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Protein

Probable L-galactonate transporter

Gene

lgoT

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably responsible for the transport of L-galactonate from the periplasm across the inner membrane. Is essential for growth on L-galactonate as the sole carbon source.1 Publication

GO - Molecular functioni

GO - Biological processi

  • aldonate transmembrane transport Source: EcoCyc
  • transmembrane transport Source: GO_Central

Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:YJIZ-MONOMER
MetaCyc:YJIZ-MONOMER

Protein family/group databases

TCDBi2.A.1.14.33 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Probable L-galactonate transporter
Alternative name(s):
Galactonate:H(+) symporter
Gene namesi
Name:lgoTImported
Synonyms:yjiZ, yjjL
Ordered Locus Names:b4356, JW4319
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12588 lgoT

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 42PeriplasmicSequence analysisAdd BLAST42
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Topological domaini64 – 71CytoplasmicSequence analysis8
Transmembranei72 – 92HelicalSequence analysisAdd BLAST21
Topological domaini93 – 107PeriplasmicSequence analysisAdd BLAST15
Transmembranei108 – 128HelicalSequence analysisAdd BLAST21
Topological domaini129 – 174CytoplasmicSequence analysisAdd BLAST46
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Topological domaini196PeriplasmicSequence analysis1
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Topological domaini218 – 259CytoplasmicSequence analysisAdd BLAST42
Transmembranei260 – 280HelicalSequence analysisAdd BLAST21
Topological domaini281 – 295PeriplasmicSequence analysisAdd BLAST15
Transmembranei296 – 316HelicalSequence analysisAdd BLAST21
Topological domaini317 – 332CytoplasmicSequence analysisAdd BLAST16
Transmembranei333 – 353HelicalSequence analysisAdd BLAST21
Topological domaini354 – 359PeriplasmicSequence analysis6
Transmembranei360 – 380HelicalSequence analysisAdd BLAST21
Topological domaini381 – 394CytoplasmicSequence analysisAdd BLAST14
Transmembranei395 – 415HelicalSequence analysisAdd BLAST21
Topological domaini416 – 422PeriplasmicSequence analysis7
Transmembranei423 – 443HelicalSequence analysisAdd BLAST21
Topological domaini444 – 453Cytoplasmic1 Publication10

GO - Cellular componenti

  • integral component of membrane Source: GO_Central
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Cells lacking this gene fail to grow on L-galactonate as sole carbon source.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001213911 – 453Probable L-galactonate transporterAdd BLAST453

Proteomic databases

PaxDbiP39398
PRIDEiP39398

Expressioni

Inductioni

Highly up-regulated during growth on L-galactonate.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4262773, 125 interactors
DIPiDIP-12656N
IntActiP39398, 1 interactor
STRINGi316407.85677096

Structurei

3D structure databases

ProteinModelPortaliP39398
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108I5G Bacteria
ENOG410XRW2 LUCA
HOGENOMiHOG000113641
InParanoidiP39398
OMAiHAVWARW
PhylomeDBiP39398

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR000849 Sugar_P_transporter
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
PIRSFiPIRSF002808 Hexose_phosphate_transp, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

P39398-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKENITIDP RSSFTPSSSA DIPVPPDGLV QRSTRIKRIQ TTAMLLLFFA
60 70 80 90 100
AVINYLDRSS LSVANLTIRE ELGLSATEIG ALLSVFSLAY GIAQLPCGPL
110 120 130 140 150
LDRKGPRLML GLGMFFWSLF QAMSGMVHNF TQFVLVRIGM GIGEAPMNPC
160 170 180 190 200
GVKVINDWFN IKERGRPMGF FNAASTIGVA VSPPILAAMM LVMGWRGMFI
210 220 230 240 250
TIGVLGIFLA IGWYMLYRNR EHVELTAVEQ AYLNAGSVNA RRDPLSFAEW
260 270 280 290 300
RSLFRNRTMW GMMLGFSGIN YTAWLYLAWL PGYLQTAYNL DLKSTGLMAA
310 320 330 340 350
IPFLFGAAGM LVNGYVTDWL VKGGMAPIKS RKICIIAGMF CSAAFTLIVP
360 370 380 390 400
QATTSMTAVL LIGMALFCIH FAGTSCWGLI HVAVASRMTA SVGSIQNFAS
410 420 430 440 450
FICASFAPII TGFIVDTTHS FRLALIICGC VTAAGALAYI FLVRQPINDP

RKD
Length:453
Mass (Da):49,440
Last modified:July 15, 1998 - v2
Checksum:i43156D106B7FCFFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA Translation: AAA97254.1 Frameshift.
U14003 Genomic DNA Translation: AAA97253.1 Frameshift.
U00096 Genomic DNA Translation: AAC77312.1
AP009048 Genomic DNA Translation: BAE78346.1
PIRiF65250
S56583
RefSeqiNP_418776.1, NC_000913.3
WP_000410113.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77312; AAC77312; b4356
BAE78346; BAE78346; BAE78346
GeneIDi948879
KEGGiecj:JW4319
eco:b4356
PATRICifig|1411691.4.peg.2330

Similar proteinsi

Entry informationi

Entry nameiLGOT_ECOLI
AccessioniPrimary (citable) accession number: P39398
Secondary accession number(s): P39397, Q2M5W0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 15, 1998
Last modified: April 25, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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