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Protein

HTH-type transcriptional regulator YjiE

Gene

yjiE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protects cells from HOCl (hypochlorite) stress but not peroxide or diamide stress. Decreases the intracellular load of reactive oxygen species by up-regulating genes involved in methionine and cysteine biosynthesis and down-regulating Fur-regulated genes involved in iron acquisition. Has also been suggested to down-regulate expression of the flagellar regulon, decreasing motility, but this activity was not confirmed in a second study (PubMed:22223481).1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi28 – 47H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

  • bacterial-type RNA polymerase regulatory region DNA binding Source: EcoCyc
  • DNA binding transcription factor activity Source: InterPro
  • identical protein binding Source: EcoCyc
  • transcription regulatory region sequence-specific DNA binding Source: EcoCyc

GO - Biological processi

  • regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: EcoCyc

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:G7924-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator YjiE
Alternative name(s):
Hypochlorite-response regulator protein YjiE
Quorum-sensing regulator protein D
Gene namesi
Name:yjiE
Synonyms:qseD
Ordered Locus Names:b4327, JW4290
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12566 yjiE

Pathology & Biotechi

Disruption phenotypei

Controversial. Hypermotility, up-regulation of flagellar genes and up-regulation of flagellar protein FliC (PubMed:20494990). Decreased viability following HOCl stress; no effect on motility was seen in this study (PubMed:22223481).2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001058071 – 303HTH-type transcriptional regulator YjiEAdd BLAST303

Proteomic databases

PaxDbiP39376
PRIDEiP39376

Expressioni

Inductioni

Transcription increases throughout growth and is maximal during stationary phase. Is not up-regulated upon exposure to HOCl.2 Publications

Interactioni

Subunit structurei

Forms dimers, tetramers and possibly dodecameric complexes; oligomerization may be governed by cellular concentrations. DNA-binding seems to decrease oligomerization.1 Publication

GO - Molecular functioni

  • identical protein binding Source: EcoCyc

Protein-protein interaction databases

BioGridi4261004, 6 interactors
DIPiDIP-12633N
IntActiP39376, 3 interactors
STRINGi316407.85677070

Structurei

3D structure databases

ProteinModelPortaliP39376
SMRiP39376
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 68HTH lysR-typePROSITE-ProRule annotationAdd BLAST58

Phylogenomic databases

eggNOGiENOG4107YNJ Bacteria
ENOG410XP86 LUCA
HOGENOMiHOG000170696
InParanoidiP39376
KOiK21645
OMAiNLESKWL
PhylomeDBiP39376

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR005119 LysR_subst-bd
IPR000847 Tscrpt_reg_HTH_LysR
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00126 HTH_1, 1 hit
PF03466 LysR_substrate, 1 hit
PRINTSiPR00039 HTHLYSR
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50931 HTH_LYSR, 1 hit

Sequencei

Sequence statusi: Complete.

P39376-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDCGAILHN IETKWLYDFL TLEKCRNFSQ AAVSRNVSQP AFSRRIRALE
60 70 80 90 100
QAIGVELFNR QVTPLQLSEQ GKIFHSQIRH LLQQLESNLA ELRGGSDYAQ
110 120 130 140 150
RKIKIAAAHS LSLGLLPSII SQMPPLFTWA IEAIDVDEAV DKLREGQSDC
160 170 180 190 200
IFSFHDEDLL EAPFDHIRLF ESQLFPVCAS DEHGEALFNL AQPHFPLLNY
210 220 230 240 250
SRNSYMGRLI NRTLTRHSEL SFSTFFVSSM SELLKQVALD GCGIAWLPEY
260 270 280 290 300
AIQQEIRSGK LVVLNRDELV IPIQAYAYRM NTRMNPVAER FWRELRELEI

VLS
Length:303
Mass (Da):34,711
Last modified:February 1, 1995 - v1
Checksum:iC6E6926128C694B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA Translation: AAA97223.1
U00096 Genomic DNA Translation: AAC77283.1
AP009048 Genomic DNA Translation: BAE78320.1
U15029 Genomic DNA Translation: AAC43300.1
PIRiS56552
RefSeqiNP_418747.1, NC_000913.3
WP_000340740.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77283; AAC77283; b4327
BAE78320; BAE78320; BAE78320
GeneIDi948852
KEGGiecj:JW4290
eco:b4327
PATRICifig|511145.12.peg.4471

Similar proteinsi

Entry informationi

Entry nameiYJIE_ECOLI
AccessioniPrimary (citable) accession number: P39376
Secondary accession number(s): Q2M5Y6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

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