UniProtKB - P39713 (BDH2_YEAST)
Protein
Probable diacetyl reductase [(R)-acetoin forming] 2
Gene
BDH2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Catalyzes the irreversible reduction of 2,3-butanediol to (S)-acetoin in the presence of NADH.Curated
Miscellaneous
Present with 3090 molecules/cell in log phase SD medium.1 Publication
Catalytic activityi
- EC:1.1.1.303
Cofactori
Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 39 | Zinc 1; catalyticBy similarity | 1 | |
Metal bindingi | 64 | Zinc 1; catalyticBy similarity | 1 | |
Metal bindingi | 120 | Zinc 2By similarity | 1 | |
Metal bindingi | 123 | Zinc 2By similarity | 1 | |
Metal bindingi | 131 | Zinc 2By similarity | 1 | |
Metal bindingi | 173 | Zinc 1; catalyticBy similarity | 1 |
GO - Molecular functioni
- (R,R)-butanediol dehydrogenase activity Source: GO_Central
- diacetyl reductase ((R)-acetoin forming) activity Source: UniProtKB-EC
- oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: SGD
- zinc ion binding Source: InterPro
GO - Biological processi
- butanediol biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Oxidoreductase |
Ligand | Metal-binding, NAD, Zinc |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:BDH2 Ordered Locus Names:YAL061W ORF Names:FUN50 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YAL061W |
SGDi | S000000057, BDH2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000160897 | 1 – 417 | Probable diacetyl reductase [(R)-acetoin forming] 2Add BLAST | 417 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 63 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P39713 |
PaxDbi | P39713 |
PRIDEi | P39713 |
Expressioni
Inductioni
Expression is controlled by the PDR1 transcription factor and the glucose-responsive transcription factor RGT1.2 Publications
Interactioni
Protein-protein interaction databases
BioGRIDi | 31769, 131 interactors |
DIPi | DIP-6734N |
IntActi | P39713, 2 interactors |
MINTi | P39713 |
STRINGi | 4932.YAL061W |
Miscellaneous databases
RNActi | P39713, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the zinc-containing alcohol dehydrogenase family.Curated
Phylogenomic databases
eggNOGi | KOG0024, Eukaryota |
GeneTreei | ENSGT00940000176805 |
HOGENOMi | CLU_026673_11_0_1 |
InParanoidi | P39713 |
OMAi | CSVGRPN |
Family and domain databases
InterProi | View protein in InterPro IPR013149, ADH_C IPR013154, ADH_N IPR002328, ADH_Zn_CS IPR011032, GroES-like_sf IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF08240, ADH_N, 1 hit PF00107, ADH_zinc_N, 1 hit |
SUPFAMi | SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00059, ADH_ZINC, 1 hit |
i Sequence
Sequence statusi: Complete.
P39713-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRALAYFGKG NIRFTNHLKE PHIVAPDELV IDIEWCGICG TDLHEYTDGP
60 70 80 90 100
IFFPEDGHTH EISHNPLPQA MGHEMAGTVL EVGPGVKNLK VGDKVVVEPT
110 120 130 140 150
GTCRDRYRWP LSPNVDKEWC AACKKGYYNI CSYLGLCGAG VQSGGFAERV
160 170 180 190 200
VMNESHCYKV PDFVPLDVAA LIQPLAVCWH AIRVCEFKAG STALIIGAGP
210 220 230 240 250
IGLGTILALN AAGCKDIVVS EPAKVRRELA EKMGARVYDP TAHAAKESID
260 270 280 290 300
YLRSIADGGD GFDYTFDCSG LEVTLNAAIQ CLTFRGTAVN LAMWGHHKIQ
310 320 330 340 350
FSPMDITLHE RKYTGSMCYT HHDFEAVIEA LEEGRIDIDR ARHMITGRVN
360 370 380 390 400
IEDGLDGAIM KLINEKESTI KIILTPNNHG ELNREADNEK KEISELSSRK
410
DQERLRESIN EAKLRHT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U12980 Genomic DNA Translation: AAC04973.1 AY692730 Genomic DNA Translation: AAT92749.1 BK006935 Genomic DNA Translation: DAA06928.1 |
PIRi | S51961 |
RefSeqi | NP_009340.1, NM_001178203.1 |
Genome annotation databases
EnsemblFungii | YAL061W_mRNA; YAL061W; YAL061W |
GeneIDi | 851238 |
KEGGi | sce:YAL061W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U12980 Genomic DNA Translation: AAC04973.1 AY692730 Genomic DNA Translation: AAT92749.1 BK006935 Genomic DNA Translation: DAA06928.1 |
PIRi | S51961 |
RefSeqi | NP_009340.1, NM_001178203.1 |
3D structure databases
SMRi | P39713 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 31769, 131 interactors |
DIPi | DIP-6734N |
IntActi | P39713, 2 interactors |
MINTi | P39713 |
STRINGi | 4932.YAL061W |
Proteomic databases
MaxQBi | P39713 |
PaxDbi | P39713 |
PRIDEi | P39713 |
Genome annotation databases
EnsemblFungii | YAL061W_mRNA; YAL061W; YAL061W |
GeneIDi | 851238 |
KEGGi | sce:YAL061W |
Organism-specific databases
EuPathDBi | FungiDB:YAL061W |
SGDi | S000000057, BDH2 |
Phylogenomic databases
eggNOGi | KOG0024, Eukaryota |
GeneTreei | ENSGT00940000176805 |
HOGENOMi | CLU_026673_11_0_1 |
InParanoidi | P39713 |
OMAi | CSVGRPN |
Miscellaneous databases
PROi | PR:P39713 |
RNActi | P39713, protein |
Family and domain databases
InterProi | View protein in InterPro IPR013149, ADH_C IPR013154, ADH_N IPR002328, ADH_Zn_CS IPR011032, GroES-like_sf IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF08240, ADH_N, 1 hit PF00107, ADH_zinc_N, 1 hit |
SUPFAMi | SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00059, ADH_ZINC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BDH2_YEAST | |
Accessioni | P39713Primary (citable) accession number: P39713 Secondary accession number(s): D6VPF8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | December 2, 2020 | |
This is version 163 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome I
Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names