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Protein

Protein giant

Gene

gt

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Represses the expression of both the krueppel and knirps segmentation gap genes. Binds, in vitro, to the krueppel regulatory elements CD1 and CD2. It is required in the early embryo for the development of portions of the head and abdomen.

Caution

It is uncertain whether Met-1, Met-3, Met-8 or Met-23 is the initiator.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SignaLinkiP39572

Names & Taxonomyi

Protein namesi
Recommended name:
Protein giant
Gene namesi
Name:gt
ORF Names:CG7952
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0001150 gt

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000766371 – 448Protein giantAdd BLAST448

Post-translational modificationi

Phosphorylated at multiple sites.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP39572
PRIDEiP39572

Expressioni

Gene expression databases

BgeeiFBgn0001150 Expressed in 36 organ(s), highest expression level in embryo
GenevisibleiP39572 DM

Interactioni

Subunit structurei

Homodimer or heterodimer.Curated

Protein-protein interaction databases

BioGridi57763, 21 interactors
DIPiDIP-19651N
IntActiP39572, 2 interactors
STRINGi7227.FBpp0070444

Structurei

3D structure databases

ProteinModelPortaliP39572
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini384 – 447bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni390 – 406Basic motifPROSITE-ProRule annotationAdd BLAST17
Regioni407 – 414Leucine-zipperPROSITE-ProRule annotation8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi24 – 41His-richAdd BLAST18
Compositional biasi74 – 91Poly-GlnAdd BLAST18
Compositional biasi144 – 160Poly-GlnAdd BLAST17
Compositional biasi198 – 210Poly-AlaAdd BLAST13

Sequence similaritiesi

Belongs to the bZIP family.Curated

Phylogenomic databases

eggNOGiKOG3119 Eukaryota
ENOG410YJ8G LUCA
GeneTreeiENSGT00440000039070
InParanoidiP39572
KOiK09062
OMAiPRVERYT
OrthoDBiEOG091G0IW2
PhylomeDBiP39572

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR029859 Giant
PANTHERiPTHR11988:SF25 PTHR11988:SF25, 3 hits
PfamiView protein in Pfam
PF07716 bZIP_2, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit

Sequencei

Sequence statusi: Complete.

P39572-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLMHEKLMAG QFFDLKTDRK PLMHHHQYQH HQQQPLHHLP HSQLPVQGSL
60 70 80 90 100
GLPKMDLYTA YAYQQQLLGA ALSQQQQQQQ QQQQHQQLQQ QHTSSAEVLD
110 120 130 140 150
LSRRCDSVET PRKTPSPYQT SYSYGSGSPS ASPTSNLLYA AQMQQQQHQQ
160 170 180 190 200
QQQQQQQQQQ LASLYPAFYY SNIKQEQATP TAAPPKVTPT ANLLQTFAAA
210 220 230 240 250
SAAAAAAAAA SSTNSPRPAS NASTMQIDVL ENPLSPAVEA TTPTTSSSGE
260 270 280 290 300
AGKNTRPFKA FPRDPLVIAA NFAATDVLLD NPRVERYTEY RKRVLEQIRS
310 320 330 340 350
SNGGSRTVTN PKMRRTNSRS GSVNEGSSSN NNSESEDRAA AEESSDCDSQ
360 370 380 390 400
AGNFESKSAT SSSSNLANAT AANSGISSGS QVKDAAYYER RRKNNAAAKK
410 420 430 440
SRDRRRIKED EIAIRAAYLE RQNIELLCQI DALKVQLAAF TSAKVTTA
Length:448
Mass (Da):49,169
Last modified:November 2, 2001 - v2
Checksum:i98EB75D082129439
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti234L → Q in CAA43456 (PubMed:1576969).Curated1
Sequence conflicti383K → R in AAQ22473 (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61148 Genomic DNA Translation: CAA43456.1
AE014298 Genomic DNA Translation: AAF45780.1
AL133504 Genomic DNA Translation: CAB63520.1
BT010004 mRNA Translation: AAQ22473.1
BT057998 mRNA Translation: ACM16708.1
PIRiS17370
RefSeqiNP_525049.1, NM_080310.3
UniGeneiDm.5740

Genome annotation databases

EnsemblMetazoaiFBtr0070460; FBpp0070444; FBgn0001150
GeneIDi31227
KEGGidme:Dmel_CG7952
UCSCiCG7952-RB d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiGIANT_DROME
AccessioniPrimary (citable) accession number: P39572
Secondary accession number(s): B9EQS3, Q7YU39, Q9V3N3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 2, 2001
Last modified: September 12, 2018
This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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