UniProtKB - P39838 (RCSD_ECOLI)

BLAST

>sp|P39838|RCSD_ECOLI Phosphotransferase RcsD OS=Escherichia coli (strain K12) OX=83333 GN=rcsD PE=1 SV=3
MRQKETTATTRFSLLPGSITRFFLLLIIVLLVTMGVMVQSAVNAWLKDKSYQIVDITHAI
QKRVDNWRYVTWQIYDNIAATTSPSSGEGLQETRLKQDVYYLEKPRRKTEALIFGSHDNS
TLEMTQRMSTYLDTLWGAENVPWSMYYLNGQDNSLVLISTLPLKDLTSGFKESTVSDIVD
SRRAEMLQQANALDERESFSNMRRLAWQNGHYFTLRTTFNQPGHLATVVAFDLPINDLIP
PGMPLDSFRLEPDATATGNNDNEKEGTDSVSIHFNSTKIEISSALNSTDMRLVWQVPYGT
LLLDTLQNILLPLLLNIGLLALALFGYTTFRHFSSRSTENVPSTAVNNELRILRAINEEI
VSLLPLGLLVHDQESNRTVISNKIADHLLPHLNLQNITTMAEQHQGIIQATINNELYEIR
MFRSQVAPRTQIFIIRDQDREVLVNKKLKQAQRLYEKNQQGRMIFMKNIGDALKEPAQSL
AESAAKLNAPESKQLANQADVLVRLVDEIQLANMLADDSWKSETVLFSVQDLIDEVVPSV
LPAIKRKGLQLLINNHLKAHDMRRGDRDALRRILLLLMQYAVTSTQLGKITLEVDQDESS
EDRLTFRILDTGEGVSIHEMDNLHFPFINQTQNDRYGKADPLAFWLSDQLARKLGGHLNI
KTRDGLGTRYSVHIKMLAADPEVEEEEERLLDDVCVMVDVTSAEIRNIVTRQLENWGATC
ITPDERLISQDYDIFLTDNPSNLTASGLLLSDDESGVREIGPGQLCVNFNMSNAMQEAVL
QLIEVQLAQEEVTESPLGGDENAQLHASGYYALFVDTVPDDVKRLYTEAATSDFAALAQT
AHRLKGVFAMLNLVPGKQLCETLEHLIREKDVPGIEKYISDIDSYVKSLL

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History
Entry version 158 (07 Nov 2018)
Sequence version 3 (01 Nov 1997)
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Protein

Phosphotransferase RcsD

Gene

rcsD

Organism

Escherichia coli (strain K12)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Component of the Rcs signaling system, which controls transcription of numerous genes. RcsD is a phosphotransfer intermediate between the sensor kinase RcsC and the response regulator RcsB. It acquires a phosphoryl group from RcsC and transfers it to RcsB. The system controls expression of genes involved in colanic acid capsule synthesis, biofilm formation and cell division.UniRule annotation5 Publications

Caution

Contains a histidine kinase domain, but it seems to be non-functional as the highly conserved histidine residue is missing.1 Publication

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-UniRule
histidine phosphotransfer kinase activity
Source: EcoCyc
Inferred from mutant phenotypeⁱ
- 11309126
phosphotransferase activity, carboxyl group as acceptor Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

phosphorelay signal transduction system
Source: EcoCyc
Inferred from mutant phenotypeⁱ
- 11309126

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Transferase
Biological process	Two-component regulatory system
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCycⁱ	EcoCyc:EG12385-MONOMER

BioCycⁱ

EcoCyc:EG12385-MONOMER

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Phosphotransferase RcsDUniRule annotation (EC:2.7.2.-UniRule annotation) Alternative name(s): Phosphotransfer intermediate RcsDUniRule annotation
Gene namesⁱ	Name:rcsDUniRule annotation Synonyms:yojN, yojP, yojQ Ordered Locus Names:b2216, JW2204
Organismⁱ	Escherichia coli (strain K12)
Taxonomic identifierⁱ	83333 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › Escherichia coli
Proteomesⁱ	UP000000318 Componentⁱ: Chromosome UP000000625 Componentⁱ: Chromosome

