UniProtKB - P39835 (GNTT_ECOLI)
Protein
High-affinity gluconate transporter
Gene
gntT
Organism
Escherichia coli (strain K12)
Status
Functioni
Part of the gluconate utilization system Gnt-I; high-affinity intake of gluconate.
: D-gluconate degradation Pathwayi
This protein is involved in the pathway D-gluconate degradation, which is part of Carbohydrate acid metabolism.View all proteins of this organism that are known to be involved in the pathway D-gluconate degradation and in Carbohydrate acid metabolism.
GO - Molecular functioni
- gluconate transmembrane transporter activity Source: EcoliWiki
GO - Biological processi
- D-gluconate catabolic process Source: UniProtKB-UniPathway
- gluconate transmembrane transport Source: EcoliWiki
Keywordsi
Biological process | Gluconate utilization, Sugar transport, Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:GNTT-MONOMER MetaCyc:GNTT-MONOMER |
UniPathwayi | UPA00792 |
Protein family/group databases
TCDBi | 2.A.8.1.4, the gluconate:h(+) symporter (gntp) family |
Names & Taxonomyi
Protein namesi | Recommended name: High-affinity gluconate transporterAlternative name(s): Gluconate permease Gnt-I system |
Gene namesi | Name:gntT Synonyms:gntM, usgA, yhgC Ordered Locus Names:b3415, JW5690 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
- Cell inner membrane 1 Publication; Multi-pass membrane protein 1 Publication
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 2 – 22 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 23 – 43 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 52 – 72 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 108 – 128 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 134 – 154 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 174 – 194 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 222 – 242 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 258 – 278 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 292 – 312 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 327 – 347 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 349 – 369 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 370 – 390 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 418 – 438 | HelicalSequence analysisAdd BLAST | 21 |
GO - Cellular componenti
- integral component of plasma membrane Source: GO_Central
- membrane Source: EcoCyc
- plasma membrane Source: EcoCyc
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000061934 | 1 – 438 | High-affinity gluconate transporterAdd BLAST | 438 |
Proteomic databases
PaxDbi | P39835 |
PRIDEi | P39835 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4261217, 20 interactors |
STRINGi | 511145.b3415 |
Family & Domainsi
Sequence similaritiesi
Belongs to the GntP permease family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG2610, Bacteria |
HOGENOMi | CLU_027949_0_0_6 |
InParanoidi | P39835 |
PhylomeDBi | P39835 |
Family and domain databases
InterProi | View protein in InterPro IPR003474, Glcn_transporter |
PANTHERi | PTHR30354, PTHR30354, 1 hit |
Pfami | View protein in Pfam PF02447, GntP_permease, 1 hit |
PIRSFi | PIRSF002746, Gluconate_transporter, 1 hit |
TIGRFAMsi | TIGR00791, gntP, 1 hit |
i Sequence
Sequence statusi: Complete.
P39835-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPLVIVAIGV ILLLLLMIRF KMNGFIALVL VALAVGLMQG MPLDKVIGSI
60 70 80 90 100
KAGVGGTLGS LALIMGFGAM LGKMLADCGG AQRIATTLIA KFGKKHIQWA
110 120 130 140 150
VVLTGFTVGF ALFYEVGFVL MLPLVFTIAA SANIPLLYVG VPMAAALSVT
160 170 180 190 200
HGFLPPHPGP TAIATIFNAD MGKTLLYGTI LAIPTVILAG PVYARVLKGI
210 220 230 240 250
DKPIPEGLYS AKTFSEEEMP SFGVSVWTSL VPVVLMAMRA IAEMILPKGH
260 270 280 290 300
AFLPVAEFLG DPVMATLIAV LIAMFTFGLN RGRSMDQIND TLVSSIKIIA
310 320 330 340 350
MMLLIIGGGG AFKQVLVDSG VDKYIASMMH ETNISPLLMA WSIAAVLRIA
360 370 380 390 400
LGSATVAAIT AGGIAAPLIA TTGVSPELMV IAVGSGSVIF SHVNDPGFWL
410 420 430
FKEYFNLTIG ETIKSWSMLE TIISVCGLVG CLLLNMVI
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 55 – 58 | GGTL → ADV in AAA58213 (PubMed:8987614).Curated | 4 | |
Sequence conflicti | 385 | S → A (PubMed:2845225).Curated | 1 | |
Sequence conflicti | 420 – 421 | ET → VS (PubMed:2845225).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18997 Genomic DNA Translation: AAA58213.1 U00096 Genomic DNA Translation: AAT48179.1 AP009048 Genomic DNA Translation: BAE77876.1 M32793 Genomic DNA No translation available. |
PIRi | JC4988 |
RefSeqi | WP_001131758.1, NZ_STEB01000004.1 YP_026217.1, NC_000913.3 |
Genome annotation databases
EnsemblBacteriai | AAT48179; AAT48179; b3415 BAE77876; BAE77876; BAE77876 |
GeneIDi | 49582630 947924 |
KEGGi | ecj:JW5690 eco:b3415 |
PATRICi | fig|1411691.4.peg.3313 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18997 Genomic DNA Translation: AAA58213.1 U00096 Genomic DNA Translation: AAT48179.1 AP009048 Genomic DNA Translation: BAE77876.1 M32793 Genomic DNA No translation available. |
PIRi | JC4988 |
RefSeqi | WP_001131758.1, NZ_STEB01000004.1 YP_026217.1, NC_000913.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4261217, 20 interactors |
STRINGi | 511145.b3415 |
Protein family/group databases
TCDBi | 2.A.8.1.4, the gluconate:h(+) symporter (gntp) family |
Proteomic databases
PaxDbi | P39835 |
PRIDEi | P39835 |
Protocols and materials databases
DNASUi | 947924 |
Genome annotation databases
EnsemblBacteriai | AAT48179; AAT48179; b3415 BAE77876; BAE77876; BAE77876 |
GeneIDi | 49582630 947924 |
KEGGi | ecj:JW5690 eco:b3415 |
PATRICi | fig|1411691.4.peg.3313 |
Organism-specific databases
EchoBASEi | EB2282 |
Phylogenomic databases
eggNOGi | COG2610, Bacteria |
HOGENOMi | CLU_027949_0_0_6 |
InParanoidi | P39835 |
PhylomeDBi | P39835 |
Enzyme and pathway databases
UniPathwayi | UPA00792 |
BioCyci | EcoCyc:GNTT-MONOMER MetaCyc:GNTT-MONOMER |
Miscellaneous databases
PROi | PR:P39835 |
Family and domain databases
InterProi | View protein in InterPro IPR003474, Glcn_transporter |
PANTHERi | PTHR30354, PTHR30354, 1 hit |
Pfami | View protein in Pfam PF02447, GntP_permease, 1 hit |
PIRSFi | PIRSF002746, Gluconate_transporter, 1 hit |
TIGRFAMsi | TIGR00791, gntP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GNTT_ECOLI | |
Accessioni | P39835Primary (citable) accession number: P39835 Secondary accession number(s): Q2M780, Q6BF35 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | October 11, 2004 | |
Last modified: | December 2, 2020 | |
This is version 148 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families