UniProtKB - P39520 (IFH1_YEAST)
Protein
Protein IFH1
Gene
IFH1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Controls the pre-rRNA processing machinery in conjunction with FHL1. Could convert FHL1 from a repressor to an activator.
Miscellaneous
Present with 1430 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- transcription coactivator activity Source: SGD
- transcription coregulator activity Source: GO_Central
GO - Biological processi
- chromatin silencing at telomere Source: SGD
- positive regulation of ribosomal protein gene transcription by RNA polymerase II Source: SGD
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Protein IFH1Alternative name(s): Ribosomal RNA-processing protein 3 |
Gene namesi | Name:IFH1 Synonyms:RRP3 Ordered Locus Names:YLR223C ORF Names:L8083.9 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000004213, IFH1 |
VEuPathDBi | FungiDB:YLR223C |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- CURI complex Source: SGD
- nuclear chromatin Source: SGD
- nucleolus Source: SGD
- nucleus Source: SGD
Other locations
- chromosome, telomeric region Source: GOC
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000084164 | 1 – 1085 | Protein IFH1Add BLAST | 1085 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 208 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1041 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P39520 |
PaxDbi | P39520 |
PRIDEi | P39520 |
PTM databases
iPTMneti | P39520 |
Interactioni
Binary interactionsi
P39520
With | #Exp. | IntAct |
---|---|---|
UTP22 [P53254] | 6 | EBI-9054,EBI-1878 |
Protein-protein interaction databases
BioGRIDi | 31490, 49 interactors |
ComplexPortali | CPX-774, CURI complex variant 1 CPX-775, CURI complex variant 2 CPX-776, CURI complex variant 3 |
DIPi | DIP-905N |
IntActi | P39520, 13 interactors |
MINTi | P39520 |
STRINGi | 4932.YLR223C |
Miscellaneous databases
RNActi | P39520, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 122 – 163 | Asp/Glu-rich (highly acidic)Add BLAST | 42 |
Sequence similaritiesi
Belongs to the IFH1 family.Curated
Phylogenomic databases
eggNOGi | ENOG502QQB6, Eukaryota |
GeneTreei | ENSGT00940000176808 |
HOGENOMi | CLU_009986_0_0_1 |
InParanoidi | P39520 |
OMAi | KLGTWET |
Family and domain databases
InterProi | View protein in InterPro IPR018837, TF_CRF1/IFH1 |
PANTHERi | PTHR28057, PTHR28057, 1 hit |
Pfami | View protein in Pfam PF10380, CRF1, 1 hit |
i Sequence
Sequence statusi: Complete.
P39520-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGKKSPRKS TINHSTHSGK LPANIKRLIK KGESDTKSRQ SPPTLSTTRP
60 70 80 90 100
RRFSLIYSSE SSLSDVSDSD KNKSTNPHKI KRKAKNISNN SQGKKSKLIQ
110 120 130 140 150
RQIDNDDEGT ESSDYQAVTD GEESENEEEE SEEEEEDDDE DDDDDDDDGS
160 170 180 190 200
DSDSDSETSS DDENIDFVKL TAQRKKRAMK ALSAMNTNSN TLYSSRENSN
210 220 230 240 250
KNKSVKLSPK KENEEEQKEE KEKEKEEQQK QQESNKKEVN GSGTTTTQQA
260 270 280 290 300
LSFKFKKEDD GISFGNGNEG YNEDIGEEVL DLKNKENNGN EEDKLDSKVM
310 320 330 340 350
LGNNDELRFP NISESDESEY DIDQDAYFDV INNEDSHGEI GTDLETGEDD
360 370 380 390 400
LPILEEEEQN IVSELQNDDE LSFDGSIHEE GSDPVEDAEN KFLQNEYNQE