Organism-specific databases

EcoGeneⁱ	EG12385 rcsD

EcoGeneⁱ

EG12385 rcsD

Subcellular locationⁱ

Cell inner membrane
1 Publication
Manual assertion inferred by curator fromⁱ
- Ref.9
  "A novel feature of the multistep phosphorelay in Escherichia coli: a revised model of the RcsC->YojN->RcsB signalling pathway implicated in capsular synthesis and swarming behaviour."
  Takeda S.-H., Fujisawa Y., Matsubara M., Aiba H., Mizuno T.
  Mol. Microbiol. 40:440-450(2001) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, PHOSPHORYLATION AT HIS-842, PHOSPHORELAY, SUBCELLULAR LOCATION, MUTAGENESIS OF HIS-842.
; Multi-pass membrane protein
1 Publication
Manual assertion inferred by curator fromⁱ
- Ref.9
  "A novel feature of the multistep phosphorelay in Escherichia coli: a revised model of the RcsC->YojN->RcsB signalling pathway implicated in capsular synthesis and swarming behaviour."
  Takeda S.-H., Fujisawa Y., Matsubara M., Aiba H., Mizuno T.
  Mol. Microbiol. 40:440-450(2001) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, PHOSPHORYLATION AT HIS-842, PHOSPHORELAY, SUBCELLULAR LOCATION, MUTAGENESIS OF HIS-842.

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 21	CytoplasmicSequence analysisAdd BLAST	21
Transmembraneⁱ	22 – 42	HelicalUniRule annotationAdd BLAST	21
Topological domainⁱ	43 – 308	PeriplasmicSequence analysisAdd BLAST	266
Transmembraneⁱ	309 – 329	HelicalUniRule annotationAdd BLAST	21
Topological domainⁱ	330 – 890	CytoplasmicSequence analysisAdd BLAST	561

GO - Cellular componentⁱ

integral component of plasma membrane
Source: EcoCyc
Inferred from direct assayⁱ
- 11309126
intracellular Source: GOC
plasma membrane
Source: EcoCyc
Inferred from direct assayⁱ
- 17309111

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	842	H → R: Lack of activity. 1 Publication		1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000074916	1 – 890	Phosphotransferase RcsDAdd BLAST		890

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	842	PhosphohistidineUniRule annotation1 Publication		1

Post-translational modificationⁱ

Phosphorylated by RcsC.1 Publication

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	P39838
PRIDEⁱ	P39838

PTM databases

iPTMnetⁱ	P39838

iPTMnetⁱ

P39838

Interactionⁱ

Subunit structureⁱ

Interacts with RcsC and RcsB. Has a higher affinity for RcsB than for RcsC.UniRule annotation1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
rcsB	P0DMC7	5	EBI-556803,EBI-369670

With

Entry

#Exp.

IntAct

Notes

rcsB

P0DMC7

EBI-556803,EBI-369670

Protein-protein interaction databases

BioGridⁱ	4261921, 3 interactors
Database of interacting proteins More...DIPⁱ	DIP-12815N
IntActⁱ	P39838, 4 interactors
STRINGⁱ	316385.ECDH10B_2374

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	690 – 699	Combined sources	10
Helixⁱ	703 – 715	Combined sources	13
Beta strandⁱ	718 – 721	Combined sources	4
Beta strandⁱ	725 – 728	Combined sources	4
Beta strandⁱ	733 – 739	Combined sources	7
Helixⁱ	740 – 742	Combined sources	3
Beta strandⁱ	744 – 750	Combined sources	7
Beta strandⁱ	755 – 761	Combined sources	7
Beta strandⁱ	764 – 767	Combined sources	4
Beta strandⁱ	784 – 787	Combined sources	4
Helixⁱ	801 – 808	Combined sources	8
Helixⁱ	811 – 814	Combined sources	4
Turnⁱ	815 – 817	Combined sources	3
Helixⁱ	818 – 831	Combined sources	14
Helixⁱ	834 – 851	Combined sources	18
Helixⁱ	854 – 868	Combined sources	15
Helixⁱ	872 – 889	Combined sources	18

