UniProtKB - P39880 (CUX1_HUMAN)

BLAST

>sp|P39880|CUX1_HUMAN Homeobox protein cut-like 1 OS=Homo sapiens OX=9606 GN=CUX1 PE=1 SV=3
MLCVAGARLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSF
QGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRE
TLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQ
ETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERAN
QRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIA
QLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNI
LKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQPES
RRPGSLPAPPPSQLPRNPGEQASNTNGTHQFSPAGLSQDFFSSSLASPSLPLASTGKFAL
NSLLQRQLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQQSPDVNGMAPSPSQSE
SAGSVSEGEEMDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNKLT
VRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQEVPKRRNGSEGNITTRI
RASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSASGSGNSDDAIRSILQQARREMEAQ
QAALDPALKQAPLSQSDITILTPKLLSTSPMPTVSSYPPLAISLKKPSAAPEAGASALPN
PPALKKEAQDAPGLDPQGAADCAQGVLRQVKNEVGRSGAWKDHWWSAVQPERRNAASSEE
AKAEETGGGKEKGSGGSGGGSQPRAERSQLQGPSSSEYWKEWPSAESPYSQSSELSLTGA
SRSETPQNSPLPSSPIVPMSKPTKPSVPPLTPEQYEVYMYQEVDTIELTRQVKEKLAKNG
ICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLNGELGQGVLPVQGQ
QQGPVLHSVTSLQDPLQQGCVSSESTPKTSASCSPAPESPMSSSESVKSLTELVQQPCPP
IEASKDSKPPEPSDPPASDSQPTTPLPLSGHSALSIQELVAMSPELDTYGITKRVKEVLT
DNNLGQRLFGETILGLTQGSVSDLLARPKPWHKLSLKGREPFVRMQLWLNDPNNVEKLMD
MKRMEKKAYMKRRHSSVSDSQPCEPPSVGTEYSQGASPQPQHQLKKPRVVLAPEEKEALK
RAYQQKPYPSPKTIEDLATQLNLKTSTVINWFHNYRSRIRRELFIEEIQAGSQGQAGASD
SPSARSGRAAPSSEGDSCDGVEATEGPGSADTEEPKSQGEAEREEVPRPAEQTEPPPSGT
PGPDDARDDDHEGGPVEGPGPLPSPASATATAAPAAPEDAATSAAAAPGEGPAAPSSAPP
PSNSSSSSAPRRPSSLQSLFGLPEAAGARDSRDNPLRKKKAANLNSIIHRLEKAASREEP
IEWEF

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History
Entry version 177 (12 Sep 2018)
Sequence version 3 (18 May 2010)
Previous versions | rss
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Protein

Homeobox protein cut-like 1

Gene

CUX1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator (By similarity).By similarity

Miscellaneous

Asn-1290 may participate in regulating DNA-binding activity by promoting homo- and heterodimerization.

Regions

Feature key	Position(s)	DescriptionActions	Length
DNA bindingⁱ	542 – 629	CUT 1PROSITE-ProRule annotationAdd BLAST	88
DNA bindingⁱ	934 – 1021	CUT 2PROSITE-ProRule annotationAdd BLAST	88
DNA bindingⁱ	1117 – 1204	CUT 3PROSITE-ProRule annotationAdd BLAST	88
DNA bindingⁱ	1244 – 1303	HomeoboxPROSITE-ProRule annotationAdd BLAST	60

GO - Molecular functionⁱ

protein binding, bridging Source: Ensembl
protein tyrosine kinase activity Source: Reactome
RNA polymerase II regulatory region sequence-specific DNA binding Source: UniProtKB
sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 15656993

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

Golgi vesicle transport Source: GO_Central
multicellular organism development
Source: ProtInc
Traceable author statementⁱ
- 1301999
negative regulation of transcription by RNA polymerase II
Source: ProtInc
Traceable author statementⁱ
- 1301999
positive regulation of dendrite morphogenesis Source: UniProtKB
regulation of transcription by RNA polymerase II
Source: ProtInc
Traceable author statementⁱ
- 1301999
retrograde transport, vesicle recycling within Golgi Source: Ensembl
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding, Repressor
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants R-HSA-5655302 Signaling by FGFR1 in disease
SIGNORⁱ	P39880

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Homeobox protein cut-like 1 Alternative name(s): CCAAT displacement protein Short name: CDP Homeobox protein cux-1
Gene namesⁱ	Name:CUX1 Synonyms:CUTL1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000257923.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2557 CUX1
MIMⁱ	116896 gene
neXtProtⁱ	NX_P39880

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1523
Open Targets More...OpenTargetsⁱ	ENSG00000257923
PharmGKBⁱ	PA162382924

Polymorphism and mutation databases

BioMutaⁱ	UGT3A1

BioMutaⁱ

UGT3A1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000202393	1 – 1505	Homeobox protein cut-like 1Add BLAST		1505

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	763	PhosphoserineCombined sources	1
Cross-linkⁱ	785	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	811	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	842	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	909	PhosphoserineBy similarity	1
Modified residueⁱ	1059	PhosphoserineCombined sources	1
Modified residueⁱ	1069	PhosphoserineBy similarity	1
Modified residueⁱ	1270	PhosphoserineCombined sources	1
Cross-linkⁱ	1284	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	1337	PhosphoserineBy similarity	1
Modified residueⁱ	1455	PhosphoserineCombined sources	1
Modified residueⁱ	1486	PhosphoserineCombined sources	1
Modified residueⁱ	1496	PhosphoserineBy similarity	1
Isoform 11 (identifier: P39880-9)
Modified residueⁱ	540	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P39880
PaxDbⁱ	P39880
PeptideAtlas More...PeptideAtlasⁱ	P39880
PRIDEⁱ	P39880
ProteomicsDBⁱ	55321 55322 [P39880-2] 55323 [P39880-3] 55324 [P39880-4] 55325 [P39880-5] 55326 [P39880-6]

PTM databases

iPTMnetⁱ	P39880
PhosphoSitePlusⁱ	P39880

Miscellaneous databases

PMAP-CutDBⁱ	P39880

PMAP-CutDBⁱ

P39880

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000257923 Expressed in 235 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_CUX1
ExpressionAtlasⁱ	P39880 baseline and differential
Genevisibleⁱ	P39880 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA003277 HPA003317

