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UniProtKB - P39745 (MPK1_CAEEL)

Entry version 186 (07 Apr 2021)
Sequence version 2 (25 Nov 2002)
Previous versions | rss
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Protein

Mitogen-activated protein kinase mpk-1

Gene

mpk-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Function in let-60 Ras signaling pathway; acts downstream of lin-45 raf kinase, but before the lin-1 gene product in controlling vulval cell differentiation (PubMed:8299935, PubMed:8299936). Plays a negative role in proximal germline proliferation in the mitotic zone (PubMed:16319922). Required for progression of developing oocytes through the pachytene stage (PubMed:16319922, PubMed:19826475, PubMed:21901106). In oocytes, inhibits the activity of the chloride channel clh-3, likely by activating gck-3 (PubMed:21160027). Plays a role in response to M.nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation (PubMed:15268855). Involved in fluid homeostasis (PubMed:11689700). In addition, involved in the up-regulation of lysozyme ilys-3 expression in the intestine in responses to M.nematophilum-mediated bacterial infection (PubMed:27525822). By phosphorylating transcription factor skn-1 (isoform c) may play a role in increasing life span downstream of lin-45, let-60 and mek-2 (PubMed:20624915). By up-regulating cep-1 and down-regulating gld-1 expression in the late pachytene stage, plays a role in germline apoptosis in response to DNA damage (PubMed:21901106). Regulates egl-1 expression in response to DNA damage, probably upstream of cep-1 (PubMed:21901106).10 Publications
Suppresses germline tumor formation by preventing the dedifferentiation of secondary spermatocytes probably upstream of rskn-1.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by dual phosphorylation at Thr-256 and Tyr-258 (PubMed:20624915). May be inactivated by lip-1-mediated dephosphorylation (PubMed:21901106).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei125ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei220Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi102 – 110ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processCell cycle, Differentiation, Meiosis, Oogenesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.11.24, 1045

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-CEL-110056, MAPK3 (ERK1) activation
R-CEL-112409, RAF-independent MAPK1/3 activation
R-CEL-112411, MAPK1 (ERK2) activation
R-CEL-162658, Golgi Cisternae Pericentriolar Stack Reorganization
R-CEL-170968, Frs2-mediated activation
R-CEL-198753, ERK/MAPK targets
R-CEL-202670, ERKs are inactivated
R-CEL-2029482, Regulation of actin dynamics for phagocytic cup formation
R-CEL-2559580, Oxidative Stress Induced Senescence
R-CEL-2559582, Senescence-Associated Secretory Phenotype (SASP)
R-CEL-2871796, FCERI mediated MAPK activation
R-CEL-3371453, Regulation of HSF1-mediated heat shock response
R-CEL-375165, NCAM signaling for neurite out-growth
R-CEL-437239, Recycling pathway of L1
R-CEL-445144, Signal transduction by L1
R-CEL-450341, Activation of the AP-1 family of transcription factors
R-CEL-456926, Thrombin signalling through proteinase activated receptors (PARs)
R-CEL-5654726, Negative regulation of FGFR1 signaling
R-CEL-5654733, Negative regulation of FGFR4 signaling
R-CEL-5663213, RHO GTPases Activate WASPs and WAVEs
R-CEL-5673001, RAF/MAP kinase cascade
R-CEL-5674135, MAP2K and MAPK activation
R-CEL-5674499, Negative feedback regulation of MAPK pathway
R-CEL-5675221, Negative regulation of MAPK pathway
R-CEL-6798695, Neutrophil degranulation
R-CEL-881907, Gastrin-CREB signalling pathway via PKC and MAPK
R-CEL-9634635, Estrogen-stimulated signaling through PRKCZ
R-CEL-9634638, Estrogen-dependent nuclear events downstream of ESR-membrane signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P39745

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mitogen-activated protein kinase mpk-1 (EC:2.7.11.241 Publication)
Alternative name(s):
MAP kinase sur-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mpk-1
Synonyms:sur-1
ORF Names:F43C1.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