Show more details

3D structure databases

ProteinModelPortalⁱ	P39838
SMRⁱ	P39838
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P39838

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	803 – 890	HPtUniRule annotationAdd BLAST		88

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	468 – 678	Histidine-like kinaseAdd BLAST		211

Sequence similaritiesⁱ

Belongs to the RcsD family.UniRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG4105E3G Bacteria COG2198 LUCA
HOGENOMⁱ	HOG000122289
KEGG Orthology (KO) More...KOⁱ	K07676

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00075 HATPase_c, 1 hit cd00088 HPT, 1 hit
Gene3Dⁱ	1.20.120.160, 1 hit 3.30.565.10, 1 hit 3.40.50.11620, 1 hit
HAMAPⁱ	MF_00980 RcsD, 1 hit
InterProⁱ	View protein in InterPro IPR003594 HATPase_C IPR036890 HATPase_C_sf IPR005467 His_kinase_dom IPR036641 HPT_dom_sf IPR030861 Ptransferase_RcsD IPR032306 RcsD_ABL IPR038616 RcsD_ABL_sf IPR008207 Sig_transdc_His_kin_Hpt_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02518 HATPase_c, 1 hit PF01627 Hpt, 1 hit PF16359 RcsD_ABL, 1 hit
SMARTⁱ	View protein in SMART SM00387 HATPase_c, 1 hit
SUPFAMⁱ	SSF47226 SSF47226, 1 hit SSF55874 SSF55874, 1 hit
PROSITEⁱ	View protein in PROSITE PS50109 HIS_KIN, 1 hit PS50894 HPT, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P39838-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRQKETTATT RFSLLPGSIT RFFLLLIIVL LVTMGVMVQS AVNAWLKDKS 
        60         70         80         90        100
YQIVDITHAI QKRVDNWRYV TWQIYDNIAA TTSPSSGEGL QETRLKQDVY 
       110        120        130        140        150
YLEKPRRKTE ALIFGSHDNS TLEMTQRMST YLDTLWGAEN VPWSMYYLNG 
       160        170        180        190        200
QDNSLVLIST LPLKDLTSGF KESTVSDIVD SRRAEMLQQA NALDERESFS 
       210        220        230        240        250
NMRRLAWQNG HYFTLRTTFN QPGHLATVVA FDLPINDLIP PGMPLDSFRL 
       260        270        280        290        300
EPDATATGNN DNEKEGTDSV SIHFNSTKIE ISSALNSTDM RLVWQVPYGT 
       310        320        330        340        350
LLLDTLQNIL LPLLLNIGLL ALALFGYTTF RHFSSRSTEN VPSTAVNNEL 
       360        370        380        390        400
RILRAINEEI VSLLPLGLLV HDQESNRTVI SNKIADHLLP HLNLQNITTM 
       410        420        430        440        450
AEQHQGIIQA TINNELYEIR MFRSQVAPRT QIFIIRDQDR EVLVNKKLKQ 
       460        470        480        490        500
AQRLYEKNQQ GRMIFMKNIG DALKEPAQSL AESAAKLNAP ESKQLANQAD 
       510        520        530        540        550
VLVRLVDEIQ LANMLADDSW KSETVLFSVQ DLIDEVVPSV LPAIKRKGLQ 
       560        570        580        590        600
LLINNHLKAH DMRRGDRDAL RRILLLLMQY AVTSTQLGKI TLEVDQDESS 
       610        620        630        640        650
EDRLTFRILD TGEGVSIHEM DNLHFPFINQ TQNDRYGKAD PLAFWLSDQL 
       660        670        680        690        700
ARKLGGHLNI KTRDGLGTRY SVHIKMLAAD PEVEEEEERL LDDVCVMVDV 
       710        720        730        740        750
TSAEIRNIVT RQLENWGATC ITPDERLISQ DYDIFLTDNP SNLTASGLLL 
       760        770        780        790        800
SDDESGVREI GPGQLCVNFN MSNAMQEAVL QLIEVQLAQE EVTESPLGGD 
       810        820        830        840        850
ENAQLHASGY YALFVDTVPD DVKRLYTEAA TSDFAALAQT AHRLKGVFAM 
       860        870        880        890
LNLVPGKQLC ETLEHLIREK DVPGIEKYIS DIDSYVKSLL