HPAⁱ

HPA003277
HPA003317

Interactionⁱ

Subunit structureⁱ

Interacts with BANP. Interacts with SATB1 (via DNA-binding domains); the interaction inhibits the attachment of both proteins to DNA (By similarity).By similarity

GO - Molecular functionⁱ

protein binding, bridging Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107903, 58 interactors
ELMⁱ	P39880
IntActⁱ	P39880, 27 interactors
Molecular INTeraction database More...MINTⁱ	P39880
STRINGⁱ	9606.ENSP00000353401

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P39880
SMRⁱ	P39880
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	56 – 407	Sequence analysisAdd BLAST		352

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	1406 – 1438	Ala-richAdd BLAST		33

Sequence similaritiesⁱ

Belongs to the CUT homeobox family.Curated

Keywords - Domainⁱ

Coiled coil, Homeobox, Repeat

Phylogenomic databases

eggNOGⁱ	KOG0963 Eukaryota KOG2252 Eukaryota ENOG410XPKP LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063019
HOVERGENⁱ	HBG051268
InParanoidⁱ	P39880
OMAⁱ	VANWRRT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G011E
PhylomeDBⁱ	P39880
TreeFamⁱ	TF318206

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR003350 CUT_dom IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR010982 Lambda_DNA-bd_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02376 CUT, 3 hits PF00046 Homeobox, 1 hit
SMARTⁱ	View protein in SMART SM01109 CUT, 3 hits SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit SSF47413 SSF47413, 3 hits
PROSITEⁱ	View protein in PROSITE PS51042 CUT, 3 hits PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit

Sequences (11+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 11 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Additional isoforms seem to exist.

This entry has 11 described isoforms and 3 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: P39880-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MLCVAGARLK RELDATATVL ANRQDESEQS RKRLIEQSRE FKKNTPEDLR 
        60         70         80         90        100
KQVAPLLKSF QGEIDALSKR SKEAEAAFLN VYKRLIDVPD PVPALDLGQQ 
       110        120        130        140        150
LQLKVQRLHD IETENQKLRE TLEEYNKEFA EVKNQEVTIK ALKEKIREYE 
       160        170        180        190        200
QTLKNQAETI ALEKEQKLQN DFAEKERKLQ ETQMSTTSKL EEAEHKVQSL 
       210        220        230        240        250
QTALEKTRTE LFDLKTKYDE ETTAKADEIE MIMTDLERAN QRAEVAQREA 
       260        270        280        290        300
ETLREQLSSA NHSLQLASQI QKAPDVEQAI EVLTRSSLEV ELAAKEREIA 
       310        320        330        340        350
QLVEDVQRLQ ASLTKLRENS ASQISQLEQQ LSAKNSTLKQ LEEKLKGQAD 
       360        370        380        390        400
YEEVKKELNI LKSMEFAPSE GAGTQDAAKP LEVLLLEKNR SLQSENAALR 
       410        420        430        440        450
ISNSDLSGSA RRKGKDQPES RRPGSLPAPP PSQLPRNPGE QASNTNGTHQ 
       460        470        480        490        500
FSPAGLSQDF FSSSLASPSL PLASTGKFAL NSLLQRQLMQ SFYSKAMQEA 
       510        520        530        540        550
GSTSMIFSTG PYSTNSISSQ SPLQQSPDVN GMAPSPSQSE SAGSVSEGEE 
       560        570        580        590        600
MDTAEIARQV KEQLIKHNIG QRIFGHYVLG LSQGSVSEIL ARPKPWNKLT 
       610        620        630        640        650
VRGKEPFHKM KQFLSDEQNI LALRSIQGRQ RENPGQSLNR LFQEVPKRRN 
       660        670        680        690        700
GSEGNITTRI RASETGSDEA IKSILEQAKR ELQVQKTAEP AQPSSASGSG 
       710        720        730        740        750
NSDDAIRSIL QQARREMEAQ QAALDPALKQ APLSQSDITI LTPKLLSTSP 
       760        770        780        790        800
MPTVSSYPPL AISLKKPSAA PEAGASALPN PPALKKEAQD APGLDPQGAA 
       810        820        830        840        850
DCAQGVLRQV KNEVGRSGAW KDHWWSAVQP ERRNAASSEE AKAEETGGGK 
       860        870        880        890        900
EKGSGGSGGG SQPRAERSQL QGPSSSEYWK EWPSAESPYS QSSELSLTGA 
       910        920        930        940        950
SRSETPQNSP LPSSPIVPMS KPTKPSVPPL TPEQYEVYMY QEVDTIELTR 
       960        970        980        990       1000
QVKEKLAKNG ICQRIFGEKV LGLSQGSVSD MLSRPKPWSK LTQKGREPFI 
      1010       1020       1030       1040       1050
RMQLWLNGEL GQGVLPVQGQ QQGPVLHSVT SLQDPLQQGC VSSESTPKTS 
      1060       1070       1080       1090       1100
ASCSPAPESP MSSSESVKSL TELVQQPCPP IEASKDSKPP EPSDPPASDS 
      1110       1120       1130       1140       1150
QPTTPLPLSG HSALSIQELV AMSPELDTYG ITKRVKEVLT DNNLGQRLFG 
      1160       1170       1180       1190       1200
ETILGLTQGS VSDLLARPKP WHKLSLKGRE PFVRMQLWLN DPNNVEKLMD 
      1210       1220       1230       1240       1250
MKRMEKKAYM KRRHSSVSDS QPCEPPSVGT EYSQGASPQP QHQLKKPRVV 
      1260       1270       1280       1290       1300
LAPEEKEALK RAYQQKPYPS PKTIEDLATQ LNLKTSTVIN WFHNYRSRIR 
      1310       1320       1330       1340       1350
RELFIEEIQA GSQGQAGASD SPSARSGRAA PSSEGDSCDG VEATEGPGSA 
      1360       1370       1380       1390       1400
DTEEPKSQGE AEREEVPRPA EQTEPPPSGT PGPDDARDDD HEGGPVEGPG 
      1410       1420       1430       1440       1450
PLPSPASATA TAAPAAPEDA ATSAAAAPGE GPAAPSSAPP PSNSSSSSAP 
      1460       1470       1480       1490       1500
RRPSSLQSLF GLPEAAGARD SRDNPLRKKK AANLNSIIHR LEKAASREEP 

IEWEF

Length:1,505

Mass (Da):164,187

Last modified:May 18, 2010 - v3

Checksum:ⁱ0F9027E5B8F08D95

Isoform 2 (identifier: P39880-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
632-653: Missing.

