UniProtKB - P39880 (CUX1_HUMAN)
Homeobox protein cut-like 1
CUX1
Functioni
Miscellaneous
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 542 – 629 | CUT 1PROSITE-ProRule annotationAdd BLAST | 88 | |
DNA bindingi | 934 – 1021 | CUT 2PROSITE-ProRule annotationAdd BLAST | 88 | |
DNA bindingi | 1117 – 1204 | CUT 3PROSITE-ProRule annotationAdd BLAST | 88 | |
DNA bindingi | 1244 – 1303 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- protein-macromolecule adaptor activity Source: Ensembl
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: UniProtKB
- sequence-specific DNA binding Source: UniProtKB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- Golgi vesicle transport Source: GO_Central
- multicellular organism development Source: ProtInc
- negative regulation of transcription by RNA polymerase II Source: GO_Central
- positive regulation of dendrite morphogenesis Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: ProtInc
- retrograde transport, vesicle recycling within Golgi Source: Ensembl
Keywordsi
Molecular function | Developmental protein, DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P39880 |
Reactomei | R-HSA-1839117, Signaling by cytosolic FGFR1 fusion mutants R-HSA-5655302, Signaling by FGFR1 in disease |
SIGNORi | P39880 |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein cut-like 1CuratedAlternative name(s): CCAAT displacement protein Short name: CDP CDP/Cux p2001 Publication Homeobox protein cux-1 Cleaved into the following chain: CDP/Cux p1101 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000257923.9 |
HGNCi | HGNC:2557, CUX1 |
MIMi | 116896, gene |
neXtProti | NX_P39880 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Cytosol
- cytosol Source: Reactome
Golgi apparatus
- Golgi apparatus Source: HPA
- Golgi membrane Source: GO_Central
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Global developmental delay with or without impaired intellectual development (GDDI)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_081977 | 862 – 1505 | Missing in GDDI. 1 PublicationAdd BLAST | 644 |
Keywords - Diseasei
Disease mutation, Mental retardationOrganism-specific databases
DisGeNETi | 1523 |
MalaCardsi | CUX1 |
MIMi | 618330, phenotype |
OpenTargetsi | ENSG00000257923 |
Orphaneti | 178469, Autosomal dominant non-syndromic intellectual disability |
PharmGKBi | PA162382924 |
Miscellaneous databases
Pharosi | P39880, Tbio |
Polymorphism and mutation databases
BioMutai | CUX1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000202393 | 1 – 1505 | Homeobox protein cut-like 1Add BLAST | 1505 | |
ChainiPRO_0000450797 | 756 – 1505 | CDP/Cux p1101 PublicationAdd BLAST | 750 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 763 | PhosphoserineCombined sources | 1 | ||
Cross-linki | 785 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Cross-linki | 811 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Cross-linki | 842 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Modified residuei | 909 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 1059 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1069 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 1270 | PhosphoserineCombined sources | 1 | ||
Cross-linki | 1284 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Modified residuei | 1337 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 1455 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1486 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1496 | PhosphoserineBy similarity | 1 | ||
Isoform 11 (identifier: P39880-9) | |||||
Modified residuei | 540 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 643 – 644 | Cleavage; by CTSL1 Publication | 2 | |
Sitei | 747 – 755 | Cleavage; by CTSL1 Publication | 9 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P39880 |
jPOSTi | P39880 |
MassIVEi | P39880 |
PaxDbi | P39880 |
PeptideAtlasi | P39880 |
PRIDEi | P39880 |
ProteomicsDBi | 55321 [P39880-1] 55322 [P39880-2] 55323 [P39880-3] 55324 [P39880-4] 55325 [P39880-5] 55326 [P39880-6] |
PTM databases
iPTMneti | P39880 |
MetOSitei | P39880 |
PhosphoSitePlusi | P39880 |
Expressioni
Gene expression databases
Bgeei | ENSG00000257923, Expressed in secondary oocyte and 246 other tissues |
ExpressionAtlasi | P39880, baseline and differential |
Genevisiblei | P39880, HS |
Organism-specific databases
HPAi | ENSG00000257923, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with BANP.