Length:890

Mass (Da):100,372

Last modified:November 1, 1997 - v3

Checksum:ⁱAE26E2E70E363830

Sequence cautionⁱ

The sequence AAA81025 differs from that shown. Reason: Frameshift at positions 145 and 488.Curated

The sequence AAA81026 differs from that shown. Reason: Frameshift at positions 145 and 488.Curated

The sequence AAA81027 differs from that shown. Reason: Frameshift at positions 145 and 488.Curated

The sequence M28242 differs from that shown. Reason: Frameshift at positions 597 and 702.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	61	Q → L in AAA81025 (Ref. 4) Curated	1
Sequence conflictⁱ	164	K → E in AAA81026 (Ref. 4) Curated	1
Sequence conflictⁱ	174	T → A in AAA81026 (Ref. 4) Curated	1
Sequence conflictⁱ	176	S → N in AAA81026 (Ref. 4) Curated	1
Sequence conflictⁱ	179	V → G in AAA81026 (Ref. 4) Curated	1
Sequence conflictⁱ	184	A → T in AAA81026 (Ref. 4) Curated	1
Sequence conflictⁱ	267	T → A in AAA81026 (Ref. 4) Curated	1
Sequence conflictⁱ	598 – 599	ES → DA in M28242 (PubMed:2404948).Curated	2

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U00096 Genomic DNA Translation: AAC75276.1 AP009048 Genomic DNA Translation: BAA15999.1 U38659 Genomic DNA Translation: AAA81025.1 Frameshift. U38659 Genomic DNA Translation: AAA81026.1 Frameshift. U38659 Genomic DNA Translation: AAA81027.1 Frameshift. M28242 Genomic DNA No translation available.
PIRⁱ	F64991
NCBI Reference Sequences More...RefSeqⁱ	NP_416720.1, NC_000913.3 WP_001249081.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaⁱ	AAC75276; AAC75276; b2216 BAA15999; BAA15999; BAA15999
GeneIDⁱ	946717
KEGGⁱ	ecj:JW2204 eco:b2216
PATRICⁱ	fig\|1411691.4.peg.19

Protein	Similar proteins		Species	Score	Length	Source
P39838	Phosphotransferase RcsD		Shigella sp.		890	UniRef100_P39838
Phosphotransferase RcsD		Klebsiella pneumoniae IS22		890
Phosphotransferase RcsD		ECOLX		890
Phosphotransferase RcsD		SHIBO		890
Phosphotransferase RcsD		SHIDY		890
+21

Protein	Similar proteins		Species	Score	Length	Source
P39838	Phosphotransferase RcsD		Shigella sp.		890	UniRef90_P39838
Phosphotransferase RcsD		Klebsiella pneumoniae IS22		890
Phosphotransferase RcsD		ECOLX		890
Phosphotransferase RcsD		SHIBO		890
Phosphotransferase RcsD		SHIDY		890
+1076