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        10         20         30         40         50
MLCVAGARLK RELDATATVL ANRQDESEQS RKRLIEQSRE FKKNTPEDLR 
        60         70         80         90        100
KQVAPLLKSF QGEIDALSKR SKEAEAAFLN VYKRLIDVPD PVPALDLGQQ 
       110        120        130        140        150
LQLKVQRLHD IETENQKLRE TLEEYNKEFA EVKNQEVTIK ALKEKIREYE 
       160        170        180        190        200
QTLKNQAETI ALEKEQKLQN DFAEKERKLQ ETQMSTTSKL EEAEHKVQSL 
       210        220        230        240        250
QTALEKTRTE LFDLKTKYDE ETTAKADEIE MIMTDLERAN QRAEVAQREA 
       260        270        280        290        300
ETLREQLSSA NHSLQLASQI QKAPDVEQAI EVLTRSSLEV ELAAKEREIA 
       310        320        330        340        350
QLVEDVQRLQ ASLTKLRENS ASQISQLEQQ LSAKNSTLKQ LEEKLKGQAD 
       360        370        380        390        400
YEEVKKELNI LKSMEFAPSE GAGTQDAAKP LEVLLLEKNR SLQSENAALR 
       410        420        430        440        450
ISNSDLSGSA RRKGKDQPES RRPGSLPAPP PSQLPRNPGE QASNTNGTHQ 
       460        470        480        490        500
FSPAGLSQDF FSSSLASPSL PLASTGKFAL NSLLQRQLMQ SFYSKAMQEA 
       510        520        530        540        550
GSTSMIFSTG PYSTNSISSQ SPLQQSPDVN GMAPSPSQSE SAGSVSEGEE 
       560        570        580        590        600
MDTAEIARQV KEQLIKHNIG QRIFGHYVLG LSQGSVSEIL ARPKPWNKLT 
       610        620        630        640        650
VRGKEPFHKM KQFLSDEQNI LALRSIQGRQ RGNITTRIRA SETGSDEAIK 
       660        670        680        690        700
SILEQAKREL QVQKTAEPAQ PSSASGSGNS DDAIRSILQQ ARREMEAQQA 
       710        720        730        740        750
ALDPALKQAP LSQSDITILT PKLLSTSPMP TVSSYPPLAI SLKKPSAAPE 
       760        770        780        790        800
AGASALPNPP ALKKEAQDAP GLDPQGAADC AQGVLRQVKN EVGRSGAWKD 
       810        820        830        840        850
HWWSAVQPER RNAASSEEAK AEETGGGKEK GSGGSGGGSQ PRAERSQLQG 
       860        870        880        890        900
PSSSEYWKEW PSAESPYSQS SELSLTGASR SETPQNSPLP SSPIVPMSKP 
       910        920        930        940        950
TKPSVPPLTP EQYEVYMYQE VDTIELTRQV KEKLAKNGIC QRIFGEKVLG 
       960        970        980        990       1000
LSQGSVSDML SRPKPWSKLT QKGREPFIRM QLWLNGELGQ GVLPVQGQQQ 
      1010       1020       1030       1040       1050
GPVLHSVTSL QDPLQQGCVS SESTPKTSAS CSPAPESPMS SSESVKSLTE 
      1060       1070       1080       1090       1100
LVQQPCPPIE ASKDSKPPEP SDPPASDSQP TTPLPLSGHS ALSIQELVAM 
      1110       1120       1130       1140       1150
SPELDTYGIT KRVKEVLTDN NLGQRLFGET ILGLTQGSVS DLLARPKPWH 
      1160       1170       1180       1190       1200
KLSLKGREPF VRMQLWLNDP NNVEKLMDMK RMEKKAYMKR RHSSVSDSQP 
      1210       1220       1230       1240       1250
CEPPSVGTEY SQGASPQPQH QLKKPRVVLA PEEKEALKRA YQQKPYPSPK 
      1260       1270       1280       1290       1300
TIEDLATQLN LKTSTVINWF HNYRSRIRRE LFIEEIQAGS QGQAGASDSP 
      1310       1320       1330       1340       1350
SARSGRAAPS SEGDSCDGVE ATEGPGSADT EEPKSQGEAE REEVPRPAEQ 
      1360       1370       1380       1390       1400
TEPPPSGTPG PDDARDDDHE GGPVEGPGPL PSPASATATA APAAPEDAAT 
      1410       1420       1430       1440       1450
SAAAAPGEGP AAPSSAPPPS NSSSSSAPRR PSSLQSLFGL PEAAGARDSR 
      1460       1470       1480 
DNPLRKKKAA NLNSIIHRLE KAASREEPIE WEF

Show »

Length:1,483

Mass (Da):161,650

Checksum:ⁱ369D44022E3FF3D7

Isoform 3 (identifier: P39880-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-10: MLCVAGARLK → MAANVGSMFQYWKRFDLQQLQ

