UniProtKB - P39398 (LGOT_ECOLI)
Protein
Probable L-galactonate transporter
Gene
lgoT
Organism
Escherichia coli (strain K12)
Status
Functioni
Probably responsible for the transport of L-galactonate from the periplasm across the inner membrane. Is essential for growth on L-galactonate as the sole carbon source.1 Publication
GO - Molecular functioni
- transmembrane transporter activity Source: InterPro
GO - Biological processi
- aldonate transmembrane transport Source: EcoCyc
Keywordsi
Biological process | Sugar transport, Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:YJIZ-MONOMER MetaCyc:YJIZ-MONOMER |
Protein family/group databases
TCDBi | 2.A.1.14.33, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Probable L-galactonate transporterAlternative name(s): Galactonate:H(+) symporter |
Gene namesi | Name:lgoT Synonyms:yjiZ, yjjL Ordered Locus Names:b4356, JW4319 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
- Cell inner membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 42 | PeriplasmicSequence analysisAdd BLAST | 42 | |
Transmembranei | 43 – 63 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 64 – 71 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 72 – 92 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 93 – 107 | PeriplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 108 – 128 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 129 – 174 | CytoplasmicSequence analysisAdd BLAST | 46 | |
Transmembranei | 175 – 195 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 196 | PeriplasmicSequence analysis | 1 | |
Transmembranei | 197 – 217 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 218 – 259 | CytoplasmicSequence analysisAdd BLAST | 42 | |
Transmembranei | 260 – 280 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 281 – 295 | PeriplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 296 – 316 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 317 – 332 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 333 – 353 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 354 – 359 | PeriplasmicSequence analysis | 6 | |
Transmembranei | 360 – 380 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 381 – 394 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 395 – 415 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 416 – 422 | PeriplasmicSequence analysis | 7 | |
Transmembranei | 423 – 443 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 444 – 453 | Cytoplasmic1 Publication | 10 |
GO - Cellular componenti
- integral component of membrane Source: UniProtKB-KW
- plasma membrane Source: EcoCyc
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
Cells lacking this gene fail to grow on L-galactonate as sole carbon source.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000121391 | 1 – 453 | Probable L-galactonate transporterAdd BLAST | 453 |
Proteomic databases
PaxDbi | P39398 |
PRIDEi | P39398 |
Expressioni
Inductioni
Highly up-regulated during growth on L-galactonate.1 Publication
Interactioni
Protein-protein interaction databases
BioGRIDi | 4262773, 125 interactors |
DIPi | DIP-12656N |
IntActi | P39398, 1 interactor |
STRINGi | 511145.b4356 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG2271, Bacteria |
HOGENOMi | CLU_001265_5_1_6 |
InParanoidi | P39398 |
PhylomeDBi | P39398 |
Family and domain databases
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR000849, Sugar_P_transporter |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
PIRSFi | PIRSF002808, Hexose_phosphate_transp, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
i Sequence
Sequence statusi: Complete.
P39398-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEKENITIDP RSSFTPSSSA DIPVPPDGLV QRSTRIKRIQ TTAMLLLFFA
60 70 80 90 100
AVINYLDRSS LSVANLTIRE ELGLSATEIG ALLSVFSLAY GIAQLPCGPL
110 120 130 140 150
LDRKGPRLML GLGMFFWSLF QAMSGMVHNF TQFVLVRIGM GIGEAPMNPC
160 170 180 190 200
GVKVINDWFN IKERGRPMGF FNAASTIGVA VSPPILAAMM LVMGWRGMFI
210 220 230 240 250
TIGVLGIFLA IGWYMLYRNR EHVELTAVEQ AYLNAGSVNA RRDPLSFAEW
260 270 280 290 300
RSLFRNRTMW GMMLGFSGIN YTAWLYLAWL PGYLQTAYNL DLKSTGLMAA
310 320 330 340 350
IPFLFGAAGM LVNGYVTDWL VKGGMAPIKS RKICIIAGMF CSAAFTLIVP
360 370 380 390 400
QATTSMTAVL LIGMALFCIH FAGTSCWGLI HVAVASRMTA SVGSIQNFAS
410 420 430 440 450
FICASFAPII TGFIVDTTHS FRLALIICGC VTAAGALAYI FLVRQPINDP
RKD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U14003 Genomic DNA Translation: AAA97254.1 Frameshift. U14003 Genomic DNA Translation: AAA97253.1 Frameshift. U00096 Genomic DNA Translation: AAC77312.1 AP009048 Genomic DNA Translation: BAE78346.1 |
PIRi | F65250 S56583 |
RefSeqi | NP_418776.1, NC_000913.3 WP_000410113.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC77312; AAC77312; b4356 BAE78346; BAE78346; BAE78346 |
GeneIDi | 49586239 948879 |
KEGGi | ecj:JW4319 eco:b4356 |
PATRICi | fig|1411691.4.peg.2330 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U14003 Genomic DNA Translation: AAA97254.1 Frameshift. U14003 Genomic DNA Translation: AAA97253.1 Frameshift. U00096 Genomic DNA Translation: AAC77312.1 AP009048 Genomic DNA Translation: BAE78346.1 |
PIRi | F65250 S56583 |
RefSeqi | NP_418776.1, NC_000913.3 WP_000410113.1, NZ_LN832404.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4262773, 125 interactors |
DIPi | DIP-12656N |
IntActi | P39398, 1 interactor |
STRINGi | 511145.b4356 |
Protein family/group databases
TCDBi | 2.A.1.14.33, the major facilitator superfamily (mfs) |
Proteomic databases
PaxDbi | P39398 |
PRIDEi | P39398 |
Genome annotation databases
EnsemblBacteriai | AAC77312; AAC77312; b4356 BAE78346; BAE78346; BAE78346 |
GeneIDi | 49586239 948879 |
KEGGi | ecj:JW4319 eco:b4356 |
PATRICi | fig|1411691.4.peg.2330 |
Organism-specific databases
EchoBASEi | EB2473 |
Phylogenomic databases
eggNOGi | COG2271, Bacteria |
HOGENOMi | CLU_001265_5_1_6 |
InParanoidi | P39398 |
PhylomeDBi | P39398 |
Enzyme and pathway databases
BioCyci | EcoCyc:YJIZ-MONOMER MetaCyc:YJIZ-MONOMER |
Miscellaneous databases
PROi | PR:P39398 |
Family and domain databases
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR000849, Sugar_P_transporter |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
PIRSFi | PIRSF002808, Hexose_phosphate_transp, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LGOT_ECOLI | |
Accessioni | P39398Primary (citable) accession number: P39398 Secondary accession number(s): P39397, Q2M5W0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | July 15, 1998 | |
Last modified: | December 2, 2020 | |
This is version 150 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families