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UniProtKB - P39768 (OPA_DROME)
Protein
Pair-rule protein odd-paired
Gene
opa
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Transcription factor essential for parasegmental subdivision of the embryo. It is involved in the activation of wingless (wg) in odd parasegments. It is also required for the timely activation of wg in the remaining parasegments and for the timely activation of engrailed (en) in all parasegments.
2 PublicationsRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 210 – 249 | C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST | 40 | |
Zinc fingeri | 258 – 285 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 28 | |
Zinc fingeri | 291 – 315 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 321 – 345 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 351 – 375 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: FlyBase
- DNA-binding transcription factor activity Source: FlyBase
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: FlyBase
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: FlyBase
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: FlyBase
GO - Biological processi
- central nervous system development Source: GO_Central
- eye-antennal disc morphogenesis Source: FlyBase
- germ cell migration Source: FlyBase
- midgut development Source: FlyBase
- periodic partitioning by pair rule gene Source: UniProtKB-KW
- positive regulation of transcription by RNA polymerase II Source: FlyBase
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, Developmental protein, DNA-binding, Pair-rule protein |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
SignaLinki | P39768 |
Names & Taxonomyi
Protein namesi | Recommended name: Pair-rule protein odd-paired |
Gene namesi | Name:opa ORF Names:CG1133 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0003002, opa |
VEuPathDBi | VectorBase:FBgn0003002 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: FlyBase
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047015 | 1 – 609 | Pair-rule protein odd-pairedAdd BLAST | 609 |
Proteomic databases
PaxDbi | P39768 |
Expressioni
Tissue specificityi
Expressed throughout all segment primordia; expressed ubiquitously in the ectoderm and mesoderm precursors.2 Publications
Developmental stagei
The peak expression is seen between 2 and 12 hours of embryogenesis. Expression continues through the larval instars and during pupation although at lower levels compared with embryogenesis.2 Publications
Gene expression databases
Bgeei | FBgn0003002, Expressed in embryo and 34 other tissues |
Genevisiblei | P39768, DM |
Interactioni
Binary interactionsi
P39768
With | #Exp. | IntAct |
---|---|---|
Dmel\CG17376 [Q9VM83] | 4 | EBI-93813,EBI-15116127 |
Protein-protein interaction databases
BioGRIDi | 65820, 36 interactors |
DIPi | DIP-17067N |
IntActi | P39768, 25 interactors |
STRINGi | 7227.FBpp0078477 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 20 – 41 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 373 – 550 | DisorderedSequence analysisAdd BLAST | 178 | |
Regioni | 583 – 609 | DisorderedSequence analysisAdd BLAST | 27 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 373 – 388 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 389 – 511 | Polar residuesSequence analysisAdd BLAST | 123 |
Sequence similaritiesi
Belongs to the GLI C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 210 – 249 | C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST | 40 | |
Zinc fingeri | 258 – 285 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 28 | |
Zinc fingeri | 291 – 315 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 321 – 345 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 351 – 375 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000165216 |
HOGENOMi | CLU_002678_37_2_1 |
InParanoidi | P39768 |
