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Protein

S-(hydroxymethyl)glutathione dehydrogenase

Gene

frmA

Organism
Photobacterium damsela subsp. piscicida (Pasteurella piscicida)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H.
A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi40Zinc 1; catalyticBy similarity1
Metal bindingi62Zinc 1; catalyticBy similarity1
Metal bindingi92Zinc 2By similarity1
Metal bindingi95Zinc 2By similarity1
Metal bindingi98Zinc 2By similarity1
Metal bindingi106Zinc 2By similarity1
Metal bindingi169Zinc 1; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
S-(hydroxymethyl)glutathione dehydrogenase (EC:1.1.1.284)
Alternative name(s):
Alcohol dehydrogenase class-3 (EC:1.1.1.1)
Alcohol dehydrogenase class-III
Glutathione-dependent formaldehyde dehydrogenase (EC:1.1.1.-)
Short name:
FALDH
Short name:
FDH
Short name:
GSH-FDH
Gene namesi
Name:frmA
Encoded oniPlasmid R1 Publication
OrganismiPhotobacterium damsela subsp. piscicida (Pasteurella piscicida)
Taxonomic identifieri38294 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607771 – 369S-(hydroxymethyl)glutathione dehydrogenaseAdd BLAST369

Proteomic databases

PRIDEiP39450

Structurei

3D structure databases

ProteinModelPortaliP39450
SMRiP39450
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

CDDicd08300 alcohol_DH_class_III, 1 hit
InterProiView protein in InterPro
IPR014183 ADH_3
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR02818 adh_III_F_hyde, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

P39450-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKSRAAVAFG PGLPLEIVEI DVAPPKKGEV LVKISHTGVC HTDAYTLSGD
60 70 80 90 100
DPEGLFPVVL GHEGAGVVVE VGEGVTSVKP GDHVIPLYTA ECGECDFCTS
110 120 130 140 150
GKTNLCVAVR ETQGKGVMPD ATSRFFVNGQ PLYHYMGCST FSEYTVVAEV
160 170 180 190 200
SLAKINPQAN AEQVCLLGCG VTTGIGAVHN TAKVQEGDSV AVFGLGGIGL
210 220 230 240 250
AVVQGARQAK AGRIFAIDTN PSKFELAKQF GATDCINPND YDKPVQQVLV
260 270 280 290 300
EMTKWGVDHT FECIGNVNVM RSALESAHRG WGQSVIIGVA GAGKEISTRP
310 320 330 340 350
FQLVTGRVWK GTAFGGVKGR TQLPGMVEDA MSGKIELAPF VTHTMELDKI
360
NEAFDLMHDG KSIRTVIHY
Length:369
Mass (Da):39,094
Last modified:February 1, 1995 - v1
Checksum:iACAEA4581048901C
GO

Sequence cautioni

The sequence BAA03719 differs from that shown. Reason: Frameshift at position 128.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16172 Genomic DNA Translation: BAA03719.1 Frameshift.
RefSeqiYP_003023972.1, NC_012919.1
YP_908417.1, NC_008612.1
YP_908601.1, NC_008613.1

Genome annotation databases

GeneIDi4549487
4549496
8242395

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16172 Genomic DNA Translation: BAA03719.1 Frameshift.
RefSeqiYP_003023972.1, NC_012919.1
YP_908417.1, NC_008612.1
YP_908601.1, NC_008613.1

3D structure databases

ProteinModelPortaliP39450
SMRiP39450
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP39450

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4549487
4549496
8242395

Family and domain databases

CDDicd08300 alcohol_DH_class_III, 1 hit
InterProiView protein in InterPro
IPR014183 ADH_3
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR02818 adh_III_F_hyde, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFRMA_PHODP
AccessioniPrimary (citable) accession number: P39450
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 22, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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