WormBase

More...WormBasei		F43C1.2a ; CE01583 ; WBGene00003401 ; mpk-1
F43C1.2b ; CE24971 ; WBGene00003401 ; mpk-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown causes an increase in the number of germline cells in the mitotic zone, a lack of transition zone and a defect in pachytene progression resulting in a proximal gonad devoid of nuclei (PubMed:19826475, PubMed:16319922). Causes sterility (PubMed:19826475). RNAi-mediated knockdown in adults decreases lifespan (PubMed:20624915). RNAi-mediated knockdown of isoform b in lip-1 and puf-8 double mutant causes a decrease in number of germline tumors (PubMed:22820175). RNAi-mediated knockdown causes a reduction in intestinal ilys-3 expression in response to M.nematophilum-mediated bacterial infection (PubMed:27525822).5 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi106A → V in ku1; loss of function and ATP-binding. Lack of tail swelling, severe constipation and loss of ilys-3 expression up-regulation following M.nematophilium infection. 3 Publications1
Mutagenesisi216V → G in ga111; at the restrictive temperature of 25 degrees Celsius, causes an increase in gld-1 expression and a loss of cep-1 expression in late pachytene germ cells. Loss of egl-1 mRNA expression in response to gamma irradiation. 70 percent of mutants have germ cells arrested at the pachytene stage. Partial phosphorylation at Thr-256 and Tyr-258. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001863061 – 444Mitogen-activated protein kinase mpk-1Add BLAST444

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei256Phosphothreonine4 Publications1
Modified residuei258Phosphotyrosine4 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Isoform a is phosphorylated at the pachytene stage during oogenesis and is negatively regulated by gck-1. Isoform b is phosphorylated in proximal oocytes.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P39745

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P39745

PeptideAtlas

More...PeptideAtlasi		P39745

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P39745

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in cells lining the rectum (PubMed:15268855, PubMed:20624915). Isoform a is expressed in nervous system, body wall muscles and posterior intestine (PubMed:20624915). Isoform b expression may be restricted to germline (PubMed:22820175).3 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

The phosphorylated form is present in early to mid pachytene, is absent in late pachytene and diplotene/diakinesis stages and is again present in oocytes when they reach the spermatheca (PubMed:19826475, PubMed:21901106, PubMed:22820175). The phosphorylated form is also present in sperm (PubMed:22820175).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		WBGene00003401, Expressed in germ line (C elegans) and 6 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Isoform a interacts with gck-1 (via N-terminus).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		40782, 96 interactors

Database of interacting proteins

More...DIPi		DIP-26227N

Protein interaction database and analysis system

More...IntActi		P39745, 52 interactors

Molecular INTeraction database

More...MINTi		P39745

STRING: functional protein association networks

More...STRINGi		6239.F43C1.2b

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P39745

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini96 – 384Protein kinasePROSITE-ProRule annotationAdd BLAST289

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi256 – 258TXY3

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0660, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156771

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P39745

Identification of Orthologs from Complete Genome Data

More...OMAi		DIYIVQC

Database of Orthologous Groups

More...OrthoDBi		741207at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P39745

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR003527, MAP_kinase_CS
IPR008349, MAPK_ERK1/2
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00069, Pkinase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01770, ERK1ERK2MAPK

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01351, MAPK, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform b (identifier: P39745-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPTWIPNNLC AQPTTRNAKP PSNGHPQATQ QQSAPGSLAY RNSSNIPNGA 
        60         70         80         90        100
TNHVRQQKWQ YTRSGHRKMA DGEAVISTVN NVEEVHGQLF EVAPRYVNLS 
       110        120        130        140        150
YIGEGAYGMV ASALDTITRD RVAIKKISPF EHQTFCQRTL REIKILNRFK 
       160        170        180        190        200
HENIINIQEI IRSETVDSLK DIYIVQCLME TDLYKLLKTQ KLSNDHVCYF 
       210        220        230        240        250
LYQILRGLKY IHSANVLHRD LKPSNLLLNT TCDLKICDFG LARVTDPQTD 
       260        270        280        290        300
HTGFLTEYVA TRWYRAPEIM LNSKGYTKSI DVWSVGCILA EMLSNRPLFP 
       310        320        330        340        350
GKHYLDQLNL ILAVVGSPSN ADLQCIINDK ARSYLISLPH KPKQPWARLY 
       360        370        380        390        400
PGADPRALDL LDKMLTFNPH NRIDIEQALA HPYLEQYYDP GDEPVCEEPF 
       410        420        430        440 
TLEMEFDDLP KEKLKELIWE EAEAHHRRME AEAAARNNGG QNPV
Length:444
Mass (Da):50,663
Last modified:November 25, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i11BA27D17641980D
GO
Isoform a (identifier: P39745-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: Missing.