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        10         20         30         40         50
MAANVGSMFQ YWKRFDLQQL QRELDATATV LANRQDESEQ SRKRLIEQSR 
        60         70         80         90        100
EFKKNTPEDL RKQVAPLLKS FQGEIDALSK RSKEAEAAFL NVYKRLIDVP 
       110        120        130        140        150
DPVPALDLGQ QLQLKVQRLH DIETENQKLR ETLEEYNKEF AEVKNQEVTI 
       160        170        180        190        200
KALKEKIREY EQTLKNQAET IALEKEQKLQ NDFAEKERKL QETQMSTTSK 
       210        220        230        240        250
LEEAEHKVQS LQTALEKTRT ELFDLKTKYD EETTAKADEI EMIMTDLERA 
       260        270        280        290        300
NQRAEVAQRE AETLREQLSS ANHSLQLASQ IQKAPDVEQA IEVLTRSSLE 
       310        320        330        340        350
VELAAKEREI AQLVEDVQRL QASLTKLREN SASQISQLEQ QLSAKNSTLK 
       360        370        380        390        400
QLEEKLKGQA DYEEVKKELN ILKSMEFAPS EGAGTQDAAK PLEVLLLEKN 
       410        420        430        440        450
RSLQSENAAL RISNSDLSGS ARRKGKDQPE SRRPGSLPAP PPSQLPRNPG 
       460        470        480        490        500
EQASNTNGTH QFSPAGLSQD FFSSSLASPS LPLASTGKFA LNSLLQRQLM 
       510        520        530        540        550
QSFYSKAMQE AGSTSMIFST GPYSTNSISS QSPLQQSPDV NGMAPSPSQS 
       560        570        580        590        600
ESAGSVSEGE EMDTAEIARQ VKEQLIKHNI GQRIFGHYVL GLSQGSVSEI 
       610        620        630        640        650
LARPKPWNKL TVRGKEPFHK MKQFLSDEQN ILALRSIQGR QRENPGQSLN 
       660        670        680        690        700
RLFQEVPKRR NGSEGNITTR IRASETGSDE AIKSILEQAK RELQVQKTAE 
       710        720        730        740        750
PAQPSSASGS GNSDDAIRSI LQQARREMEA QQAALDPALK QAPLSQSDIT 
       760        770        780        790        800
ILTPKLLSTS PMPTVSSYPP LAISLKKPSA APEAGASALP NPPALKKEAQ 
       810        820        830        840        850
DAPGLDPQGA ADCAQGVLRQ VKNEVGRSGA WKDHWWSAVQ PERRNAASSE 
       860        870        880        890        900
EAKAEETGGG KEKGSGGSGG GSQPRAERSQ LQGPSSSEYW KEWPSAESPY 
       910        920        930        940        950
SQSSELSLTG ASRSETPQNS PLPSSPIVPM SKPTKPSVPP LTPEQYEVYM 
       960        970        980        990       1000
YQEVDTIELT RQVKEKLAKN GICQRIFGEK VLGLSQGSVS DMLSRPKPWS 
      1010       1020       1030       1040       1050
KLTQKGREPF IRMQLWLNGE LGQGVLPVQG QQQGPVLHSV TSLQDPLQQG 
      1060       1070       1080       1090       1100
CVSSESTPKT SASCSPAPES PMSSSESVKS LTELVQQPCP PIEASKDSKP 
      1110       1120       1130       1140       1150
PEPSDPPASD SQPTTPLPLS GHSALSIQEL VAMSPELDTY GITKRVKEVL 
      1160       1170       1180       1190       1200
TDNNLGQRLF GETILGLTQG SVSDLLARPK PWHKLSLKGR EPFVRMQLWL 
      1210       1220       1230       1240       1250
NDPNNVEKLM DMKRMEKKAY MKRRHSSVSD SQPCEPPSVG TEYSQGASPQ 
      1260       1270       1280       1290       1300
PQHQLKKPRV VLAPEEKEAL KRAYQQKPYP SPKTIEDLAT QLNLKTSTVI 
      1310       1320       1330       1340       1350
NWFHNYRSRI RRELFIEEIQ AGSQGQAGAS DSPSARSGRA APSSEGDSCD 
      1360       1370       1380       1390       1400
GVEATEGPGS ADTEEPKSQG EAEREEVPRP AEQTEPPPSG TPGPDDARDD 
      1410       1420       1430       1440       1450
DHEGGPVEGP GPLPSPASAT ATAAPAAPED AATSAAAAPG EGPAAPSSAP 
      1460       1470       1480       1490       1500
PPSNSSSSSA PRRPSSLQSL FGLPEAAGAR DSRDNPLRKK KAANLNSIIH 
      1510 
RLEKAASREE PIEWEF

Note: No experimental confirmation available.

Show »

Length:1,516

Mass (Da):165,688

Checksum:ⁱ13E5E97E8569C5AA

Isoform 5 (identifier: P39880-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
408-509: Missing.

