Protein IFH1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• transcription coactivator activity Source: SGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "TOR regulates ribosomal protein gene expression via PKA and the forkhead transcription factor FHL1."
    Martin D.E., Soulard A., Hall M.N.
    Cell 119:969-979(2004) [PubMed] [Europe PMC] [Abstract]
• transcription coregulator activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• chromatin silencing at telomere Source: SGDInferred from mutant phenotypeⁱ
  • "Identification of high-copy disruptors of telomeric silencing in Saccharomyces cerevisiae."
    Singer M.S., Kahana A., Wolf A.J., Meisinger L.L., Peterson S.E., Goggin C., Mahowald M., Gottschling D.E.
    Genetics 150:613-632(1998) [PubMed] [Europe PMC] [Abstract]
• positive regulation of ribosomal protein gene transcription by RNA polymerase II Source: SGDInferred from mutant phenotypeⁱ
  • "Growth-regulated recruitment of the essential yeast ribosomal protein gene activator Ifh1."
    Schawalder S.B., Kabani M., Howald I., Choudhury U., Werner M., Shore D.
    Nature 432:1058-1061(2004) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MAGKKSPRKS TINHSTHSGK LPANIKRLIK KGESDTKSRQ SPPTLSTTRP 
        60         70         80         90        100
RRFSLIYSSE SSLSDVSDSD KNKSTNPHKI KRKAKNISNN SQGKKSKLIQ 
       110        120        130        140        150
RQIDNDDEGT ESSDYQAVTD GEESENEEEE SEEEEEDDDE DDDDDDDDGS 
       160        170        180        190        200
DSDSDSETSS DDENIDFVKL TAQRKKRAMK ALSAMNTNSN TLYSSRENSN 
       210        220        230        240        250
KNKSVKLSPK KENEEEQKEE KEKEKEEQQK QQESNKKEVN GSGTTTTQQA 
       260        270        280        290        300
LSFKFKKEDD GISFGNGNEG YNEDIGEEVL DLKNKENNGN EEDKLDSKVM 
       310        320        330        340        350
LGNNDELRFP NISESDESEY DIDQDAYFDV INNEDSHGEI GTDLETGEDD 
       360        370        380        390        400
LPILEEEEQN IVSELQNDDE LSFDGSIHEE GSDPVEDAEN KFLQNEYNQE 
       410        420        430        440        450
NGYDEEDDEE DEIMSDFDMP FYEDPKFANL YYYGDGSEPK LSLSTSLPLM 
       460        470        480        490        500
LNDEKLSKLK KKEAKKREQE ERKQRRKLYK KTQKPSTRTT SNVDNDEYIF 
       510        520        530        540        550
NVFFQSDDEN SGHKSKKGRH KSGKSHIEHK NKGSNLIKSN DDLEPSTHST 
       560        570        580        590        600
VLNSGKYDSS DDEYDNILLD VAHMPSDDEC SESETSHDAD TDEELRALDS 
       610        620        630        640        650
DSLDIGTELD DDYEDDDDDS SVTNVFIDID DLDPDSFYFH YDSDGSSSLI 
       660        670        680        690        700
SSNSDKENSD GSKDCKHDLL ETVVYVDDES TDEDDNLPPP SSRSKNIGSK 
       710        720        730        740        750
AKEIVSSNVV GLRPPKLGTW ETDNKPFSII DGLSTKSLYA LIQEHQQLRE 
       760        770        780        790        800
QHQRAQTPDV KREGSSNGNN GDELTLNELL NMSELEDDSP SHTDDMENNY 
       810        820        830        840        850
NDAINSKSTN GHAADWYEVP KVPLSAFRNK GINAYEEDEY MIPANSNRKV 
       860        870        880        890        900
PIGYIGNERT RKKIDKMKEL QRKKTEKKRQ LKKKKKLLKI RKQRQKAIKE 
       910        920        930        940        950
QETMNLQLGI NGHEIIGNNN SHSDINTGTD FTTNENTPMN ELPSHAPEDA 
       960        970        980        990       1000
SLIPHNSDLA VDSNTRKNST KSVGLDEIHE ILGKDENDLL SVGDINGYDA 
      1010       1020       1030       1040       1050
QEGHVIEDTD ADILASLTAP VQFDNTLSHE NSNSMWRRRQ SMVEAAAENL 
      1060       1070       1080 
RFTKNGLFSE SALADIEGIM GNDVNHSFEF NDVLQ                 

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Yeast
   Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
2. Yeast chromosome XII
   Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names
3. SIMILARITY comments
   Index of protein domains and families