UniProtKB - P39779 (CODY_BACSU)
Protein
GTP-sensing transcriptional pleiotropic repressor CodY
Gene
codY
Organism
Bacillus subtilis (strain 168)
Status
Functioni
DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase and sporulation. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor.2 Publications
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 202 – 221 | H-T-H motifSequence analysisAdd BLAST | 20 |
GO - Molecular functioni
- DNA-binding transcription repressor activity Source: CollecTF
- GTP binding Source: UniProtKB-UniRule
- transcription regulatory region sequence-specific DNA binding Source: CollecTF
GO - Biological processi
- regulation of transcription, DNA-templated Source: CACAO
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | BSUB:BSU16170-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: GTP-sensing transcriptional pleiotropic repressor CodYAlternative name(s): Vegetative protein 286B Short name: VEG286B |
Gene namesi | Name:codY Ordered Locus Names:BSU16170 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
Subcellular locationi
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
- protein-DNA complex Source: CollecTF
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000213221 | 2 – 259 | GTP-sensing transcriptional pleiotropic repressor CodYAdd BLAST | 258 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 215 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | P39779 |
PaxDbi | P39779 |
PRIDEi | P39779 |
PTM databases
iPTMneti | P39779 |
Interactioni
Binary interactionsi
Hide detailsProtein-protein interaction databases
IntActi | P39779, 2 interactors |
MINTi | P39779 |
STRINGi | 224308.BSU16170 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P39779 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P39779 |
Family & Domainsi
Sequence similaritiesi
Belongs to the CodY family.Curated
Phylogenomic databases
eggNOGi | COG4465, Bacteria |
OMAi | FPEEYNE |
PhylomeDBi | P39779 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 3.30.450.40, 1 hit |
HAMAPi | MF_00621, HTH_type_CodY, 1 hit |
InterProi | View protein in InterPro IPR014154, CodY IPR029016, GAF-like_dom_sf IPR010312, GTP_sensing_CodY_N IPR013198, GTP_sensing_HTH_CodY_C IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR40062, PTHR40062, 1 hit |
Pfami | View protein in Pfam PF06018, CodY, 1 hit PF08222, HTH_CodY, 1 hit |
PIRSFi | PIRSF011572, GTP_sensing_CodY, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
TIGRFAMsi | TIGR02787, codY_Gpos, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P39779-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALLQKTRII NSMLQAAAGK PVNFKEMAET LRDVIDSNIF VVSRRGKLLG
60 70 80 90 100
YSINQQIEND RMKKMLEDRQ FPEEYTKNLF NVPETSSNLD INSEYTAFPV
110 120 130 140 150
ENRDLFQAGL TTIVPIIGGG ERLGTLILSR LQDQFNDDDL ILAEYGATVV
160 170 180 190 200
GMEILREKAE EIEEEARSKA VVQMAISSLS YSELEAIEHI FEELDGNEGL
210 220 230 240 250
LVASKIADRV GITRSVIVNA LRKLESAGVI ESRSLGMKGT YIKVLNNKFL
IELENLKSH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U13634 Genomic DNA Translation: AAB03372.1 AL009126 Genomic DNA Translation: CAB13490.1 |
PIRi | S61496 |
RefSeqi | NP_389499.1, NC_000964.3 WP_003220850.1, NZ_JNCM01000035.1 |
Genome annotation databases
EnsemblBacteriai | CAB13490; CAB13490; BSU16170 |
GeneIDi | 50133528 936491 |
KEGGi | bsu:BSU16170 |
PATRICi | fig|224308.179.peg.1757 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U13634 Genomic DNA Translation: AAB03372.1 AL009126 Genomic DNA Translation: CAB13490.1 |
PIRi | S61496 |
RefSeqi | NP_389499.1, NC_000964.3 WP_003220850.1, NZ_JNCM01000035.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2B0L | X-ray | 2.90 | A/B/C | 168-259 | [»] | |
2B18 | X-ray | 1.80 | A | 1-155 | [»] | |
2GX5 | X-ray | 1.74 | A/B/C/D | 2-160 | [»] | |
2HGV | X-ray | 2.30 | A | 1-155 | [»] | |
5LNH | X-ray | 3.00 | A/B/C/D/E/F/G/H/I/K | 2-259 | [»] | |
5LOE | X-ray | 3.00 | A/B/C/D | 1-259 | [»] | |
5LOJ | X-ray | 3.71 | A/B | 2-259 | [»] | |
5LOO | X-ray | 4.50 | A/B/C/D/E/F/G/H/I/J/K/L/M/N | 2-259 | [»] | |
SMRi | P39779 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | P39779, 2 interactors |
MINTi | P39779 |
STRINGi | 224308.BSU16170 |
PTM databases
iPTMneti | P39779 |
Proteomic databases
jPOSTi | P39779 |
PaxDbi | P39779 |
PRIDEi | P39779 |
Genome annotation databases
EnsemblBacteriai | CAB13490; CAB13490; BSU16170 |
GeneIDi | 50133528 936491 |
KEGGi | bsu:BSU16170 |
PATRICi | fig|224308.179.peg.1757 |
Phylogenomic databases
eggNOGi | COG4465, Bacteria |
OMAi | FPEEYNE |
PhylomeDBi | P39779 |
Enzyme and pathway databases
BioCyci | BSUB:BSU16170-MONOMER |
Miscellaneous databases
EvolutionaryTracei | P39779 |
PROi | PR:P39779 |
Gene expression databases
CollecTFi | EXPREG_00000a80 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 3.30.450.40, 1 hit |
HAMAPi | MF_00621, HTH_type_CodY, 1 hit |
InterProi | View protein in InterPro IPR014154, CodY IPR029016, GAF-like_dom_sf IPR010312, GTP_sensing_CodY_N IPR013198, GTP_sensing_HTH_CodY_C IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR40062, PTHR40062, 1 hit |
Pfami | View protein in Pfam PF06018, CodY, 1 hit PF08222, HTH_CodY, 1 hit |
PIRSFi | PIRSF011572, GTP_sensing_CodY, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
TIGRFAMsi | TIGR02787, codY_Gpos, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CODY_BACSU | |
Accessioni | P39779Primary (citable) accession number: P39779 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 10, 2021 | |
This is version 159 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families