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        10         20         30         40         50
MLCVAGARLK RELDATATVL ANRQDESEQS RKRLIEQSRE FKKNTPEDLR 
        60         70         80         90        100
KQVAPLLKSF QGEIDALSKR SKEAEAAFLN VYKRLIDVPD PVPALDLGQQ 
       110        120        130        140        150
LQLKVQRLHD IETENQKLRE TLEEYNKEFA EVKNQEVTIK ALKEKIREYE 
       160        170        180        190        200
QTLKNQAETI ALEKEQKLQN DFAEKERKLQ ETQMSTTSKL EEAEHKVQSL 
       210        220        230        240        250
QTALEKTRTE LFDLKTKYDE ETTAKADEIE MIMTDLERAN QRAEVAQREA 
       260        270        280        290        300
ETLREQLSSA NHSLQLASQI QKAPDVEQAI EVLTRSSLEV ELAAKEREIA 
       310        320        330        340        350
QLVEDVQRLQ ASLTKLRENS ASQISQLEQQ LSAKNSTLKQ LEEKLKGQAD 
       360        370        380        390        400
YEEVKKELNI LKSMEFAPSE GAGTQDAAKP LEVLLLEKNR SLQSENAALR 
       410        420        430        440        450
ISNSDLSGPY STNSISSQSP LQQSPDVNGM APSPSQSESA GSVSEGEEMD 
       460        470        480        490        500
TAEIARQVKE QLIKHNIGQR IFGHYVLGLS QGSVSEILAR PKPWNKLTVR 
       510        520        530        540        550
GKEPFHKMKQ FLSDEQNILA LRSIQGRQRE NPGQSLNRLF QEVPKRRNGS 
       560        570        580        590        600
EGNITTRIRA SETGSDEAIK SILEQAKREL QVQKTAEPAQ PSSASGSGNS 
       610        620        630        640        650
DDAIRSILQQ ARREMEAQQA ALDPALKQAP LSQSDITILT PKLLSTSPMP 
       660        670        680        690        700
TVSSYPPLAI SLKKPSAAPE AGASALPNPP ALKKEAQDAP GLDPQGAADC 
       710        720        730        740        750
AQGVLRQVKN EVGRSGAWKD HWWSAVQPER RNAASSEEAK AEETGGGKEK 
       760        770        780        790        800
GSGGSGGGSQ PRAERSQLQG PSSSEYWKEW PSAESPYSQS SELSLTGASR 
       810        820        830        840        850
SETPQNSPLP SSPIVPMSKP TKPSVPPLTP EQYEVYMYQE VDTIELTRQV 
       860        870        880        890        900
KEKLAKNGIC QRIFGEKVLG LSQGSVSDML SRPKPWSKLT QKGREPFIRM 
       910        920        930        940        950
QLWLNGELGQ GVLPVQGQQQ GPVLHSVTSL QDPLQQGCVS SESTPKTSAS 
       960        970        980        990       1000
CSPAPESPMS SSESVKSLTE LVQQPCPPIE ASKDSKPPEP SDPPASDSQP 
      1010       1020       1030       1040       1050
TTPLPLSGHS ALSIQELVAM SPELDTYGIT KRVKEVLTDN NLGQRLFGET 
      1060       1070       1080       1090       1100
ILGLTQGSVS DLLARPKPWH KLSLKGREPF VRMQLWLNDP NNVEKLMDMK 
      1110       1120       1130       1140       1150
RMEKKAYMKR RHSSVSDSQP CEPPSVGTEY SQGASPQPQH QLKKPRVVLA 
      1160       1170       1180       1190       1200
PEEKEALKRA YQQKPYPSPK TIEDLATQLN LKTSTVINWF HNYRSRIRRE 
      1210       1220       1230       1240       1250
LFIEEIQAGS QGQAGASDSP SARSGRAAPS SEGDSCDGVE ATEGPGSADT 
      1260       1270       1280       1290       1300
EEPKSQGEAE REEVPRPAEQ TEPPPSGTPG PDDARDDDHE GGPVEGPGPL 
      1310       1320       1330       1340       1350
PSPASATATA APAAPEDAAT SAAAAPGEGP AAPSSAPPPS NSSSSSAPRR 
      1360       1370       1380       1390       1400
PSSLQSLFGL PEAAGARDSR DNPLRKKKAA NLNSIIHRLE KAASREEPIE 

WEF

Show »

Length:1,403

Mass (Da):153,364

Checksum:ⁱB10F9B5E864C9D8F

Isoform 6 (identifier: P39880-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
632-687: Missing.

« Hide

        10         20         30         40         50
MLCVAGARLK RELDATATVL ANRQDESEQS RKRLIEQSRE FKKNTPEDLR 
        60         70         80         90        100
KQVAPLLKSF QGEIDALSKR SKEAEAAFLN VYKRLIDVPD PVPALDLGQQ 
       110        120        130        140        150
LQLKVQRLHD IETENQKLRE TLEEYNKEFA EVKNQEVTIK ALKEKIREYE 
       160        170        180        190        200
QTLKNQAETI ALEKEQKLQN DFAEKERKLQ ETQMSTTSKL EEAEHKVQSL 
       210        220        230        240        250
QTALEKTRTE LFDLKTKYDE ETTAKADEIE MIMTDLERAN QRAEVAQREA 
       260        270        280        290        300
ETLREQLSSA NHSLQLASQI QKAPDVEQAI EVLTRSSLEV ELAAKEREIA 
       310        320        330        340        350
QLVEDVQRLQ ASLTKLRENS ASQISQLEQQ LSAKNSTLKQ LEEKLKGQAD 
       360        370        380        390        400
YEEVKKELNI LKSMEFAPSE GAGTQDAAKP LEVLLLEKNR SLQSENAALR 
       410        420        430        440        450
ISNSDLSGSA RRKGKDQPES RRPGSLPAPP PSQLPRNPGE QASNTNGTHQ 
       460        470        480        490        500
FSPAGLSQDF FSSSLASPSL PLASTGKFAL NSLLQRQLMQ SFYSKAMQEA 
       510        520        530        540        550
GSTSMIFSTG PYSTNSISSQ SPLQQSPDVN GMAPSPSQSE SAGSVSEGEE 
       560        570        580        590        600
MDTAEIARQV KEQLIKHNIG QRIFGHYVLG LSQGSVSEIL ARPKPWNKLT 
       610        620        630        640        650
VRGKEPFHKM KQFLSDEQNI LALRSIQGRQ RAEPAQPSSA SGSGNSDDAI 
       660        670        680        690        700
RSILQQARRE MEAQQAALDP ALKQAPLSQS DITILTPKLL STSPMPTVSS 
       710        720        730        740        750
YPPLAISLKK PSAAPEAGAS ALPNPPALKK EAQDAPGLDP QGAADCAQGV 
       760        770        780        790        800
LRQVKNEVGR SGAWKDHWWS AVQPERRNAA SSEEAKAEET GGGKEKGSGG 
       810        820        830        840        850
SGGGSQPRAE RSQLQGPSSS EYWKEWPSAE SPYSQSSELS LTGASRSETP 
       860        870        880        890        900
QNSPLPSSPI VPMSKPTKPS VPPLTPEQYE VYMYQEVDTI ELTRQVKEKL 
       910        920        930        940        950
AKNGICQRIF GEKVLGLSQG SVSDMLSRPK PWSKLTQKGR EPFIRMQLWL 
       960        970        980        990       1000
NGELGQGVLP VQGQQQGPVL HSVTSLQDPL QQGCVSSEST PKTSASCSPA 
      1010       1020       1030       1040       1050
PESPMSSSES VKSLTELVQQ PCPPIEASKD SKPPEPSDPP ASDSQPTTPL 
      1060       1070       1080       1090       1100
PLSGHSALSI QELVAMSPEL DTYGITKRVK EVLTDNNLGQ RLFGETILGL 
      1110       1120       1130       1140       1150
TQGSVSDLLA RPKPWHKLSL KGREPFVRMQ LWLNDPNNVE KLMDMKRMEK 
      1160       1170       1180       1190       1200
KAYMKRRHSS VSDSQPCEPP SVGTEYSQGA SPQPQHQLKK PRVVLAPEEK 
      1210       1220       1230       1240       1250
EALKRAYQQK PYPSPKTIED LATQLNLKTS TVINWFHNYR SRIRRELFIE 
      1260       1270       1280       1290       1300
EIQAGSQGQA GASDSPSARS GRAAPSSEGD SCDGVEATEG PGSADTEEPK 
      1310       1320       1330       1340       1350
SQGEAEREEV PRPAEQTEPP PSGTPGPDDA RDDDHEGGPV EGPGPLPSPA 
      1360       1370       1380       1390       1400
SATATAAPAA PEDAATSAAA APGEGPAAPS SAPPPSNSSS SSAPRRPSSL 
      1410       1420       1430       1440 
QSLFGLPEAA GARDSRDNPL RKKKAANLNS IIHRLEKAAS REEPIEWEF

