIDVPD PVPALDLGQQ 
       110        120        130        140        150
LQLKVQRLHD IETENQKLRE TLEEYNKEFA EVKNQEVTIK ALKEKIREYE 
       160        170        180        190        200
QTLKNQAETI ALEKEQKLQN DFAEKERKLQ ETQMSTTSKL EEAEHKVQSL 
       210        220        230        240        250
QTALEKTRTE LFDLKTKYDE ETTAKADEIE MIMTDLERAN QRAEVAQREA 
       260        270        280        290        300
ETLREQLSSA NHSLQLASQI QKAPDVEQAI EVLTRSSLEV ELAAKEREIA 
       310        320        330        340        350
QLVEDVQRLQ ASLTKLRENS ASQISQLEQQ LSAKNSTLKQ LEEKLKGQAD 
       360        370        380        390        400
YEEVKKELNI LKSMEFAPSE GAGTQDAAKP LEVLLLEKNR SLQSENAALR 
       410        420        430        440        450
ISNSDLSGSA RRKGKDQPES RRPGSLPAPP PSQLPRNPGE QASNTNGTHQ 
       460        470        480        490        500
FSPAGLSQDF FSSSLASPSL PLASTGKFAL NSLLQRQLMQ SFYSKAMQEA 
       510        520        530        540        550
GSTSMIFSTG PYSTNSISSQ SPLQQSPDVN GMAPSPSQSE SAGSVSEGEE 
       560        570        580        590        600
MDTAEIARQV KEQLIKHNIG QRIFGHYVLG LSQGSVSEIL ARPKPWNKLT 
       610        620        630        640        650
VRGKEPFHKM KQFLSDEQNI LALRSIQGRQ RENPGQSLNR LFQEVPKRRN 
       660        670        680        690        700
GSEGNITTRI RASETGSDEA IKSILEQAKR ELQVQKTAEP AQPSSASGSG 
       710        720        730        740        750
NSDDAIRSIL QQARREMEAQ QAALDPALKQ APLSQSDITI LTPKLLSTSP 
       760        770        780        790        800
MPTVSSYPPL AISLKKPSAA PEAGASALPN PPALKKEAQD APGLDPQGAA 
       810        820        830        840        850
DCAQGVLRQV KNEVGRSGAW KDHWWSAVQP ERRNAASSEE AKAEETGGGK 
       860        870        880        890        900
EKGSGGSGGG SQPRAERSQL QGPSSSEYWK EWPSAESPYS QSSELSLTGA 
       910        920        930        940        950
SRSETPQNSP LPSSPIVPMS KPTKPSVPPL TPEQYEVYMY QEVDTIELTR 
       960        970        980        990       1000
QVKEKLAKNG ICQRIFGEKV LGLSQGSVSD MLSRPKPWSK LTQKGREPFI 
      1010       1020       1030       1040       1050
RMQLWLNGEL GQGVLPVQGQ QQGPVLHSVT SLQDPLQQGC VSSESTPKTS 
      1060       1070       1080       1090       1100
ASCSPAPESP MSSSESVKSL TELVQQPCPP IEASKDSKPP EPSDPPASDS 
      1110       1120       1130       1140       1150
QPTTPLPLSG HSALSIQELV AMSPELDTYG ITKRVKEVLT DNNLGQRLFG 
      1160       1170       1180       1190       1200
ETILGLTQGS VSDLLARPKP WHKLSLKGRE PFVRMQLWLN DPNNVEKLMD 
      1210       1220       1230       1240       1250
MKRMEKKAYM KRRHSSVSDS QPCEPPSVGT EYSQGASPQP QHQLKKPRVV 
      1260       1270       1280       1290       1300
LAPEEKEALK RAYQQKPYPS PKTIEDLATQ LNLKTSTVIN WFHNYRSRIR 
      1310       1320       1330       1340       1350
RELFIEEIQA GSQGQAGASD SPSARSGRAA PSSEGDSCDG VEATEGPGSA 
      1360       1370       1380       1390       1400
DTEEPKSQGE AEREEVPRPA EQTEPPPSGT PGPDDARDDD HEGGPVEGPG 
      1410       1420       1430       1440       1450
PLPSPASATA TAAPAAPEDA ATSAAAAPGE GPAAPSSAPP PSNSSSSSAP 
      1460       1470       1480       1490       1500
RRPSSLQSLF GLPEAAGARD SRDNPLRKKK AANLNSIIHR LEKAASREEP 

IEWEF
Length:1,505
Mass (Da):164,187
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0F9027E5B8F08D95
GO
Isoform 2 (identifier: P39880-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     632-653: Missing.

Show »
Length:1,483
Mass (Da):161,650
Checksum:i369D44022E3FF3D7
GO
Isoform 3 (identifier: P39880-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MLCVAGARLK → MAANVGSMFQYWKRFDLQQLQ

Show »
Length:1,516
Mass (Da):165,688
Checksum:i13E5E97E8569C5AA
GO
Isoform 5 (identifier: P39880-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     408-509: Missing.

