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Entry version 127 (03 Jul 2019)
Sequence version 1 (01 Feb 1995)
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Protein

Probable transporter SEO1

Gene

SEO1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Not known; suppressor of sulfoxide ethionine resistance.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • transmembrane transporter activity Source: GO_Central
  • transporter activity Source: SGD

GO - Biological processi

  • transmembrane transport Source: SGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
YEAST:G3O-28866-MONOMER

Protein family/group databases

Transport Classification Database

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TCDBi
2.A.1.14.37 the major facilitator superfamily (mfs)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable transporter SEO1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SEO1
Ordered Locus Names:YAL067C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:YAL067C

Saccharomyces Genome Database

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SGDi
S000000062 SEO1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 130CytoplasmicSequence analysisAdd BLAST130
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Topological domaini152 – 175ExtracellularSequence analysisAdd BLAST24
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Topological domaini197 – 200CytoplasmicSequence analysis4
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Topological domaini222 – 234ExtracellularSequence analysisAdd BLAST13
Transmembranei235 – 255HelicalSequence analysisAdd BLAST21
Topological domaini256 – 265CytoplasmicSequence analysis10
Transmembranei266 – 286HelicalSequence analysisAdd BLAST21
Topological domaini287 – 302ExtracellularSequence analysisAdd BLAST16
Transmembranei303 – 323HelicalSequence analysisAdd BLAST21
Topological domaini324 – 363CytoplasmicSequence analysisAdd BLAST40
Transmembranei364 – 384HelicalSequence analysisAdd BLAST21
Topological domaini385 – 411ExtracellularSequence analysisAdd BLAST27
Transmembranei412 – 432HelicalSequence analysisAdd BLAST21
Topological domaini433 – 438CytoplasmicSequence analysis6
Transmembranei439 – 459HelicalSequence analysisAdd BLAST21
Topological domaini460 – 466ExtracellularSequence analysis7
Transmembranei467 – 487HelicalSequence analysisAdd BLAST21
Topological domaini488 – 499CytoplasmicSequence analysisAdd BLAST12
Transmembranei500 – 520HelicalSequence analysisAdd BLAST21
Topological domaini521 – 532ExtracellularSequence analysisAdd BLAST12
Transmembranei533 – 553HelicalSequence analysisAdd BLAST21
Topological domaini554 – 593CytoplasmicSequence analysisAdd BLAST40

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001213681 – 593Probable transporter SEO1Add BLAST593

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P39709

PRoteomics IDEntifications database

More...
PRIDEi
P39709

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P39709

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
31762, 48 interactors

Database of interacting proteins

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DIPi
DIP-8291N

Protein interaction database and analysis system

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IntActi
P39709, 2 interactors

Molecular INTeraction database

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MINTi
P39709

STRING: functional protein association networks

More...
STRINGi
4932.YAL067C

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000179304

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P39709

Identification of Orthologs from Complete Genome Data

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OMAi
WNIFCWN

Family and domain databases

Conserved Domains Database

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CDDi
cd06174 MFS, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07690 MFS_1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473 SSF103473, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P39709-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYSIVKEIIV DPYKRLKWGF IPVKRQVEDL PDDLNSTEIV TISNSIQSHE
60 70 80 90 100
TAENFITTTS EKDQLHFETS SYSEHKDNVN VTRSYEYRDE ADRPWWRFFD
110 120 130 140 150
EQEYRINEKE RSHNKWYSWF KQGTSFKEKK LLIKLDVLLA FYSCIAYWVK
160 170 180 190 200
YLDTVNINNA YVSGMKEDLG FQGNDLVHTQ VMYTVGNIIF QLPFLIYLNK
210 220 230 240 250
LPLNYVLPSL DLCWSLLTVG AAYVNSVPHL KAIRFFIGAF EAPSYLAYQY
260 270 280 290 300
LFGSFYKHDE MVRRSAFYYL GQYIGILSAG GIQSAVYSSL NGVNGLEGWR
310 320 330 340 350
WNFIIDAIVS VVVGLIGFYS LPGDPYNCYS IFLTDDEIRL ARKRLKENQT
360 370 380 390 400
GKSDFETKVF DIKLWKTIFS DWKIYILTLW NIFCWNDSNV SSGAYLLWLK
410 420 430 440 450
SLKRYSIPKL NQLSMITPGL GMVYLMLTGI IADKLHSRWF AIIFTQVFNI
460 470 480 490 500
IGNSILAAWD VAEGAKWFAF MLQCFGWAMA PVLYSWQNDI CRRDAQTRAI
510 520 530 540 550
TLVTMNIMAQ SSTAWISVLV WKTEEAPRYL KGFTFTACSA FCLSIWTFVV
560 570 580 590
LYFYKRDERN NAKKNGIVLY NSKHGVEKPT SKDVETLSVS DEK
Length:593
Mass (Da):68,842
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6B7B1A2A7D5EAA44
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U12980 Genomic DNA Translation: AAC04968.1
BK006935 Genomic DNA Translation: DAA06920.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S51956

NCBI Reference Sequences

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RefSeqi
NP_009333.1, NM_001178208.1

Genome annotation databases

Ensembl fungal genome annotation project

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EnsemblFungii
YAL067C_mRNA; YAL067C_mRNA; YAL067C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
851230

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YAL067C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12980 Genomic DNA Translation: AAC04968.1
BK006935 Genomic DNA Translation: DAA06920.1
PIRiS51956
RefSeqiNP_009333.1, NM_001178208.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi31762, 48 interactors
DIPiDIP-8291N
IntActiP39709, 2 interactors
MINTiP39709
STRINGi4932.YAL067C

Protein family/group databases

TCDBi2.A.1.14.37 the major facilitator superfamily (mfs)

PTM databases

iPTMnetiP39709

Proteomic databases

PaxDbiP39709
PRIDEiP39709

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYAL067C_mRNA; YAL067C_mRNA; YAL067C
GeneIDi851230
KEGGisce:YAL067C

Organism-specific databases

EuPathDBiFungiDB:YAL067C
SGDiS000000062 SEO1

Phylogenomic databases

HOGENOMiHOG000179304
InParanoidiP39709
OMAiWNIFCWN

Enzyme and pathway databases

BioCyciYEAST:G3O-28866-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P39709

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSEO1_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P39709
Secondary accession number(s): D6VPF0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 3, 2019
This is version 127 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names
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