Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acidic leucine-rich nuclear phosphoprotein 32 family member A

Gene

ANP32A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1-mediated transcriptional repression.4 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-450520 HuR (ELAVL1) binds and stabilizes mRNA

Names & Taxonomyi

Protein namesi
Recommended name:
Acidic leucine-rich nuclear phosphoprotein 32 family member A
Alternative name(s):
Acidic nuclear phosphoprotein pp32
Short name:
pp32
Leucine-rich acidic nuclear protein
Short name:
LANP
Mapmodulin
Potent heat-stable protein phosphatase 2A inhibitor I1PP2A
Putative HLA-DR-associated protein I
Short name:
PHAPI
Gene namesi
Name:ANP32A
Synonyms:C15orf1, LANP, MAPM, PHAP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000140350.15
HGNCiHGNC:13233 ANP32A
MIMi600832 gene
neXtProtiNX_P39687

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi8125
OpenTargetsiENSG00000140350
PharmGKBiPA24811

Polymorphism and mutation databases

BioMutaiANP32A
DMDMi730318

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001375921 – 249Acidic leucine-rich nuclear phosphoprotein 32 family member AAdd BLAST249

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15PhosphothreonineCombined sources1
Modified residuei17PhosphoserineCombined sources1
Modified residuei158PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated on serine residues.
The N-terminus is blocked.
Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP39687
MaxQBiP39687
PaxDbiP39687
PeptideAtlasiP39687
PRIDEiP39687
ProteomicsDBi55318
TopDownProteomicsiP39687

2D gel databases

SWISS-2DPAGEiP39687

PTM databases

iPTMnetiP39687
PhosphoSitePlusiP39687
SwissPalmiP39687

Miscellaneous databases

PMAP-CutDBiP39687

Expressioni

Tissue specificityi

Expressed in all tissues tested. Highly expressed in kidney and skeletal muscle, moderate levels of expression in brain, placenta and pancreas, and weakly expressed in lung. Found in all regions of the brain examined (amygdala, caudate nucleus, corpus callosum, hippocampus and thalamus), with highest levels in amygdala.1 Publication

Gene expression databases

BgeeiENSG00000140350 Expressed in 239 organ(s), highest expression level in female gonad
CleanExiHS_ANP32A
ExpressionAtlasiP39687 baseline and differential
GenevisibleiP39687 HS

Organism-specific databases

HPAiCAB005231
HPA063133
HPA067561

Interactioni

Subunit structurei

Component of the SET complex, composed of at least ANP32A, APEX1, HMGB2, NME1, SET and TREX1. Directly interacts with SET. Interacts with ATXN1/SCA1. Interacts with MAP1B. Interacts with ELAVL1. Part of the INHAT (inhibitor of histone acetyltransferases) complex. Interacts with E4F1.6 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113791, 58 interactors
CORUMiP39687
IntActiP39687, 20 interactors
MINTiP39687
STRINGi9606.ENSP00000417864

Structurei

Secondary structure

1249
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP39687
SMRiP39687
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP39687

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati18 – 38LRR 11 PublicationAdd BLAST21
Repeati43 – 64LRR 21 PublicationAdd BLAST22
Repeati65 – 87LRR 31 PublicationAdd BLAST23
Repeati89 – 110LRR 41 PublicationAdd BLAST22
Domaini123 – 161LRRCTAdd BLAST39

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni150 – 174Necessary for tumor-suppressive functionAdd BLAST25
Regioni165 – 249Interaction with E4F1By similarityAdd BLAST85

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi168 – 249Asp/Glu-rich (highly acidic)Add BLAST82

Sequence similaritiesi

Belongs to the ANP32 family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG2739 Eukaryota
ENOG4111HZT LUCA
GeneTreeiENSGT00560000077130
HOGENOMiHOG000007361
HOVERGENiHBG053102
InParanoidiP39687
KOiK18646
OMAiDCNDEEA
OrthoDBiEOG091G0R8Z
PhylomeDBiP39687
TreeFamiTF317206

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR003603 U2A'_phosphoprotein32A_C
SMARTiView protein in SMART
SM00446 LRRcap, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P39687-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEMGRRIHLE LRNRTPSDVK ELVLDNSRSN EGKLEGLTDE FEELEFLSTI
60 70 80 90 100
NVGLTSIANL PKLNKLKKLE LSDNRVSGGL EVLAEKCPNL THLNLSGNKI
110 120 130 140 150
KDLSTIEPLK KLENLKSLDL FNCEVTNLND YRENVFKLLP QLTYLDGYDR
160 170 180 190 200
DDKEAPDSDA EGYVEGLDDE EEDEDEEEYD EDAQVVEDEE DEDEEEEGEE
210 220 230 240
EDVSGEEEED EEGYNDGEVD DEEDEEELGE EERGQKRKRE PEDEGEDDD
Length:249
Mass (Da):28,585
Last modified:February 1, 1995 - v1
Checksum:iCA2D1A756FBAEA04
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YN26H0YN26_HUMAN
Acidic leucine-rich nuclear phospho...
ANP32A
177Annotation score:
H7BZ09H7BZ09_HUMAN
Acidic leucine-rich nuclear phospho...
ANP32A
79Annotation score:

