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Protein

Mitochondrial Rho GTPase 1

Gene

GEM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (Probable).1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi12 – 19GTP 1Curated8
Nucleotide bindingi62 – 64GTP 1Sequence analysis3
Nucleotide bindingi116 – 119GTP 1Sequence analysis4
<p>This subsection of the ‘Function’ section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi214 – 2251CuratedAdd BLAST12
Calcium bindingi343 – 3542CuratedAdd BLAST12
Nucleotide bindingi455 – 462GTP 2Curated8
Nucleotide bindingi491 – 495GTP 2Sequence analysis5
Nucleotide bindingi560 – 563GTP 2Sequence analysis4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: SGD
  • GTPase activity Source: SGD
  • GTP binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandCalcium, GTP-binding, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-28855-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-194840 Rho GTPase cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mitochondrial Rho GTPase 1 (EC:3.6.5.-)
Alternative name(s):
GTPase EF-hand protein of mitochondria 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GEM1
Ordered Locus Names:YAL048C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000000046 GEM1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 634Mitochondrial intermembraneSequence analysisAdd BLAST634
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei635 – 655Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini656 – 662CytoplasmicSequence analysis7

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Collapsed, globular, or grape-like mitochondria.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi18K → A: Loss of function. 1 Publication1
Mutagenesisi19S → N: Loss of function. 1 Publication1
Mutagenesisi33T → A: No effect. 1 Publication1
Mutagenesisi225E → K: Induces collapsed, globular or grape-like mitochondria; when associated with A-354. 1 Publication1
Mutagenesisi354E → K: Induces collapsed, globular or grape-like mitochondria; when associated with A-225. 1 Publication1
Mutagenesisi461K → A: Induces collapsed, globular or grape-like mitochondria. 1 Publication1
Mutagenesisi462S → N: Induces collapsed, globular or grape-like mitochondria. 1 Publication1
Mutagenesisi480T → A: Induces collapsed, globular or grape-like mitochondria. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002024221 – 662Mitochondrial Rho GTPase 1Add BLAST662

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P39722

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P39722

PRoteomics IDEntifications database

More...
PRIDEi
P39722

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
31779, 337 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-3196 ERMES complex

Database of interacting proteins

More...
DIPi
DIP-8142N

Protein interaction database and analysis system

More...
IntActi
P39722, 18 interactors

Molecular INTeraction database

More...
MINTi
P39722

STRING: functional protein association networks

More...
STRINGi
4932.YAL048C

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P39722

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P39722

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 140Miro 1Add BLAST140
Domaini201 – 236EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini330 – 365EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini442 – 662Miro 2Add BLAST221

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the mitochondrial Rho GTPase family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000173880

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000215553

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P39722

KEGG Orthology (KO)

More...
KOi
K07870

Identification of Orthologs from Complete Genome Data

More...
OMAi
CSAKTLH

Database of Orthologous Groups

More...
OrthoDBi
EOG092C13Q5

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011992 EF-hand-dom_pair
IPR013566 EF_hand_assoc_1
IPR013567 EF_hand_assoc_2
IPR002048 EF_hand_dom
IPR021181 Miro
IPR020860 MIRO_dom
IPR027417 P-loop_NTPase
IPR001806 Small_GTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08355 EF_assoc_1, 1 hit
PF08356 EF_assoc_2, 1 hit
PF00071 Ras, 2 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037488 Mt_Rho_GTPase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473 SSF47473, 1 hit
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50222 EF_HAND_2, 2 hits
PS51423 MIRO, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P39722-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTKETIRVVI CGDEGVGKSS LIVSLTKAEF IPTIQDVLPP ISIPRDFSSS
60 70 80 90 100
PTYSPKNTVL IDTSDSDLIA LDHELKSADV IWLVYCDHES YDHVSLFWLP
110 120 130 140 150
HFRSLGLNIP VILCKNKCDS ISNVNANAMV VSENSDDDID TKVEDEEFIP
160 170 180 190 200
ILMEFKEIDT CIKTSAKTQF DLNQAFYLCQ RAITHPISPL FDAMVGELKP
210 220 230 240 250
LAVMALKRIF LLSDLNQDSY LDDNEILGLQ KKCFNKSIDV NELNFIKDLL
260 270 280 290 300
LDISKHDQEY INRKLYVPGK GITKDGFLVL NKIYAERGRH ETTWAILRTF
310 320 330 340 350
HYTDSLCIND KILHPRLVVP DTSSVELSPK GYRFLVDIFL KFDIDNDGGL
360 370 380 390 400
NNQELHRLFK CTPGLPKLWT STNFPFSTVV NNKGCITLQG WLAQWSMTTF
410 420 430 440 450
LNYSTTTAYL VYFGFQEDAR LALQVTKPRK MRRRSGKLYR SNINDRKVFN
460 470 480 490 500
CFVIGKPCCG KSSLLEAFLG RSFSEEYSPT IKPRIAVNSL ELKGGKQYYL
510 520 530 540 550
ILQELGEQEY AILENKDKLK ECDVICLTYD SSDPESFSYL VSLLDKFTHL
560 570 580 590 600
QDLPLVFVAS KADLDKQQQR CQIQPDELAD ELFVNHPLHI SSRWLSSLNE
610 620 630 640 650
LFIKITEAAL DPGKNTPGLP EETAAKDVDY RQTALIFGST VGFVALCSFT
660
LMKLFKSSKF SK
Length:662
Mass (Da):75,150
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA68CDA15D79E5910
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U12980 Genomic DNA Translation: AAC04983.1
BK006935 Genomic DNA Translation: DAA06938.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S51971

NCBI Reference Sequences

More...
RefSeqi
NP_009351.1, NM_001178193.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YAL048C_mRNA; YAL048C_mRNA; YAL048C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
851249

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YAL048C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12980 Genomic DNA Translation: AAC04983.1
BK006935 Genomic DNA Translation: DAA06938.1
PIRiS51971
RefSeqiNP_009351.1, NM_001178193.1

3D structure databases

ProteinModelPortaliP39722
SMRiP39722
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31779, 337 interactors
ComplexPortaliCPX-3196 ERMES complex
DIPiDIP-8142N
IntActiP39722, 18 interactors
MINTiP39722
STRINGi4932.YAL048C

Proteomic databases

MaxQBiP39722
PaxDbiP39722
PRIDEiP39722

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYAL048C_mRNA; YAL048C_mRNA; YAL048C
GeneIDi851249
KEGGisce:YAL048C

Organism-specific databases

SGDiS000000046 GEM1

Phylogenomic databases

GeneTreeiENSGT00940000173880
HOGENOMiHOG000215553
InParanoidiP39722
KOiK07870
OMAiCSAKTLH
OrthoDBiEOG092C13Q5

Enzyme and pathway databases

BioCyciYEAST:G3O-28855-MONOMER
ReactomeiR-SCE-194840 Rho GTPase cycle

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P39722

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR013566 EF_hand_assoc_1
IPR013567 EF_hand_assoc_2
IPR002048 EF_hand_dom
IPR021181 Miro
IPR020860 MIRO_dom
IPR027417 P-loop_NTPase
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF08355 EF_assoc_1, 1 hit
PF08356 EF_assoc_2, 1 hit
PF00071 Ras, 2 hits
PIRSFiPIRSF037488 Mt_Rho_GTPase, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 2 hits
PS51423 MIRO, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGEM1_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P39722
Secondary accession number(s): D6VPG8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: December 5, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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