UniProtKB - P39344 (IDNT_ECOLI)
Protein
Gnt-II system L-idonate transporter
Gene
idnT
Organism
Escherichia coli (strain K12)
Status
Functioni
Transports L-idonate, D-gluconate and 5-keto-D-gluconate, from the periplasm across the inner membrane.2 Publications
: L-idonate degradation Pathwayi
This protein is involved in the pathway L-idonate degradation, which is part of Carbohydrate acid metabolism.View all proteins of this organism that are known to be involved in the pathway L-idonate degradation and in Carbohydrate acid metabolism.
GO - Molecular functioni
- gluconate transmembrane transporter activity Source: EcoCyc
- L-idonate transmembrane transporter activity Source: EcoCyc
GO - Biological processi
- carbohydrate transport Source: EcoCyc
- D-gluconate metabolic process Source: UniProtKB-KW
- gluconate transmembrane transport Source: GO_Central
- L-idonate catabolic process Source: UniProtKB-UniPathway
- L-idonate transmembrane transport Source: EcoCyc
Keywordsi
Biological process | Gluconate utilization, Sugar transport, Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:YJGT-MONOMER MetaCyc:YJGT-MONOMER |
UniPathwayi | UPA00793 |
Protein family/group databases
TCDBi | 2.A.8.1.2, the gluconate:h(+) symporter (gntp) family |
Names & Taxonomyi
Protein namesi | Recommended name: Gnt-II system L-idonate transporterShort name: L-Ido transporter Alternative name(s): 5-keto-D-gluconate transporter |
Gene namesi | Name:idnT Synonyms:gntW, yjgT Ordered Locus Names:b4265, JW4222 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 | PeriplasmicSequence analysis | 1 | |
Transmembranei | 2 – 22 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 23 – 24 | CytoplasmicSequence analysis | 2 | |
Transmembranei | 25 – 45 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 46 – 51 | PeriplasmicSequence analysis | 6 | |
Transmembranei | 52 – 72 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 73 – 105 | CytoplasmicSequence analysisAdd BLAST | 33 | |
Transmembranei | 106 – 126 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 127 – 147 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 148 – 151 | CytoplasmicSequence analysis | 4 | |
Transmembranei | 152 – 172 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 173 – 193 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 194 – 225 | CytoplasmicSequence analysisAdd BLAST | 32 | |
Transmembranei | 226 – 246 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 247 – 254 | PeriplasmicSequence analysis | 8 | |
Transmembranei | 255 – 275 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 276 – 290 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 291 – 311 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 312 – 326 | PeriplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 327 – 347 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 348 | CytoplasmicSequence analysis | 1 | |
Transmembranei | 349 – 369 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 370 | PeriplasmicSequence analysis | 1 | |
Transmembranei | 371 – 391 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 392 – 417 | CytoplasmicSequence analysisAdd BLAST | 26 | |
Transmembranei | 418 – 438 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 439 | PeriplasmicSequence analysis | 1 |
GO - Cellular componenti
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: EcoCyc
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
Reduced growth rate when grown on 5-keto-D-gluconate as sole carbon source.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000061940 | 1 – 439 | Gnt-II system L-idonate transporterAdd BLAST | 439 |
Proteomic databases
PaxDbi | P39344 |
PRIDEi | P39344 |
Expressioni
Inductioni
Up-regulated by 5-keto-D-gluconate.1 Publication
Interactioni
Protein-protein interaction databases
BioGRIDi | 4262729, 6 interactors |
DIPi | DIP-10014N |
IntActi | P39344, 1 interactor |
STRINGi | 511145.b4265 |
Family & Domainsi
Sequence similaritiesi
Belongs to the GntP permease family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG2610, Bacteria |
HOGENOMi | CLU_027949_0_0_6 |
InParanoidi | P39344 |
PhylomeDBi | P39344 |
Family and domain databases
InterProi | View protein in InterPro IPR003474, Glcn_transporter |
PANTHERi | PTHR30354, PTHR30354, 1 hit |
Pfami | View protein in Pfam PF02447, GntP_permease, 1 hit |
PIRSFi | PIRSF002746, Gluconate_transporter, 1 hit |
TIGRFAMsi | TIGR00791, gntP, 1 hit |
i Sequence
Sequence statusi: Complete.