Show »
Length:1,403
Mass (Da):153,364
Checksum:iB10F9B5E864C9D8F
GO
Isoform 6 (identifier: P39880-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     632-687: Missing.

Show »
Length:1,449
Mass (Da):157,895
Checksum:iEC08BD990BA5321C
GO
Isoform 7 (identifier: P39880-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     408-509: Missing.
     632-687: Missing.

Show »
Length:1,347
Mass (Da):147,072
Checksum:iD50586280B4D0B81
GO
Isoform 11 (identifier: P39880-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MLCVAGARLK → MAANVGSMFQYWKRFDLQQLQ
     90-135: Missing.
     409-667: SARRKGKDQP...TRIRASETGS → RCAELQVRIT...NGAAAGDLWQ
     668-1505: Missing.

Show »
Length:632
Mass (Da):72,024
Checksum:iA399B4B63B891AA6
GO
Isoform 4 (identifier: Q13948-1) [UniParc]FASTAAdd to basket
Also known as: CASP
The sequence of this isoform can be found in the external entry Q13948.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:678
Mass (Da):77,455
GO
Isoform 8 (identifier: Q13948-2) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q13948.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:676
Mass (Da):77,198
GO
Isoform 9 (identifier: Q13948-9) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q13948.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:639
Mass (Da):72,841
GO
Isoform 10 (identifier: Q13948-10) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q13948.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:662
Mass (Da):75,644
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y852A0A2R8Y852_HUMAN
Homeobox protein cut-like
CUX1
1,460Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YDI1A0A2R8YDI1_HUMAN
Homeobox protein cut-like
CUX1
1,358Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y8D0A0A2R8Y8D0_HUMAN
Protein CASP
CUX1
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti5A → R in M74099 (PubMed:1301999).Curated1
Sequence conflicti145K → I in BAG53691 (PubMed:14702039).Curated1
Sequence conflicti260A → V in BAG53691 (PubMed:14702039).Curated1
Sequence conflicti704 – 705DA → EP in M74099 (PubMed:1301999).Curated2
Sequence conflicti844E → R in M74099 (PubMed:1301999).Curated1
Sequence conflicti1436S → T in M74099 (PubMed:1301999).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_081977862 – 1505Missing in GDDI. 1 PublicationAdd BLAST644

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0157471 – 10MLCVAGARLK → MAANVGSMFQYWKRFDLQQL Q in isoform 3 and isoform 11. 2 Publications10
Alternative sequenceiVSP_04592490 – 135Missing in isoform 11. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_017358408 – 509Missing in isoform 5 and isoform 7. CuratedAdd BLAST102
Alternative sequenceiVSP_045925409 – 667SARRK…SETGS → RCAELQVRITEAVATATEQR ELIARLEQDLSIIQSIQRPD AEGAAEHRLEKIPEPIKEAT ALFYGPAAPASGALPEGQVD SLLSIISSQRERFRARNQEL EAENRLAQHTLQALQSELDS LRADNIKLFEKIKFLQSYPG RGSGSDDTELRYSSQYEERL DPFSSFSKRERQRKYLSLSP WDKATLSMGRLVLSNKMART IGFFYTLFLHCLVFLVLYKL AWSESMERDCATFCAKKFAD HLHKFHENDNGAAAGDLWQ in isoform 11. 1 PublicationAdd BLAST259
Alternative sequenceiVSP_017359632 – 687Missing in isoform 6 and isoform 7. CuratedAdd BLAST56
Alternative sequenceiVSP_002310632 – 653Missing in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_045926668 – 1505Missing in isoform 11. 1 PublicationAdd BLAST838

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M74099 mRNA No translation available.
AK122726 mRNA Translation: BAG53691.1
AC005072 Genomic DNA No translation available.
AC005086 Genomic DNA Translation: AAP22331.1
AC005088 Genomic DNA No translation available.
AC005096 Genomic DNA Translation: AAS07410.1
AC005103 Genomic DNA Translation: AAS07388.1
AC092788 Genomic DNA Translation: AAS07523.1
BC066592 mRNA Translation: AAH66592.1
AF047825 Genomic DNA Translation: AAC78778.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS56498.1 [P39880-3]
CCDS56499.1 [P39880-9]
CCDS5721.1 [P39880-1]

NCBI Reference Sequences

More...RefSeqi		NP_001189472.1, NM_001202543.1 [P39880-3]
NP_001189473.1, NM_001202544.2
NP_001189474.1, NM_001202545.2 [P39880-9]
NP_852477.1, NM_181500.3
NP_853530.2, NM_181552.3 [P39880-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000292535; ENSP00000292535; ENSG00000257923 [P39880-1]
ENST00000360264; ENSP00000353401; ENSG00000257923 [P39880-3]
ENST00000425244; ENSP00000409745; ENSG00000257923 [P39880-9]
ENST00000546411; ENSP00000450125; ENSG00000257923 [P39880-1]
ENST00000549414; ENSP00000446630; ENSG00000257923 [P39880-2]
ENST00000550008; ENSP00000447373; ENSG00000257923 [P39880-5]
ENST00000556210; ENSP00000451558; ENSG00000257923 [P39880-6]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1523

