UniProtKB - P39401 (OPGB_ECOLI)
Protein
Phosphoglycerol transferase I
Gene
mdoB
Organism
Escherichia coli (strain K12)
Status
Functioni
Transfers a phosphoglycerol residue from phosphatidylglycerol to the membrane-bound nascent glucan backbones.2 Publications
Catalytic activityi
- Phosphatidylglycerol + membrane-derived-oligosaccharide D-glucose = 1,2-diacyl-sn-glycerol + membrane-derived-oligosaccharide 6-(glycerophospho)-D-glucose. EC:2.7.8.20
: osmoregulated periplasmic glucan (OPG) biosynthesis Pathwayi
This protein is involved in the pathway osmoregulated periplasmic glucan (OPG) biosynthesis, which is part of Glycan metabolism.View all proteins of this organism that are known to be involved in the pathway osmoregulated periplasmic glucan (OPG) biosynthesis and in Glycan metabolism.
GO - Molecular functioni
- arylsulfatase activity Source: GO_Central
- phosphatidylglycerol-membrane-oligosaccharide glycerophosphotransferase activity Source: EcoCyc
GO - Biological processi
- glucan biosynthetic process Source: UniProtKB-UniRule
- oligosaccharide-lipid intermediate biosynthetic process Source: EcoCyc
Keywordsi
Molecular function | Transferase |
Enzyme and pathway databases
BioCyci | EcoCyc:PGLYCEROLTRANSI-MONOMER ECOL316407:JW5794-MONOMER MetaCyc:PGLYCEROLTRANSI-MONOMER |
UniPathwayi | UPA00637 |
Names & Taxonomyi
Protein namesi | Recommended name: Phosphoglycerol transferase I (EC:2.7.8.20)Alternative name(s): Phosphatidylglycerol--membrane-oligosaccharide glycerophosphotransferase |
Gene namesi | Name:mdoB Synonyms:opgB, yjjO Ordered Locus Names:b4359, JW5794 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
- Cell inner membrane 1 Publication; Multi-pass membrane protein 1 Publication
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 1 – 21 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 26 – 46 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 77 – 97 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 108 – 128 | HelicalSequence analysisAdd BLAST | 21 |
GO - Cellular componenti
- integral component of membrane Source: UniProtKB-KW
- membrane Source: EcoCyc
- periplasmic space Source: EcoCyc
- plasma membrane Source: EcoCyc
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000213059 | 1 – 763 | Phosphoglycerol transferase IAdd BLAST | 763 |
Proteomic databases
PaxDbi | P39401 |
PRIDEi | P39401 |
Interactioni
Protein-protein interaction databases
BioGridi | 4261390, 165 interactors |
DIPi | DIP-10175N |
IntActi | P39401, 1 interactor |
STRINGi | 511145.b4359 |
Family & Domainsi
Sequence similaritiesi
Belongs to the OpgB family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG4107RES Bacteria COG1368 LUCA |
HOGENOMi | HOG000127573 |
KOi | K01002 |
Family and domain databases
Gene3Di | 3.40.720.10, 1 hit |
HAMAPi | MF_01070 MdoB_OpgB, 1 hit |
InterProi | View protein in InterPro IPR017850 Alkaline_phosphatase_core_sf IPR020881 Phosphoglycerol_transferase_I IPR000917 Sulfatase_N |
Pfami | View protein in Pfam PF00884 Sulfatase, 1 hit |
SUPFAMi | SSF53649 SSF53649, 1 hit |
i Sequence
Sequence statusi: Complete.