P39344-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPLIIIAAGV ALLLILMIGF KVNGFIALVL VAAVVGFAEG MDAQAVLHSI
60 70 80 90 100
QNGIGSTLGG LAMILGFGAM LGKLISDTGA AQRIATTLIA TFGKKRVQWA
110 120 130 140 150
LVITGLVVGL AMFFEVGFVL LLPLVFTIVA SSGLPLLYVG VPMVAALSVT
160 170 180 190 200
HCFLPPHPGP TAIATIFEAN LGTTLLYGFI ITIPTVIVAG PLFSKLLTRF
210 220 230 240 250
EKAPPEGLFN PHLFSEEEMP SFWNSIFAAV IPVILMAIAA VCEITLPKTN
260 270 280 290 300
TVRLFFEFVG NPAVALFIAI VIAIFTLGRR NGRTIEQIMD IIGDSIGAIA
310 320 330 340 350
MIVFIIAGGG AFKQVLVDSG VGHYISHLMT GTTLSPLLMC WTVAALLRIA
360 370 380 390 400
LGSATVAAIT TAGVVLPIIN VTHADPALMV LATGAGSVIA SHVNDPGFWL
410 420 430
FKGYFNLTVG ETLRTWTVME TLISIMGLLG VLAINAVLH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U14003 Genomic DNA Translation: AAA97162.1 U00096 Genomic DNA Translation: AAC77222.1 AP009048 Genomic DNA Translation: BAE78262.1 |
PIRi | S56491 |
RefSeqi | NP_418686.1, NC_000913.3 WP_001128335.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC77222; AAC77222; b4265 BAE78262; BAE78262; BAE78262 |
GeneIDi | 948798 |
KEGGi | ecj:JW4222 eco:b4265 |
PATRICi | fig|1411691.4.peg.2438 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U14003 Genomic DNA Translation: AAA97162.1 U00096 Genomic DNA Translation: AAC77222.1 AP009048 Genomic DNA Translation: BAE78262.1 |
PIRi | S56491 |
RefSeqi | NP_418686.1, NC_000913.3 WP_001128335.1, NZ_LN832404.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4262729, 6 interactors |
DIPi | DIP-10014N |
IntActi | P39344, 1 interactor |
STRINGi | 511145.b4265 |
Protein family/group databases
TCDBi | 2.A.8.1.2, the gluconate:h(+) symporter (gntp) family |
Proteomic databases
PaxDbi | P39344 |
PRIDEi | P39344 |
Protocols and materials databases
DNASUi | 948798 |
Genome annotation databases
EnsemblBacteriai | AAC77222; AAC77222; b4265 BAE78262; BAE78262; BAE78262 |
GeneIDi | 948798 |
KEGGi | ecj:JW4222 eco:b4265 |
PATRICi | fig|1411691.4.peg.2438 |
Organism-specific databases
EchoBASEi | EB2428 |
Phylogenomic databases
eggNOGi | COG2610, Bacteria |
HOGENOMi | CLU_027949_0_0_6 |
InParanoidi | P39344 |
PhylomeDBi | P39344 |
Enzyme and pathway databases
UniPathwayi | UPA00793 |
BioCyci | EcoCyc:YJGT-MONOMER MetaCyc:YJGT-MONOMER |
Miscellaneous databases
PROi | PR:P39344 |
Family and domain databases
InterProi | View protein in InterPro IPR003474, Glcn_transporter |
PANTHERi | PTHR30354, PTHR30354, 1 hit |
Pfami | View protein in Pfam PF02447, GntP_permease, 1 hit |
PIRSFi | PIRSF002746, Gluconate_transporter, 1 hit |
TIGRFAMsi | TIGR00791, gntP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IDNT_ECOLI | |
Accessioni | P39344Primary (citable) accession number: P39344 Secondary accession number(s): Q2M644 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | December 2, 2020 | |
This is version 151 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families