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UniProtKB - P39520 (IFH1_YEAST)

Entry version 155 (10 Feb 2021)
Sequence version 1 (01 Feb 1995)
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Protein

Protein IFH1

Gene

IFH1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Controls the pre-rRNA processing machinery in conjunction with FHL1. Could convert FHL1 from a repressor to an activator.

Miscellaneous

Present with 1430 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • transcription coactivator activity Source: SGD
  • transcription coregulator activity Source: GO_Central
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein IFH1
Alternative name(s):
Ribosomal RNA-processing protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IFH1
Synonyms:RRP3
Ordered Locus Names:YLR223C
ORF Names:L8083.9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XII

Organism-specific databases

Saccharomyces Genome Database

More...SGDi		S000004213, IFH1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		FungiDB:YLR223C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000841641 – 1085Protein IFH1Add BLAST1085

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei208PhosphoserineCombined sources1
Modified residuei1041PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		P39520

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P39520

PRoteomics IDEntifications database

More...PRIDEi		P39520

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P39520

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		31490, 49 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-774, CURI complex variant 1
CPX-775, CURI complex variant 2
CPX-776, CURI complex variant 3

Database of interacting proteins

More...DIPi		DIP-905N

Protein interaction database and analysis system

More...IntActi		P39520, 13 interactors

Molecular INTeraction database

More...MINTi		P39520

STRING: functional protein association networks

More...STRINGi		4932.YLR223C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P39520, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi122 – 163Asp/Glu-rich (highly acidic)Add BLAST42

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IFH1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QQB6, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000176808

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009986_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P39520

Identification of Orthologs from Complete Genome Data

More...OMAi		KLGTWET

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR018837, TF_CRF1/IFH1

The PANTHER Classification System

More...PANTHERi		PTHR28057, PTHR28057, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF10380, CRF1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P39520-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGKKSPRKS TINHSTHSGK LPANIKRLIK KGESDTKSRQ SPPTLSTTRP 
        60         70         80         90        100
RRFSLIYSSE SSLSDVSDSD KNKSTNPHKI KRKAKNISNN SQGKKSKLIQ 
       110        120        130        140        150
RQIDNDDEGT ESSDYQAVTD GEESENEEEE SEEEEEDDDE DDDDDDDDGS 
       160        170        180        190        200
DSDSDSETSS DDENIDFVKL TAQRKKRAMK ALSAMNTNSN TLYSSRENSN 
       210        220        230        240        250
KNKSVKLSPK KENEEEQKEE KEKEKEEQQK QQESNKKEVN GSGTTTTQQA 
       260        270        280        290        300
LSFKFKKEDD GISFGNGNEG YNEDIGEEVL DLKNKENNGN EEDKLDSKVM 
       310        320        330        340        350
LGNNDELRFP NISESDESEY DIDQDAYFDV INNEDSHGEI GTDLETGEDD 
       360        370        380        390        400
LPILEEEEQN IVSELQNDDE LSFDGSIHEE GSDPVEDAEN KFLQNEYNQE 
       410        420        430        440        450
NGYDEEDDEE DEIMSDFDMP FYEDPKFANL YYYGDGSEPK LSLSTSLPLM 
       460        470        480        490        500
LNDEKLSKLK KKEAKKREQE ERKQRRKLYK KTQKPSTRTT SNVDNDEYIF 
       510        520        530        540        550
NVFFQSDDEN SGHKSKKGRH KSGKSHIEHK NKGSNLIKSN DDLEPSTHST 
       560        570        580        590        600
VLNSGKYDSS DDEYDNILLD VAHMPSDDEC SESETSHDAD TDEELRALDS 
       610        620        630        640        650
DSLDIGTELD DDYEDDDDDS SVTNVFIDID DLDPDSFYFH YDSDGSSSLI 
       660        670        680        690        700
SSNSDKENSD GSKDCKHDLL ETVVYVDDES TDEDDNLPPP SSRSKNIGSK 
       710        720        730        740        750
AKEIVSSNVV GLRPPKLGTW ETDNKPFSII DGLSTKSLYA LIQEHQQLRE 
       760        770        780        790        800
QHQRAQTPDV KREGSSNGNN GDELTLNELL NMSELEDDSP SHTDDMENNY 
       810        820        830        840        850
NDAINSKSTN GHAADWYEVP KVPLSAFRNK GINAYEEDEY MIPANSNRKV 
       860        870        880        890        900
PIGYIGNERT RKKIDKMKEL QRKKTEKKRQ LKKKKKLLKI RKQRQKAIKE 
       910        920        930        940        950
QETMNLQLGI NGHEIIGNNN SHSDINTGTD FTTNENTPMN ELPSHAPEDA 
       960        970        980        990       1000
SLIPHNSDLA VDSNTRKNST KSVGLDEIHE ILGKDENDLL SVGDINGYDA 
      1010       1020       1030       1040       1050
QEGHVIEDTD ADILASLTAP VQFDNTLSHE NSNSMWRRRQ SMVEAAAENL 
      1060       1070       1080 
RFTKNGLFSE SALADIEGIM GNDVNHSFEF NDVLQ
Length:1,085
Mass (Da):122,492
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBE1C7DEF06213FE0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Z29488 Genomic DNA Translation: CAA82624.1
U19027 Genomic DNA Translation: AAB67412.1
BK006945 Genomic DNA Translation: DAA09539.1

Protein sequence database of the Protein Information Resource

More...PIRi		S55352

NCBI Reference Sequences

More...RefSeqi		NP_013324.1, NM_001182110.1

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		YLR223C_mRNA; YLR223C; YLR223C

Database of genes from NCBI RefSeq genomes

More...GeneIDi		850920

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		sce:YLR223C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z29488 Genomic DNA Translation: CAA82624.1
U19027 Genomic DNA Translation: AAB67412.1
BK006945 Genomic DNA Translation: DAA09539.1
PIRiS55352
RefSeqiNP_013324.1, NM_001182110.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi31490, 49 interactors
ComplexPortaliCPX-774, CURI complex variant 1
CPX-775, CURI complex variant 2
CPX-776, CURI complex variant 3
DIPiDIP-905N
IntActiP39520, 13 interactors
MINTiP39520
STRINGi4932.YLR223C

PTM databases

iPTMnetiP39520

Proteomic databases

MaxQBiP39520
PaxDbiP39520
PRIDEiP39520

Genome annotation databases

EnsemblFungiiYLR223C_mRNA; YLR223C; YLR223C
GeneIDi850920
KEGGisce:YLR223C

Organism-specific databases

SGDiS000004213, IFH1
VEuPathDBiFungiDB:YLR223C

Phylogenomic databases

eggNOGiENOG502QQB6, Eukaryota
GeneTreeiENSGT00940000176808
HOGENOMiCLU_009986_0_0_1
InParanoidiP39520
OMAiKLGTWET

Miscellaneous databases

Protein Ontology

More...PROi		PR:P39520
RNActiP39520, protein

Family and domain databases

InterProiView protein in InterPro
IPR018837, TF_CRF1/IFH1
PANTHERiPTHR28057, PTHR28057, 1 hit
PfamiView protein in Pfam
PF10380, CRF1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIFH1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P39520
Secondary accession number(s): D6VYM3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: February 10, 2021
This is version 155 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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