Sequence cautioni

The sequence BAD97000 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti186V → A in BAD97000 (Ref. 8) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75090 mRNA Translation: CAA52981.1
U60823 mRNA Translation: AAC50570.1
U73477 mRNA Translation: AAB39706.1
AF025684 mRNA Translation: AAB91548.1
AY349171 mRNA Translation: AAQ79832.1
BT007436 mRNA Translation: AAP36104.1
AK223280 mRNA Translation: BAD97000.1 Different initiation.
AK312703 mRNA Translation: BAG35581.1
CH471082 Genomic DNA Translation: EAW77824.1
BC007200 mRNA Translation: AAH07200.1
CCDSiCCDS45292.1
PIRiS36375
S43309
RefSeqiNP_006296.1, NM_006305.3
UniGeneiHs.458747

Genome annotation databases

EnsembliENST00000465139; ENSP00000417864; ENSG00000140350
GeneIDi8125
KEGGihsa:8125
UCSCiuc002arl.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75090 mRNA Translation: CAA52981.1
U60823 mRNA Translation: AAC50570.1
U73477 mRNA Translation: AAB39706.1
AF025684 mRNA Translation: AAB91548.1
AY349171 mRNA Translation: AAQ79832.1
BT007436 mRNA Translation: AAP36104.1
AK223280 mRNA Translation: BAD97000.1 Different initiation.
AK312703 mRNA Translation: BAG35581.1
CH471082 Genomic DNA Translation: EAW77824.1
BC007200 mRNA Translation: AAH07200.1
CCDSiCCDS45292.1
PIRiS36375
S43309
RefSeqiNP_006296.1, NM_006305.3
UniGeneiHs.458747

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JE0X-ray2.40A/B/C/D/E/F1-149[»]
2JE1X-ray2.69A/B/C/D1-149[»]
4XOSX-ray1.56A/B1-149[»]
ProteinModelPortaliP39687
SMRiP39687
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113791, 58 interactors
CORUMiP39687
IntActiP39687, 20 interactors
MINTiP39687
STRINGi9606.ENSP00000417864

PTM databases

iPTMnetiP39687
PhosphoSitePlusiP39687
SwissPalmiP39687

Polymorphism and mutation databases

BioMutaiANP32A
DMDMi730318

2D gel databases

SWISS-2DPAGEiP39687

Proteomic databases

EPDiP39687
MaxQBiP39687
PaxDbiP39687
PeptideAtlasiP39687
PRIDEiP39687
ProteomicsDBi55318
TopDownProteomicsiP39687

Protocols and materials databases

DNASUi8125
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000465139; ENSP00000417864; ENSG00000140350
GeneIDi8125
KEGGihsa:8125
UCSCiuc002arl.4 human

Organism-specific databases

CTDi8125
DisGeNETi8125
EuPathDBiHostDB:ENSG00000140350.15
GeneCardsiANP32A
HGNCiHGNC:13233 ANP32A
HPAiCAB005231
HPA063133
HPA067561
MIMi600832 gene
neXtProtiNX_P39687
OpenTargetsiENSG00000140350
PharmGKBiPA24811
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2739 Eukaryota
ENOG4111HZT LUCA
GeneTreeiENSGT00560000077130
HOGENOMiHOG000007361
HOVERGENiHBG053102
InParanoidiP39687
KOiK18646
OMAiDCNDEEA
OrthoDBiEOG091G0R8Z
PhylomeDBiP39687
TreeFamiTF317206

Enzyme and pathway databases

ReactomeiR-HSA-450520 HuR (ELAVL1) binds and stabilizes mRNA

Miscellaneous databases

ChiTaRSiANP32A human
EvolutionaryTraceiP39687
GenomeRNAii8125
PMAP-CutDBiP39687
PROiPR:P39687
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000140350 Expressed in 239 organ(s), highest expression level in female gonad
CleanExiHS_ANP32A
ExpressionAtlasiP39687 baseline and differential
GenevisibleiP39687 HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR003603 U2A'_phosphoprotein32A_C
SMARTiView protein in SMART
SM00446 LRRcap, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiAN32A_HUMAN
AccessioniPrimary (citable) accession number: P39687
Secondary accession number(s): B2R6T4
, Q53FK4, Q5J8L8, Q7M4N6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 12, 2018
This is version 186 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again