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Entry version 147 (18 Sep 2019)
Sequence version 1 (01 Feb 1995)
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Protein

Protein IFH1

Gene

IFH1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Controls the pre-rRNA processing machinery in conjunction with FHL1. Could convert FHL1 from a repressor to an activator.

Miscellaneous

Present with 1430 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • transcription coactivator activity Source: SGD

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-32337-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein IFH1
Alternative name(s):
Ribosomal RNA-processing protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IFH1
Synonyms:RRP3
Ordered Locus Names:YLR223C
ORF Names:L8083.9
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XII

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:YLR223C

Saccharomyces Genome Database

More...
SGDi
S000004213 IFH1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000841641 – 1085Protein IFH1Add BLAST1085

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei208PhosphoserineCombined sources1
Modified residuei1041PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
P39520

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P39520

PRoteomics IDEntifications database

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PRIDEi
P39520

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P39520

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
UTP22P532546EBI-9054,EBI-1878

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
31490, 49 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-774 CURI complex variant 1
CPX-775 CURI complex variant 2
CPX-776 CURI complex variant 3

Database of interacting proteins

More...
DIPi
DIP-905N

Protein interaction database and analysis system

More...
IntActi
P39520, 13 interactors

Molecular INTeraction database

More...
MINTi
P39520

STRING: functional protein association networks

More...
STRINGi
4932.YLR223C

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi122 – 163Asp/Glu-rich (highly acidic)Add BLAST42

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IFH1 family.Curated

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113003

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P39520

KEGG Orthology (KO)

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KOi
K21627

Identification of Orthologs from Complete Genome Data

More...
OMAi
KLGTWET

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018837 TF_CRF1/IFH1

The PANTHER Classification System

More...
PANTHERi
PTHR28057 PTHR28057, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10380 CRF1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P39520-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGKKSPRKS TINHSTHSGK LPANIKRLIK KGESDTKSRQ SPPTLSTTRP
60 70 80 90 100
RRFSLIYSSE SSLSDVSDSD KNKSTNPHKI KRKAKNISNN SQGKKSKLIQ
110 120 130 140 150
RQIDNDDEGT ESSDYQAVTD GEESENEEEE SEEEEEDDDE DDDDDDDDGS
160 170 180 190 200
DSDSDSETSS DDENIDFVKL TAQRKKRAMK ALSAMNTNSN TLYSSRENSN
210 220 230 240 250
KNKSVKLSPK KENEEEQKEE KEKEKEEQQK QQESNKKEVN GSGTTTTQQA
260 270 280 290 300
LSFKFKKEDD GISFGNGNEG YNEDIGEEVL DLKNKENNGN EEDKLDSKVM
310 320 330 340 350
LGNNDELRFP NISESDESEY DIDQDAYFDV INNEDSHGEI GTDLETGEDD
360 370 380 390 400
LPILEEEEQN IVSELQNDDE LSFDGSIHEE GSDPVEDAEN KFLQNEYNQE
410 420 430 440 450
NGYDEEDDEE DEIMSDFDMP FYEDPKFANL YYYGDGSEPK LSLSTSLPLM
460 470 480 490 500
LNDEKLSKLK KKEAKKREQE ERKQRRKLYK KTQKPSTRTT SNVDNDEYIF
510 520 530 540 550
NVFFQSDDEN SGHKSKKGRH KSGKSHIEHK NKGSNLIKSN DDLEPSTHST
560 570 580 590 600
VLNSGKYDSS DDEYDNILLD VAHMPSDDEC SESETSHDAD TDEELRALDS
610 620 630 640 650
DSLDIGTELD DDYEDDDDDS SVTNVFIDID DLDPDSFYFH YDSDGSSSLI
660 670 680 690 700
SSNSDKENSD GSKDCKHDLL ETVVYVDDES TDEDDNLPPP SSRSKNIGSK
710 720 730 740 750
AKEIVSSNVV GLRPPKLGTW ETDNKPFSII DGLSTKSLYA LIQEHQQLRE
760 770 780 790 800
QHQRAQTPDV KREGSSNGNN GDELTLNELL NMSELEDDSP SHTDDMENNY
810 820 830 840 850
NDAINSKSTN GHAADWYEVP KVPLSAFRNK GINAYEEDEY MIPANSNRKV
860 870 880 890 900
PIGYIGNERT RKKIDKMKEL QRKKTEKKRQ LKKKKKLLKI RKQRQKAIKE
910 920 930 940 950
QETMNLQLGI NGHEIIGNNN SHSDINTGTD FTTNENTPMN ELPSHAPEDA
960 970 980 990 1000
SLIPHNSDLA VDSNTRKNST KSVGLDEIHE ILGKDENDLL SVGDINGYDA
1010 1020 1030 1040 1050
QEGHVIEDTD ADILASLTAP VQFDNTLSHE NSNSMWRRRQ SMVEAAAENL
1060 1070 1080
RFTKNGLFSE SALADIEGIM GNDVNHSFEF NDVLQ
Length:1,085
Mass (Da):122,492
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBE1C7DEF06213FE0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z29488 Genomic DNA Translation: CAA82624.1
U19027 Genomic DNA Translation: AAB67412.1
BK006945 Genomic DNA Translation: DAA09539.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S55352

NCBI Reference Sequences

More...
RefSeqi
NP_013324.1, NM_001182110.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YLR223C_mRNA; YLR223C; YLR223C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
850920

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YLR223C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z29488 Genomic DNA Translation: CAA82624.1
U19027 Genomic DNA Translation: AAB67412.1
BK006945 Genomic DNA Translation: DAA09539.1
PIRiS55352
RefSeqiNP_013324.1, NM_001182110.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi31490, 49 interactors
ComplexPortaliCPX-774 CURI complex variant 1
CPX-775 CURI complex variant 2
CPX-776 CURI complex variant 3
DIPiDIP-905N
IntActiP39520, 13 interactors
MINTiP39520
STRINGi4932.YLR223C

PTM databases

iPTMnetiP39520

Proteomic databases

MaxQBiP39520
PaxDbiP39520
PRIDEiP39520

Genome annotation databases

EnsemblFungiiYLR223C_mRNA; YLR223C; YLR223C
GeneIDi850920
KEGGisce:YLR223C

Organism-specific databases

EuPathDBiFungiDB:YLR223C
SGDiS000004213 IFH1

Phylogenomic databases

HOGENOMiHOG000113003
InParanoidiP39520
KOiK21627
OMAiKLGTWET

Enzyme and pathway databases

BioCyciYEAST:G3O-32337-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P39520

Family and domain databases

InterProiView protein in InterPro
IPR018837 TF_CRF1/IFH1
PANTHERiPTHR28057 PTHR28057, 1 hit
PfamiView protein in Pfam
PF10380 CRF1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIFH1_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P39520
Secondary accession number(s): D6VYM3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 18, 2019
This is version 147 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
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