OMAi | AHPHHAM |
OrthoDBi | 592023at2759 |
PhylomeDBi | P39768 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type IPR041643, Znf_ZIC |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits PF18366, zf_ZIC, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P39768-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMMNAFIEPA QHHLASYGLR MSPNTTASNS NAQQQQQQQL EMTQQQQQQQ
60 70 80 90 100
QQQQQQQQQD QESAAATAAA YQNSGYGHFN SYASRDFLLG RREAEYGVAG
110 120 130 140 150
SAGQASAAAD SMLFSGFPAQ AAELGSGFGQ HPFHSHHHHH QMRMGMADAY
160 170 180 190 200
AAGHPYNHHG NFPTAAVHHP VVHHPSHHAM SAMHPAGAGA FLRYMRHQPA
210 220 230 240 250
SSASSVKQEM QCLWIDPDQP GLVPPGGRKT CNKVFHSMHE IVTHLTVEHV
260 270 280 290 300
GGPECTTHAC FWVGCSRNGR PFKAKYKLVN HIRVHTGEKP FACPHPGCGK
310 320 330 340 350
VFARSENLKI HKRTHTGEKP FKCEHEGCDR RFANSSDRKK HSHVHTSDKP
360 370 380 390 400
YNCRINGCDK SYTHPSSLRK HMKVHGNVDE KSPSHGYDSE GEESSSSSII
410 420 430 440 450
TGGAQTPPST RLDGSAGSSS GVSSLSGGSG IKSSPHSIKS EPNPMHSVHL
460 470 480 490 500
GASSSGSSST ASSSASHLLQ HQQHQHQQQQ QQQQHQQQAQ QQQQLTAHPS
510 520 530 540 550
DPKSSPALQL MAASASAYLP PPLGPPPSHH HHPHHHQAAP SPGAAAASAS
560 570 580 590 600
MLHHNHHLLY HPAAQHHPPS DWYHTTAPSG SAEAMNPLNH FGHHHHHHHL
MHPGAATAY
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A6H2EF55 | A0A6H2EF55_DROME | Odd paired, isoform B | opa Dmel\CG1133, Opa, CG1133, Dmel_CG1133 | 688 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 587 | P → S in AAK93207 (PubMed:12537569).Curated | 1 | |
Sequence conflicti | 606 | A → R in AAA18958 (PubMed:8288124).Curated | 1 | |
Sequence conflicti | 606 | A → R in AAB34592 (PubMed:7781900).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U04435 mRNA Translation: AAA18958.1 S78339 mRNA Translation: AAB34592.1 AE014297 Genomic DNA Translation: AAF52084.1 AY051783 mRNA Translation: AAK93207.1 BT029391 mRNA Translation: ABK56895.1 |
PIRi | A49839 |
RefSeqi | NP_524228.2, NM_079504.4 |
Genome annotation databases
EnsemblMetazoai | FBtr0078836; FBpp0078477; FBgn0003002 |
GeneIDi | 40605 |
KEGGi | dme:Dmel_CG1133 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U04435 mRNA Translation: AAA18958.1 S78339 mRNA Translation: AAB34592.1 AE014297 Genomic DNA Translation: AAF52084.1 AY051783 mRNA Translation: AAK93207.1 BT029391 mRNA Translation: ABK56895.1 |
PIRi | A49839 |
RefSeqi | NP_524228.2, NM_079504.4 |
3D structure databases
AlphaFoldDBi | P39768 |
SMRi | P39768 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 65820, 36 interactors |
DIPi | DIP-17067N |
IntActi | P39768, 25 interactors |
STRINGi | 7227.FBpp0078477 |
Proteomic databases
PaxDbi | P39768 |
Protocols and materials databases
DNASUi | 40605 |
Genome annotation databases
EnsemblMetazoai | FBtr0078836; FBpp0078477; FBgn0003002 |
GeneIDi | 40605 |
KEGGi | dme:Dmel_CG1133 |
Organism-specific databases
CTDi | 40605 |
FlyBasei | FBgn0003002, opa |
VEuPathDBi | VectorBase:FBgn0003002 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000165216 |
HOGENOMi | CLU_002678_37_2_1 |
InParanoidi | P39768 |
OMAi | AHPHHAM |
OrthoDBi | 592023at2759 |
PhylomeDBi | P39768 |
Enzyme and pathway databases
SignaLinki | P39768 |
Miscellaneous databases
BioGRID-ORCSi | 40605, 0 hits in 3 CRISPR screens |
GenomeRNAii | 40605 |
PROi | PR:P39768 |
Gene expression databases
Bgeei | FBgn0003002, Expressed in embryo and 34 other tissues |
Genevisiblei | P39768, DM |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type IPR041643, Znf_ZIC |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits PF18366, zf_ZIC, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | OPA_DROME | |
Accessioni | P39768Primary (citable) accession number: P39768 Secondary accession number(s): A0JQ21, Q960Y0, Q9VN66 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | May 29, 2007 | |
Last modified: | May 25, 2022 | |
This is version 178 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families