UCSC genome browser

More...UCSCi		uc003uys.5, human [P39880-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74099 mRNA No translation available.
AK122726 mRNA Translation: BAG53691.1
AC005072 Genomic DNA No translation available.
AC005086 Genomic DNA Translation: AAP22331.1
AC005088 Genomic DNA No translation available.
AC005096 Genomic DNA Translation: AAS07410.1
AC005103 Genomic DNA Translation: AAS07388.1
AC092788 Genomic DNA Translation: AAS07523.1
BC066592 mRNA Translation: AAH66592.1
AF047825 Genomic DNA Translation: AAC78778.1
CCDSiCCDS56498.1 [P39880-3]
CCDS56499.1 [P39880-9]
CCDS5721.1 [P39880-1]
RefSeqiNP_001189472.1, NM_001202543.1 [P39880-3]
NP_001189473.1, NM_001202544.2
NP_001189474.1, NM_001202545.2 [P39880-9]
NP_852477.1, NM_181500.3
NP_853530.2, NM_181552.3 [P39880-1]

3D structure databases

SMRiP39880
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi107903, 91 interactors
ELMiP39880
IntActiP39880, 39 interactors
MINTiP39880
STRINGi9606.ENSP00000353401

PTM databases

GlyGeniP39880, 1 site, 1 O-linked glycan (1 site)
iPTMnetiP39880
MetOSiteiP39880
PhosphoSitePlusiP39880

Genetic variation databases

BioMutaiCUX1

Proteomic databases

EPDiP39880
jPOSTiP39880
MassIVEiP39880
PaxDbiP39880
PeptideAtlasiP39880
PRIDEiP39880
ProteomicsDBi55321 [P39880-1]
55322 [P39880-2]
55323 [P39880-3]
55324 [P39880-4]
55325 [P39880-5]
55326 [P39880-6]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		48390, 420 antibodies

The DNASU plasmid repository

More...DNASUi		1523

Genome annotation databases

EnsembliENST00000292535; ENSP00000292535; ENSG00000257923 [P39880-1]
ENST00000360264; ENSP00000353401; ENSG00000257923 [P39880-3]
ENST00000425244; ENSP00000409745; ENSG00000257923 [P39880-9]
ENST00000546411; ENSP00000450125; ENSG00000257923 [P39880-1]
ENST00000549414; ENSP00000446630; ENSG00000257923 [P39880-2]
ENST00000550008; ENSP00000447373; ENSG00000257923 [P39880-5]
ENST00000556210; ENSP00000451558; ENSG00000257923 [P39880-6]
GeneIDi1523
UCSCiuc003uys.5, human [P39880-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1523
DisGeNETi1523

GeneCards: human genes, protein and diseases

More...GeneCardsi		CUX1
HGNCiHGNC:2557, CUX1
HPAiENSG00000257923, Low tissue specificity
MalaCardsiCUX1
MIMi116896, gene
618330, phenotype
neXtProtiNX_P39880
OpenTargetsiENSG00000257923
Orphaneti178469, Autosomal dominant non-syndromic intellectual disability
PharmGKBiPA162382924
VEuPathDBiHostDB:ENSG00000257923

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0963, Eukaryota
KOG2252, Eukaryota
GeneTreeiENSGT00940000159751
HOGENOMiCLU_016758_0_0_1
InParanoidiP39880
OMAiVANWRRT
OrthoDBi181575at2759
PhylomeDBiP39880
TreeFamiTF318206

Enzyme and pathway databases

PathwayCommonsiP39880
ReactomeiR-HSA-1839117, Signaling by cytosolic FGFR1 fusion mutants
R-HSA-5655302, Signaling by FGFR1 in disease
SIGNORiP39880

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1523, 11 hits in 1051 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CUX1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CUTL1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1523
PharosiP39880, Tbio
RNActiP39880, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000257923, Expressed in secondary oocyte and 246 other tissues
ExpressionAtlasiP39880, baseline and differential
GenevisibleiP39880, HS

Family and domain databases

CDDicd00086, homeodomain, 1 hit
Gene3Di1.10.260.40, 3 hits
InterProiView protein in InterPro
IPR003350, CUT_dom
IPR009057, Homeobox-like_sf
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR010982, Lambda_DNA-bd_dom_sf
PfamiView protein in Pfam
PF02376, CUT, 3 hits
PF00046, Homeodomain, 1 hit
SMARTiView protein in SMART
SM01109, CUT, 3 hits
SM00389, HOX, 1 hit
SUPFAMiSSF46689, SSF46689, 1 hit
SSF47413, SSF47413, 3 hits
PROSITEiView protein in PROSITE
PS51042, CUT, 3 hits
PS00027, HOMEOBOX_1, 1 hit
PS50071, HOMEOBOX_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCUX1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P39880
Secondary accession number(s): B3KV79
, J3KQV9, Q6NYH4, Q75LE5, Q75MT2, Q75MT3, Q86UJ7, Q9UEV5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: May 18, 2010
Last modified: September 29, 2021
This is version 198 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
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