Protein	Similar proteins		Species	Score	Length	Source
P39838	Phosphotransferase RcsD		Shigella sp.		890	UniRef50_P39838
Phosphotransferase RcsD		Klebsiella pneumoniae IS22		890
Phosphotransferase RcsD		ECOLX		890
Phosphotransferase RcsD		SHIBO		890
Phosphotransferase RcsD		SHIDY		890
+2588

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U00096 Genomic DNA Translation: AAC75276.1 AP009048 Genomic DNA Translation: BAA15999.1 U38659 Genomic DNA Translation: AAA81025.1 Frameshift. U38659 Genomic DNA Translation: AAA81026.1 Frameshift. U38659 Genomic DNA Translation: AAA81027.1 Frameshift. M28242 Genomic DNA No translation available.
PIRⁱ	F64991
RefSeqⁱ	NP_416720.1, NC_000913.3 WP_001249081.1, NZ_LN832404.1

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1SR2	NMR	-	A	775-890	[»]
	2KX7	NMR	-	A	688-795	[»]
ProteinModelPortalⁱ	P39838
SMRⁱ	P39838
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	4261921, 3 interactors
DIPⁱ	DIP-12815N
IntActⁱ	P39838, 4 interactors
STRINGⁱ	316385.ECDH10B_2374

PTM databases

iPTMnetⁱ	P39838

iPTMnetⁱ

P39838

Proteomic databases

PaxDbⁱ	P39838
PRIDEⁱ	P39838

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAC75276; AAC75276; b2216 BAA15999; BAA15999; BAA15999
GeneIDⁱ	946717
KEGGⁱ	ecj:JW2204 eco:b2216
PATRICⁱ	fig\|1411691.4.peg.19

Organism-specific databases

EchoBASEⁱ	EB2286
EcoGeneⁱ	EG12385 rcsD

Phylogenomic databases

eggNOGⁱ	ENOG4105E3G Bacteria COG2198 LUCA
HOGENOMⁱ	HOG000122289
KOⁱ	K07676

Enzyme and pathway databases

BioCycⁱ	EcoCyc:EG12385-MONOMER

BioCycⁱ

EcoCyc:EG12385-MONOMER

Miscellaneous databases

EvolutionaryTraceⁱ	P39838
Protein Ontology More...PROⁱ	PR:P39838

Family and domain databases

CDDⁱ	cd00075 HATPase_c, 1 hit cd00088 HPT, 1 hit
Gene3Dⁱ	1.20.120.160, 1 hit 3.30.565.10, 1 hit 3.40.50.11620, 1 hit
HAMAPⁱ	MF_00980 RcsD, 1 hit
InterProⁱ	View protein in InterPro IPR003594 HATPase_C IPR036890 HATPase_C_sf IPR005467 His_kinase_dom IPR036641 HPT_dom_sf IPR030861 Ptransferase_RcsD IPR032306 RcsD_ABL IPR038616 RcsD_ABL_sf IPR008207 Sig_transdc_His_kin_Hpt_dom
Pfamⁱ	View protein in Pfam PF02518 HATPase_c, 1 hit PF01627 Hpt, 1 hit PF16359 RcsD_ABL, 1 hit
SMARTⁱ	View protein in SMART SM00387 HATPase_c, 1 hit
SUPFAMⁱ	SSF47226 SSF47226, 1 hit SSF55874 SSF55874, 1 hit
PROSITEⁱ	View protein in PROSITE PS50109 HIS_KIN, 1 hit PS50894 HPT, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RCSD_ECOLI
Accessionⁱ	P39838Primary (citable) accession number: P39838 Secondary accession number(s): P47725, P47726, P76456
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
	Last sequence update:	November 1, 1997
	Last modified:	November 7, 2018
	This is version 158 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Escherichia coli
Escherichia coli (strain K12): entries and cross-references to EcoGene

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Supporting data

UniProtKB - P39838 (RCSD_ECOLI)

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Phosphotransferase RcsD

rcsD

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

GO - Cellular componenti

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