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UniProtKB - P39344 (IDNT_ECOLI)

Entry version 151 (02 Dec 2020)
Sequence version 1 (01 Feb 1995)
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Protein

Gnt-II system L-idonate transporter

Gene

idnT

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transports L-idonate, D-gluconate and 5-keto-D-gluconate, from the periplasm across the inner membrane.

2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-idonate degradation

This protein is involved in the pathway L-idonate degradation, which is part of Carbohydrate acid metabolism.
View all proteins of this organism that are known to be involved in the pathway L-idonate degradation and in Carbohydrate acid metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processGluconate utilization, Sugar transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:YJGT-MONOMER
MetaCyc:YJGT-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00793

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.8.1.2, the gluconate:h(+) symporter (gntp) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Gnt-II system L-idonate transporter
Short name:
L-Ido transporter
Alternative name(s):
5-keto-D-gluconate transporter
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:idnT
Synonyms:gntW, yjgT
Ordered Locus Names:b4265, JW4222
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1PeriplasmicSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2 – 22HelicalSequence analysisAdd BLAST21
Topological domaini23 – 24CytoplasmicSequence analysis2
Transmembranei25 – 45HelicalSequence analysisAdd BLAST21
Topological domaini46 – 51PeriplasmicSequence analysis6
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Topological domaini73 – 105CytoplasmicSequence analysisAdd BLAST33
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Transmembranei127 – 147HelicalSequence analysisAdd BLAST21
Topological domaini148 – 151CytoplasmicSequence analysis4
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Topological domaini194 – 225CytoplasmicSequence analysisAdd BLAST32
Transmembranei226 – 246HelicalSequence analysisAdd BLAST21
Topological domaini247 – 254PeriplasmicSequence analysis8
Transmembranei255 – 275HelicalSequence analysisAdd BLAST21
Topological domaini276 – 290CytoplasmicSequence analysisAdd BLAST15
Transmembranei291 – 311HelicalSequence analysisAdd BLAST21
Topological domaini312 – 326PeriplasmicSequence analysisAdd BLAST15
Transmembranei327 – 347HelicalSequence analysisAdd BLAST21
Topological domaini348CytoplasmicSequence analysis1
Transmembranei349 – 369HelicalSequence analysisAdd BLAST21
Topological domaini370PeriplasmicSequence analysis1
Transmembranei371 – 391HelicalSequence analysisAdd BLAST21
Topological domaini392 – 417CytoplasmicSequence analysisAdd BLAST26
Transmembranei418 – 438HelicalSequence analysisAdd BLAST21
Topological domaini439PeriplasmicSequence analysis1

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Reduced growth rate when grown on 5-keto-D-gluconate as sole carbon source.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000619401 – 439Gnt-II system L-idonate transporterAdd BLAST439

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P39344

PRoteomics IDEntifications database

More...PRIDEi		P39344

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by 5-keto-D-gluconate.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4262729, 6 interactors

Database of interacting proteins

More...DIPi		DIP-10014N

Protein interaction database and analysis system

More...IntActi		P39344, 1 interactor

STRING: functional protein association networks

More...STRINGi		511145.b4265

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GntP permease family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG2610, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_027949_0_0_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P39344

Database for complete collections of gene phylogenies

More...PhylomeDBi		P39344

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003474, Glcn_transporter

The PANTHER Classification System

More...PANTHERi		PTHR30354, PTHR30354, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02447, GntP_permease, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF002746, Gluconate_transporter, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00791, gntP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P39344-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLIIIAAGV ALLLILMIGF KVNGFIALVL VAAVVGFAEG MDAQAVLHSI 
        60         70         80         90        100
QNGIGSTLGG LAMILGFGAM LGKLISDTGA AQRIATTLIA TFGKKRVQWA 
       110        120        130        140        150
LVITGLVVGL AMFFEVGFVL LLPLVFTIVA SSGLPLLYVG VPMVAALSVT 
       160        170        180        190        200
HCFLPPHPGP TAIATIFEAN LGTTLLYGFI ITIPTVIVAG PLFSKLLTRF 
       210        220        230        240        250
EKAPPEGLFN PHLFSEEEMP SFWNSIFAAV IPVILMAIAA VCEITLPKTN 
       260        270        280        290        300
TVRLFFEFVG NPAVALFIAI VIAIFTLGRR NGRTIEQIMD IIGDSIGAIA 
       310        320        330        340        350
MIVFIIAGGG AFKQVLVDSG VGHYISHLMT GTTLSPLLMC WTVAALLRIA 
       360        370        380        390        400
LGSATVAAIT TAGVVLPIIN VTHADPALMV LATGAGSVIA SHVNDPGFWL 
       410        420        430 
FKGYFNLTVG ETLRTWTVME TLISIMGLLG VLAINAVLH
Length:439
Mass (Da):46,041
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEA6CBCA88D6C042C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U14003 Genomic DNA Translation: AAA97162.1
U00096 Genomic DNA Translation: AAC77222.1
AP009048 Genomic DNA Translation: BAE78262.1

Protein sequence database of the Protein Information Resource

More...PIRi		S56491

NCBI Reference Sequences

More...RefSeqi		NP_418686.1, NC_000913.3
WP_001128335.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC77222; AAC77222; b4265
BAE78262; BAE78262; BAE78262

Database of genes from NCBI RefSeq genomes

More...GeneIDi		948798

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW4222
eco:b4265

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.2438

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA Translation: AAA97162.1
U00096 Genomic DNA Translation: AAC77222.1
AP009048 Genomic DNA Translation: BAE78262.1
PIRiS56491
RefSeqiNP_418686.1, NC_000913.3
WP_001128335.1, NZ_LN832404.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi4262729, 6 interactors
DIPiDIP-10014N
IntActiP39344, 1 interactor
STRINGi511145.b4265

Protein family/group databases

TCDBi2.A.8.1.2, the gluconate:h(+) symporter (gntp) family

Proteomic databases

PaxDbiP39344
PRIDEiP39344

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		948798

Genome annotation databases

EnsemblBacteriaiAAC77222; AAC77222; b4265
BAE78262; BAE78262; BAE78262
GeneIDi948798
KEGGiecj:JW4222
eco:b4265
PATRICifig|1411691.4.peg.2438

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB2428

Phylogenomic databases

eggNOGiCOG2610, Bacteria
HOGENOMiCLU_027949_0_0_6
InParanoidiP39344
PhylomeDBiP39344

Enzyme and pathway databases

UniPathwayiUPA00793
BioCyciEcoCyc:YJGT-MONOMER
MetaCyc:YJGT-MONOMER

Miscellaneous databases

Protein Ontology

More...PROi		PR:P39344

Family and domain databases

InterProiView protein in InterPro
IPR003474, Glcn_transporter
PANTHERiPTHR30354, PTHR30354, 1 hit
PfamiView protein in Pfam
PF02447, GntP_permease, 1 hit
PIRSFiPIRSF002746, Gluconate_transporter, 1 hit
TIGRFAMsiTIGR00791, gntP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIDNT_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P39344
Secondary accession number(s): Q2M644
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: December 2, 2020
This is version 151 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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