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UniProtKB - P39769 (PHP_DROME)

Entry version 188 (23 Feb 2022)
Sequence version 2 (16 Jan 2004)
Previous versions | rss
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Protein

Polyhomeotic-proximal chromatin protein

Gene

ph-p

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Component of the PcG multiprotein PRC1 complex, a complex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-118', rendering chromatin heritably changed in its expressibility. Plays a role in regulating the expression of other pair-rule genes such as eve, ftz, and H.

1 Publication

Caution

It is uncertain whether Met-1 or Met-9 is the initiator.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1365ZincPROSITE-ProRule annotation1
Metal bindingi1368ZincPROSITE-ProRule annotation1
Metal bindingi1383ZincPROSITE-ProRule annotation1
Metal bindingi1387ZincPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1356 – 1389FCS-typePROSITE-ProRule annotationAdd BLAST34

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DME-2559580, Oxidative Stress Induced Senescence
R-DME-3108214, SUMOylation of DNA damage response and repair proteins
R-DME-3899300, SUMOylation of transcription cofactors
R-DME-4570464, SUMOylation of RNA binding proteins
R-DME-8939243, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-DME-8943724, Regulation of PTEN gene transcription
R-DME-8953750, Transcriptional Regulation by E2F6

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P39769

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Polyhomeotic-proximal chromatin protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ph-p
ORF Names:CG18412
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0004861, ph-p

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		VectorBase:FBgn0004861

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1513W → A: Significant loss of Scm-binding activity. 1 Publication1
Mutagenesisi1545L → A: Little effect on Scm-binding activity. 1 Publication1
Mutagenesisi1553L → A: Little effect on Scm-binding activity. 1 Publication1
Mutagenesisi1562G → A: Significant loss of Scm-binding activity. 1 Publication1
Mutagenesisi1574I → D: Little effect on Scm-binding activity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000584061 – 1589Polyhomeotic-proximal chromatin proteinAdd BLAST1589

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1145Phosphoserine1 Publication1
Modified residuei1148Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P39769

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P39769

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Salivary glands.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0004861, Expressed in wing disc (Drosophila) and 40 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P39769, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P39769, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of PRC1 complex, which contains many PcG proteins like Pc, ph, Scm, Psc, Sce and also chromatin-remodeling proteins such as histone deacetylases. This complex is distinct from the Esc/E(z) complex, at least composed of esc, E(z), Su(z)12, HDAC1/Rpd3 and Caf1-55. The 2 complexes however cooperate and interact together during the first 3 hours of development to establish PcG silencing.

Interacts with the SAM domain of Scm via its SAM domain in vitro.

Interacts with Trl in vivo and with corto in vitro.

6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		57724, 63 interactors

Database of interacting proteins

More...DIPi		DIP-19426N

Protein interaction database and analysis system

More...IntActi		P39769, 10 interactors

Molecular INTeraction database

More...MINTi		P39769

STRING: functional protein association networks

More...STRINGi		7227.FBpp0070416

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11589
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P39769

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P39769

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1513 – 1577SAMPROSITE-ProRule annotationAdd BLAST65

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 85DisorderedSequence analysisAdd BLAST85
Regioni107 – 174DisorderedSequence analysisAdd BLAST68
Regioni252 – 290DisorderedSequence analysisAdd BLAST39
Regioni1112 – 1244DisorderedSequence analysisAdd BLAST133
Regioni1260 – 1294DisorderedSequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi15 – 35Polar residuesSequence analysisAdd BLAST21
Compositional biasi59 – 84Polar residuesSequence analysisAdd BLAST26
Compositional biasi117 – 174Polar residuesSequence analysisAdd BLAST58
Compositional biasi272 – 290Polar residuesSequence analysisAdd BLAST19
Compositional biasi1112 – 1135Polar residuesSequence analysisAdd BLAST24
Compositional biasi1150 – 1223Polar residuesSequence analysisAdd BLAST74

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1356 – 1389FCS-typePROSITE-ProRule annotationAdd BLAST34

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QS5Q, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154964

