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UniProtKB - P39359 (YJHH_ECOLI)
Protein
Probable 2-dehydro-3-deoxy-D-pentonate aldolase YjhH
Gene
yjhH
Organism
Escherichia coli (strain K12)
Status
Functioni
Functions as a 2-dehydro-3-deoxy-D-pentonate aldolase.
1 PublicationCatalytic activityi
- EC:4.1.2.281 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 46 | Charge relay systemBy similarity | 1 | |
Active sitei | 109 | Charge relay systemBy similarity | 1 | |
Active sitei | 135 | Proton donorBy similarity | 1 | |
Active sitei | 164 | Schiff-base intermediate with substrateBy similarity | 1 |
GO - Molecular functioni
- 2-dehydro-3-deoxy-D-pentonate aldolase activity Source: EcoCyc
GO - Biological processi
- aldonic acid catabolic process Source: EcoCyc
Keywordsi
Molecular function | Lyase |
Ligand | Schiff base |
Enzyme and pathway databases
BioCyci | EcoCyc:G7911-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Probable 2-dehydro-3-deoxy-D-pentonate aldolase YjhHCurated (EC:4.1.2.281 Publication) |
Gene namesi | Name:yjhH Ordered Locus Names:b4298, JW5775 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm Curated
Cytosol
- cytosol Source: GO_Central
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Disruption phenotypei
Disruption mutant has reduced ability to catabolize D-xylonic acid. YjhH-yagE double mutant cannot use D-xylonate as the sole source of carbon.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000103245 | 1 – 301 | Probable 2-dehydro-3-deoxy-D-pentonate aldolase YjhHAdd BLAST | 301 |
Proteomic databases
PaxDbi | P39359 |
PRIDEi | P39359 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4260972, 5 interactors |
DIPi | DIP-12622N |
IntActi | P39359, 1 interactor |
STRINGi | 511145.b4298 |
Family & Domainsi
Sequence similaritiesi
Belongs to the DapA family.Curated
Phylogenomic databases
eggNOGi | COG0329, Bacteria |
HOGENOMi | CLU_049343_5_1_6 |
InParanoidi | P39359 |
PhylomeDBi | P39359 |
Family and domain databases
Gene3Di | 3.20.20.70, 1 hit |
InterProi | View protein in InterPro IPR013785, Aldolase_TIM IPR002220, DapA-like IPR020625, Schiff_base-form_aldolases_AS IPR020624, Schiff_base-form_aldolases_CS |
PANTHERi | PTHR12128, PTHR12128, 1 hit |
Pfami | View protein in Pfam PF00701, DHDPS, 1 hit |
PIRSFi | PIRSF001365, DHDPS, 1 hit |
PRINTSi | PR00146, DHPICSNTHASE |
SMARTi | View protein in SMART SM01130, DHDPS, 1 hit |
PROSITEi | View protein in PROSITE PS00665, DHDPS_1, 1 hit PS00666, DHDPS_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P39359-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKKFSGIIPP VSSTFHRDGT LDKKAMREVA DFLINKGVDG LFYLGTGGEF
60 70 80 90 100
SQMNTAQRMA LAEEAVTIVD GRVPVLIGVG SPSTDEAVKL AQHAQAYGAD
110 120 130 140 150
GIVAINPYYW KVAPRNLDDY YQQIARSVTL PVILYNFPDL TGQDLTPETV
160 170 180 190 200
TRLALQNENI VGIKDTIDSV GHLRTMINTV KSVRPSFSVF CGYDDHLLNT
210 220 230 240 250
MLLGGDGAIT ASANFAPELS VGIYRAWREG DLATAATLNK KLLQLPAIYA
260 270 280 290 300
LETPFVSLIK YSMQCVGLPV ETYCLPPILE ASEEAKDKVH VLLTAQGILP
V
Sequence cautioni
The sequence AAA97194 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U14003 Genomic DNA Translation: AAA97194.1 Different initiation. U00096 Genomic DNA Translation: AAC77254.2 AP009048 Genomic DNA Translation: BAE78289.1 |
PIRi | S56523 |
RefSeqi | NP_418718.4, NC_000913.3 WP_000714563.1, NZ_SSUV01000012.1 |
Genome annotation databases
EnsemblBacteriai | AAC77254; AAC77254; b4298 BAE78289; BAE78289; BAE78289 |
GeneIDi | 948825 |
KEGGi | ecj:JW5775 eco:b4298 |
PATRICi | fig|511145.12.peg.4434 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U14003 Genomic DNA Translation: AAA97194.1 Different initiation. U00096 Genomic DNA Translation: AAC77254.2 AP009048 Genomic DNA Translation: BAE78289.1 |
PIRi | S56523 |
RefSeqi | NP_418718.4, NC_000913.3 WP_000714563.1, NZ_SSUV01000012.1 |
3D structure databases
SMRi | P39359 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4260972, 5 interactors |
DIPi | DIP-12622N |
IntActi | P39359, 1 interactor |
STRINGi | 511145.b4298 |
Proteomic databases
PaxDbi | P39359 |
PRIDEi | P39359 |
Genome annotation databases
EnsemblBacteriai | AAC77254; AAC77254; b4298 BAE78289; BAE78289; BAE78289 |
GeneIDi | 948825 |
KEGGi | ecj:JW5775 eco:b4298 |
PATRICi | fig|511145.12.peg.4434 |
Organism-specific databases
EchoBASEi | EB2438 |
Phylogenomic databases
eggNOGi | COG0329, Bacteria |
HOGENOMi | CLU_049343_5_1_6 |
InParanoidi | P39359 |
PhylomeDBi | P39359 |
Enzyme and pathway databases
BioCyci | EcoCyc:G7911-MONOMER |
Miscellaneous databases
PROi | PR:P39359 |
Family and domain databases
Gene3Di | 3.20.20.70, 1 hit |
InterProi | View protein in InterPro IPR013785, Aldolase_TIM IPR002220, DapA-like IPR020625, Schiff_base-form_aldolases_AS IPR020624, Schiff_base-form_aldolases_CS |
PANTHERi | PTHR12128, PTHR12128, 1 hit |
Pfami | View protein in Pfam PF00701, DHDPS, 1 hit |
PIRSFi | PIRSF001365, DHDPS, 1 hit |
PRINTSi | PR00146, DHPICSNTHASE |
SMARTi | View protein in SMART SM01130, DHDPS, 1 hit |
PROSITEi | View protein in PROSITE PS00665, DHDPS_1, 1 hit PS00666, DHDPS_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | YJHH_ECOLI | |
Accessioni | P39359Primary (citable) accession number: P39359 Secondary accession number(s): Q2M617 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | May 30, 2000 | |
Last modified: | February 23, 2022 | |
This is version 146 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families