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Protein

Probable phospholipid-transporting ATPase DRS2

Gene

DRS2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly.Curated

Miscellaneous

Present with 606 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei5604-aspartylphosphate intermediateBy similarity1

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • magnesium ion binding Source: InterPro
  • phospholipid-translocating ATPase activity Source: SGD

GO - Biological processi

  • endocytic recycling Source: SGD
  • endocytosis Source: SGD
  • Golgi vesicle budding Source: GO_Central
  • intracellular protein transport Source: SGD
  • phospholipid translocation Source: SGD
  • post-Golgi vesicle-mediated transport Source: SGD
  • response to pheromone triggering conjugation with cellular fusion Source: SGD
  • ribosomal small subunit assembly Source: SGD

Keywordsi

Molecular functionHydrolase
LigandATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-28837-MONOMER
BRENDAi3.6.3.1 984
ReactomeiR-SCE-6798695 Neutrophil degranulation
R-SCE-936837 Ion transport by P-type ATPases

Protein family/group databases

TCDBi3.A.3.8.2 the p-type atpase (p-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phospholipid-transporting ATPase DRS2 (EC:3.6.3.1)
Gene namesi
Name:DRS2
Ordered Locus Names:YAL026C
ORF Names:FUN38
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:YAL026C
SGDiS000000024 DRS2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 221CytoplasmicSequence analysisAdd BLAST221
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Topological domaini243 – 246LumenalSequence analysis4
Transmembranei247 – 267HelicalSequence analysisAdd BLAST21
Topological domaini268 – 449CytoplasmicSequence analysisAdd BLAST182
Transmembranei450 – 470HelicalSequence analysisAdd BLAST21
Topological domaini471 – 490LumenalSequence analysisAdd BLAST20
Transmembranei491 – 511HelicalSequence analysisAdd BLAST21
Topological domaini512 – 1012CytoplasmicSequence analysisAdd BLAST501
Transmembranei1013 – 1033HelicalSequence analysisAdd BLAST21
Topological domaini1034 – 1043LumenalSequence analysis10
Transmembranei1044 – 1064HelicalSequence analysisAdd BLAST21
Topological domaini1065 – 1094CytoplasmicSequence analysisAdd BLAST30
Transmembranei1095 – 1115HelicalSequence analysisAdd BLAST21
Topological domaini1116 – 1131LumenalSequence analysisAdd BLAST16
Transmembranei1132 – 1152HelicalSequence analysisAdd BLAST21
Topological domaini1153 – 1161CytoplasmicSequence analysis9
Transmembranei1162 – 1182HelicalSequence analysisAdd BLAST21
Topological domaini1183 – 1202LumenalSequence analysisAdd BLAST20
Transmembranei1203 – 1223HelicalSequence analysisAdd BLAST21
Topological domaini1224 – 1355CytoplasmicSequence analysisAdd BLAST132

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000462331 – 1355Probable phospholipid-transporting ATPase DRS2Add BLAST1355

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei102PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP39524
PaxDbiP39524
PRIDEiP39524

PTM databases

iPTMnetiP39524

Interactioni

Subunit structurei

Interacts with CDC50.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi31740, 596 interactors
ComplexPortaliCPX-1018 DRS2-CDC50 P4-ATPase complex
DIPiDIP-2216N
IntActiP39524, 18 interactors
MINTiP39524
STRINGi4932.YAL026C

Structurei

3D structure databases

ProteinModelPortaliP39524
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00910000144008
HOGENOMiHOG000202528
InParanoidiP39524
KOiK14802
OMAiRMRKQRG
OrthoDBiEOG092C0BQ4

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006539 P-type_ATPase_IV
IPR032631 P-type_ATPase_N
IPR001757 P_typ_ATPase
IPR032630 P_typ_ATPase_c
PANTHERiPTHR24092 PTHR24092, 1 hit
PfamiView protein in Pfam
PF16212 PhoLip_ATPase_C, 1 hit
PF16209 PhoLip_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 3 hits
SSF81653 SSF81653, 2 hits
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01652 ATPase-Plipid, 1 hit
TIGR01494 ATPase_P-type, 1 hit
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequencei

Sequence statusi: Complete.