410 420 430 440 450
NGYDEEDDEE DEIMSDFDMP FYEDPKFANL YYYGDGSEPK LSLSTSLPLM
460 470 480 490 500
LNDEKLSKLK KKEAKKREQE ERKQRRKLYK KTQKPSTRTT SNVDNDEYIF
510 520 530 540 550
NVFFQSDDEN SGHKSKKGRH KSGKSHIEHK NKGSNLIKSN DDLEPSTHST
560 570 580 590 600
VLNSGKYDSS DDEYDNILLD VAHMPSDDEC SESETSHDAD TDEELRALDS
610 620 630 640 650
DSLDIGTELD DDYEDDDDDS SVTNVFIDID DLDPDSFYFH YDSDGSSSLI
660 670 680 690 700
SSNSDKENSD GSKDCKHDLL ETVVYVDDES TDEDDNLPPP SSRSKNIGSK
710 720 730 740 750
AKEIVSSNVV GLRPPKLGTW ETDNKPFSII DGLSTKSLYA LIQEHQQLRE
760 770 780 790 800
QHQRAQTPDV KREGSSNGNN GDELTLNELL NMSELEDDSP SHTDDMENNY
810 820 830 840 850
NDAINSKSTN GHAADWYEVP KVPLSAFRNK GINAYEEDEY MIPANSNRKV
860 870 880 890 900
PIGYIGNERT RKKIDKMKEL QRKKTEKKRQ LKKKKKLLKI RKQRQKAIKE
910 920 930 940 950
QETMNLQLGI NGHEIIGNNN SHSDINTGTD FTTNENTPMN ELPSHAPEDA
960 970 980 990 1000
SLIPHNSDLA VDSNTRKNST KSVGLDEIHE ILGKDENDLL SVGDINGYDA
1010 1020 1030 1040 1050
QEGHVIEDTD ADILASLTAP VQFDNTLSHE NSNSMWRRRQ SMVEAAAENL
1060 1070 1080
RFTKNGLFSE SALADIEGIM GNDVNHSFEF NDVLQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z29488 Genomic DNA Translation: CAA82624.1 U19027 Genomic DNA Translation: AAB67412.1 BK006945 Genomic DNA Translation: DAA09539.1 |
PIRi | S55352 |
RefSeqi | NP_013324.1, NM_001182110.1 |
Genome annotation databases
EnsemblFungii | YLR223C_mRNA; YLR223C; YLR223C |
GeneIDi | 850920 |
KEGGi | sce:YLR223C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z29488 Genomic DNA Translation: CAA82624.1 U19027 Genomic DNA Translation: AAB67412.1 BK006945 Genomic DNA Translation: DAA09539.1 |
PIRi | S55352 |
RefSeqi | NP_013324.1, NM_001182110.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 31490, 49 interactors |
ComplexPortali | CPX-774, CURI complex variant 1 CPX-775, CURI complex variant 2 CPX-776, CURI complex variant 3 |
DIPi | DIP-905N |
IntActi | P39520, 13 interactors |
MINTi | P39520 |
STRINGi | 4932.YLR223C |
PTM databases
iPTMneti | P39520 |
Proteomic databases
MaxQBi | P39520 |
PaxDbi | P39520 |
PRIDEi | P39520 |
Genome annotation databases
EnsemblFungii | YLR223C_mRNA; YLR223C; YLR223C |
GeneIDi | 850920 |
KEGGi | sce:YLR223C |
Organism-specific databases
SGDi | S000004213, IFH1 |
VEuPathDBi | FungiDB:YLR223C |
Phylogenomic databases
eggNOGi | ENOG502QQB6, Eukaryota |
GeneTreei | ENSGT00940000176808 |
HOGENOMi | CLU_009986_0_0_1 |
InParanoidi | P39520 |
OMAi | KLGTWET |
Miscellaneous databases
PROi | PR:P39520 |
RNActi | P39520, protein |
Family and domain databases
InterProi | View protein in InterPro IPR018837, TF_CRF1/IFH1 |
PANTHERi | PTHR28057, PTHR28057, 1 hit |
Pfami | View protein in Pfam PF10380, CRF1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IFH1_YEAST | |
Accessioni | P39520Primary (citable) accession number: P39520 Secondary accession number(s): D6VYM3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | February 10, 2021 | |
This is version 155 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XII
Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names - SIMILARITY comments
Index of protein domains and families