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Protein

Calcium-dependent phospholipase A2

Gene

PLA2G5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. This isozyme hydrolyzes more efficiently L-alpha-1-palmitoyl-2-oleoyl phosphatidylcholine than L-alpha-1-palmitoyl-2-arachidonyl phosphatidylcholine, L-alpha-1-palmitoyl-2-arachidonyl phosphatidylethanolamine, or L-alpha-1-stearoyl-2-arachidonyl phosphatidylinositol. May be involved in the production of lung surfactant, the remodeling or regulation of cardiac muscle.

Catalytic activityi

Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.PROSITE-ProRule annotation

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

pH dependencei

Optimum pH is 6.5. Activity remains high up to pH 9.0.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47Calcium; via carbonyl oxygenBy similarity1
Metal bindingi49Calcium; via carbonyl oxygenBy similarity1
Metal bindingi51Calcium; via carbonyl oxygenBy similarity1
Active sitei67By similarity1
Metal bindingi68CalciumBy similarity1
Active sitei111By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-1482788 Acyl chain remodelling of PC
R-HSA-1482801 Acyl chain remodelling of PS
R-HSA-1482839 Acyl chain remodelling of PE
R-HSA-1482922 Acyl chain remodelling of PI
R-HSA-1482925 Acyl chain remodelling of PG
R-HSA-1483166 Synthesis of PA

Chemistry databases

SwissLipidsiSLP:000000140

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-dependent phospholipase A2 (EC:3.1.1.4)
Alternative name(s):
Group V phospholipase A2
PLA2-10
Phosphatidylcholine 2-acylhydrolase 5
Gene namesi
Name:PLA2G5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000127472.10
HGNCiHGNC:9038 PLA2G5
MIMi601192 gene
neXtProtiNX_P39877

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Fleck retina, familial benign (FRFB)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive condition associated with a distinctive retinal appearance and no apparent visual or electrophysiologic deficits. Affected individuals are asymptomatic, but fundus examination reveals a striking pattern of diffuse, yellow-white, fleck-like lesions extending to the far periphery of the retina but sparing the foveal region.
See also OMIM:228980
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06734345G → C in FRFB. 1 PublicationCorresponds to variant dbSNP:rs387906795EnsemblClinVar.1
Natural variantiVAR_06734449G → S in FRFB. 1 PublicationCorresponds to variant dbSNP:rs387906796EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi5322
MalaCardsiPLA2G5
MIMi228980 phenotype
OpenTargetsiENSG00000127472
Orphaneti363989 Familial benign flecked retina
PharmGKBiPA33366

Chemistry databases

ChEMBLiCHEMBL4323
GuidetoPHARMACOLOGYi1430

Polymorphism and mutation databases

BioMutaiPLA2G5
DMDMi730258

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000002276121 – 138Calcium-dependent phospholipase A2Add BLAST118

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 137By similarity
Disulfide bondi48 ↔ 64By similarity
Disulfide bondi63 ↔ 117By similarity
Disulfide bondi70 ↔ 110By similarity
Disulfide bondi79 ↔ 103By similarity
Disulfide bondi97 ↔ 108By similarity

Post-translational modificationi

This enzyme lacks one of the seven disulfide bonds found in similar PA2 proteins.

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP39877
PeptideAtlasiP39877
PRIDEiP39877
ProteomicsDBi55320

Expressioni

Tissue specificityi

Heart, placenta and less abundantly, in lung. Detected in the outer and inner plexiform layers of the retina (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000127472 Expressed in 142 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_PLA2G5
GenevisibleiP39877 HS

Organism-specific databases

HPAiHPA053361

Interactioni

Protein-protein interaction databases

BioGridi111339, 12 interactors
STRINGi9606.ENSP00000364249

Chemistry databases

BindingDBiP39877

Structurei

3D structure databases

ProteinModelPortaliP39877
SMRiP39877
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phospholipase A2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4087 Eukaryota
ENOG411283D LUCA
GeneTreeiENSGT00760000119160
HOGENOMiHOG000231749
HOVERGENiHBG008137
InParanoidiP39877
KOiK01047
OMAiYCLKRNL
OrthoDBiEOG091G0UZ3
PhylomeDBiP39877
TreeFamiTF319283

