UniProtKB - P39751 (MBL_BACSU)
Cell shape-determining protein Mbl
mbl
Functioni
Forms membrane-associated dynamic filaments that are essential for cell shape determination (PubMed:11290328, PubMed:19659933).
Acts by regulating cell wall synthesis and cell elongation, and thus cell shape (PubMed:19659933).
A feedback loop between cell geometry and Mbl localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature (By similarity).
Filaments rotate around the cell circumference in concert with the cell wall synthesis enzymes. The process is driven by the cell wall synthesis machinery and does not depend on Mbl polymerization (PubMed:21636745, PubMed:21636744).
Organizes peptidoglycan synthesis in the lateral cell wall (PubMed:19659933).
Also required for proper chromosome segregation (PubMed:14588250).
By similarity5 PublicationsMiscellaneous
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 12 – 14 | ATPUniRule annotation | 3 | |
Nucleotide bindingi | 156 – 158 | ATPUniRule annotation | 3 | |
Nucleotide bindingi | 204 – 207 | ATPUniRule annotation | 4 | |
Nucleotide bindingi | 284 – 287 | ATPUniRule annotation | 4 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
GO - Biological processi
- cell morphogenesis Source: InterPro
- regulation of cell shape Source: UniProtKB-UniRule
Keywordsi
Biological process | Cell shape |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | BSUB:BSU36410-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Cell shape-determining protein MblCuratedAlternative name(s): Actin-like Mbl proteinCurated Rod shape-determining protein MblCurated |
Gene namesi | Name:mbl Ordered Locus Names:BSU36410 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
Subcellular locationi
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000062755 | 1 – 333 | Cell shape-determining protein MblAdd BLAST | 333 |
Proteomic databases
jPOSTi | P39751 |
PaxDbi | P39751 |
Interactioni
Subunit structurei
Binary interactionsi
P39751
With | #Exp. | IntAct |
---|---|---|
tuf [P33166] | 3 | EBI-2122805,EBI-2122675 |
Protein-protein interaction databases
DIPi | DIP-52430N |
IntActi | P39751, 2 interactors |
STRINGi | 224308.BSU36410 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG1077, Bacteria |
InParanoidi | P39751 |
OMAi | MDIFQPS |
PhylomeDBi | P39751 |
Family and domain databases
CDDi | cd10225, MreB_like, 1 hit |
HAMAPi | MF_02207, MreB, 1 hit |
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR004753, MreB |
PRINTSi | PR01652, SHAPEPROTEIN |
SUPFAMi | SSF53067, SSF53067, 2 hits |
TIGRFAMsi | TIGR00904, mreB, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MFARDIGIDL GTANVLIHVK GKGIVLNEPS VVALDKNSGK VLAVGEEARR
60 70 80 90 100
MVGRTPGNIV AIRPLKDGVI ADFEVTEAML KHFINKLNVK GLFSKPRMLI
110 120 130 140 150
CCPTNITSVE QKAIKEAAEK SGGKHVYLEE EPKVAAIGAG MEIFQPSGNM
160 170 180 190 200
VVDIGGGTTD IAVISMGDIV TSSSIKMAGD KFDMEILNYI KREYKLLIGE
210 220 230 240 250
RTAEDIKIKV ATVFPDARHE EISIRGRDMV SGLPRTITVN SKEVEEALRE
260 270 280 290 300
SVAVIVQAAK QVLERTPPEL SADIIDRGVI ITGGGALLNG LDQLLAEELK
310 320 330
VPVLVAENPM DCVAIGTGVM LDNMDKLPKR KLS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U12962 Genomic DNA Translation: AAA67878.1 AL009126 Genomic DNA Translation: CAB15658.2 Z82987 Genomic DNA Translation: CAB05381.1 |
PIRi | I40531 |
RefSeqi | NP_391522.2, NC_000964.3 WP_003227776.1, NZ_JNCM01000034.1 |
Genome annotation databases
EnsemblBacteriai | CAB15658; CAB15658; BSU_36410 |
GeneIDi | 936916 |
KEGGi | bsu:BSU36410 |
PATRICi | fig|224308.179.peg.3941 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U12962 Genomic DNA Translation: AAA67878.1 AL009126 Genomic DNA Translation: CAB15658.2 Z82987 Genomic DNA Translation: CAB05381.1 |
PIRi | I40531 |
RefSeqi | NP_391522.2, NC_000964.3 WP_003227776.1, NZ_JNCM01000034.1 |
3D structure databases
SMRi | P39751 |
ModBasei | Search... |
Protein-protein interaction databases
DIPi | DIP-52430N |
IntActi | P39751, 2 interactors |
STRINGi | 224308.BSU36410 |
Proteomic databases
jPOSTi | P39751 |
PaxDbi | P39751 |
Genome annotation databases
EnsemblBacteriai | CAB15658; CAB15658; BSU_36410 |
GeneIDi | 936916 |
KEGGi | bsu:BSU36410 |
PATRICi | fig|224308.179.peg.3941 |
Phylogenomic databases
eggNOGi | COG1077, Bacteria |
InParanoidi | P39751 |
OMAi | MDIFQPS |
PhylomeDBi | P39751 |
Enzyme and pathway databases
BioCyci | BSUB:BSU36410-MONOMER |
Family and domain databases
CDDi | cd10225, MreB_like, 1 hit |
HAMAPi | MF_02207, MreB, 1 hit |
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR004753, MreB |
PRINTSi | PR01652, SHAPEPROTEIN |
SUPFAMi | SSF53067, SSF53067, 2 hits |
TIGRFAMsi | TIGR00904, mreB, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MBL_BACSU | |
Accessioni | P39751Primary (citable) accession number: P39751 Secondary accession number(s): O32275 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | February 23, 2022 | |
This is version 126 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families