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P39769

Identification of Orthologs from Complete Genome Data

More...OMAi		YAAIQVK

Database for complete collections of gene phylogenies

More...PhylomeDBi		P39769

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.150.50, 1 hit
3.30.60.160, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001660, SAM
IPR013761, SAM/pointed_sf
IPR012313, Znf_FCS
IPR038603, Znf_FCS_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00536, SAM_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00454, SAM, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47769, SSF47769, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50105, SAM_DOMAIN, 1 hit
PS51024, ZF_FCS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P39769-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDRRALKFMQ KRADTESDTT TPVSTTASQG ISASAILAGG TLPLKDNSNI 
        60         70         80         90        100
REKPLHHNYN HNNNNSSQHS HSHQQQQQQQ VGGKQLERPL KCLETLAQKA 
       110        120        130        140        150
GITFDEKYDV ASPPHPGIAQ QQATSGTGPA TGSGSVTPTS HRHGTPPTGR 
       160        170        180        190        200
RQTHTPSTPN RPSAPSTPNT NCNSIARHTS LTLEKAQNPG QQVAATTTVP 
       210        220        230        240        250
LQISPEQLQQ FYASNPYAIQ VKQEFPTHTT SGSGTELKHA TNIMEVQQQL 
       260        270        280        290        300
QLQQQLSEAN GGGAASAGAG GAASPANSQQ SQQQQHSTAI STMSPMQLAA 
       310        320        330        340        350
ATGGVGGDWT QGRTVQLMQP STSFLYPQMI VSGNLLHPGG LGQQPIQVIT 
       360        370        380        390        400
AGKPFQGNGP QMLTTTTQNA KQMIGGQAGF AGGNYATCIP TNHNQSPQTV 
       410        420        430        440        450
LFSPMNVISP QQQQNLLQSM AAAAQQQQLT QQQQQFNQQQ QQQLTQQQQQ 
       460        470        480        490        500
LTAALAKVGV DAQGKLAQKV VQKVTTTSSA VQAATGPGST GSTQTQQVQQ 
       510        520        530        540        550
VQQQQQQTTQ TTQQCVQVSQ STLPVGVGGQ SVQTAQLLNA GQAQQMQIPW 
       560        570        580        590        600
FLQNAAGLQP FGPNQIILRN QPDGTQGMFI QQQPATQTLQ TQQNQIIQCN 
       610        620        630        640        650
VTQTPTKART QLDALAPKQQ QQQQQVGTTN QTQQQQLAVA TAQLQQQQQQ 
       660        670        680        690        700
LTAAALQRPG APVMPHNGTQ VRPASSVSTQ TAQNQSLLKA KMRNKQQPVR 
       710        720        730        740        750
PALATLKTEI GQVAGQNKVV GHLTTVQQQQ QATNLQQVVN AAGNKMVVMS 
       760        770        780        790        800
TTGTPITLQN GQTLHAATAA GVDKQQQQLQ LFQKQQILQQ QQMLQQQIAA 
       810        820        830        840        850
IQMQQQQAAV QAQQQQQQQV SQQQQVNAQQ QQAVAQQQQA VAQAQQQQRE 
       860        870        880        890        900
QQQQVAQAQA QHQQALANAT QQILQVAPNQ FITSHQQQQQ QQLHNQLIQQ 
       910        920        930        940        950
QLQQQAQAQV QAQVQAQAQQ QQQQREQQQN IIQQIVVQQS GATSQQTSQQ 
       960        970        980        990       1000
QQHHQSGQLQ LSSVPFSVSS STTPAGIATS SALQAALSAS GAIFQTAKPG 
      1010       1020       1030       1040       1050
TCSSSSPTSS VVTITNQSST PLVTSSTVAS IQQAQTQSAQ VHQHQQLISA 
      1060       1070       1080       1090       1100
TIAGGTQQQP QGPPSLTPTT NPILAMTSMM NATVGHLSTA PPVTVSVTST 
      1110       1120       1130       1140       1150
AVTSSPGQLV LLSTASSGGG GSIPATPTKE TPSKGPTATL VPIGSPKTPV 
      1160       1170       1180       1190       1200
SGKDTCTTPK SSTPATVSAS VEASSSTGEA LSNGDASDRS STPSKGATTP 
      1210       1220       1230       1240       1250
TSKQSNAAVQ PPSSTTPNSV SGKEEPKLAT CGSLTSATST STTTTITNGI 
      1260       1270       1280       1290       1300
GVARTTASTA VSTASTTTTS SGTFITSCTS TTTTTTSSIS NGSKDLPKAM 
      1310       1320       1330       1340       1350
IKPNVLTHVI DGFIIQEANE PFPVTRQRYA DKDVSDEPPK KKATMQEDIK 
      1360       1370       1380       1390       1400
LSGIASAPGS DMVACEQCGK MEHKAKLKRK RYCSPGCSRQ AKNGIGGVGS 
      1410       1420       1430       1440       1450
GETNGLGTGG IVGVDAMALV DRLDEAMAEE KMQTEATPKL SESFPILGAS 
      1460       1470       1480       1490       1500
TEVPPMSLPV QAAISAPSPL AMPLGSPLSV ALPTLAPLSV VTSGAAPKSS 
      1510       1520       1530       1540       1550
EVNGTDRPPI SSWSVDDVSN FIRELPGCQD YVDDFIQQEI DGQALLLLKE 
      1560       1570       1580 
KHLVNAMGMK LGPALKIVAK VESIKEVPPP GEAKDPGAQ
Length:1,589
Mass (Da):167,281
Last modified:January 16, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCF9B543DDBC79FBC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5U0W8Q5U0W8_DROME
LD01444p
ph-p CG18414, Dmel\CG18412, dPh, EG:87B1.5, PH
1,346Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti253Missing (PubMed:1937015).Curated1
Sequence conflicti1011V → A in CAB10975 (PubMed:10731137).Curated1
Sequence conflicti1193P → L in CAA45211 (PubMed:1346609).Curated1
Sequence conflicti1275I → T in CAB10975 (PubMed:10731137).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M64750 Genomic DNA No translation available.
X63672 mRNA Translation: CAA45211.1
AE014298 Genomic DNA Translation: AAF45727.3
Z98269 Genomic DNA Translation: CAB10975.1