Interacts with SATB1 (via DNA-binding domains); the interaction inhibits the attachment of both proteins to DNA (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 107903, 80 interactors |
ELMi | P39880 |
IntActi | P39880, 36 interactors |
MINTi | P39880 |
STRINGi | 9606.ENSP00000353401 |
Miscellaneous databases
RNActi | P39880, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 56 – 407 | Sequence analysisAdd BLAST | 352 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1406 – 1438 | Ala-richAdd BLAST | 33 |
Sequence similaritiesi
Keywords - Domaini
Coiled coil, Homeobox, RepeatPhylogenomic databases
eggNOGi | KOG0963, Eukaryota KOG2252, Eukaryota |
GeneTreei | ENSGT00940000159751 |
HOGENOMi | CLU_016758_0_0_1 |
InParanoidi | P39880 |
OMAi | VANWRRT |
OrthoDBi | 181575at2759 |
PhylomeDBi | P39880 |
TreeFami | TF318206 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
Gene3Di | 1.10.260.40, 3 hits |
InterProi | View protein in InterPro IPR003350, CUT_dom IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR010982, Lambda_DNA-bd_dom_sf |
Pfami | View protein in Pfam PF02376, CUT, 3 hits PF00046, Homeodomain, 1 hit |
SMARTi | View protein in SMART SM01109, CUT, 3 hits SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit SSF47413, SSF47413, 3 hits |
PROSITEi | View protein in PROSITE PS51042, CUT, 3 hits PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
s (11+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 11 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 11 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLCVAGARLK RELDATATVL ANRQDESEQS RKRLIEQSRE FKKNTPEDLR
60 70 80 90 100
KQVAPLLKSF QGEIDALSKR SKEAEAAFLN VYKRLIDVPD PVPALDLGQQ
110 120 130 140 150
LQLKVQRLHD IETENQKLRE TLEEYNKEFA EVKNQEVTIK ALKEKIREYE
160 170 180 190 200
QTLKNQAETI ALEKEQKLQN DFAEKERKLQ ETQMSTTSKL EEAEHKVQSL
210 220 230 240 250
QTALEKTRTE LFDLKTKYDE ETTAKADEIE MIMTDLERAN QRAEVAQREA
260 270 280 290 300
ETLREQLSSA NHSLQLASQI QKAPDVEQAI EVLTRSSLEV ELAAKEREIA
310 320 330 340 350
QLVEDVQRLQ ASLTKLRENS ASQISQLEQQ LSAKNSTLKQ LEEKLKGQAD
360 370 380 390 400
YEEVKKELNI LKSMEFAPSE GAGTQDAAKP LEVLLLEKNR SLQSENAALR
410 420 430 440 450
ISNSDLSGSA RRKGKDQPES RRPGSLPAPP PSQLPRNPGE QASNTNGTHQ
460 470 480 490 500
FSPAGLSQDF FSSSLASPSL PLASTGKFAL NSLLQRQLMQ SFYSKAMQEA
510 520 530 540 550
GSTSMIFSTG PYSTNSISSQ SPLQQSPDVN GMAPSPSQSE SAGSVSEGEE
560 570 580 590 600
MDTAEIARQV KEQLIKHNIG QRIFGHYVLG LSQGSVSEIL ARPKPWNKLT
610 620 630 640 650
VRGKEPFHKM KQFLSDEQNI LALRSIQGRQ RENPGQSLNR LFQEVPKRRN
660 670 680 690 700
GSEGNITTRI RASETGSDEA IKSILEQAKR ELQVQKTAEP AQPSSASGSG
710 720 730 740 750
NSDDAIRSIL QQARREMEAQ QAALDPALKQ APLSQSDITI LTPKLLSTSP
760 770 780 790 800
MPTVSSYPPL AISLKKPSAA PEAGASALPN PPALKKEAQD APGLDPQGAA
810 820 830 840 850
DCAQGVLRQV KNEVGRSGAW KDHWWSAVQP ERRNAASSEE AKAEETGGGK
860 870 880 890 900
EKGSGGSGGG SQPRAERSQL QGPSSSEYWK EWPSAESPYS QSSELSLTGA
910 920 930 940 950
SRSETPQNSP LPSSPIVPMS KPTKPSVPPL TPEQYEVYMY QEVDTIELTR
960 970 980 990 1000
QVKEKLAKNG ICQRIFGEKV LGLSQGSVSD MLSRPKPWSK LTQKGREPFI
1010 1020 1030 1040 1050
RMQLWLNGEL GQGVLPVQGQ QQGPVLHSVT SLQDPLQQGC VSSESTPKTS
1060 1070 1080 1090 1100
ASCSPAPESP MSSSESVKSL TELVQQPCPP IEASKDSKPP EPSDPPASDS
1110 1120 1130 1140 1150
QPTTPLPLSG HSALSIQELV AMSPELDTYG ITKRVKEVLT DNNLGQRLFG
1160 1170 1180 1190 1200
ETILGLTQGS VSDLLARPKP WHKLSLKGRE PFVRMQLWLN DPNNVEKLMD
1210 1220 1230 1240 1250
MKRMEKKAYM KRRHSSVSDS QPCEPPSVGT EYSQGASPQP QHQLKKPRVV
1260 1270 1280 1290 1300
LAPEEKEALK RAYQQKPYPS PKTIEDLATQ LNLKTSTVIN WFHNYRSRIR
1310 1320 1330 1340 1350
RELFIEEIQA GSQGQAGASD SPSARSGRAA PSSEGDSCDG VEATEGPGSA
1360 1370 1380 1390 1400
DTEEPKSQGE AEREEVPRPA EQTEPPPSGT PGPDDARDDD HEGGPVEGPG
1410 1420 1430 1440 1450
PLPSPASATA TAAPAAPEDA ATSAAAAPGE GPAAPSSAPP PSNSSSSSAP
1460 1470 1480 1490 1500
RRPSSLQSLF GLPEAAGARD SRDNPLRKKK AANLNSIIHR LEKAASREEP
IEWEF
The sequence of this isoform differs from the canonical sequence as follows:
1-10: MLCVAGARLK → MAANVGSMFQYWKRFDLQQLQ
90-135: Missing.