Show »

Length:1,449

Mass (Da):157,895

Checksum:ⁱEC08BD990BA5321C

Isoform 7 (identifier: P39880-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
408-509: Missing.
632-687: Missing.

« Hide

        10         20         30         40         50
MLCVAGARLK RELDATATVL ANRQDESEQS RKRLIEQSRE FKKNTPEDLR 
        60         70         80         90        100
KQVAPLLKSF QGEIDALSKR SKEAEAAFLN VYKRLIDVPD PVPALDLGQQ 
       110        120        130        140        150
LQLKVQRLHD IETENQKLRE TLEEYNKEFA EVKNQEVTIK ALKEKIREYE 
       160        170        180        190        200
QTLKNQAETI ALEKEQKLQN DFAEKERKLQ ETQMSTTSKL EEAEHKVQSL 
       210        220        230        240        250
QTALEKTRTE LFDLKTKYDE ETTAKADEIE MIMTDLERAN QRAEVAQREA 
       260        270        280        290        300
ETLREQLSSA NHSLQLASQI QKAPDVEQAI EVLTRSSLEV ELAAKEREIA 
       310        320        330        340        350
QLVEDVQRLQ ASLTKLRENS ASQISQLEQQ LSAKNSTLKQ LEEKLKGQAD 
       360        370        380        390        400
YEEVKKELNI LKSMEFAPSE GAGTQDAAKP LEVLLLEKNR SLQSENAALR 
       410        420        430        440        450
ISNSDLSGPY STNSISSQSP LQQSPDVNGM APSPSQSESA GSVSEGEEMD 
       460        470        480        490        500
TAEIARQVKE QLIKHNIGQR IFGHYVLGLS QGSVSEILAR PKPWNKLTVR 
       510        520        530        540        550
GKEPFHKMKQ FLSDEQNILA LRSIQGRQRA EPAQPSSASG SGNSDDAIRS 
       560        570        580        590        600
ILQQARREME AQQAALDPAL KQAPLSQSDI TILTPKLLST SPMPTVSSYP 
       610        620        630        640        650
PLAISLKKPS AAPEAGASAL PNPPALKKEA QDAPGLDPQG AADCAQGVLR 
       660        670        680        690        700
QVKNEVGRSG AWKDHWWSAV QPERRNAASS EEAKAEETGG GKEKGSGGSG 
       710        720        730        740        750
GGSQPRAERS QLQGPSSSEY WKEWPSAESP YSQSSELSLT GASRSETPQN 
       760        770        780        790        800
SPLPSSPIVP MSKPTKPSVP PLTPEQYEVY MYQEVDTIEL TRQVKEKLAK 
       810        820        830        840        850
NGICQRIFGE KVLGLSQGSV SDMLSRPKPW SKLTQKGREP FIRMQLWLNG 
       860        870        880        890        900
ELGQGVLPVQ GQQQGPVLHS VTSLQDPLQQ GCVSSESTPK TSASCSPAPE 
       910        920        930        940        950
SPMSSSESVK SLTELVQQPC PPIEASKDSK PPEPSDPPAS DSQPTTPLPL 
       960        970        980        990       1000
SGHSALSIQE LVAMSPELDT YGITKRVKEV LTDNNLGQRL FGETILGLTQ 
      1010       1020       1030       1040       1050
GSVSDLLARP KPWHKLSLKG REPFVRMQLW LNDPNNVEKL MDMKRMEKKA 
      1060       1070       1080       1090       1100
YMKRRHSSVS DSQPCEPPSV GTEYSQGASP QPQHQLKKPR VVLAPEEKEA 
      1110       1120       1130       1140       1150
LKRAYQQKPY PSPKTIEDLA TQLNLKTSTV INWFHNYRSR IRRELFIEEI 
      1160       1170       1180       1190       1200
QAGSQGQAGA SDSPSARSGR AAPSSEGDSC DGVEATEGPG SADTEEPKSQ 
      1210       1220       1230       1240       1250
GEAEREEVPR PAEQTEPPPS GTPGPDDARD DDHEGGPVEG PGPLPSPASA 
      1260       1270       1280       1290       1300
TATAAPAAPE DAATSAAAAP GEGPAAPSSA PPPSNSSSSS APRRPSSLQS 
      1310       1320       1330       1340 
LFGLPEAAGA RDSRDNPLRK KKAANLNSII HRLEKAASRE EPIEWEF

Show »

Length:1,347

Mass (Da):147,072

Checksum:ⁱD50586280B4D0B81

Isoform 11 (identifier: P39880-9) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MLCVAGARLK → MAANVGSMFQYWKRFDLQQLQ
     90-135: Missing.
     409-667: SARRKGKDQP...TRIRASETGS → RCAELQVRIT...NGAAAGDLWQ
     668-1505: Missing.

