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UniProtKB - P39366 (SGCX_ECOLI)
Protein
Putative aminopeptidase SgcX
Gene
sgcX
Organism
Escherichia coli (strain K12)
Status
Functioni
Cofactori
a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 67 | Divalent metal cation 1By similarity | 1 | |
Metal bindingi | 180 | Divalent metal cation 1By similarity | 1 | |
Metal bindingi | 180 | Divalent metal cation 2By similarity | 1 | |
Active sitei | 212 | Proton acceptorBy similarity | 1 | |
Metal bindingi | 213 | Divalent metal cation 2By similarity | 1 | |
Metal bindingi | 235 | Divalent metal cation 1By similarity | 1 | |
Metal bindingi | 329 | Divalent metal cation 2By similarity | 1 |
GO - Molecular functioni
- aminopeptidase activity Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- metallopeptidase activity Source: UniProtKB-KW
Keywordsi
Molecular function | Aminopeptidase, Hydrolase, Metalloprotease, Protease |
Ligand | Metal-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:SGCB-MONOMER |
Protein family/group databases
MEROPSi | M42.A01 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:sgcX Synonyms:yjhO Ordered Locus Names:b4305, JW5776 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000071656 | 1 – 373 | Putative aminopeptidase SgcXAdd BLAST | 373 |
Proteomic databases
PaxDbi | P39366 |
PRIDEi | P39366 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4262743, 3 interactors |
DIPi | DIP-10881N |
STRINGi | 511145.b4305 |
Family & Domainsi
Sequence similaritiesi
Belongs to the peptidase M42 family.Curated
Phylogenomic databases
eggNOGi | COG1363, Bacteria |
HOGENOMi | CLU_047249_0_1_6 |
InParanoidi | P39366 |
PhylomeDBi | P39366 |
Family and domain databases
Gene3Di | 2.40.30.40, 1 hit |
InterProi | View protein in InterPro IPR008007, Peptidase_M42 IPR023367, Peptidase_M42_dom2 |
Pfami | View protein in Pfam PF05343, Peptidase_M42, 1 hit |
PIRSFi | PIRSF001123, PepA_GA, 1 hit |
i Sequence
Sequence statusi: Complete.
P39366-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSFSVQETLF SLLQHNAISG HENAVADVML CEFRRQAKEV WRDRLGNVVA
60 70 80 90 100
RYGSDKPDAL RLMIFAHMDE VGFMVRKIEP SGFLRFERVG GPAQVTMAGS
110 120 130 140 150
IVTLTGDKGP VMGCIGIKSY HFAKGDERTQ SPSVDKLWID IGAKDKDDAI
160 170 180 190 200
RMGIQVGTPV TLYNPPQLLA NDLVCSKALD DRLGCTALLG VADAISTMEL
210 220 230 240 250
DIAVYLVASV QEEFNIRGIV PVLRRVKPDL AIGIDITPSC DTPDLHDYSE
260 270 280 290 300
VRINQGVGIT CLNYHGRGTL AGLITPPRLI RMLEQTALEH NIPVQREVAP
310 320 330 340 350
GVITETGYIQ VEQDGIPCAS LSIPCRYTHS PAEVASLRDL TDCIRLLTAL
360 370
AGMSAAHFPV EPDSGTTQEA HPL
Sequence cautioni
The sequence AAA97201 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 125 | G → A in AAA97201 (PubMed:7610040).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U14003 Genomic DNA Translation: AAA97201.1 Different initiation. U00096 Genomic DNA Translation: AAC77261.2 AP009048 Genomic DNA Translation: BAE78297.1 |
PIRi | C65244 |
RefSeqi | NP_418725.4, NC_000913.3 WP_000010829.1, NZ_SSUV01000012.1 |
Genome annotation databases
EnsemblBacteriai | AAC77261; AAC77261; b4305 BAE78297; BAE78297; BAE78297 |
GeneIDi | 948840 |
KEGGi | ecj:JW5776 eco:b4305 |
PATRICi | fig|1411691.4.peg.2391 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U14003 Genomic DNA Translation: AAA97201.1 Different initiation. U00096 Genomic DNA Translation: AAC77261.2 AP009048 Genomic DNA Translation: BAE78297.1 |
PIRi | C65244 |
RefSeqi | NP_418725.4, NC_000913.3 WP_000010829.1, NZ_SSUV01000012.1 |
3D structure databases
SMRi | P39366 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4262743, 3 interactors |
DIPi | DIP-10881N |
STRINGi | 511145.b4305 |
Protein family/group databases
MEROPSi | M42.A01 |
Proteomic databases
PaxDbi | P39366 |
PRIDEi | P39366 |
Genome annotation databases
EnsemblBacteriai | AAC77261; AAC77261; b4305 BAE78297; BAE78297; BAE78297 |
GeneIDi | 948840 |
KEGGi | ecj:JW5776 eco:b4305 |
PATRICi | fig|1411691.4.peg.2391 |
Organism-specific databases
EchoBASEi | EB2445 |
Phylogenomic databases
eggNOGi | COG1363, Bacteria |
HOGENOMi | CLU_047249_0_1_6 |
InParanoidi | P39366 |
PhylomeDBi | P39366 |
Enzyme and pathway databases
BioCyci | EcoCyc:SGCB-MONOMER |
Miscellaneous databases
PROi | PR:P39366 |
Family and domain databases
Gene3Di | 2.40.30.40, 1 hit |
InterProi | View protein in InterPro IPR008007, Peptidase_M42 IPR023367, Peptidase_M42_dom2 |
Pfami | View protein in Pfam PF05343, Peptidase_M42, 1 hit |
PIRSFi | PIRSF001123, PepA_GA, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SGCX_ECOLI | |
Accessioni | P39366Primary (citable) accession number: P39366 Secondary accession number(s): Q2M609 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | January 23, 2002 | |
Last modified: | February 10, 2021 | |
This is version 134 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - SIMILARITY comments
Index of protein domains and families