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UniProtKB - P39768 (OPA_DROME)

Entry version 175 (10 Feb 2021)
Sequence version 2 (29 May 2007)
Previous versions | rss
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Protein

Pair-rule protein odd-paired

Gene

opa

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor essential for parasegmental subdivision of the embryo. It is involved in the activation of wingless (wg) in odd parasegments. It is also required for the timely activation of wg in the remaining parasegments and for the timely activation of engrailed (en) in all parasegments.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri210 – 249C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST40
Zinc fingeri258 – 285C2H2-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri291 – 315C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri321 – 345C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri351 – 375C2H2-type 5PROSITE-ProRule annotationAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding, Pair-rule protein
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P39768

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pair-rule protein odd-paired
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:opa
ORF Names:CG1133
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0003002, opa

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000470151 – 609Pair-rule protein odd-pairedAdd BLAST609

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P39768

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed throughout all segment primordia; expressed ubiquitously in the ectoderm and mesoderm precursors.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

The peak expression is seen between 2 and 12 hours of embryogenesis. Expression continues through the larval instars and during pupation although at lower levels compared with embryogenesis.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0003002, Expressed in embryo and 34 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P39768, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		65820, 36 interactors

Database of interacting proteins

More...DIPi		DIP-17067N

Protein interaction database and analysis system

More...IntActi		P39768, 10 interactors

STRING: functional protein association networks

More...STRINGi		7227.FBpp0078477

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P39768

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi33 – 61Gln-richAdd BLAST29
Compositional biasi94 – 122Ala-richAdd BLAST29
Compositional biasi136 – 140Poly-His5
Compositional biasi394 – 398Poly-Ser5
Compositional biasi414 – 434Ser-richAdd BLAST21
Compositional biasi453 – 466Ser-richAdd BLAST14
Compositional biasi470 – 494Gln-richAdd BLAST25
Compositional biasi529 – 567Ala/His-richAdd BLAST39
Compositional biasi593 – 599Poly-His7

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GLI C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri210 – 249C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST40
Zinc fingeri258 – 285C2H2-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri291 – 315C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri321 – 345C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri351 – 375C2H2-type 5PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000165216

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002678_37_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P39768

Identification of Orthologs from Complete Genome Data

More...OMAi		IFHSMHE

Database of Orthologous Groups

More...OrthoDBi		592023at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
IPR041643, Znf_ZIC

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00096, zf-C2H2, 2 hits
PF18366, zf_ZIC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00355, ZnF_C2H2, 5 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57667, SSF57667, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 3 hits
PS50157, ZINC_FINGER_C2H2_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P39768-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMMNAFIEPA QHHLASYGLR MSPNTTASNS NAQQQQQQQL EMTQQQQQQQ 
        60         70         80         90        100
QQQQQQQQQD QESAAATAAA YQNSGYGHFN SYASRDFLLG RREAEYGVAG 
       110        120        130        140        150
SAGQASAAAD SMLFSGFPAQ AAELGSGFGQ HPFHSHHHHH QMRMGMADAY 
       160        170        180        190        200
AAGHPYNHHG NFPTAAVHHP VVHHPSHHAM SAMHPAGAGA FLRYMRHQPA 
       210        220        230        240        250
SSASSVKQEM QCLWIDPDQP GLVPPGGRKT CNKVFHSMHE IVTHLTVEHV 
       260        270        280        290        300
GGPECTTHAC FWVGCSRNGR PFKAKYKLVN HIRVHTGEKP FACPHPGCGK 
       310        320        330        340        350
VFARSENLKI HKRTHTGEKP FKCEHEGCDR RFANSSDRKK HSHVHTSDKP 
       360        370        380        390        400
YNCRINGCDK SYTHPSSLRK HMKVHGNVDE KSPSHGYDSE GEESSSSSII 
       410        420        430        440        450
TGGAQTPPST RLDGSAGSSS GVSSLSGGSG IKSSPHSIKS EPNPMHSVHL 
       460        470        480        490        500
GASSSGSSST ASSSASHLLQ HQQHQHQQQQ QQQQHQQQAQ QQQQLTAHPS 
       510        520        530        540        550
DPKSSPALQL MAASASAYLP PPLGPPPSHH HHPHHHQAAP SPGAAAASAS 
       560        570        580        590        600
MLHHNHHLLY HPAAQHHPPS DWYHTTAPSG SAEAMNPLNH FGHHHHHHHL 

MHPGAATAY
Length:609
Mass (Da):66,238
Last modified:May 29, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i434CF5B7212FD6CD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A6H2EF55A0A6H2EF55_DROME
Odd paired, isoform B
opa Dmel\CG1133, Opa, CG1133, Dmel_CG1133
688Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti587P → S in AAK93207 (PubMed:12537569).Curated1
Sequence conflicti606A → R in AAA18958 (PubMed:8288124).Curated1
Sequence conflicti606A → R in AAB34592 (PubMed:7781900).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U04435 mRNA Translation: AAA18958.1
S78339 mRNA Translation: AAB34592.1
AE014297 Genomic DNA Translation: AAF52084.1
AY051783 mRNA Translation: AAK93207.1
BT029391 mRNA Translation: ABK56895.1

Protein sequence database of the Protein Information Resource

More...PIRi		A49839

NCBI Reference Sequences

More...RefSeqi		NP_524228.2, NM_079504.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0078836; FBpp0078477; FBgn0003002

Database of genes from NCBI RefSeq genomes

More...GeneIDi		40605

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG1133

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04435 mRNA Translation: AAA18958.1
S78339 mRNA Translation: AAB34592.1
AE014297 Genomic DNA Translation: AAF52084.1
AY051783 mRNA Translation: AAK93207.1
BT029391 mRNA Translation: ABK56895.1
PIRiA49839
RefSeqiNP_524228.2, NM_079504.4

3D structure databases

SMRiP39768
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi65820, 36 interactors
DIPiDIP-17067N
IntActiP39768, 10 interactors
STRINGi7227.FBpp0078477

Proteomic databases

PaxDbiP39768

Genome annotation databases

EnsemblMetazoaiFBtr0078836; FBpp0078477; FBgn0003002
GeneIDi40605
KEGGidme:Dmel_CG1133

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		40605
FlyBaseiFBgn0003002, opa

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000165216
HOGENOMiCLU_002678_37_2_1
InParanoidiP39768
OMAiIFHSMHE
OrthoDBi592023at2759

Enzyme and pathway databases

SignaLinkiP39768

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		40605, 0 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		40605

Protein Ontology

More...PROi		PR:P39768

Gene expression databases

BgeeiFBgn0003002, Expressed in embryo and 34 other tissues
GenevisibleiP39768, DM

Family and domain databases

InterProiView protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
IPR041643, Znf_ZIC
PfamiView protein in Pfam
PF00096, zf-C2H2, 2 hits
PF18366, zf_ZIC, 1 hit
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 5 hits
SUPFAMiSSF57667, SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 3 hits
PS50157, ZINC_FINGER_C2H2_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOPA_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P39768
Secondary accession number(s): A0JQ21, Q960Y0, Q9VN66
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: May 29, 2007
Last modified: February 10, 2021
This is version 175 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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