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Entry version 161 (23 Feb 2022)
Sequence version 2 (27 Jul 2011)
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Protein

Flavin carrier protein 2

Gene

FLC2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be responsible for the transport of FAD into the endoplasmic reticulum lumen, where it is required for oxidative protein folding.

1 Publication

Miscellaneous

Present with 414 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • FAD transmembrane transporter activity Source: SGD

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.4.9.3, the transient receptor potential ca(2+) channel (trp-cc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Flavin carrier protein 2
Alternative name(s):
FAD transporter 2
TRP-like ion channel FLC2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FLC2
Ordered Locus Names:YAL053W
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000000049, FLC2

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YAL053W

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini23 – 182LumenalSequence analysisAdd BLAST160
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei183 – 203HelicalSequence analysisAdd BLAST21
Topological domaini204 – 211CytoplasmicSequence analysis8
Transmembranei212 – 232HelicalSequence analysisAdd BLAST21
Topological domaini233 – 347LumenalSequence analysisAdd BLAST115
Transmembranei348 – 368HelicalSequence analysisAdd BLAST21
Topological domaini369 – 402CytoplasmicSequence analysisAdd BLAST34
Transmembranei403 – 423HelicalSequence analysisAdd BLAST21
Topological domaini424 – 430LumenalSequence analysis7
Transmembranei431 – 451HelicalSequence analysisAdd BLAST21
Topological domaini452 – 492CytoplasmicSequence analysisAdd BLAST41
Transmembranei493 – 513HelicalSequence analysisAdd BLAST21
Topological domaini514 – 521LumenalSequence analysis8
Transmembranei522 – 542HelicalSequence analysisAdd BLAST21
Topological domaini543 – 547CytoplasmicSequence analysis5
Transmembranei548 – 568HelicalSequence analysisAdd BLAST21
Topological domaini569 – 581LumenalSequence analysisAdd BLAST13
Transmembranei582 – 602HelicalSequence analysisAdd BLAST21
Topological domaini603 – 783CytoplasmicSequence analysisAdd BLAST181

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000020242423 – 783Flavin carrier protein 2Add BLAST761

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi28N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi81N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi156N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi323N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P39719

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P39719

PRoteomics IDEntifications database

More...
PRIDEi
P39719

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P39719

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
31776, 135 interactors

Database of interacting proteins

More...
DIPi
DIP-6708N

Protein interaction database and analysis system

More...
IntActi
P39719, 29 interactors

Molecular INTeraction database

More...
MINTi
P39719

STRING: functional protein association networks

More...
STRINGi
4932.YAL053W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P39719, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni681 – 783DisorderedSequence analysisAdd BLAST103

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QSVZ, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000176312

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_010226_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P39719

Identification of Orthologs from Complete Genome Data

More...
OMAi
FLYVQFK

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010308, TRP_C
IPR040241, TRP_Flc/Pkd2-like
IPR032800, TRP_N