Family and domain databases

CDDicd00125 PLA2c, 1 hit
Gene3Di1.20.90.10, 1 hit
InterProiView protein in InterPro
IPR001211 PLipase_A2
IPR033112 PLipase_A2_Asp_AS
IPR016090 PLipase_A2_dom
IPR036444 PLipase_A2_dom_sf
IPR033113 PLipase_A2_His_AS
PANTHERiPTHR11716 PTHR11716, 1 hit
PfamiView protein in Pfam
PF00068 Phospholip_A2_1, 1 hit
PRINTSiPR00389 PHPHLIPASEA2
SMARTiView protein in SMART
SM00085 PA2c, 1 hit
SUPFAMiSSF48619 SSF48619, 1 hit
PROSITEiView protein in PROSITE
PS00119 PA2_ASP, 1 hit
PS00118 PA2_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P39877-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKGLLPLAWF LACSVPAVQG GLLDLKSMIE KVTGKNALTN YGFYGCYCGW
60 70 80 90 100
GGRGTPKDGT DWCCWAHDHC YGRLEEKGCN IRTQSYKYRF AWGVVTCEPG
110 120 130
PFCHVNLCAC DRKLVYCLKR NLRSYNPQYQ YFPNILCS
Length:138
Mass (Da):15,674
Last modified:February 1, 1995 - v1
Checksum:i0D17DC76E55F42BC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06734345G → C in FRFB. 1 PublicationCorresponds to variant dbSNP:rs387906795EnsemblClinVar.1
Natural variantiVAR_06734449G → S in FRFB. 1 PublicationCorresponds to variant dbSNP:rs387906796EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03090 mRNA Translation: AAC28886.1
AY524778 Genomic DNA Translation: AAR92480.1
AL158172 Genomic DNA No translation available.
BC036792 mRNA Translation: AAH36792.2
CCDSiCCDS202.1
PIRiA49959
RefSeqiNP_000920.1, NM_000929.2
XP_005245950.1, XM_005245893.4
XP_011539889.1, XM_011541587.2
XP_011539890.1, XM_011541588.2
XP_011539891.1, XM_011541589.2
XP_011539892.1, XM_011541590.2
XP_011539893.1, XM_011541591.2
XP_011539894.1, XM_011541592.2
UniGeneiHs.319438

Genome annotation databases

EnsembliENST00000375108; ENSP00000364249; ENSG00000127472
GeneIDi5322
KEGGihsa:5322
UCSCiuc001bcy.4 human

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03090 mRNA Translation: AAC28886.1
AY524778 Genomic DNA Translation: AAR92480.1
AL158172 Genomic DNA No translation available.
BC036792 mRNA Translation: AAH36792.2
CCDSiCCDS202.1
PIRiA49959
RefSeqiNP_000920.1, NM_000929.2
XP_005245950.1, XM_005245893.4
XP_011539889.1, XM_011541587.2
XP_011539890.1, XM_011541588.2
XP_011539891.1, XM_011541589.2
XP_011539892.1, XM_011541590.2
XP_011539893.1, XM_011541591.2
XP_011539894.1, XM_011541592.2
UniGeneiHs.319438

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GHNmodel-A21-138[»]
ProteinModelPortaliP39877
SMRiP39877
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111339, 12 interactors
STRINGi9606.ENSP00000364249

Chemistry databases

BindingDBiP39877
ChEMBLiCHEMBL4323
GuidetoPHARMACOLOGYi1430
SwissLipidsiSLP:000000140

Polymorphism and mutation databases

BioMutaiPLA2G5
DMDMi730258

Proteomic databases

PaxDbiP39877
PeptideAtlasiP39877
PRIDEiP39877
ProteomicsDBi55320

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375108; ENSP00000364249; ENSG00000127472
GeneIDi5322
KEGGihsa:5322
UCSCiuc001bcy.4 human

Organism-specific databases

CTDi5322
DisGeNETi5322
EuPathDBiHostDB:ENSG00000127472.10
GeneCardsiPLA2G5
HGNCiHGNC:9038 PLA2G5
HPAiHPA053361
MalaCardsiPLA2G5
MIMi228980 phenotype
601192 gene
neXtProtiNX_P39877
OpenTargetsiENSG00000127472
Orphaneti363989 Familial benign flecked retina
PharmGKBiPA33366
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4087 Eukaryota
ENOG411283D LUCA
GeneTreeiENSGT00760000119160
HOGENOMiHOG000231749
HOVERGENiHBG008137
InParanoidiP39877
KOiK01047
OMAiYCLKRNL
OrthoDBiEOG091G0UZ3
PhylomeDBiP39877
TreeFamiTF319283

Enzyme and pathway databases

ReactomeiR-HSA-1482788 Acyl chain remodelling of PC
R-HSA-1482801 Acyl chain remodelling of PS
R-HSA-1482839 Acyl chain remodelling of PE
R-HSA-1482922 Acyl chain remodelling of PI
R-HSA-1482925 Acyl chain remodelling of PG
R-HSA-1483166 Synthesis of PA

Miscellaneous databases

ChiTaRSiPLA2G5 human
GeneWikiiPLA2G5
GenomeRNAii5322
PROiPR:P39877
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000127472 Expressed in 142 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_PLA2G5
GenevisibleiP39877 HS

Family and domain databases

CDDicd00125 PLA2c, 1 hit
Gene3Di1.20.90.10, 1 hit
InterProiView protein in InterPro
IPR001211 PLipase_A2
IPR033112 PLipase_A2_Asp_AS
IPR016090 PLipase_A2_dom
IPR036444 PLipase_A2_dom_sf
IPR033113 PLipase_A2_His_AS
PANTHERiPTHR11716 PTHR11716, 1 hit
PfamiView protein in Pfam
PF00068 Phospholip_A2_1, 1 hit
PRINTSiPR00389 PHPHLIPASEA2
SMARTiView protein in SMART
SM00085 PA2c, 1 hit
SUPFAMiSSF48619 SSF48619, 1 hit
PROSITEiView protein in PROSITE
PS00119 PA2_ASP, 1 hit
PS00118 PA2_HIS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPA2G5_HUMAN
AccessioniPrimary (citable) accession number: P39877
Secondary accession number(s): Q8N435
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 12, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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