« Hide

        10         20         30         40         50
MAANVGSMFQ YWKRFDLQQL QRELDATATV LANRQDESEQ SRKRLIEQSR 
        60         70         80         90        100
EFKKNTPEDL RKQVAPLLKS FQGEIDALSK RSKEAEAAFL NVYKRLIDVP 
       110        120        130        140        150
EVTIKALKEK IREYEQTLKN QAETIALEKE QKLQNDFAEK ERKLQETQMS 
       160        170        180        190        200
TTSKLEEAEH KVQSLQTALE KTRTELFDLK TKYDEETTAK ADEIEMIMTD 
       210        220        230        240        250
LERANQRAEV AQREAETLRE QLSSANHSLQ LASQIQKAPD VEQAIEVLTR 
       260        270        280        290        300
SSLEVELAAK EREIAQLVED VQRLQASLTK LRENSASQIS QLEQQLSAKN 
       310        320        330        340        350
STLKQLEEKL KGQADYEEVK KELNILKSME FAPSEGAGTQ DAAKPLEVLL 
       360        370        380        390        400
LEKNRSLQSE NAALRISNSD LSGRCAELQV RITEAVATAT EQRELIARLE 
       410        420        430        440        450
QDLSIIQSIQ RPDAEGAAEH RLEKIPEPIK EATALFYGPA APASGALPEG 
       460        470        480        490        500
QVDSLLSIIS SQRERFRARN QELEAENRLA QHTLQALQSE LDSLRADNIK 
       510        520        530        540        550
LFEKIKFLQS YPGRGSGSDD TELRYSSQYE ERLDPFSSFS KRERQRKYLS 
       560        570        580        590        600
LSPWDKATLS MGRLVLSNKM ARTIGFFYTL FLHCLVFLVL YKLAWSESME 
       610        620        630 
RDCATFCAKK FADHLHKFHE NDNGAAAGDL WQ

Note: No experimental confirmation available.Combined sources

Show »

Length:632

Mass (Da):72,024

Checksum:ⁱA399B4B63B891AA6

Isoform 4 (identifier: Q13948-1) [UniParc]FASTA Add to basket

Also known as: CASP

The sequence of this isoform can be found in the external entry Q13948.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Length:678

Mass (Da):77,455

Isoform 8 (identifier: Q13948-2) [UniParc]FASTA Add to basket

The sequence of this isoform can be found in the external entry Q13948.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: No experimental confirmation available.

Length:676

Mass (Da):77,198

Isoform 9 (identifier: Q13948-9) [UniParc]FASTA Add to basket

The sequence of this isoform can be found in the external entry Q13948.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: No experimental confirmation available.

Length:639

Mass (Da):72,841

Isoform 10 (identifier: Q13948-10) [UniParc]FASTA Add to basket

The sequence of this isoform can be found in the external entry Q13948.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: No experimental confirmation available.

Length:662

Mass (Da):75,644

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation
A0A2R8Y852	A0A2R8Y852_HUMAN	Homeobox protein cut-like Homeobox protein cut-like	CUX1	1,460	Annotation score:
A0A2R8YDI1	A0A2R8YDI1_HUMAN	Homeobox protein cut-like Homeobox protein cut-like	CUX1	1,358	Annotation score:
A0A2R8Y8D0	A0A2R8Y8D0_HUMAN	Protein CASP Protein CASP	CUX1	117	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	5	A → R in M74099 (PubMed:1301999).Curated	1
Sequence conflictⁱ	145	K → I in BAG53691 (PubMed:14702039).Curated	1
Sequence conflictⁱ	260	A → V in BAG53691 (PubMed:14702039).Curated	1
Sequence conflictⁱ	704 – 705	DA → EP in M74099 (PubMed:1301999).Curated	2
Sequence conflictⁱ	844	E → R in M74099 (PubMed:1301999).Curated	1
Sequence conflictⁱ	1436	S → T in M74099 (PubMed:1301999).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_015747	1 – 10	MLCVAGARLK → MAANVGSMFQYWKRFDLQQL Q in isoform 3 and isoform 11. 2 Publications	10
Alternative sequenceⁱVSP_045924	90 – 135	Missing in isoform 11. 1 PublicationAdd BLAST	46
Alternative sequenceⁱVSP_017358	408 – 509	Missing in isoform 5 and isoform 7. CuratedAdd BLAST	102
Alternative sequenceⁱVSP_045925	409 – 667	SARRK…SETGS → RCAELQVRITEAVATATEQR ELIARLEQDLSIIQSIQRPD AEGAAEHRLEKIPEPIKEAT ALFYGPAAPASGALPEGQVD SLLSIISSQRERFRARNQEL EAENRLAQHTLQALQSELDS LRADNIKLFEKIKFLQSYPG RGSGSDDTELRYSSQYEERL DPFSSFSKRERQRKYLSLSP WDKATLSMGRLVLSNKMART IGFFYTLFLHCLVFLVLYKL AWSESMERDCATFCAKKFAD HLHKFHENDNGAAAGDLWQ in isoform 11. 1 PublicationAdd BLAST	259
Alternative sequenceⁱVSP_017359	632 – 687	Missing in isoform 6 and isoform 7. CuratedAdd BLAST	56
Alternative sequenceⁱVSP_002310	632 – 653	Missing in isoform 2. 1 PublicationAdd BLAST	22
Alternative sequenceⁱVSP_045926	668 – 1505	Missing in isoform 11. 1 PublicationAdd BLAST	838

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M74099 mRNA No translation available. AK122726 mRNA Translation: BAG53691.1 AC005072 Genomic DNA No translation available. AC005086 Genomic DNA Translation: AAP22331.1 AC005088 Genomic DNA No translation available. AC005096 Genomic DNA Translation: AAS07410.1 AC005103 Genomic DNA Translation: AAS07388.1 AC092788 Genomic DNA Translation: AAS07523.1 BC066592 mRNA Translation: AAH66592.1 AF047825 Genomic DNA Translation: AAC78778.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS56498.1 [P39880-3] CCDS56499.1 [P39880-9] CCDS5721.1 [P39880-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001189472.1, NM_001202543.1 [P39880-3] NP_001189473.1, NM_001202544.2 NP_001189474.1, NM_001202545.2 [P39880-9] NP_852477.1, NM_181500.3 NP_853530.2, NM_181552.3 [P39880-1]
UniGeneⁱ	Hs.191482