P39401-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSELLSFALF LASVLIYAWK AGRNTWWFAA TLTVLGLFVV LNITLFASDY
60 70 80 90 100
FTGDGINDAV LYTLTNSLTG AGVSKYILPG IGIVLGLTAV FGALGWILRR
110 120 130 140 150
RRHHPHHFGY SLLALLLALG SVDASPAFRQ ITELVKSQSR DGDPDFAAYY
160 170 180 190 200
KEPSKTIPDP KLNLVYIYGE SLERTYFDNE AFPDLTPELG ALKNEGLDFS
210 220 230 240 250
HTQQLPGTDY TIAGMVASQC GIPLFAPFEG NASASVSSFF PQNICLGDIL
260 270 280 290 300
KNSGYQNYFV QGANLRFAGK DVFLKSHGFD HLYGSEELKS VVADPHYRND
310 320 330 340 350
WGFYDDTVLD EAWKKFEELS RSGQRFSLFT LTVDTHHPDG FISRTCNRKK
360 370 380 390 400
YDFDGKPNQS FSAVSCSQEN IATFINKIKA SPWFKDTVIV VSSDHLAMNN
410 420 430 440 450
TAWKYLNKQD RNNLFFVIRG DKPQQETLAV KRNTMDNGAT VLDILGGDNY
460 470 480 490 500
LGLGRSSLSG QSMSEIFLNI KEKTLAWKPD IIRLWKFPKE MKEFTIDQQK
510 520 530 540 550
NMIAFSGSHF RLPLLLRVSD KRVEPLPESE YSAPLRFQLA DFAPRDNFVW
560 570 580 590 600
VDRCYKMAQL WAPELALSTD WCVSQGQLGG QQIVQHVDKT TWQGKTAFKD
610 620 630 640 650
TVIDMARYKG NVDTLKIVDN DIRYKADSFI FNVAGAPEEV KQFSGISRPE
660 670 680 690 700
SWGRWSNAQL GDEVKIEYKH PLPKKFDLVI TAKAYGNNAS RPIPVRVGNE
710 720 730 740 750
EQTLVLGNEV TTTTLHFDNP TDADTLVIVP PEPVSTNEGN ILGHSPRKLG
760
IGMVEIKVVE REG
Sequence cautioni
The sequence AAA97258 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U14003 Genomic DNA Translation: AAA97258.1 Different initiation. U00096 Genomic DNA Translation: AAC77315.2 AP009048 Genomic DNA Translation: BAE78349.1 |
PIRi | S56586 |
RefSeqi | NP_418779.2, NC_000913.3 WP_001292679.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC77315; AAC77315; b4359 BAE78349; BAE78349; BAE78349 |
GeneIDi | 948888 |
KEGGi | ecj:JW5794 eco:b4359 |
PATRICi | fig|1411691.4.peg.2327 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U14003 Genomic DNA Translation: AAA97258.1 Different initiation. U00096 Genomic DNA Translation: AAC77315.2 AP009048 Genomic DNA Translation: BAE78349.1 |
PIRi | S56586 |
RefSeqi | NP_418779.2, NC_000913.3 WP_001292679.1, NZ_LN832404.1 |
3D structure databases
SMRi | P39401 |
ModBasei | Search... |
Protein-protein interaction databases
BioGridi | 4261390, 165 interactors |
DIPi | DIP-10175N |
IntActi | P39401, 1 interactor |
STRINGi | 511145.b4359 |
Proteomic databases
PaxDbi | P39401 |
PRIDEi | P39401 |
Genome annotation databases
EnsemblBacteriai | AAC77315; AAC77315; b4359 BAE78349; BAE78349; BAE78349 |
GeneIDi | 948888 |
KEGGi | ecj:JW5794 eco:b4359 |
PATRICi | fig|1411691.4.peg.2327 |
Organism-specific databases
EchoBASEi | EB2476 |
Phylogenomic databases
eggNOGi | ENOG4107RES Bacteria COG1368 LUCA |
HOGENOMi | HOG000127573 |
KOi | K01002 |
Enzyme and pathway databases
UniPathwayi | UPA00637 |
BioCyci | EcoCyc:PGLYCEROLTRANSI-MONOMER ECOL316407:JW5794-MONOMER MetaCyc:PGLYCEROLTRANSI-MONOMER |
Miscellaneous databases
PROi | PR:P39401 |
Family and domain databases
Gene3Di | 3.40.720.10, 1 hit |
HAMAPi | MF_01070 MdoB_OpgB, 1 hit |
InterProi | View protein in InterPro IPR017850 Alkaline_phosphatase_core_sf IPR020881 Phosphoglycerol_transferase_I IPR000917 Sulfatase_N |
Pfami | View protein in Pfam PF00884 Sulfatase, 1 hit |
SUPFAMi | SSF53649 SSF53649, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | OPGB_ECOLI | |
Accessioni | P39401Primary (citable) accession number: P39401 Secondary accession number(s): Q2M5V7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | July 11, 2001 | |
Last modified: | November 13, 2019 | |
This is version 147 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Escherichia coli
Escherichia coli (strain K12): entries and cross-references to EcoGene - PATHWAY comments
Index of metabolic and biosynthesis pathways