The PANTHER Classification System

More...
PANTHERi
PTHR31145, PTHR31145, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06011, TRP, 1 hit
PF14558, TRP_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01320, TRP_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P39719-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIFLNTFARC LLTCFVLCSG TARSSDTNDT TPASAKHLQT TSLLTCMDNS
60 70 80 90 100
QLTASFFDVK FYPDNNTVIF DIDATTTLNG NVTVKAELLT YGLKVLDKTF
110 120 130 140 150
DLCSLGQVSL CPLSAGRIDV MSTQVIESSI TKQFPGIAYT IPDLDAQVRV
160 170 180 190 200
VAYAQNDTEF ETPLACVQAI LSNGKTVQTK YAAWPIAAIS GVGVLTSGFV
210 220 230 240 250
SVIGYSATAA HIASNSISLF IYFQNLAITA MMGVSRVPPI AAAWTQNFQW
260 270 280 290 300
SMGIINTNFM QKIFDWYVQA TNGVSNVVVA NKDVLSISVQ KRAISMASSS
310 320 330 340 350
DYNFDTILDD SNLYTTSEKD PSNYSAKILV LRGIERVAYL ANIELSNFFL
360 370 380 390 400
TGIVFFLFFL FVVVVSLIFF KALLEVLTRA RILKETSNFF QYRKNWGSII
410 420 430 440 450
KGTLFRLSII AFPQVSLLAI WEFTQVNSPA IVVDAVVILL IITGLLVYGT
460 470 480 490 500
IRVFIKGRES LRLYKNPAYL LYSDTYFLNK FGFLYVQFKA DKFWWLLPLL
510 520 530 540 550
SYAFLRSLFV AVLQNQGKAQ AMIIFVIELA YFVCLCWIRP YLDKRTNVFN
560 570 580 590 600
IAIHLVNLIN AFFFLFFSNL FKQPAVVSSV MAVILFVLNA VFALFLLLFT
610 620 630 640 650
IVTCTLALLH RNPDVRYQPM KDDRVSFIPK IQNDFDGKNK NDSELFELRK
660 670 680 690 700
AVMDTNENEE EKMFRDDTFG KNLNANTNTA RLFDDETSSS SFKQNSSPFD
710 720 730 740 750
ASEVTEQPVQ PTSAVMGTGG SFLSPQYQRA SSASRTNLAP NNTSTSSLMK
760 770 780
PESSLYLGNS NKSYSHFNNN GSNENARNNN PYL
Length:783
Mass (Da):87,469
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF5944205A7098B89
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti111C → S in AAC04980 (PubMed:7731988).Curated1
Sequence conflicti312N → D in AAC04980 (PubMed:7731988).Curated1
Sequence conflicti641 – 643NDS → IDP in AAC04980 (PubMed:7731988).Curated3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U12980 Genomic DNA Translation: AAC04980.1
X76891 Genomic DNA Translation: CAA54219.1
BK006935 Genomic DNA Translation: DAA06935.2

Protein sequence database of the Protein Information Resource

More...
PIRi
S51968

NCBI Reference Sequences

More...
RefSeqi
NP_009348.2, NM_001178196.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YAL053W_mRNA; YAL053W; YAL053W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
851246

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YAL053W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12980 Genomic DNA Translation: AAC04980.1
X76891 Genomic DNA Translation: CAA54219.1
BK006935 Genomic DNA Translation: DAA06935.2
PIRiS51968
RefSeqiNP_009348.2, NM_001178196.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi31776, 135 interactors
DIPiDIP-6708N
IntActiP39719, 29 interactors
MINTiP39719
STRINGi4932.YAL053W

Protein family/group databases

TCDBi1.A.4.9.3, the transient receptor potential ca(2+) channel (trp-cc) family

PTM databases

iPTMnetiP39719

Proteomic databases

MaxQBiP39719
PaxDbiP39719
PRIDEiP39719

Genome annotation databases

EnsemblFungiiYAL053W_mRNA; YAL053W; YAL053W
GeneIDi851246
KEGGisce:YAL053W

Organism-specific databases

SGDiS000000049, FLC2
VEuPathDBiFungiDB:YAL053W

Phylogenomic databases

eggNOGiENOG502QSVZ, Eukaryota
GeneTreeiENSGT00940000176312
HOGENOMiCLU_010226_0_1_1
InParanoidiP39719
OMAiFLYVQFK

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P39719
RNActiP39719, protein

Family and domain databases

InterProiView protein in InterPro
IPR010308, TRP_C
IPR040241, TRP_Flc/Pkd2-like
IPR032800, TRP_N
PANTHERiPTHR31145, PTHR31145, 1 hit
PfamiView protein in Pfam
PF06011, TRP, 1 hit
PF14558, TRP_N, 1 hit
SMARTiView protein in SMART
SM01320, TRP_N, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFLC2_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P39719
Secondary accession number(s): D6VPG5, Q05165
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 27, 2011
Last modified: February 23, 2022
This is version 161 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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