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Entry version 132 (07 Apr 2021)
Sequence version 2 (30 May 2000)
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Protein

Trehalose-6-phosphate hydrolase

Gene

treA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Hydrolyzes trehalose-6-phosphate to glucose and glucose 6-phosphate. Can also very effectively hydrolyzes p-nitrophenyl-alpha-D-glucopyranoside, but not lactose, maltose, sucrose or sucrose-6-phosphate. Trehalose is also hydrolyzed, but to a much smaller extent than trehalose-6-phosphate.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activity is stimulated by high salt concentrations with different efficiencies depending on the kind of salt. In vitro, inhibited by glucose.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>pH dependencei

Optimum pH is 4.5.1 Publication

Temperature dependencei

Optimum temperature is 37 degrees Celsius.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei203NucleophileBy similarity1
Active sitei254Proton donorBy similarity1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei329Transition state stabilizerBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidase, Hydrolase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
BSUB:BSU07810-MONOMER
MetaCyc:MONOMER-5946

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GH13, Glycoside Hydrolase Family 13

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Trehalose-6-phosphate hydrolaseCurated (EC:3.2.1.932 Publications)
Alternative name(s):
Alpha,alpha-phosphotrehalase
Phospho-alpha-(1-1)-glucosidase1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:treA1 Publication
Synonyms:treC
Ordered Locus Names:BSU07810
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBacillus subtilis (strain 168)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri224308 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001570 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000543201 – 561Trehalose-6-phosphate hydrolaseAdd BLAST561

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P39795

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P39795

PRoteomics IDEntifications database

More...
PRIDEi
P39795

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced by trehalose and repressed by glucose, fructose or mannitol.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
224308.BSU07810

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P39795

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 13 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0366, Bacteria

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P39795

Identification of Orthologs from Complete Genome Data

More...
OMAi
WQAGPMY

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P39795

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.1180, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006047, Glyco_hydro_13_cat_dom
IPR013780, Glyco_hydro_b
IPR017853, Glycoside_hydrolase_SF
IPR032091, Malt_amylase_C
IPR012769, Trehalose_TreC

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00128, Alpha-amylase, 1 hit
PF16657, Malt_amylase_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00642, Aamy, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51445, SSF51445, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02403, trehalose_treC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P39795-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKTEQTPWWK KAVVYQIYPK SFNDTTGNGV GDLNGIIEKL DYLKTLQVDV
60 70 80 90 100
LWLTPIYDSP QHDNGYDIRD YYSIYPEYGT MEDFERLVSE AHKRDLKVVM
110 120 130 140 150
DLVVNHTSTE HKWFREAISS IDSPYRDFYI WKKPQENGSV PTNWESKFGG
160 170 180 190 200
SAWELDEASG QYYLHLFDVT QADLNWENEE VRKHVYDMMH FWFEKGIDGF
210 220 230 240 250
RLDVINLISK DQRFPNAEEG DGRSFYTDGP RVHEFLHEMN EKVFSHYDSM
260 270 280 290 300
TVGEMSSTTV DHCIRYTNPD NKELDMTFSF HHLKVDYPNG EKWALAPFDF
310 320 330 340 350
LKLKEILSDW QTGMHAGGGW NALFWCNHDQ PRVVSRYGDD GAYRVKSAKM
360 370 380 390 400
LATAIHMMQG TPYIYQGEEL GMTNPKFTDI SSYRDVESLN MYHAFKEKGM
410 420 430 440 450
ADQDITAILQ AKSRDNSRTP VQWDATENGG FTTGTPWIPV AGNYREINAE
460 470 480 490 500
AALRDQNSVF YHYQKLIQIR KMYDIVTEGT YEIIAKDDPN IFAYLRHGSN
510 520 530 540 550
EKLLVINNFY GTEAAFTLPD SLAPDEWKAE VLLTNDEARE GLQNMTLRPY
560
ESIVYRLTKP C
Length:561
Mass (Da):65,184
Last modified:May 30, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i12C0AC7F069139A5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti114 – 123FREAISSIDS → LRGDLFNRQ in CAA91015 (PubMed:7651129).Curated10
Sequence conflicti196G → E in CAA91015 (PubMed:7651129).Curated1
Sequence conflicti196G → E in CAA56495 (PubMed:7651129).Curated1
Sequence conflicti288 – 290PNG → LTA in CAA91015 (PubMed:7651129).Curated3
Sequence conflicti288 – 290PNG → LTA in CAA56495 (PubMed:7651129).Curated3
Sequence conflicti386V → A in CAA91015 (PubMed:7651129).Curated1
Sequence conflicti386V → A in CAA56495 (PubMed:7651129).Curated1
Sequence conflicti547 – 561LRPYE…LTKPC → VAHMSPLFIV (PubMed:7651129).CuratedAdd BLAST15

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z54245 Genomic DNA Translation: CAA91015.1
X80203 Genomic DNA Translation: CAA56495.1
D83967 Genomic DNA Translation: BAA23408.1
AL009126 Genomic DNA Translation: CAB12610.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B69725

NCBI Reference Sequences

More...
RefSeqi
NP_388662.1, NC_000964.3
WP_003244272.1, NZ_JNCM01000032.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CAB12610; CAB12610; BSU_07810

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
939690

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bsu:BSU07810

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|224308.179.peg.845

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z54245 Genomic DNA Translation: CAA91015.1
X80203 Genomic DNA Translation: CAA56495.1
D83967 Genomic DNA Translation: BAA23408.1
AL009126 Genomic DNA Translation: CAB12610.1
PIRiB69725
RefSeqiNP_388662.1, NC_000964.3
WP_003244272.1, NZ_JNCM01000032.1

3D structure databases

SMRiP39795
ModBaseiSearch...

Protein-protein interaction databases

STRINGi224308.BSU07810

Protein family/group databases

CAZyiGH13, Glycoside Hydrolase Family 13

Proteomic databases

jPOSTiP39795
PaxDbiP39795
PRIDEiP39795

Genome annotation databases

EnsemblBacteriaiCAB12610; CAB12610; BSU_07810
GeneIDi939690
KEGGibsu:BSU07810
PATRICifig|224308.179.peg.845

Phylogenomic databases

eggNOGiCOG0366, Bacteria
InParanoidiP39795
OMAiWQAGPMY
PhylomeDBiP39795

Enzyme and pathway databases

BioCyciBSUB:BSU07810-MONOMER
MetaCyc:MONOMER-5946

Family and domain databases

Gene3Di2.60.40.1180, 1 hit
InterProiView protein in InterPro
IPR006047, Glyco_hydro_13_cat_dom
IPR013780, Glyco_hydro_b
IPR017853, Glycoside_hydrolase_SF
IPR032091, Malt_amylase_C
IPR012769, Trehalose_TreC
PfamiView protein in Pfam
PF00128, Alpha-amylase, 1 hit
PF16657, Malt_amylase_C, 1 hit
SMARTiView protein in SMART
SM00642, Aamy, 1 hit
SUPFAMiSSF51445, SSF51445, 1 hit
TIGRFAMsiTIGR02403, trehalose_treC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTREC_BACSU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P39795
Secondary accession number(s): O34517
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: May 30, 2000
Last modified: April 7, 2021
This is version 132 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
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