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Protein

Alcohol dehydrogenase, propanol-preferring

Gene

adhP

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Preferred specificity is towards 1-propanol.

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi37Zinc 1; catalyticBy similarity1
Metal bindingi58Zinc 1; catalyticBy similarity1
Metal bindingi89Zinc 2By similarity1
Metal bindingi92Zinc 2By similarity1
Metal bindingi95Zinc 2By similarity1
Metal bindingi103Zinc 2By similarity1
Metal bindingi145Zinc 1; catalyticBy similarity1

GO - Molecular functioni

  • alcohol dehydrogenase (NAD) activity Source: EcoCyc
  • zinc ion binding Source: EcoCyc

GO - Biological processi

  • acetaldehyde catabolic process Source: EcoliWiki
  • cellular response to DNA damage stimulus Source: EcoliWiki
  • response to ethanol Source: EcoliWiki

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciEcoCyc:ADHP-MONOMER
MetaCyc:ADHP-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase, propanol-preferring (EC:1.1.1.1)
Gene namesi
Name:adhP
Synonyms:yddN
Ordered Locus Names:b1478, JW1474
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12622 adhP

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607401 – 336Alcohol dehydrogenase, propanol-preferringAdd BLAST336

Proteomic databases

EPDiP39451
PaxDbiP39451
PRIDEiP39451

Interactioni

Protein-protein interaction databases

BioGridi4262899, 24 interactors
IntActiP39451, 5 interactors
STRINGi316385.ECDH10B_1609

Structurei

Secondary structure

1336
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 6Combined sources5
Beta strandi12 – 16Combined sources5
Beta strandi26 – 35Combined sources10
Helixi38 – 45Combined sources8
Turni46 – 48Combined sources3
Beta strandi58 – 67Combined sources10
Beta strandi79 – 87Combined sources9
Beta strandi90 – 92Combined sources3
Helixi95 – 97Combined sources3
Helixi100 – 102Combined sources3
Turni109 – 111Combined sources3
Beta strandi116 – 124Combined sources9
Helixi125 – 127Combined sources3
Helixi137 – 143Combined sources7
Helixi146 – 156Combined sources11
Beta strandi164 – 168Combined sources5
Helixi172 – 183Combined sources12
Beta strandi188 – 194Combined sources7
Helixi196 – 204Combined sources9
Beta strandi208 – 212Combined sources5
Turni213 – 215Combined sources3
Helixi218 – 226Combined sources9
Beta strandi227 – 234Combined sources8
Helixi239 – 248Combined sources10
Beta strandi249 – 257Combined sources9
Beta strandi262 – 268Combined sources7
Helixi269 – 274Combined sources6
Beta strandi278 – 281Combined sources4
Helixi287 – 298Combined sources12
Beta strandi306 – 309Combined sources4
Helixi311 – 313Combined sources3
Helixi314 – 322Combined sources9
Beta strandi327 – 333Combined sources7

3D structure databases

ProteinModelPortaliP39451
SMRiP39451
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105DQ4 Bacteria
COG1064 LUCA
HOGENOMiHOG000294685
InParanoidiP39451
KOiK13953
OMAiARIPKEC
PhylomeDBiP39451

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

P39451-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAAVVTKDH HVDVTYKTLR SLKHGEALLK MECCGVCHTD LHVKNGDFGD
60 70 80 90 100
KTGVILGHEG IGVVAEVGPG VTSLKPGDRA SVAWFYEGCG HCEYCNSGNE
110 120 130 140 150
TLCRSVKNAG YSVDGGMAEE CIVVADYAVK VPDGLDSAAA SSITCAGVTT
160 170 180 190 200
YKAVKLSKIR PGQWIAIYGL GGLGNLALQY AKNVFNAKVI AIDVNDEQLK
210 220 230 240 250
LATEMGADLA INSHTEDAAK IVQEKTGGAH AAVVTAVAKA AFNSAVDAVR
260 270 280 290 300
AGGRVVAVGL PPESMSLDIP RLVLDGIEVV GSLVGTRQDL TEAFQFAAEG
310 320 330
KVVPKVALRP LADINTIFTE MEEGKIRGRM VIDFRH
Length:336
Mass (Da):35,380
Last modified:November 1, 1997 - v1
Checksum:i8A9080F273866947
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34C → P AA sequence (Ref. 4) Curated1
Sequence conflicti90G → R in M31532 (PubMed:2158980).Curated1
Sequence conflicti104R → P in M31532 (PubMed:2158980).Curated1
Sequence conflicti108N → K in M31532 (PubMed:2158980).Curated1
Sequence conflicti112S → G in M31532 (PubMed:2158980).Curated1
Sequence conflicti117 – 118MA → RV in M31532 (PubMed:2158980).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74551.2
AP009048 Genomic DNA Translation: BAA15126.1
M31532 Genomic DNA No translation available.
PIRiA64901
RefSeqiNP_415995.4, NC_000913.3
WP_000642433.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74551; AAC74551; b1478
BAA15126; BAA15126; BAA15126
GeneIDi946036
KEGGiecj:JW1474
eco:b1478
PATRICifig|1411691.4.peg.789

Similar proteinsi

Entry informationi

Entry nameiADHP_ECOLI
AccessioniPrimary (citable) accession number: P39451
Secondary accession number(s): P76126, P78157, P78268
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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