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Protein

Spindle pole component SPC72

Gene

SPC72

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Spindle pole body component that acts as the gamma-tubulin complex-binding protein of the SPB outer plaque. Anchors cytoplasmic microtubules at the at the half bridge of the spindle pole body (SPB) and accordingly functions in nuclear position and spindle orientation, including anaphase spindle migration into the bud. Recruits KIN4 kinase to both SPBs when cytoplasmic microtubules are defective. Links cytoplasmic microtubules with spindle orientation checkpoint (SPOC) components and, therefore, could function as part of the sensors of spindle orientation defects. Is strictly required for mating and karyogamy.5 Publications

Miscellaneous

Present with 639 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • structural constituent of cytoskeleton Source: SGD

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • karyogamy Source: UniProtKB-KW
  • microtubule nucleation Source: SGD
  • mitotic sister chromatid segregation Source: SGD
  • mitotic spindle elongation Source: SGD
  • mitotic spindle orientation checkpoint Source: SGD
  • nuclear migration along microtubule Source: SGD

Keywordsi

Biological processCell cycle, Cell division, Karyogamy

Enzyme and pathway databases

BioCyciYEAST:G3O-28854-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Spindle pole component SPC72
Gene namesi
Name:SPC72
Synonyms:LDB4, SPI6
Ordered Locus Names:YAL047C
ORF Names:FUN42
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome I

Organism-specific databases

SGDiS000000045 SPC72

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002024211 – 622Spindle pole component SPC72Add BLAST622

Post-translational modificationi

Phosphorylated by CDC5.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP39723
PaxDbiP39723
PRIDEiP39723

PTM databases

iPTMnetiP39723

Interactioni

Subunit structurei

Homooligomer. Interacts with CDC5, KAR1, KIN4, SPC97, SPC98, STU2 and TUB4.5 Publications

Protein-protein interaction databases

BioGridi31780, 130 interactors
DIPiDIP-868N
IntActiP39723, 36 interactors
MINTiP39723
STRINGi4932.YAL047C

Structurei

3D structure databases

ProteinModelPortaliP39723
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

InParanoidiP39723
OMAiKNISPWR
OrthoDBiEOG092C43DL

Family and domain databases

InterProiView protein in InterPro
IPR024545 Mto2p-binding
PfamiView protein in Pfam
PF12808 Mto2_bdg, 1 hit

Sequencei

Sequence statusi: Complete.

P39723-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVRRWIPSGR HLRNNDNTGD DDDSEFTNSM DSGMSIPSLR DSMTTRSSHN
60 70 80 90 100
DPIKPALMND SNKVKNLEKE LTNAKIKIQV LYEYIRRIPN KDGNAPSLGN
110 120 130 140 150
DTDFRNSIIE GLNLEINKLK QDLKAKEVEY QDTLQFVQEN LENSESIVNT
160 170 180 190 200
INHLLSFILT HFNEQDENAH LLDKEERETL EETLELSSDY VLEKMDTLSK
210 220 230 240 250
FIIQFLQDFL HSKSRAESKQ DKEEFLSLAQ SSPAGSQLES RDSPSSKEEN
260 270 280 290 300
TDGGYQNDEI HDSNNHIDTE NVMANSTSLP ISAVESRFEK TLDTQLEIVI
310 320 330 340 350
ENLHKEYDQF INSIRLKFEK SQKLEKIIAS KLNEQSHLLD SLELEENSSS
360 370 380 390 400
VIEKQDHLIS QLKEKIESQS VLINNLEKLK EDIIKMKQNE KVLTKELETQ
410 420 430 440 450
TKINKLKENN WDSYINDLEK QINDLQIDKS EEFHVIQNQL DKLDLENYQL
460 470 480 490 500
KNQLNTLDNQ KLILSQYESN FIKFNQNLLL HLDSIFNILQ KILQESSIAQ
510 520 530 540 550
FDRKMKSIKS VPNALKNLNL IQPKLESLYT FIETALESII NSYISSLISM
560 570 580 590 600
ETPEQPHQQG NELTATPNKE LTLRIEELQR RWISERERRK LDANASEARI
610 620
KALEQENESL RSKLFNLSIN NP
Length:622
Mass (Da):72,106
Last modified:July 27, 2011 - v2
Checksum:i33A858B9ADCAD633
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti302N → I in AAC04984 (PubMed:7731988).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12980 Genomic DNA Translation: AAC04984.1
AY723757 Genomic DNA Translation: AAU09674.1
BK006935 Genomic DNA Translation: DAA06939.2
PIRiS51972
RefSeqiNP_009352.2, NM_001178192.2

Genome annotation databases

EnsemblFungiiYAL047C; YAL047C; YAL047C
GeneIDi851250
KEGGisce:YAL047C

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12980 Genomic DNA Translation: AAC04984.1
AY723757 Genomic DNA Translation: AAU09674.1
BK006935 Genomic DNA Translation: DAA06939.2
PIRiS51972
RefSeqiNP_009352.2, NM_001178192.2

3D structure databases

ProteinModelPortaliP39723
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31780, 130 interactors
DIPiDIP-868N
IntActiP39723, 36 interactors
MINTiP39723
STRINGi4932.YAL047C

PTM databases

iPTMnetiP39723

Proteomic databases

MaxQBiP39723
PaxDbiP39723
PRIDEiP39723

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYAL047C; YAL047C; YAL047C
GeneIDi851250
KEGGisce:YAL047C

Organism-specific databases

SGDiS000000045 SPC72

Phylogenomic databases

InParanoidiP39723
OMAiKNISPWR
OrthoDBiEOG092C43DL

Enzyme and pathway databases

BioCyciYEAST:G3O-28854-MONOMER

Miscellaneous databases

PROiPR:P39723

Family and domain databases

InterProiView protein in InterPro
IPR024545 Mto2p-binding
PfamiView protein in Pfam
PF12808 Mto2_bdg, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSPC72_YEAST
AccessioniPrimary (citable) accession number: P39723
Secondary accession number(s): D6VPG9, E9P941
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names
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