Protein sequence database of the Protein Information Resource

More...PIRi		T13606

NCBI Reference Sequences

More...RefSeqi		NP_476871.2, NM_057523.5

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0070432; FBpp0070416; FBgn0004861

Database of genes from NCBI RefSeq genomes

More...GeneIDi		31181

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG18412

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64750 Genomic DNA No translation available.
X63672 mRNA Translation: CAA45211.1
AE014298 Genomic DNA Translation: AAF45727.3
Z98269 Genomic DNA Translation: CAB10975.1
PIRiT13606
RefSeqiNP_476871.2, NM_057523.5

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KW4X-ray1.75A1502-1577[»]
1PK1X-ray1.80A/C1502-1577[»]
SMRiP39769
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi57724, 63 interactors
DIPiDIP-19426N
IntActiP39769, 10 interactors
MINTiP39769
STRINGi7227.FBpp0070416

PTM databases

iPTMnetiP39769

Proteomic databases

PaxDbiP39769

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		31181

Genome annotation databases

EnsemblMetazoaiFBtr0070432; FBpp0070416; FBgn0004861
GeneIDi31181
KEGGidme:Dmel_CG18412

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		31181
FlyBaseiFBgn0004861, ph-p
VEuPathDBiVectorBase:FBgn0004861

Phylogenomic databases

eggNOGiENOG502QS5Q, Eukaryota
GeneTreeiENSGT00940000154964
InParanoidiP39769
OMAiYAAIQVK
PhylomeDBiP39769

Enzyme and pathway databases

ReactomeiR-DME-2559580, Oxidative Stress Induced Senescence
R-DME-3108214, SUMOylation of DNA damage response and repair proteins
R-DME-3899300, SUMOylation of transcription cofactors
R-DME-4570464, SUMOylation of RNA binding proteins
R-DME-8939243, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-DME-8943724, Regulation of PTEN gene transcription
R-DME-8953750, Transcriptional Regulation by E2F6
SignaLinkiP39769

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		31181, 0 hits in 3 CRISPR screens
EvolutionaryTraceiP39769

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		31181

Protein Ontology

More...PROi		PR:P39769

Gene expression databases

BgeeiFBgn0004861, Expressed in wing disc (Drosophila) and 40 other tissues
ExpressionAtlasiP39769, baseline and differential
GenevisibleiP39769, DM

Family and domain databases

Gene3Di1.10.150.50, 1 hit
3.30.60.160, 1 hit
InterProiView protein in InterPro
IPR001660, SAM
IPR013761, SAM/pointed_sf
IPR012313, Znf_FCS
IPR038603, Znf_FCS_sf
PfamiView protein in Pfam
PF00536, SAM_1, 1 hit
SMARTiView protein in SMART
SM00454, SAM, 1 hit
SUPFAMiSSF47769, SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS50105, SAM_DOMAIN, 1 hit
PS51024, ZF_FCS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPHP_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P39769
Secondary accession number(s): O46097, Q9W521, Q9W522
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 16, 2004
Last modified: February 23, 2022
This is version 188 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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