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UniProtKB - P39873 (RNBR_BOVIN)
Protein
Brain ribonuclease
Gene
BRN
Organism
Bos taurus (Bovine)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 33 | SubstrateBy similarity | 1 | |
Binding sitei | 36 | SubstrateBy similarity | 1 | |
Active sitei | 38 | Proton acceptorBy similarity | 1 | |
Binding sitei | 92 | SubstrateBy similarity | 1 | |
Binding sitei | 111 | SubstrateBy similarity | 1 | |
Active sitei | 145 | Proton donorBy similarity | 1 |
GO - Molecular functioni
- endonuclease activity Source: UniProtKB-KW
- nucleic acid binding Source: InterPro
- ribonuclease activity Source: GO_Central
GO - Biological processi
- RNA phosphodiester bond hydrolysis Source: GO_Central
Keywordsi
Molecular function | Endonuclease, Hydrolase, Nuclease |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:BRN |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSBTAG00000004950 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | 1 PublicationAdd BLAST | 26 | |
ChainiPRO_0000030909 | 27 – 167 | Brain ribonucleaseAdd BLAST | 141 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 52 ↔ 110 | By similarity | ||
Disulfide bondi | 66 ↔ 121 | By similarity | ||
Disulfide bondi | 84 ↔ 136 | By similarity | ||
GlycosylationiCAR_000005 | 88 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 91 ↔ 98 | By similarity | ||
Glycosylationi | 155 | O-linked (GalNAc...) threonine1 Publication | 1 | |
Glycosylationi | 159 | O-linked (GalNAc...) serine1 Publication | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P39873 |
PTM databases
GlyConnecti | 528, 19 N-Linked glycans (1 site) |
iPTMneti | P39873 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000004950, Expressed in placenta and 96 other tissues |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 67 – 71 | Substrate bindingBy similarity | 5 |
Sequence similaritiesi
Belongs to the pancreatic ribonuclease family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502SQ4K, Eukaryota |
GeneTreei | ENSGT00940000160869 |
HOGENOMi | CLU_117006_0_0_1 |
InParanoidi | P39873 |
OMAi | SNSTYCN |
OrthoDBi | 1549558at2759 |
TreeFami | TF333393 |
Family and domain databases
Gene3Di | 3.10.130.10, 1 hit |
InterProi | View protein in InterPro IPR001427, RNaseA IPR036816, RNaseA-like_dom_sf IPR023411, RNaseA_AS IPR023412, RNaseA_domain |
PANTHERi | PTHR11437, PTHR11437, 1 hit |
Pfami | View protein in Pfam PF00074, RnaseA, 1 hit |
PRINTSi | PR00794, RIBONUCLEASE |
SMARTi | View protein in SMART SM00092, RNAse_Pc, 1 hit |
SUPFAMi | SSF54076, SSF54076, 1 hit |
PROSITEi | View protein in PROSITE PS00127, RNASE_PANCREATIC, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P39873-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALKSLVLLS LLVLVLLLVQ VQPSLGKESA AAKFRRQHMD SGSSSSSNPN
60 70 80 90 100
YCNQMMKRRR MTHGRCKPVN TFVHESLDDV KAVCSQKNIT CKNGHPNCYQ
110 120 130 140 150
SKSTMSITDC RETGSSKYPN CAYKTSQKQK YITVACEGNP YVPVHFDGAV
160
LLPATPVPSL PPPHRLL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 155 | T → S AA sequence (PubMed:3243767).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X59767 Genomic DNA Translation: CAA42439.1 BC114791 mRNA Translation: AAI14792.1 S81744 Genomic DNA Translation: AAB36138.1 |
PIRi | S20066 |
RefSeqi | NP_776316.1, NM_173891.2 |
Genome annotation databases
Ensembli | ENSBTAT00000006510; ENSBTAP00000006510; ENSBTAG00000004950 |
GeneIDi | 280720 |
KEGGi | bta:280720 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X59767 Genomic DNA Translation: CAA42439.1 BC114791 mRNA Translation: AAI14792.1 S81744 Genomic DNA Translation: AAB36138.1 |
PIRi | S20066 |
RefSeqi | NP_776316.1, NM_173891.2 |
3D structure databases
SMRi | P39873 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000006510 |
PTM databases
GlyConnecti | 528, 19 N-Linked glycans (1 site) |
iPTMneti | P39873 |
Proteomic databases
PaxDbi | P39873 |
Genome annotation databases
Ensembli | ENSBTAT00000006510; ENSBTAP00000006510; ENSBTAG00000004950 |
GeneIDi | 280720 |
KEGGi | bta:280720 |
Organism-specific databases
CTDi | 247925 |
VEuPathDBi | HostDB:ENSBTAG00000004950 |
Phylogenomic databases
eggNOGi | ENOG502SQ4K, Eukaryota |
GeneTreei | ENSGT00940000160869 |
HOGENOMi | CLU_117006_0_0_1 |
InParanoidi | P39873 |
OMAi | SNSTYCN |
OrthoDBi | 1549558at2759 |
TreeFami | TF333393 |
Gene expression databases
Bgeei | ENSBTAG00000004950, Expressed in placenta and 96 other tissues |
Family and domain databases
Gene3Di | 3.10.130.10, 1 hit |
InterProi | View protein in InterPro IPR001427, RNaseA IPR036816, RNaseA-like_dom_sf IPR023411, RNaseA_AS IPR023412, RNaseA_domain |
PANTHERi | PTHR11437, PTHR11437, 1 hit |
Pfami | View protein in Pfam PF00074, RnaseA, 1 hit |
PRINTSi | PR00794, RIBONUCLEASE |
SMARTi | View protein in SMART SM00092, RNAse_Pc, 1 hit |
SUPFAMi | SSF54076, SSF54076, 1 hit |
PROSITEi | View protein in PROSITE PS00127, RNASE_PANCREATIC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RNBR_BOVIN | |
Accessioni | P39873Primary (citable) accession number: P39873 Secondary accession number(s): Q1RMP6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | October 17, 2006 | |
Last modified: | September 29, 2021 | |
This is version 134 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families