Show »
Length:376
Mass (Da):43,102
Checksum:i9974B791EFE16838
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti9 – 10LC → FF in AAA18956 (PubMed:8299936).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0048481 – 68Missing in isoform a. 1 PublicationAdd BLAST68

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U03879 mRNA Translation: AAA18956.1
U27124 mRNA Translation: AAA73482.1
Z46937 Genomic DNA Translation: CAA87057.1
Z46937 Genomic DNA Translation: CAB60996.1

Protein sequence database of the Protein Information Resource

More...PIRi		A36977
A36978

NCBI Reference Sequences

More...RefSeqi		NP_001022583.1, NM_001027412.3
NP_001022584.1, NM_001027413.2 [P39745-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		F43C1.2a.1; F43C1.2a.1; WBGene00003401 [P39745-2]
F43C1.2b.1; F43C1.2b.1; WBGene00003401 [P39745-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		175545

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		cel:CELE_F43C1.2

UCSC genome browser

More...UCSCi		F43C1.2a.1, c. elegans [P39745-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03879 mRNA Translation: AAA18956.1
U27124 mRNA Translation: AAA73482.1
Z46937 Genomic DNA Translation: CAA87057.1
Z46937 Genomic DNA Translation: CAB60996.1
PIRiA36977
A36978
RefSeqiNP_001022583.1, NM_001027412.3
NP_001022584.1, NM_001027413.2 [P39745-1]

3D structure databases

SMRiP39745
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi40782, 96 interactors
DIPiDIP-26227N
IntActiP39745, 52 interactors
MINTiP39745
STRINGi6239.F43C1.2b

PTM databases

iPTMnetiP39745

Proteomic databases

EPDiP39745
PaxDbiP39745
PeptideAtlasiP39745

Genome annotation databases

EnsemblMetazoaiF43C1.2a.1; F43C1.2a.1; WBGene00003401 [P39745-2]
F43C1.2b.1; F43C1.2b.1; WBGene00003401 [P39745-1]
GeneIDi175545
KEGGicel:CELE_F43C1.2
UCSCiF43C1.2a.1, c. elegans [P39745-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		175545
WormBaseiF43C1.2a ; CE01583 ; WBGene00003401 ; mpk-1
F43C1.2b ; CE24971 ; WBGene00003401 ; mpk-1

Phylogenomic databases

eggNOGiKOG0660, Eukaryota
GeneTreeiENSGT00940000156771
InParanoidiP39745
OMAiDIYIVQC
OrthoDBi741207at2759
PhylomeDBiP39745

Enzyme and pathway databases

BRENDAi2.7.11.24, 1045
ReactomeiR-CEL-110056, MAPK3 (ERK1) activation
R-CEL-112409, RAF-independent MAPK1/3 activation
R-CEL-112411, MAPK1 (ERK2) activation
R-CEL-162658, Golgi Cisternae Pericentriolar Stack Reorganization
R-CEL-170968, Frs2-mediated activation
R-CEL-198753, ERK/MAPK targets
R-CEL-202670, ERKs are inactivated
R-CEL-2029482, Regulation of actin dynamics for phagocytic cup formation
R-CEL-2559580, Oxidative Stress Induced Senescence
R-CEL-2559582, Senescence-Associated Secretory Phenotype (SASP)
R-CEL-2871796, FCERI mediated MAPK activation
R-CEL-3371453, Regulation of HSF1-mediated heat shock response
R-CEL-375165, NCAM signaling for neurite out-growth
R-CEL-437239, Recycling pathway of L1
R-CEL-445144, Signal transduction by L1
R-CEL-450341, Activation of the AP-1 family of transcription factors
R-CEL-456926, Thrombin signalling through proteinase activated receptors (PARs)
R-CEL-5654726, Negative regulation of FGFR1 signaling
R-CEL-5654733, Negative regulation of FGFR4 signaling
R-CEL-5663213, RHO GTPases Activate WASPs and WAVEs
R-CEL-5673001, RAF/MAP kinase cascade
R-CEL-5674135, MAP2K and MAPK activation
R-CEL-5674499, Negative feedback regulation of MAPK pathway
R-CEL-5675221, Negative regulation of MAPK pathway
R-CEL-6798695, Neutrophil degranulation
R-CEL-881907, Gastrin-CREB signalling pathway via PKC and MAPK
R-CEL-9634635, Estrogen-stimulated signaling through PRKCZ
R-CEL-9634638, Estrogen-dependent nuclear events downstream of ESR-membrane signaling
SignaLinkiP39745

Miscellaneous databases

Protein Ontology

More...PROi		PR:P39745

Gene expression databases

BgeeiWBGene00003401, Expressed in germ line (C elegans) and 6 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR003527, MAP_kinase_CS
IPR008349, MAPK_ERK1/2
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069, Pkinase, 1 hit
PRINTSiPR01770, ERK1ERK2MAPK
SMARTiView protein in SMART
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS01351, MAPK, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMPK1_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P39745
Secondary accession number(s): Q9U3F3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 25, 2002
Last modified: April 7, 2021
This is version 186 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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