409-667: SARRKGKDQP...TRIRASETGS → RCAELQVRIT...NGAAAGDLWQ
668-1505: Missing.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A2R8Y852 | A0A2R8Y852_HUMAN | Homeobox protein cut-like | CUX1 | 1,460 | Annotation score: | ||
A0A2R8YDI1 | A0A2R8YDI1_HUMAN | Homeobox protein cut-like | CUX1 | 1,358 | Annotation score: | ||
A0A2R8Y8D0 | A0A2R8Y8D0_HUMAN | Protein CASP | CUX1 | 117 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 5 | A → R in M74099 (PubMed:1301999).Curated | 1 | |
Sequence conflicti | 145 | K → I in BAG53691 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 260 | A → V in BAG53691 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 704 – 705 | DA → EP in M74099 (PubMed:1301999).Curated | 2 | |
Sequence conflicti | 844 | E → R in M74099 (PubMed:1301999).Curated | 1 | |
Sequence conflicti | 1436 | S → T in M74099 (PubMed:1301999).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_081977 | 862 – 1505 | Missing in GDDI. 1 PublicationAdd BLAST | 644 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_015747 | 1 – 10 | MLCVAGARLK → MAANVGSMFQYWKRFDLQQL Q in isoform 3 and isoform 11. 2 Publications | 10 | |
Alternative sequenceiVSP_045924 | 90 – 135 | Missing in isoform 11. 1 PublicationAdd BLAST | 46 | |
Alternative sequenceiVSP_017358 | 408 – 509 | Missing in isoform 5 and isoform 7. CuratedAdd BLAST | 102 | |
Alternative sequenceiVSP_045925 | 409 – 667 | SARRK…SETGS → RCAELQVRITEAVATATEQR ELIARLEQDLSIIQSIQRPD AEGAAEHRLEKIPEPIKEAT ALFYGPAAPASGALPEGQVD SLLSIISSQRERFRARNQEL EAENRLAQHTLQALQSELDS LRADNIKLFEKIKFLQSYPG RGSGSDDTELRYSSQYEERL DPFSSFSKRERQRKYLSLSP WDKATLSMGRLVLSNKMART IGFFYTLFLHCLVFLVLYKL AWSESMERDCATFCAKKFAD HLHKFHENDNGAAAGDLWQ in isoform 11. 1 PublicationAdd BLAST | 259 | |
Alternative sequenceiVSP_017359 | 632 – 687 | Missing in isoform 6 and isoform 7. CuratedAdd BLAST | 56 | |
Alternative sequenceiVSP_002310 | 632 – 653 | Missing in isoform 2. 1 PublicationAdd BLAST | 22 | |
Alternative sequenceiVSP_045926 | 668 – 1505 | Missing in isoform 11. 1 PublicationAdd BLAST | 838 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M74099 mRNA No translation available. AK122726 mRNA Translation: BAG53691.1 AC005072 Genomic DNA No translation available. AC005086 Genomic DNA Translation: AAP22331.1 AC005088 Genomic DNA No translation available. AC005096 Genomic DNA Translation: AAS07410.1 AC005103 Genomic DNA Translation: AAS07388.1 AC092788 Genomic DNA Translation: AAS07523.1 BC066592 mRNA Translation: AAH66592.1 AF047825 Genomic DNA Translation: AAC78778.1 |
CCDSi | CCDS56498.1 [P39880-3] CCDS56499.1 [P39880-9] CCDS5721.1 [P39880-1] |
RefSeqi | NP_001189472.1, NM_001202543.1 [P39880-3] NP_001189473.1, NM_001202544.2 NP_001189474.1, NM_001202545.2 [P39880-9] NP_852477.1, NM_181500.3 NP_853530.2, NM_181552.3 [P39880-1] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M74099 mRNA No translation available. AK122726 mRNA Translation: BAG53691.1 AC005072 Genomic DNA No translation available. AC005086 Genomic DNA Translation: AAP22331.1 AC005088 Genomic DNA No translation available. AC005096 Genomic DNA Translation: AAS07410.1 AC005103 Genomic DNA Translation: AAS07388.1 AC092788 Genomic DNA Translation: AAS07523.1 BC066592 mRNA Translation: AAH66592.1 AF047825 Genomic DNA Translation: AAC78778.1 |