Genome annotation databases

Ensemblⁱ	ENST00000292535; ENSP00000292535; ENSG00000257923 [P39880-1] ENST00000360264; ENSP00000353401; ENSG00000257923 [P39880-3] ENST00000425244; ENSP00000409745; ENSG00000257923 [P39880-9] ENST00000546411; ENSP00000450125; ENSG00000257923 [P39880-1] ENST00000549414; ENSP00000446630; ENSG00000257923 [P39880-2] ENST00000550008; ENSP00000447373; ENSG00000257923 [P39880-5] ENST00000556210; ENSP00000451558; ENSG00000257923 [P39880-6]
GeneIDⁱ	1523
UCSC genome browser More...UCSCⁱ	uc003uys.5 human [P39880-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P39880	Homeobox protein cut-like 1		MOUSE		1515	UniRef90_P53564
protein CASP isoform X1		DELLE		1627
protein CASP isoform X1		Enhydra lutris kenyoni		1552
Cut-like homeobox 1 (Fragment)		MUSPF		397
Protein CASP (Fragment)		NEOVI		287
+78
P39880-2	Homeobox protein cut-like		CERAT		1492	UniRef90_P39880-2
Homeobox protein cut-like		MACNE		1488
Homeobox protein cut-like		MACMU		1484
Homeobox protein cut-like		Cebus capucinus imitator		1484
Homeobox protein cut-like		MACFA		1484
+23
P39880-4	Homeobox protein cut-like		PONAB		1415	UniRef90_P39880-4
Homeobox protein cut-like		PANTR		1402
UPI0005F3BFD0		CERAT		1512
UPI000989AC38		MICMU		1511
UPI00045D681C		CHLSB		1510
+16
P39880-5	Homeobox protein cut-like		PONAB		1461	UniRef90_P39880-5
Homeobox protein cut-like		HUMAN		1460
Homeobox protein cut-like		CERAT		1458
Homeobox protein cut-like		MACNE		1454
Homeobox protein cut-like		Cebus capucinus imitator		1450
+12
P39880-6	Homeobox protein cut-like		PONAB		1359	UniRef90_P39880-6
Homeobox protein cut-like		HUMAN		1358
Homeobox protein cut-like		PANTR		1346
P39880-9	Cut like homeobox 1		PANTR		632	UniRef90_A0A2I3TTW5
Cut like homeobox 1		PROCO		632
protein CASP isoform X8		Enhydra lutris kenyoni		632
Cut like homeobox 1		PAPAN		632
Cut like homeobox 1		CALJA		632
+13
Q13948-2	Protein CASP		HUMAN		678	UniRef90_Q13948
Protein CASP		MOUSE		678
Protein CASP		PONAB		678
Cut-like homeobox 1		PANTR		678
Uncharacterized protein		FELCA		692
+144
Q13948-9	Cut like homeobox 1		NOMLE		628	UniRef90_A0A2I3GKB1
Cut like homeobox 1		PIG		770
Uncharacterized protein		MUSPF		767
Cut-like 1 (Fragment)		PANTR		83
protein CASP isoform X7		DELLE		767
+59
Q13948-10	Protein CASP		HUMAN		678	UniRef90_Q13948
Protein CASP		MOUSE		678
Protein CASP		PONAB		678
Cut-like homeobox 1		PANTR		678
Uncharacterized protein		FELCA		692
+144

Protein	Similar proteins		Species	Score	Length	Source
P39880	Homeobox protein cut-like 1		MOUSE		1515	UniRef50_P53564
protein CASP isoform X1		DELLE		1627
protein CASP isoform X1		Enhydra lutris kenyoni		1552
Cut-like homeobox 1 (Fragment)		MUSPF		397
protein CASP isoform X4		PHYCD		1538
+120
P39880-2	Isoform 3 of Homeobox protein cut-like 1		MOUSE		1504	UniRef50_P53564-3
Homeobox protein cut-like 1		RAT		1504
Homeobox protein cut-like		MESAU		1504
Homeobox protein cut-like		AILME		1302
Homeobox protein cut-like		PIG		1339
+248
P39880-4	Isoform 3 of Homeobox protein cut-like 1		MOUSE		1504	UniRef50_P53564-3
Homeobox protein cut-like 1		RAT		1504
Homeobox protein cut-like		MESAU		1504
Homeobox protein cut-like		AILME		1302
Homeobox protein cut-like		PIG		1339
+248
P39880-5	Isoform 3 of Homeobox protein cut-like 1		MOUSE		1504	UniRef50_P53564-3
Homeobox protein cut-like 1		RAT		1504
Homeobox protein cut-like		MESAU		1504
Homeobox protein cut-like		AILME		1302
Homeobox protein cut-like		PIG		1339
+248
P39880-6	Homeobox protein cut-like		PONAB		1359	UniRef50_P39880-6
Homeobox protein cut-like		HUMAN		1358
Homeobox protein cut-like		PANTR		1346
protein CASP isoform X4		DELLE		1605
Homeobox protein cut-like		PIG		1409
+31
P39880-9	Protein CASP		HUMAN		678	UniRef50_Q13948
Protein CASP		MOUSE		678
Protein CASP		PONAB		678
Cut-like homeobox 1		PANTR		678
Uncharacterized protein		FELCA		692
+281
Q13948-2	Protein CASP		HUMAN		678	UniRef50_Q13948
Protein CASP		MOUSE		678
Protein CASP		PONAB		678
Cut-like homeobox 1		PANTR		678
Uncharacterized protein		FELCA		692
+281
Q13948-9	Uncharacterized protein		CHICK		678	UniRef50_F1NGM7
Cut like homeobox 1		MELGA		675
protein CASP isoform X4		ODORO		639
Cut like homeobox 1		PIG		770
Cut like homeobox 1		RHIBE		767
+92
Q13948-10	Protein CASP		HUMAN		678	UniRef50_Q13948
Protein CASP		MOUSE		678
Protein CASP		PONAB		678
Cut-like homeobox 1		PANTR		678
Uncharacterized protein		FELCA		692
+281

Entry informationⁱ

Entry nameⁱ	CUX1_HUMAN
Accessionⁱ	P39880Primary (citable) accession number: P39880 Secondary accession number(s): B3KV79 Q9UEV5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
	Last sequence update:	May 18, 2010
	Last modified:	September 12, 2018
	This is version 177 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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UniProtKB - P39880 (CUX1_HUMAN)

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Homeobox protein cut-like 1

CUX1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

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Proteomic databases

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Coiled coil

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