P39524-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDDRETPPK RKPGEDDTLF DIDFLDDTTS HSGSRSKVTN SHANANYIPP
60 70 80 90 100
SHVLPEETID LDADDDNIEN DVHENLFMSN NHDDQTSWNA NRFDSDAYQP
110 120 130 140 150
QSLRAVKPPG LFARFGNGLK NAFTFKRKKG PESFEMNHYN AVTNNELDDN
160 170 180 190 200
YLDSRNKFNI KILFNRYILR KNVGDAEGNG EPRVIHINDS LANSSFGYSD
210 220 230 240 250
NHISTTKYNF ATFLPKFLFQ EFSKYANLFF LCTSAIQQVP HVSPTNRYTT
260 270 280 290 300
IGTLLVVLIV SAMKECIEDI KRANSDKELN NSTAEIFSEA HDDFVEKRWI
310 320 330 340 350
DIRVGDIIRV KSEEPIPADT IILSSSEPEG LCYIETANLD GETNLKIKQS
360 370 380 390 400
RVETAKFIDV KTLKNMNGKV VSEQPNSSLY TYEGTMTLND RQIPLSPDQM
410 420 430 440 450
ILRGATLRNT AWIFGLVIFT GHETKLLRNA TATPIKRTAV EKIINRQIIA
460 470 480 490 500
LFTVLIVLIL ISSIGNVIMS TADAKHLSYL YLEGTNKAGL FFKDFLTFWI
510 520 530 540 550
LFSNLVPISL FVTVELIKYY QAFMIGSDLD LYYEKTDTPT VVRTSSLVEE
560 570 580 590 600
LGQIEYIFSD KTGTLTRNIM EFKSCSIAGH CYIDKIPEDK TATVEDGIEV
610 620 630 640 650
GYRKFDDLKK KLNDPSDEDS PIINDFLTLL ATCHTVIPEF QSDGSIKYQA
660 670 680 690 700
ASPDEGALVQ GGADLGYKFI IRKPNSVTVL LEETGEEKEY QLLNICEFNS
710 720 730 740 750
TRKRMSAIFR FPDGSIKLFC KGADTVILER LDDEANQYVE ATMRHLEDYA
760 770 780 790 800
SEGLRTLCLA MRDISEGEYE EWNSIYNEAA TTLDNRAEKL DEAANLIEKN
810 820 830 840 850
LILIGATAIE DKLQDGVPET IHTLQEAGIK IWVLTGDRQE TAINIGMSCR
860 870 880 890 900
LLSEDMNLLI INEETRDDTE RNLLEKINAL NEHQLSTHDM NTLALVIDGK
910 920 930 940 950
SLGFALEPEL EDYLLTVAKL CKAVICCRVS PLQKALVVKM VKRKSSSLLL
960 970 980 990 1000
AIGDGANDVS MIQAAHVGVG ISGMEGMQAA RSADIAVGQF KFLKKLLLVH
1010 1020 1030 1040 1050
GSWSYQRISV AILYSFYKNT ALYMTQFWYV FANAFSGQSI MESWTMSFYN
1060 1070 1080 1090 1100
LFFTVWPPFV IGVFDQFVSS RLLERYPQLY KLGQKGQFFS VYIFWGWIIN
1110 1120 1130 1140 1150
GFFHSAIVFI GTILIYRYGF ALNMHGELAD HWSWGVTVYT TSVIIVLGKA
1160 1170 1180 1190 1200
ALVTNQWTKF TLIAIPGSLL FWLIFFPIYA SIFPHANISR EYYGVVKHTY
1210 1220 1230 1240 1250
GSGVFWLTLI VLPIFALVRD FLWKYYKRMY EPETYHVIQE MQKYNISDSR
1260 1270 1280 1290 1300
PHVQQFQNAI RKVRQVQRMK KQRGFAFSQA EEGGQEKIVR MYDTTQKRGK
1310 1320 1330 1340 1350
YGELQDASAN PFNDNNGLGS NDFESAEPFI ENPFADGNQN SNRFSSSRDD

ISFDI
Length:1,355
Mass (Da):153,765
Last modified:July 27, 2011 - v2
Checksum:i5745B92901F8E1AE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti45 – 46AN → GY in AAA16891 (PubMed:8247005).Curated2
Sequence conflicti45 – 46AN → GY in AAC05006 (PubMed:7731988).Curated2
Sequence conflicti450A → R in AAA16891 (PubMed:8247005).Curated1
Sequence conflicti450A → R in AAC05006 (PubMed:7731988).Curated1
Sequence conflicti674P → G in AAA16891 (PubMed:8247005).Curated1
Sequence conflicti674P → G in AAC05006 (PubMed:7731988).Curated1
Sequence conflicti891 – 892NT → KS in AAA16891 (PubMed:8247005).Curated2
Sequence conflicti891 – 892NT → KS in AAC05006 (PubMed:7731988).Curated2
Sequence conflicti953 – 954GD → AS in AAA16891 (PubMed:8247005).Curated2
Sequence conflicti953 – 954GD → AS in AAC05006 (PubMed:7731988).Curated2
Sequence conflicti987V → L in AAA16891 (PubMed:8247005).Curated1
Sequence conflicti987V → L in AAC05006 (PubMed:7731988).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01795 Unassigned RNA Translation: AAA16891.1
U12980 Genomic DNA Translation: AAC05006.1
BK006935 Genomic DNA Translation: DAA06962.2
PIRiS51995
RefSeqiNP_009376.2, NM_001178171.2

Genome annotation databases

EnsemblFungiiYAL026C; YAL026C; YAL026C
GeneIDi851207
KEGGisce:YAL026C

Similar proteinsi

Entry informationi

Entry nameiATC3_YEAST
AccessioniPrimary (citable) accession number: P39524
Secondary accession number(s): D6VPJ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 27, 2011
Last modified: July 18, 2018
This is version 185 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

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