CCDSi | CCDS56498.1 [P39880-3] CCDS56499.1 [P39880-9] CCDS5721.1 [P39880-1] |
RefSeqi | NP_001189472.1, NM_001202543.1 [P39880-3] NP_001189473.1, NM_001202544.2 NP_001189474.1, NM_001202545.2 [P39880-9] NP_852477.1, NM_181500.3 NP_853530.2, NM_181552.3 [P39880-1] |
3D structure databases
SMRi | P39880 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 107903, 80 interactors |
ELMi | P39880 |
IntActi | P39880, 36 interactors |
MINTi | P39880 |
STRINGi | 9606.ENSP00000353401 |
PTM databases
iPTMneti | P39880 |
MetOSitei | P39880 |
PhosphoSitePlusi | P39880 |
Polymorphism and mutation databases
BioMutai | CUX1 |
Proteomic databases
EPDi | P39880 |
jPOSTi | P39880 |
MassIVEi | P39880 |
PaxDbi | P39880 |
PeptideAtlasi | P39880 |
PRIDEi | P39880 |
ProteomicsDBi | 55321 [P39880-1] 55322 [P39880-2] 55323 [P39880-3] 55324 [P39880-4] 55325 [P39880-5] 55326 [P39880-6] |
Protocols and materials databases
Antibodypediai | 48390, 392 antibodies |
DNASUi | 1523 |
Genome annotation databases
Organism-specific databases
CTDi | 1523 |
DisGeNETi | 1523 |
EuPathDBi | HostDB:ENSG00000257923.9 |
GeneCardsi | CUX1 |
HGNCi | HGNC:2557, CUX1 |
HPAi | ENSG00000257923, Low tissue specificity |
MalaCardsi | CUX1 |
MIMi | 116896, gene 618330, phenotype |
neXtProti | NX_P39880 |
OpenTargetsi | ENSG00000257923 |
Orphaneti | 178469, Autosomal dominant non-syndromic intellectual disability |
PharmGKBi | PA162382924 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0963, Eukaryota KOG2252, Eukaryota |
GeneTreei | ENSGT00940000159751 |
HOGENOMi | CLU_016758_0_0_1 |
InParanoidi | P39880 |
OMAi | VANWRRT |
OrthoDBi | 181575at2759 |
PhylomeDBi | P39880 |
TreeFami | TF318206 |
Enzyme and pathway databases
PathwayCommonsi | P39880 |
Reactomei | R-HSA-1839117, Signaling by cytosolic FGFR1 fusion mutants R-HSA-5655302, Signaling by FGFR1 in disease |
SIGNORi | P39880 |
Miscellaneous databases
BioGRID-ORCSi | 1523, 10 hits in 873 CRISPR screens |
ChiTaRSi | CUX1, human |
GeneWikii | CUTL1 |
GenomeRNAii | 1523 |
Pharosi | P39880, Tbio |
RNActi | P39880, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000257923, Expressed in secondary oocyte and 246 other tissues |
ExpressionAtlasi | P39880, baseline and differential |
Genevisiblei | P39880, HS |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
Gene3Di | 1.10.260.40, 3 hits |
InterProi | View protein in InterPro IPR003350, CUT_dom IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR010982, Lambda_DNA-bd_dom_sf |
Pfami | View protein in Pfam PF02376, CUT, 3 hits PF00046, Homeodomain, 1 hit |
SMARTi | View protein in SMART SM01109, CUT, 3 hits SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit SSF47413, SSF47413, 3 hits |
PROSITEi | View protein in PROSITE PS51042, CUT, 3 hits PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CUX1_HUMAN | |
Accessioni | P39880Primary (citable) accession number: P39880 Secondary accession number(s): B3KV79 Q9UEV5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | May 18, 2010 | |
Last modified: | December 2, 2020 | |
This is version 194 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations